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Pertaining
Kinds of Pertaining Selected AbstractsGuidelines for treatment of neonatal jaundice.ACTA PAEDIATRICA, Issue 3 2001Is there a place for evidence-based medicine? Treatment of neonatal jaundice continues to be a controversial issue. Arguments that traditional practice results in over-treatment have led to the adoption of more liberal guidelines in some countries. The importation of liberal guidelines from one country to the next, however, is fraught with danger, because differences in epidemiology, sociology and healthcare delivery systems between countries may not be adequately reflected. The unreflected extension of liberalization to non-target groups of patients can expose the latter to significant risk. It is not clear that the evidence on which guidelines for treatment of neonatal jaundice are based satisfy the requirements for evidence-based medicine. Evidence of adequate quality may be hard to obtain. Conclusions: Introduction of more liberal guidelines for the treatment of neonatal jaundice, if at all contemplated, must be adapted to local circumstances, and any available evidence pertaining to local epidemiology, sociology and healthcare organization has to be carefully weighed and incorporated. The time is ripe for a joint international effort to secure adequate funding for basic and applied research within the mechanisms of bilirubin encephalopathy in the newborn. [source] The Green Onion: a corporate environmental strategy frameworkCORPORATE SOCIAL RESPONSIBILITY AND ENVIRONMENTAL MANAGEMENT, Issue 5 2010Scott Victor Valentine Abstract Since the 1990s, there has been a proliferation of research exploring the benefits of proactive corporate environmental management initiatives. Unfortunately, the absence of a comprehensive, strategic planning framework relegates much of this valuable research to a study of good ideas for making money while operating more sustainably. This paper presents a framework for guiding corporate environmental strategy to bring order to existing observations and allow social scientists to begin the process of ,orderly control and prediction'. The research is based on modified grounded theory and an extensive literature review pertaining to the benefits of corporate environmental management. The framework has been named the ,Green Onion' to highlight the multiple strategic layers of influence uncovered and the importance of retaining resilient outer layers (i.e., stakeholder management) to protect the highly potent core of functional environmental management initiatives (i.e., cost saving initiatives). Copyright © 2009 John Wiley & Sons, Ltd and ERP Environment. [source] Understanding sexual offending in schizophreniaCRIMINAL BEHAVIOUR AND MENTAL HEALTH, Issue 2 2004Christopher R. Drake M Clin Psych MAPS Background Studies have found an elevated incidence of violent sexual offences in males with schizophrenia. The relationship between sexual offending and psychiatric illness is, however, complex and poorly defined. Aims The aim of the present article is to delineate possible mechanisms that underlie offensive sexual behaviour in schizophrenia that can be used as a framework for assessing and treating these behaviours. A review of research pertaining to the aetiology of sexual deviance in schizophrenia was conducted, focusing in particular on the role of early childhood experiences, deviant sexual preferences, antisocial personality traits, psychiatric symptomatology and associated treatment effects, the impact of mental illness on sexual and social functioning, and other potential contributory factors. Towards a typology It is proposed that schizophrenic patients who engage in sexually offensive activities fall into four broad groups: (1) those with a pre-existing paraphilia; (2) those whose deviant sexuality arises in the context of illness and/or its treatment; (3) those whose deviant sexuality is one manifestation of more generalized antisocial behaviour, and (4) factors other than the above. This classification provides a useful framework for evaluating and treating sexually offensive behaviours in schizophrenic patients. Copyright © 2004 Whurr Publishers Ltd. [source] Bacteria of asymptomatic periradicular endodontic lesions identified by DNA-DNA hybridizationDENTAL TRAUMATOLOGY, Issue 5 2000J. J. Gatti Abstract , Possible inclusion of contaminant bacteria during surgery has been problematic in studies of periradicular lesions of endodontic origin. Therefore, in this study, two different surgical techniques were compared. A second problem is that some difficult to cultivate species may not be detected using bacteriological methods. Molecular techniques may resolve this problem. DNA-DNA hybridization technology has the additional advantage that DNA is not amplified. The purpose of this investigation was to determine if bacteria from periradicular endodontic lesions could be identified using DNA-DNA hybridization. A full thickness intrasulcular mucoperiosteal (IS) flap (n=20) or a submarginal (SM) flap (n=16) was reflected in patients with asymptomatic apical periodontitis. DNA was extracted and incubated with 40 digoxigenin-labeled whole genomic probes. Bacterial DNA was detected in all 36 lesions. Seven probes were negative for all lesions. In patients with sinus tract communication, in teeth lacking intact full coverage crowns, and in patients with a history of trauma, 4,13 probes provided positive signals. Seven probes were positive in lesions obtained by the IS, but not the SM technique. Two probes were in samples obtained