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Peptide Coupling Reagents (peptide + coupling_reagent)

Distribution by Scientific Domains
Chemistry100%

Selected Abstracts

Ethyl Propiolate: A Simple and Convenient Peptide Coupling Reagent.

CHEMINFORM, Issue 1 2005
Bogdan Iorga
Abstract For Abstract see ChemInform Abstract in Full Text. [source]

Blind crystal structure prediction of a novel second polymorph of 1-hydroxy-7-azabenzotriazole

ACTA CRYSTALLOGRAPHICA SECTION B, Issue 4 2006
Harriott Nowell
The commercially available peptide coupling reagent 1-hydroxy-7-azabenzotriazole has been shown to crystallize in two polymorphic forms. The two polymorphs differ in their hydrogen-bonding motif, with form I having an (10) dimer motif and form II having a C(5) chain motif. The previously unreported form II was used as an informal blind test of computational crystal structure prediction for flexible molecules. The crystal structure of form II has been successfully predicted blind from lattice-energy minimization calculations following a series of searches using a large number of rigid conformers. The structure for form II was the third lowest in energy with form I found as the global minimum, with the energy calculated as the sum of the ab initio intramolecular energy penalty for conformational distortion and the intermolecular lattice energy which is calculated from a distributed multipole representation of the charge density. The predicted structure was sufficiently close to the experimental structure that it could be used as a starting model for crystal structure refinement. A subsequent limited polymorph screen failed to yield a third polymorphic form, but demonstrated that alcohol solvents are implicated in the formation of the form I dimer structure. [source]

Highly efficient synthesis of peptides by rational utilization of novel coupling reagents

CHINESE JOURNAL OF CHEMISTRY, Issue 4 2000
Li Peng
Abstract The efficiency of different peptide coupling reagents, including carbodiimides, HOBt or HOAt-derived uronium, phosphonium and immonium salts, halouronium, halophosphonium, 2-halopyridinium and 2-halothiazolium salts, was evaluated. The synthetic strategy for coded peptides and nonribosomal peptides was discussed with an emphasis on the rational selection of peptide coupling reagents. [source]