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PCL Film (pcl + film)
Selected AbstractsSynthesis and characterization of fullerene grafted poly(,-caprolactone)JOURNAL OF APPLIED POLYMER SCIENCE, Issue 6 2008Weihua Kai Abstract The fullerene grafted poly(,-caprolactone) (PCL) was successfully synthesized with a graft efficiency of 80%. The fullerene moieties grafted onto the PCL chain aggregate into 1,2 ,m particles so that a physical pseudo -network is formed. Because of the existence of the network structure, the fullerene grafted PCL film can retain its shape at much higher temperatures than that of pure PCL film, as observed in dynamic mechanical tests. It shows a hydrophobic gelling behavior in chloroform solution. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci, 2008 [source] Enzymatic Degradation of Biodegradable Polyester Composites of Poly(L -lactic acid) and Poly(, -caprolactone)MACROMOLECULAR MATERIALS & ENGINEERING, Issue 10 2006Hideto Tsuji Abstract Summary: Two different types of biodegradable polyester composites, PLLA fiber-reinforced PCL and PCL/PLLA blend films were prepared at PCL/PLLA ratio of 88/12 (w/w), together with pure PCL and PLLA films. Their enzymatic degradation was investigated by the use of Rhizopus arrhizus lipase and proteinase K as degradation enzymes for PCL and PLLA chains, respectively. In the FRP film, the presence of PLLA fibers accelerated the lipase-catalyzed enzymatic degradation of PCL matrix compared with that in the pure PCL film, whereas in the blend film, the presence of PLLA chains dissolved in the continuous PCL-rich domain retarded the lipase-catalyzed enzymatic degradation of PCL chains. In contrast, in the FRP film, the proteinase K-catalyzed enzymatic degradation of PLLA fibers was disturbed compared with that of the pure PLLA film, whereas in the blend film, the proteinase K-catalyzed enzymatic degradation rate of particulate PLLA-rich domains was higher than that of pure PLLA film. The reasons for aforementioned enhanced and disturbed enzymatic degradation are discussed. Normalized PCL weight loss of pure PCL, FRP, and blend films as a function of Rhizopus arrhizus lipase-catalyzed enzymatic degradation time. [source] A Customizable Instrument for Measuring the Mechanical Properties of Thin Biomedical MembranesMACROMOLECULAR MATERIALS & ENGINEERING, Issue 10 2005Gracián Triviño Abstract Summary: A customized instrument has been developed as part of multidisciplinary research work relating to the development of a biodegradable vascular scaffold. This instrument aims to measure the mechanical properties of elastic and viscoelastic thin membranes with tissue engineering applications. Uniform and omni-directional pressure is applied on the whole membrane which is uniformly clamped and submerged into a liquid medium. The mechanical testing described in this study is focused on the stress-strain curves of polycaprolactone (PCL) films after different treatments. The influence of Dulbecco's modified Eagle's culture medium, L929 fibroblast culture, NaOH treatment and film thickness on the mechanical properties of PCL films was evaluated after different times. These studies show that the PCL degradation process is influenced by immersion in the culture medium, inducing an increment in the slope of the pressure-dilation curve which is indicative of an increase in the polymer stiffness. On the other hand, long NaOH treatments make PCL films have more flexible behavior. A computerized version of the instrument: (1) Electrical compressor; (2) Filter; (3) Voltage-pressure converter; (5) Pressure sensor; (6) Differential pressure sensor; (7,8) Main and auxiliary pipettes; (9) Printed circuit board; (10) Personal computer. [source] Application of Polycaprolactone as an Anti-Adhesion Biomaterial FilmARTIFICIAL ORGANS, Issue 8 2010Hsien-Yi Lo Abstract Adhesions are unavoidable consequences of surgery and other trauma. How to prevent the adhesions remains a big issue in healthcare system. The objective of this study is to test the efficacy of polycaprolactone (PCL) films as physical barriers in reducing postoperative intra-abdominal adhesions in the rat cecum-abdominal wall model. PCL is quite cheap compared with the agents recently used in the market. The fabrication method is also very easy to perform. Scanning electron microscope (SEM) showed multiple pores over upper and bottom surfaces but too small to permit cells to migrate from one surface onto another surface. Those pores were proven to be not interconnected. The PCL film did not show any evidence of cytotoxic effects as it did not induce any significant increase in cytoplasmic lactate dehydrogenase release from the NIH3T3 cells that it came in contact with. In animal studies, the PCL films led to fewer adhesions than Seprafilm in rat adhesion model. PCL films were efficacious in reducing postoperative intra-abdominal adhesion formation in rat cecum-abdominal wall models. [source] | ||||||||||