with the SM technique, but not the IS. Only Bacteroides forsythus and Actinomyces naeslundii genospecies 2 were present in large numbers using either the IS or the SM technique. The SM flap technique, in combination with DNA-DNA hybridization, appeared to provide excellent data pertaining to periradicular bacteria. These results supported other studies that provide evidence of a bacterial presence and persistence in periradicular lesions. [source] Enhancing the Growth of Natural Eyelashes: The Mechanism of Bimatoprost-Induced Eyelash GrowthDERMATOLOGIC SURGERY, Issue 9 20102Article first published online: 2 APR 2010, JOEL L. COHEN MD BACKGROUND Many women desire prominent eyelashes. In December 2008, bimatoprost ophthalmic solution 0.03% was approved for the treatment of hypotrichosis of the eyelashes in the United States. OBJECTIVE To review eyelash physiology and the proposed mechanisms by which the topical pros-tamide product bimatoprost enhances eyelash growth. METHODS AND MATERIALS Clinical and preclinical studies pertaining to the efficacy, safety, and mechanisms of action of bimatoprost are presented. RESULTS Treatment with bimatoprost increases the percentage of eyelash follicles in anagen at any one time. This probably accounts for its ability to lengthen lashes. Bimatoprost-induced stimulation of melanogenesis appears to result in darker lashes and, at the same time, appears to increase the size of the dermal papilla and hair bulb, affecting lash thickness and fullness. Such effects, largely demonstrated in animal studies, are consistent with the results of a recent Food and Drug Administration phase III clinical trial. The favorable safety profile of bimatoprost in human subjects is probably secondary to the limited exposure of ocular tissues resulting from topical application at the base of the upper lashes. CONCLUSION By influencing the eyelash hair cycle and follicles, bimatoprost ophthalmic solution 0.03% is a safe and effective means of enhancing eyelash growth. Dr. Cohen has served as a consultant and clinical trial participant for Allergan, Inc. [source] Mania associated with antidepressant treatment: comprehensive meta-analytic reviewACTA PSYCHIATRICA SCANDINAVICA, Issue 6 2010L. Tondo Tondo L, Vázquez G, Baldessarini RJ. Mania associated with antidepressant treatment: comprehensive meta-analytic review. Objective:, To review available data pertaining to risk of mania,hypomania among bipolar (BPD) and major depressive disorder (MDD) patients with vs. without exposure to antidepressant drugs (ADs) and consider effects of mood stabilizers. Method:, Computerized searching yielded 73 reports (109 trials, 114 521 adult patients); 35 were suitable for random effects meta-analysis, and multivariate-regression modeling included all available trials to test for effects of trial design, AD type, and mood-stabilizer use. Results:, The overall risk of mania with/without ADs averaged 12.5%/7.5%. The AD-associated mania was more frequent in BPD than MDD patients, but increased more in MDD cases. Tricyclic antidepressants were riskier than serotonin-reuptake inhibitors (SRIs); data for other types of ADs were inconclusive. Mood stabilizers had minor effects probably confounded by their preferential use in mania-prone patients. Conclusion:, Use of ADs in adults with BPD or MDD was highly prevalent and moderately increased the risk of mania overall, with little protection by mood stabilizers. [source] Treatment of Vitiligo on Difficult-to-Treat Sites Using Autologous Noncultured Cellular GraftingDERMATOLOGIC SURGERY, Issue 1 2009SANJEEV V. MULEKAR MD BACKGROUND Because of the limitations of medical treatment, various surgical therapies have been developed and are being accepted to treat vitiligo. However, certain areas such as the fingers and toes, palms and soles, lips, eyelids, nipples and areolas, elbows and knees, and genitals are considered difficult-to-treat areas. OBJECTIVE To evaluate data pertaining to individual sites considered to be difficult to treat and highlight that noncultured melanocyte,keratinocyte transplantation (MKT) does not require any special precautions to treat these anatomical sites. METHODS AND MATERIALS Forty patients (13 male and 27 female) with bilateral vitiligo and nine (4 male and 5 female) with unilateral vitiligo were treated using noncultured MKT, for "difficult-to-treat" sites at the National Center for Vitiligo and Psoriasis, Riyadh, Saudi Arabia, and were analyzed for response according to region. Repigmentation was graded as excellent with 95% to 100% pigmentation, good with 65% to 94%, fair with 25% to 64%, and poor with 0% to 24% of the treated area. RESULTS For bilateral vitiligo, more than 50% of patients treated for difficult sites showed more than 65% repigmentation of the treated areas. For unilateral vitiligo, all of the patients except for two treated for the eyelids showed more than 65% repigmentation of the treated area. CONCLUSIONS The concept of a "difficult-to-treat site" is a relative term and depends upon the technique used. The noncultured MKT does not require any special precautions to treat these anatomical sites. This review may help physicians to change the concept of "difficult-to-treat site." [source] Why Are There Differences in the Perceived Safety of Office-Based Surgery?DERMATOLOGIC SURGERY, Issue 11 2004John G. Hancox MD Background. Office-based surgery has become an important method of health-care delivery, but there is controversy about its safety and which practitioners should perform it. Several states have already or are preparing to enact legislation