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Particular Promise (particular + promise)

Distribution by Scientific Domains

Psychology	33%

Selected Abstracts

Glucose-responsive insulin-producing cells from stem cells

DIABETES/METABOLISM: RESEARCH AND REVIEWS, Issue 6 2002
David J. Kaczorowski
Abstract Recent success with immunosuppression following islet cell transplantation offers hope that a cell transplantation treatment for type 1 (juvenile) diabetes may be possible if sufficient quantities of safe and effective cells can be produced. For the treatment of type 1 diabetes, the two therapeutically essential functions are the ability to monitor blood glucose levels and the production of corresponding and sufficient levels of mature insulin to maintain glycemic control. Stem cells can replicate themselves and produce cells that take on more specialized functions. If a source of stem cells capable of yielding glucose-responsive insulin-producing (GRIP) cells can be identified, then transplantation-based treatment for type 1 diabetes may become widely available. Currently, stem cells from embryonic and adult sources are being investigated for their ability to proliferate and differentiate into cells with GRIP function. Human embryonic pluripotent stem cells, commonly referred to as embryonic stem (ES) cells and embryonic germ (EG) cells, have received significant attention owing to their broad capacity to differentiate and ability to proliferate well in culture. Their application to diabetes research is of particular promise, as it has been demonstrated that mouse ES cells are capable of producing cells able to normalize glucose levels of diabetic mice, and human ES cells can differentiate into cells capable of insulin production. Cells with GRIP function have also been derived from stem cells residing in adult organisms, here referred to as endogenous stem cell sources. Independent of source, stem cells capable of producing cells with GRIP function may provide a widely available cell transplantation treatment for type 1 diabetes. Copyright © 2002 John Wiley & Sons, Ltd. [source]

Carbon Nanotubes Anchored to Silicon for Device Fabrication

ADVANCED MATERIALS, Issue 5 2010
Kristina T. Constantopoulos
Abstract This report highlights recent progress in the fabrication of vertically aligned carbon nanotubes (VA-CNTs) on silicon-based materials. Research into these nanostructured composite materials is spurred by the importance of silicon as a basis for most current devices and the disruptive properties of CNTs. Various CNT attachments methods of covalent and adsorptive nature are critically compared. Selected examples of device applications where the VA-CNT on silicon assemblies are showing particular promise are discussed. These applications include field emitters, filtration membranes, dry adhesives, sensors and scaffolds for biointerfaces. [source]

Polymeric Materials for Gene Delivery and DNA Vaccination

ADVANCED MATERIALS, Issue 8 2009
David N. Nguyen
Abstract Gene delivery holds great potential for the treatment of many different diseases. Vaccination with DNA holds particular promise, and may provide a solution to many technical challenges that hinder traditional vaccine systems including rapid development and production and induction of robust cell-mediated immune responses. However, few candidate DNA vaccines have progressed past preclinical development and none have been approved for human use. This Review focuses on the recent progress and challenges facing materials design for nonviral DNA vaccine drug delivery systems. In particular, we highlight work on new polymeric materials and their effects on protective immune activation, gene delivery, and current efforts to optimize polymeric delivery systems for DNA vaccination. [source]

Towards Finding the Person in the Data of Personality

JOURNAL OF PERSONALITY, Issue 3 2003
Stephen G. West
This article is based on an address given on the occasion of receiving the 2000 Henry A. Murray award. The article presents a glimpse of my life story in personality and contributions to the field. These are placed in the context of observations about the recent history and sociology of the field. I outline some perspectives on the data that are collected and missing in personality research as well as the analyses that are conducted and those that are not conducted. These considerations identify both some persisting limitations in personality research and alternative analytic approaches that may prove useful in framing and answering new questions. Of particular promise are intensive studies that allow researchers to maintain a clear focus on the individual person. [source]

Multiple pathways to adulthood: Expanding the learning options for urban youth

NEW DIRECTIONS FOR YOUTH DEVELOPMENT, Issue 97 2003
Adria Steinberg
Some learning environments show particular promise of creating pathways to postsecondary education, careers, and engaged citizenship for urban young adults from ages fifteen to twenty-four. [source]

The methodological potential of focus groups in population geography

POPULATION, SPACE AND PLACE (PREVIOUSLY:-INT JOURNAL OF POPULATION GEOGRAPHY), Issue 2 2006
Emily Skop
Abstract Within population geography, the last decade has seen an explosion in qualitative work in terms of the types of work, the topics addressed, and the potential theoretical consequences. Yet focus groups have received less attention as an alternative method. This paper highlights the particular promises, challenges, and practicality of doing focus group research in population geography. I begin by addressing how this research method answers ongoing pleas within the subdiscipline for non-essentialist ways of thinking about taken-for-granted social categories and labels. I then outline two other promising outcomes of this method, including the potential for unique and spontaneous group interactions, and the potential for the empowerment of participants. I use the rest of the paper to provide a review of some of the methodological details of focus group research, with the idea of encouraging more population geographers to engage with this method. Throughout, I contend that focus groups have the capability to further our understanding of population processes, and to connect population geography research to ongoing debates within the broader discipline. Observations stem from an extensive review of existing focus group research, along with my own focus group research conducted with residents living in multiracial suburban communities. Copyright © 2006 John Wiley & Sons, Ltd. [source]