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Peel Extract (peel + extract)
Selected AbstractsNovel terpenyl esters from Australian finger lime (Citrus australasica) peel extractFLAVOUR AND FRAGRANCE JOURNAL, Issue 3 2009Estelle Delort Abstract The volatile constituents of the peel solvent extract of the Australian finger lime Citrus australasica were analysed by GC,MS. Besides limonene, isomenthone was a major component, which is rare in Citrus species. Six new terpenyl esters were also identified and confirmed by chemical synthesis: citronellyl 2-methylbutanoate; 1,8(10)- p -menthadien-9-yl propanoate; 1,8(10)- p -menthadien-9-yl 2-methylbutanoate; 1,8(10)- p -menthadien-9-yl 3-methylbutanoate; 1- p -menthen-9-yl 2-methylbutanoate; and 1- p -menthen-9-yl 3-methylbutanoate. To the best of our knowledge, the last four compounds have never before been identified in a natural product extract. Copyright © 2009 John Wiley & Sons, Ltd. [source] Pomegranate peel extract prevents liver fibrosis in biliary-obstructed ratsJOURNAL OF PHARMACY AND PHARMACOLOGY: AN INTERNATI ONAL JOURNAL OF PHARMACEUTICAL SCIENCE, Issue 9 2007Hale Z. Toklu ABSTRACT Punica granatum L. (pomegranate) is a widely used plant that has high nutritional value. The aim of this study was to assess the effect of chronic administration of pomegranate peel extract (PPE) on liver fibrosis induced by bile duct ligation (BDL) in rats. PPE (50 mg kg,1) or saline was administered orally for 28 days. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) levels were determined to assess liver function and tissue damage. Proinflammatory cytokines (tumor necrosis factor-alpha and interleukin 1 beta) in the serum and anti-oxidant capacity (AOC) were measured in plasma samples. Samples of liver tissue were taken for measurement of hepatic malondialdehyde (MDA) and glutathione (GSH) levels, myeloperoxidase (MPO) activity and collagen content. Production of reactive oxidants was monitored by chemilumi-nescence assay. Serum AST, ALT, LDH and cytokines were elevated in the BDL group compared with the control group; this increase was significantly decreased by PPE treatment. Plasma AOC and hepatic GSH levels were significantly depressed by BDL but were increased back to control levels in the PPE-treated BDL group. Increases in tissue MDA levels and MPO activity due to BDL were reduced back to control levels by PPE treatment. Similarly, increased hepatic collagen content in the BDL rats was reduced to the level of the control group with PPE treatment. Thus, chronic PPE administration alleviated the BDL-induced oxidative injury of the liver and improved the hepatic structure and function. It therefore seems likely that PPE, with its antioxidant and antifibrotic properties, may be of potential therapeutic value in protecting the liver from fibrosis and oxidative injury due to biliary obstruction. [source] Synthesis of high fluorescent silica hybrid materials by immobilization of orange peel extract in silica-silsesquioxane matrixJOURNAL OF PHYSICAL ORGANIC CHEMISTRY, Issue 11 2009I. Lacatusu Abstract Sol,gel chemistry can be easily modified to the changing needs of society to produce fine-tuned sol,gel nanostructured materials for relevant applications. In this context, there is an increasing need for natural and versatile raw materials as well as biocompatible compounds that could be extensively used as biomarkers for bioimaging in diagnosis or therapy. Silica-based materials are widely used in the field of biomedicine due to their chemical inertness and biocompatibility. In the present paper, orange peel extract was immobilized inside inorganic silica and hybrid silica-silsesquioxane polymeric networks. Silica and organo-modified silica matrices were synthesized through a templated sol,gel route of TEOS and an organosilsesquioxane (octaisobutyltetracyclo[7.3.3.15,11] octasiloxane- endo -3,7-diol), with D -glucose as template, and for comparison a non-ionic surfactant (tetraethylene glycol mono-hexadecyl ether) was also used. The bioactive properties of the molecules from orange peel extract were preserved after immobilization in both silica and silica-silsesquioxane networks. Moreover, the fluorescence properties were amplified by 10,20 times more than the native orange peel extract. The structural properties of the final materials have been studied by FT-IR, UV,Vis-NIR, and fluorescence spectroscopy. Dynamic light scattering measurements and transmission electron microscopy were used to estimate the size and morphology of the hybrid materials with orange peel extract immobilized in silica networks. Copyright © 2009 John Wiley & Sons, Ltd. [source] Monodemethylated polymethoxyflavones from sweet orange (Citrus sinensis) peel Inhibit growth of human lung cancer cells by apoptosisMOLECULAR NUTRITION & FOOD RESEARCH (FORMERLY NAHRUNG/FOOD), Issue 3 2009Hang Xiao Abstract Polymethoxyflavones (PMFs) are almost exclusively found in the Citrus genus, particularly in the peels of sweet orange (Citrus sinensis L. Osbeck) and mandarin (C. reticulate Blanco). We studied the effects of two major PMFs, namely, nobiletin and 3,5,6,7,8,3,,4,-heptamethoxyflavone (HMF), and two major monodemethylated PMFs, namely 5-hydroxy-3,7,8,3,,4,-pentamethoxyflavone (5HPMF), and 5-hydroxy-3,6,7,8,3,,4,-hexamethoxyflavone (5HHMF), on the growth of human lung cancer H1299, H441, and H460 cells. Monodemethylated PMFs were much more potent in growth inhibition of lung cancer cells than their permethoxylated counterpart PMFs. In H1299 cells, cell cycle analyses further revealed that monodemethylated PMFs caused significant increase in sub-G0/G1 phase, suggesting possible role of apoptosis in the growth inhibition observed, whereas the permethoxylated counterpart PMFs did not affect cell cycle distribution at same concentrations tested. These results strongly suggested that the phenolic group is essential for the growth inhibitory activity of monodemethylated PMFs. Further studies in H1299 cells demonstrated that monodemethylated PMFs downregulated oncogenic proteins, such as iNOS, COX-2, Mcl-1, and K-ras, as well as induced apoptosis evidenced by activation of caspase-3 and cleavage of PARP. Our results provide rationale to develop orange peel extract enriched with monodemethylated PMFs into value-added nutraceutical products for cancer prevention. [source] Carotenoids with anti- Helicobacter pylori activity from Golden delicious applePHYTOTHERAPY RESEARCH, Issue 5 2010Péter Molnár Abstract Previously it was reported that hypophasic carotenoids of Golden delicious apple peel showed potent anti- H. pylori activity (MIC50 = 36 µg/mL), comparable to metronidazole (MIC50 = 45 µg/mL). To further investigate the involved active carotenoids of the apple peel extracts, seven carotenoids were isolated for the current study: (all- E)-luteoxanthin, (all- E)-neoxanthin, (9,Z)-neoxanthin, (all- E)-antheraxanthin, (all- E)-violaxanthin, (9Z)-violaxanthin and (all- E)-lutein. The MIC50 values of (all- E)-luteoxanthin, (all- E)-neoxanthin and (9,Z)-neoxanthin were 7.9, 11 and 27 µg/mL, respectively. Other carotenoids and ,,,-carotene did not exhibit potent anti- H. pylori activity (MIC50 > 100 µg/mL). An examination of structure and function suggested that active carotenoids contained a monofuranoid ring or an allenic bond in addition to an epoxy group and an additional two or three hydroxyl substituents on the side group. Copyright © 2009 John Wiley & Sons, Ltd. [source] | |||||||||||||