regulating office-based surgery. Objective. The objective was to discuss recent literature pertaining to the safety of office surgery and to discuss reasons why there are perceived differences in its safety. Methods. The pertinent literature is reviewed. Results. The majority of studies suggest that office surgery is safe. A recent study that found to the contrary may have methodologic flaws. Conclusion. The medical and legislative community should seek to scientifically examine office surgery. Overregulation or loss of office surgery would have a tremendous impact on the management of skin cancers and the delivery of quality cosmetic and laser surgery. [source] Therapy of other viral infections: herpes to hepatitisDERMATOLOGIC THERAPY, Issue 6 2004Arun Chakrabarty ABSTRACT:, Over the past several years, there has been an increase in knowledge pertaining to the diagnosis and management strategies for the herpes family (Types 1,8), the pox viruses, mumps, measles, rubella, and parvovirus B19 as well as the viral etiologies of hepatitis. Various antiviral treatments, such as nucleoside analogs and interferon therapy, have been available to reduce the signs and symptoms of these common viral infections. This article summarizes the preferred treatment strategies to be employed for each of the viruses for reducing severity, duration, recurrences (notably in the herpes family), transmission rates, as well as preventive alternatives. The majority of the therapeutic options attenuate the course of disease. Treatment decisions are driven by knowledge of the natural history and often are tailored to incorporate clinical circumstances for individual patients. Promotion of community awareness and the development of vaccines should be emphasized in the battle against these common viruses, particularly the herpes simplex viruses, the pox viruses, and hepatitis B. [source] Activity-based restorative therapies: Concepts and applications in spinal cord injury-related neurorehabilitationDEVELOPMENTAL DISABILITIES RESEARCH REVIEW, Issue 2 2009Cristina L. Sadowsky Abstract Physical rehabilitation following spinal cord injury-related paralysis has traditionally focused on teaching compensatory techniques, thus enabling the individual to achieve day-to-day function despite significant neurological deficits. But the concept of an irreparable central nervous system (CNS) is slowly being replaced with evidence related to CNS plasticity, repair, and regeneration, all related to persistently maintaining appropriate levels of neurological activity both below and above the area where the damage occurred. It is now possible to envision functional repair of the nervous system by implementing rehabilitative interventions. Making the transition from "bench to bedside" requires careful analysis of existing basic science evidence, strategic focus of clinical research, and pragmatic implementation of new therapeutic tools. Activity, defined as both function specific motor task and exercise appears to be a necessity for optimization of functional, metabolic, and neurological status in chronic paralysis. Crafting a comprehensive rehabilitative intervention focused on functional improvement through neurological gains seems logical. The terms activity-based restorative therapies, activity-based therapies, and activity-based rehabilitation have been coined in the last 10 years to describe a new fundamental approach to deficits induced by neurological paralysis. The goal of this approach is to achieve activation of the neurological levels located both above and below the injury level using rehabilitation therapies. This article reviews basic and clinical science evidence pertaining to implementation of physical activity and exercise as a therapeutic tool in the management of chronic spinal cord-related neurological paralysis. © 2009 Wiley-Liss, Inc. Dev Disabil Res Rev 2009;15:112,116. [source] Disease, deficit or denial?ACTA PSYCHIATRICA SCANDINAVICA, Issue 1 2005Models of poor insight in psychosis Objective:, To examine the evidence for the three kinds of aetiological model that dominate the current literature on poor insight in psychosis: clinical models, the neuropsychological model, and the psychological denial model. Method:, Studies pertaining to one or more of these aetiological models were identified, reviewed and critically evaluated. Results:, There is little support for clinical models, partly because they lack testable hypotheses. Several studies reveal a positive relationship between insight and executive function, which may be related to frontal lobe dysfunction. However, the extent to which this relationship is specific and independent of general cognitive impairment remains unclear. There is tentative evidence to support the psychological denial model. Recent data combining the latter two approaches suggest that multiple factors contribute to poor insight. Conclusion:, Integration of different aetiological models is necessary for a fuller understanding of insight in psychosis. Future research should assess multiple aetiological mechanisms in single investigations. [source] Autism and Asperger syndrome: coexistence with other clinical disordersACTA PSYCHIATRICA SCANDINAVICA, Issue 5 2000C. Gillberg and Objective: To provide a clinically useful analysis of the extent to which autism and Asperger syndrome coexist with other disorders. Method: Selective review of the literature detailing data pertaining to symptoms and disorders sometimes encountered in connection with autism or Asperger syndrome. Results: A large number of medical conditions, psychiatric disorders and behavioural and motor dyscontrol symptoms are associated with autism and Asperger syndrome. Conclusion: Comorbidity is to be expected in autism spectrum disorders , directly or indirectly. Comorbid conditions may be markers for underlying pathophysiology and suggest a more varied treatment approach. There is a great need for in-depth research into this area, meaning that the exclusion criteria of current diagnostic manuals, i.e. those that rule out a diagnosis of autism in some disorders, and a diagnosis of certain other disorders in autism may have to be revised. [source] The significance of a small, level-3 ,semi evacuation' hospital in a terrorist attack in a nearby townDISASTERS, Issue 3 2007Moshe Pinkert Terrorist attacks can occur in remote areas causing mass-casualty incidents MCIs far away from level-1 trauma centres. This study draws lessons from an MCI pertaining to the management of primary and secondary evacuation and the operational mode practiced. Data was collected from formal debriefings during and after the event, and the medical response, interactions and main outcomes analysed using Disastrous Incidents Systematic Analysis through Components, Interactions and Results (DISAST-CIR) methodology. A total of 112 people were evacuated from the scene,66 to the nearby level 3 Laniado hospital, including the eight critically and severely injured patients. Laniado hospital was instructed to act as an evacuation hospital but the flow of patients ended rapidly and it was decided to admit moderately injured victims. We introduce a novel concept of a ,semi-evacuation hospital'. This mode of operation should be selected for small-scale events in which the evacuation hospital has hospitalization capacity and is not geographically isolated. We suggest that level-3 hospitals in remote areas should be prepared and drilled to work in semi-evacuation mode during MCIs. [source] Rapid plant diversity assessment using a pixel nested plot design: A case study in Beaver Meadows, Rocky Mountain National Park, Colorado, USADIVERSITY AND DISTRIBUTIONS, Issue 4 2007Mohammed A. Kalkhan ABSTRACT Geospatial statistical modelling and thematic maps have recently emerged as effective tools for the management of natural areas at the landscape scale. Traditional methods for the collection of field data pertaining to questions of landscape were developed without consideration for the parameters of these applications. We introduce an alternative field sampling design based on smaller unbiased random plot and subplot locations called the pixel nested plot (PNP). We demonstrate the applicability of the PNP design of 15 m × 15 m to assess patterns of plant diversity and species richness across the landscape at Rocky Mountain National Park (RMNP), Colorado, USA in a time (cost)-efficient manner for field data collection. Our results produced comparable results to a previous study in the Beaver Meadow study (BMS) area within RMNP, where there was a demonstrated focus of plant diversity. Our study used the smaller PNP sampling design for field data collection which could be linked to geospatial information data and could be used for landscape-scale analyses and assessment applications. In 2003, we established 61 PNP in the eastern region of RMNP. We present a comparison between this approach using a sub-sample of 19 PNP from this data set and 20 of Modified Whittaker nested plots (MWNP) of 20 m × 50 m that were collected in the BMS area. The PNP captured 266 unique plant species while the MWNP captured 275 unique species. Based on a comparison of PNP and MWNP in the Beaver Meadows area, RMNP, the PNP required less time and area sampled to achieve a similar number of species sampled. Using the PNP approach for data collection can facilitate the ecological monitoring of these vulnerable areas at the landscape scale in a time- and therefore cost-effective manner. [source] Amount and controls of the quaternary denudation in the Ardennes massif (western Europe)EARTH SURFACE PROCESSES AND LANDFORMS, Issue 11 2009A. Demoulin Abstract It is still debated whether the primary control on the middle Pleistocene denudation of the uplifted Ardennes massif (western Europe) is tectonic or climatic. Here, based on geomorphological observations, we calculate the amount of river incision and interfluve denudation in the Meuse basin upstream of Maastricht since 0·7 Ma and we show that the main response to tectonic forcing was incision. This allows us to provide first-order estimates of the tectonic and climatic contributions to the denudation of the Ardennes. From a dataset of 71 remnants of a terrace level dated ,0·7 Ma, we first derive a basin-scale functional relationship linking incision with distances to the regional base level (Lc) and to the source (Ls) in the Ourthe basin (pertaining to the Ardennian part of the Meuse basin). Expressed as I = I0*(1 , a*Lcb/Lsc), I0 being the incision measured at the basin outlet, this relationship calculates that river incision has removed 84 km3 of rock in the Meuse basin upstream of Maastricht since 0·7 Ma. In the same time, 292 km3 were eroded from the interfluves. A comparison of these volumes shows that the tectonically forced river incision accounts for ,22% of the total post-0·7 Ma denudation. Furthermore, the mean denudation rate corresponding to our geomorphological estimate of the overall denudation in the Meuse basin since 0·7 Ma amounts to 27 mm/ky, a figure significantly lower than the ,40 mm/ky mean rate derived from 10Be studies of terrace deposits of the Meuse (Schaller et al., 2004). This suggests that, taken as a basin average, the 10Be-derived rate is overestimated, probably due to an overrepresentation of the erosion products of the rapidly incising valleys in the alluvial deposits. Copyright © 2009 John Wiley & Sons, Ltd. [source] Rock thermal data at the grain scale: applicability to granular disintegration in cold environmentsEARTH SURFACE PROCESSES AND LANDFORMS, Issue 8 2003Kevin Hall Abstract Consideration of the mechanisms associated with the granular disintegration of rock has been limited by available data. In most instances, both the size of the transducer and the nature of the study have negated any applicability of the resulting data to the understanding of grain-to-grain separation within rock. The application of microthermocouples (,0·15 mm diameter) and high-frequency logging (20 s intervals) at a taffoni site on southern Alexander Island and from a rock outcrop on Adelaide Island (Antarctica) provide new data pertaining to the thermal conditions, at the grain scale, of the rock surface. The results show that thermal changes (,T/t) can be very high, with values of 22 °C min,1 being recorded. Although available data indicate that there can be differences in frequency and magnitude of ,uctuations as a function of aspect, all aspects experienced some large magnitude (,2 °C min,1) ,uctuations. Further, in many instances, large thermal changes in more than one direction could occur within 1 min or in subsequent minutes. These data suggest that the surface grains experience rapidly changing stress ,elds that may, with time, effect fatigue at the grain boundaries; albedo differences between grains and the resulting thermal variations are thought to exacerbate this. The available data failed to show any indication of water freezing (an exotherm) and thus it is suggested that microgelivation may not play as large a role in granular breakdown as is often postulated for cold regions, and that in this dry, Antarctic region thermal stress may play a signi,cant role. Copyright © 2003 John Wiley & Sons, Ltd. [source] The role of soil in the collapse of 18 piers of Hanshin Expressway in the Kobe earthquakeEARTHQUAKE ENGINEERING AND STRUCTURAL DYNAMICS, Issue 5 2006George Mylonakis Abstract An investigation is presented of the collapse of a 630 m segment (Fukae section) of the elevated Hanshin Expressway during the 1995 Kobe earthquake. The earthquake has, from a geotechnical viewpoint, been associated with extensive liquefactions, lateral soil spreading, and damage to waterfront structures. Evidence is presented that soil,structure interaction (SSI) in non-liquefied ground played a detrimental role in the seismic performance of this major structure. The bridge consisted of single circular concrete piers monolithically connected to a concrete deck, founded on groups of 17 piles in layers of loose to dense sands and moderate to stiff clays. There were 18 spans in total, all of which suffered a spectacular pier failure and transverse overturning. Several factors associated with poor structural design have already been identified. The scope of this work is to extend the previous studies by investigating the role of soil in the collapse. The following issues are examined: (1) seismological and geotechnical information pertaining to the site; (2) free-field soil response; (3) response of foundation-superstructure system; (4) evaluation of results against earlier studies that did not consider SSI. Results indicate that the role of soil in the collapse was multiple: First, it modified the bedrock motion so that the frequency content of the resulting surface motion became disadvantageous for the particular structure. Second, the compliance of soil and foundation altered the vibrational characteristics of the bridge and moved it to a region of stronger response. Third, the compliance of the foundation increased the participation of the fundamental mode of the structure, inducing stronger response. It is shown that the increase in inelastic seismic demand in the piers may have exceeded 100% in comparison with piers fixed at the base. These conclusions contradict a widespread view of an always-beneficial role of seismic SSI. Copyright © 2005 John Wiley & Sons, Ltd. [source] Population Growth and the Environment in Africa: Local Informal Institutions, the Missing Link,ECONOMIC GEOGRAPHY, Issue 2 2002Valentina Mazzucato Abstract: Population and environment debates regarding Africa, whether Malthusian or Boserupian in nature, focus on population levels as the driving force behind the relationship between environment and society. This article argues, instead, that how people adjust to their rise in numbers is more important than are population levels. It focuses on the role of local informal institutions, such as land tenure systems, but also on customs, norms, and networks, and their change over time in mediating the relationship between people and the environment. The article is based on fieldwork conducted between 1995 and 1998 in the Sahelian and Sudano-Sahelian zones of Africa, as well as on a review of colonial documents pertaining to the area written in the first half of the twentieth century. The article concludes that adaptations made to local, informal institutions within the past century have enabled an environmentally sustainable land use within the context of a rising population and growing scarcity of natural resources. [source] Cover Picture: Electrophoresis 18'2009ELECTROPHORESIS, Issue 18 2009Article first published online: 17 SEP 200 Issue no. 18 is a special issue on "Miniaturization in Asia-Pacific". It has 25 contributions "covering a spectrum of topics pertaining to fundamentals, basic technologies, detection approaches and applications, and it is expected to reflect the rapid progress of up-to-date microfluidics research in the Asia-Pacific region." [source] Real-time monitoring of intracellular calcium dynamic mobilization of a single cardiomyocyte in a microfluidic chip pertaining to drug discoveryELECTROPHORESIS, Issue 24 2007Xiujun Li Abstract A microfluidic method for real-time quantitative measurement of cellular response pertaining to drug discovery is reported. This method is capable of multiple-step liquid delivery for measuring the drug response of a single cardiomyocyte, due to the improved cell retention by a newly designed chip. The chip, which consists of a cell-retention chamber with a weir structure, was fabricated just by a one-photomask microfabrication procedure followed by on-chip etching. This method differs from the conventional method, which uses two-mask photolithography to fabricate the microchannel (deep etch) and the weir structure (shallow etch). The dimensions of the weir structure have been predicted by a mathematical model, and confirmed by confocal microscopy. Using this microfluidic method, the dynamic [Ca2+]i mobilization in a single cardiomyocyte during its spontaneous contraction was quantified. Furthermore, we measured the cellular response of a cardiomyocyte on (i) a known cardiotonic agent (caffeine), (ii) a cardiotoxic chemotherapeutic drug (daunorubicin), and (iii) an herbal anticancer drug candidate , isoliquiritigenin (IQ) based on the fluorescent calcium measurement. It was found that IQ had produced a less pronounced effect on calcium mobilization of the cardiomyocytes whereas caffeine and daunorubicin had much stronger effects on the cells. These three experiments on cardiomyocytes pertaining to drug discovery were only possible after the improved cell retention provided by the new chip design (MV2) required for multiple-step real-time cellular analysis on a microchip, as compared with our old chip design (MV1). [source] Entrepreneurship Research on Network Processes: A Review and Ways ForwardENTREPRENEURSHIP THEORY AND PRACTICE, Issue 1 2010Susanna Slotte-Kock Although entrepreneurship research on networks has studied issues pertaining to network content, governance and structure, we believe it requires a greater understanding of network processes. In this paper, we review how the entrepreneurship literature interprets and applies the concept of process to the study of networks. This allows us to identify areas for future investigation. Our work is also informed by social network theory and research on dyadic interactions in business networks. The paper concludes by presenting a theoretical framework for conceptualizing and studying the various processes associated with network development. [source] Making It Happen: Beyond Theories of the Firm to Theories of Firm DesignENTREPRENEURSHIP THEORY AND PRACTICE, Issue 6 2004Saras D. Sarasvathy Current theories of the firm provide no explanation for entrepreneurial success except in terms of firm success. Even when the focus is on the entrepreneur, s/he is entirely cast as a bundle of traits/behaviors or heuristics/biases that serves to explain firm performance. In this article, I suggest putting the entrepreneur center stage, adopting an instrumental view of the firm. Drawing upon the work of Simon in symbolic cognition and Lakoff in semantic cognition, I explore how we can go beyond explanations based on economic forces and evolutionary adaptation to entrepreneurial effectuation; I end with specific research questions pertaining to firm design. [source] Interpreting sustainable development and societal utility in Norwegian GMO assessmentsENVIRONMENTAL POLICY AND GOVERNANCE, Issue 4 2008G. Kristin Rosendal Abstract This article examines the process of assessing applications for genetically modified (GM) crops or plants for import or commercial planting in Norway. GMO legislation in Norway is closely linked to the EU through the Agreement on the European Economic Area (EEA), to which Norway is a party. A central difference with the EU processes emanates from specific clauses in the Norwegian Gene Technology Act on ,sustainable development' and ,societal utility', which provide a potentially wider leverage for Norwegian authorities to turn down the applications. Research material indicates evidence of an increasingly restrictive practice in the Norwegian evaluations, raising the question of how this can be explained in the face of increasing global acceptance of GMOs. A related question is to what extent and how this result is affected by the trends in the EU. An increasingly restrictive practice may be explained by changes in the access structure to the evaluating body, or it may be due to learning and a growing acceptance of the precautionary principle in this sector. Third, a higher number of rejections may largely be associated with the interest structure pertaining to GMOs in Norway. Final decisions are pending and there are uncertainties concerning how Norwegian authorities will apply the specific criteria of the Gene Technology Act. Copyright © 2008 John Wiley & Sons, Ltd and ERP Environment. [source] The validity of self-reports of alcohol consumption: state of the science and challenges for researchADDICTION, Issue 2003Frances K. Del Boca ABSTRACT Aims To review three topics pertaining to the validity of alcohol self-reports: factors that influence response accuracy; the relative merits of different self-report approaches; and the utility of using alternative measures to confirm verbal reports. Findings Response behavior is influenced by the interaction of social context factors, respondent characteristics, and task attributes. Although research has advanced our knowledge about self-report methods, many questions remain unanswered. In particular, there is a need to investigate how task demands interact with different patterns of drinking behavior to affect response accuracy. There is also a continuing need to use multiple data sources to examine the extent of self-report response bias, and to determine whether it varies as a function of respondent characteristics or assessment timing. Conclusion Self-report methods offer a reliable and valid approach to measuring alcohol consumption. The accuracy of such methods, however, can be improved by research directed at understanding the processes involved in response behavior. [source] Competition on the London Stock ExchangeEUROPEAN FINANCIAL MANAGEMENT, Issue 4 2002Nicholas Taylor This paper investigates the determinants of the level of competition on the order,driven market organised by the London Stock Exchange. In contrast to previous empirical market microstructure studies, we treat the level of competition as an endogenous variable. The statistical nature of the measures of competitive activity used in this paper necessitate use of a count regression model. Using a sample 50 stocks, we find that users of the system tend to follow the lead of other users (termed the ,herding effect') and that competition is greater during the period when the US exchanges are open (termed the ,US effect'). In addition, the level of competition is positively related to the bid,ask spread pertaining to a particular stock (termed the ,spread effect'). The latter result is most likely due to traders following a strategy where trade immediacy is traded off against price advantage. Finally, we find that the magnitude of the herding effect, the spread effect, and the fit of the count regression models (termed the ,fit effect') vary in a predictable manner across the liquidity of stocks. [source] Researching Quality in Emergency MedicineACADEMIC EMERGENCY MEDICINE, Issue 11 2002Kenneth E. Bizovi MD Research aimed at promoting quality of medical care must be quality research. This paper addresses issues of study design that can affect the validity of such research. The authors draw on previous research about medical errors,recognizing that issues of study design pertaining to medical errors apply to other research on quality of care and, indeed, to clinical research in general. The November 2000 Special Issue of Academic Emergency Medicine addressed medical errors in emergency medicine. In that issue, Kyriacou and Coben described three categories of research on medical errors: 1) research aimed at describing the magnitude of the problem; 2) research identifying causal factors for medical errors; and 3) research evaluating interventions aimed at improving quality of care. These three categories correspond to research methodologies that are, respectively, 1) descriptive; 2) qualitative; and 3) analytic. This article discusses challenges to the validity of each type of research and suggests some possible solutions to these problems. In addition, the article reviews projects that illustrate important issues in research quality. Three research projects are discussed: 1) a published project evaluating an intervention aimed at improving quality; 2) a quality improvement project that is transformed into a research project; and 3) a quality monitoring research project that exemplifies how a statistical technique borrowed from industry can offer a unique solution to quality challenges in medicine. Each of these projects demonstrates some of the challenges in researching quality and their solutions. [source] Clinical application of neurotrophic factors: the potential for primary auditory neuron protectionEUROPEAN JOURNAL OF NEUROSCIENCE, Issue 9 2005Lisa N. Gillespie Abstract Sensorineural hearing loss, as a result of damage to or destruction of the sensory epithelia within the cochlea, is a common cause of deafness. The subsequent degeneration of the neural elements within the inner ear may impinge upon the efficacy of the cochlear implant. Experimental studies have demonstrated that neurotrophic factors can prevent this degeneration in animal models of deafness, and can even provide functional benefits. Neurotrophic factor therapy may therefore provide similar protective effects in humans, resulting in improved speech perception outcomes among cochlear implant patients. There are, however, numerous issues pertaining to delivery techniques and treatment regimes that need to be addressed prior to any clinical application. This review considers these issues in view of the potential therapeutic application of neurotrophic factors within the auditory system. [source] That Which Makes the Sensation of Blue a Mental Fact: Moore on Phenomenal RelationismEUROPEAN JOURNAL OF PHILOSOPHY, Issue 3 2007Benj Hellie A gift of a dollar for each article in the philosophy of perception and consciousness published since 1990 making reference, explicitly or implicitly, to Moore's discussion in the second half of Moore 19031 of an alleged ,transparency' and ,diaphanousness' pertaining to some aspect of perceptual experience would very likely cover the tab of a mid-priced dinner for two.2 Moore's poetically expressed observations have captured the imagination of contemporary philosophers of perception and consciousness, and have served as the basis of much fruitful discussion in those areas. Still, despite all the attention these observations have received, the contemporary literature lacks a close reading of the second half of Moore's paper, without which it is impossible to understand Moore's observations in the context in which they were originally expressed. It is understandable that such a close reading is lacking: the second half of Moore's paper has been rightly described by one of his most sympathetic and dedicated interpreters as ,extremely dense and opaque' (Klemke 2000: 55).3 But despite the evident difficulties of the task, I aim here, with some trepidation, to provide the missing close reading. The main points of my interpretation will be these. The centerpiece of the anti-idealist manoeuvrings of the second half of the paper is a phenomenological argument for what I will call a relational view of perceptual phenomenal character, on which, roughly, ,that which makes the sensation of blue a mental fact' is a relation of conscious awareness, a view close to the opposite of the most characteristic contemporary view going under the transparency rubric.4 The discussion of transparency and diaphanousness is a sidelight, its principal purpose to shore up the main line of argumentation against criticism; in those passages all Moore argues is that the relation of conscious awareness is not transparent, while acknowledging that it can seem to be. My discussion will proceed as follows. In section 1, I will discuss some theses and elucidate some notions from the philosophy of perception and consciousness which will be central to my interpretation; having done so, I will be in a position to explain how an accurate understanding of Moore may contribute to theoretical advances in the philosophy of perception and consciousness. The next two sections contain the exegetical heart of the paper: section 2 provides an analysis of Moore's case for the relational view; section 3 attempts to explain the place of the relational view in the overall refutation of idealism. Section 4 critically discusses a pair of competing interpretations. Section 5 wraps things up, drawing concluding morals as to the campaigns on behalf of which Moore should and should not be enlisted. [source] Migrant mobilization between political institutions and citizenship regimes: A comparison of France and SwitzerlandEUROPEAN JOURNAL OF POLITICAL RESEARCH, Issue 1 2004Marco Giugni This article focuses on the political claims made by immigrants and ethnic minorities in France and Switzerland. We look at cross-national variations in the overall presence of immigrants and ethnic minorities in the national public space, and the forms and content of their claims. Following a political opportunity approach, we argue that claim-making is affected both by institutional opportunities and by national models of citizenship. The civic-assimilationist conception of citizenship in France gives migrants greater legitimacy to intervene in the national public space. Furthermore, the inclusive definition of ,membership in the national community' favors claims pertaining to minority integration politics. However, the pressure toward assimilation to the republican norms and values tends to provoke claims for the recognition of ethnic and cultural difference. Finally, closed institutional opportunities push migrants' mobilization to become more radical, but at the same time the more inclusive model of citizenship favors a moderate action repertoire of migrants. Conversely, the ethnic-assimilationist view in Switzerland leads migrants to stress homeland-related claims. When they do address the policy field of ethnic relations, immigration and citizenship, they focus on issues pertaining to the entry and stay in the host society. Finally, the forms of action are more moderate due to the more open institutional context, but at the same time the action repertoire of migrants is moderated by the more exclusive model of citizenship. Our article is an attempt to specify the concept of ,political opportunity structure', and to combine institutional and cultural factors in explaining claim-making by immigrants and ethnic minorities. We confront our arguments with data from a comparative project on the mobilization on ethnic relations, citizenship and immigration. [source] Evidence for canalization of Distal-less function in the leg of Drosophila melanogasterEVOLUTION AND DEVELOPMENT, Issue 2 2005Ian Dworkin Summary A considerable body of theory pertaining to the evolution of canalization has emerged recently, yet there have been few empirical investigations of their predictions. To address this, patterns of canalization and trait correlation were investigated under the individual and joint effects of the introgression of a loss-of-function allele of the Distal-less gene and high-temperature stress on a panel of iso-female lines. Variation was examined for number of sex comb teeth and the length of the basi-tarsus on the pro-thoracic leg of male Drosophila melanogaster. I demonstrate that whereas there is evidence for trait canalization, there is no evidence to support the hypothesis of the evolution of genetic canalization as a response to microenvironmental canalization. Furthermore, I demonstrate that although there are genetic correlations between these traits, there is no association between their measures of canalization. I discuss the prospects of the evolutionary lability of the Distal-less gene within the context of changes in genetic variation and covariation. [source] | |||||||||||||||||||||||||||||||||||||||||||||||||||||||