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Particular Note (particular + note)
Selected AbstractsComplementary expression and heterophilic interactions between igLON family members neurotrimin and LAMPDEVELOPMENTAL NEUROBIOLOGY, Issue 3 2002Orlando D. Gil Abstract Neurotrimin (Ntm) and the limbic system-associated membrane protein (LAMP) are members of the IgLON (LAMP, OBCAM, Ntm) family of glycorylphosphatidylinositol anchored neural cell adhesion molecules. We previously reported that LAMP and Ntm promote adhesion and neurite outgrowth via a homophilic mechanism, suggesting that these proteins promote the formation of specific neuronal circuits by homophilic interactions. In this report, we have further characterized the expression and binding specificity of Ntm. Using a newly generated monoclonal antibody to Ntm, we demonstrated that this protein is largely expressed in a complementary pattern to that of LAMP in the nervous system, with co-expression at a few sites. Ntm is expressed at high levels in sensory-motor cortex and, of particular note, is transiently expressed in neurons of cortical barrel fields and corresponding thalamic "barreloids." Binding of a recombinant, soluble form of Ntm to CHO cells expressing either Ntm or LAMP demonstrates that Ntm and LAMP interact both homophilically and heterophilically. In contrast to conventional growth-promoting activity of Ig superfamily members, LAMP strongly inhibits the outgrowth of Ntm-expressing dorsal root ganglion (DRG) neurons in a heterophilic manner. These anatomical and functional data support the concept that homophilic and heterophilic interactions between IgLON family members are likely to play a role in the specification of neuronal projections via growth promoting and inhibiting effects, respectively. © 2002 Wiley Periodicals, Inc. J Neurobiol 51: 190,204, 2002 [source] Cancer patients' satisfaction with communication, information and quality of care in a UK regionEUROPEAN JOURNAL OF CANCER CARE, Issue 1 2005R. DAVIDSON bsc, abps. consultant clinical psychologist , dphil., msc (clin. psych.) Effective patient,professional communication can be of crucial importance to long-term psycho-social outcomes in patients with cancer. This study identifies patient satisfaction with regard to various aspects of communication and perceived quality of care. A well-validated questionnaire was administered to 435 cancer patients throughout Northern Ireland during a 3-month period. Northern Ireland can be regarded as a typical UK region in terms of cancer service configuration. The cohort consisted of patients with breast, colorectal, lung, prostate, gynaecological and gastric cancers. There was a 78% response rate. Satisfaction scores were individually calculated for various aspects of care, particularly diagnosis, treatment, follow-up and overall care. Non-parametric analysis examined the interaction between satisfaction scores and primary tumour site, age and gender. While overall satisfaction scores were relatively high, there was considerable variation. Of particular note was the interaction between perceived satisfaction and quality of care, communication, tumour site and age. Key findings are that there are a number of issues with regard to information and communication which can be clearly improved within Northern Ireland cancer services. The paper concludes that patient,professional communication should be tailored to meet individual need. [source] Comprehensive geriatric assessment for community-dwelling elderly in Asia compared with those in Japan: VI.GERIATRICS & GERONTOLOGY INTERNATIONAL, Issue 4 2005Maubin in Myanmar Background: The objective of the present study is to compare the findings of comprehensive geriatric assessments of community-dwelling elderly in Maubin township, Myanmar with those in Japan. Methods: A cross-sectional, study was undertaken of community-dwelling people aged 60 years and over who were living in downtown Maubin and two rural villages near Maubin city, and 411 people aged 65 years and over who were living in Sonobe, Kyoto, Japan. They were examined using a common comprehensive geriatric assessment tool, which included interviews regarding activities of daily living (ADL), medical and social history, quality of life (QOL) and the 15-item Geriatric Depression Scale. Anthropometric, neurobehavioral and blood chemical examinations were also conducted. Using anova and Post Hoc Scheffe's F -test, findings from the three groups were compared. Results: Scores of basic ADL, instrumental self-maintenance, intellectual activities, social roles, QOL, Tokyo Metropolitan Institute of Gerontology Index of Competence, body mass index, total cholesterol levels, blood hemoglobin levels and HDL levels were lower in Myanmar's elderly subjects than in Japanese ones. There was no significant difference in prevalence of depression. Mean blood pressure measurements and rates of subjects with systolic pressure > 140 mmHg or diastolic pressure > 90 mmHg and prevalence of stroke were higher in downtown Maubin than in Japan. The atherogenic index was higher in Myanmar's elderly than in Japanese. Conclusion: In Myanmar subjects had lower ADL and QOL scores than Japanese elderly. Of particular note is the higher prevalence of anemia and subjects with history of stroke in Myanmar than in Japan. Further study is needed to detect the cause of high prevalence of stroke in Myanmar. [source] 2. PRESENCE ACHIEVED IN LANGUAGE (WITH SPECIAL ATTENTION GIVEN TO THE PRESENCE OF THE PAST)HISTORY AND THEORY, Issue 3 2006HANS ULRICH GUMBRECHT ABSTRACT The aim of this essay is to ask whether what it calls the "presence" of things, including things of the past, can be rendered in language, including the language of historians. In Part I the essay adumbrates what it means by presence (the spatio-temporally located existence of physical objects and events). It also proposes two ideal types: meaning-cultures (in which the interpretation of meaning is of paramount concern, so much so that the thinghood of things is often obscured), and presence-cultures (in which capturing the tangibility of things is of utmost importance). In the modern period, linguistic utterance has typically come to be used for, and to be interpreted as, the way by which meaning rather than presence is expressed, thereby creating a gap between language and presence. Thus, in Part II the essay explores ways that this gap might be bridged, examining seven instances in which presence can be "amalgamated" with language. These range from instances in which the physical dimensions of language itself are made manifest, to those through which the physicality of the things to which language refers is supposed to be made evident. Of particular note for theorists of history are those instances in which things can be made present by employing the deictic, poetic, and incantatory potential of linguistic expression. The essay concludes in Part III with a reflection on Heidegger's idea that language is the "house of being," now interpreted as the idea that language can be the medium through which the separation of humans and the (physical) things of their environment may be overcome. The hope of achieving presence in language is no less than a reconciliation of humans with their world, including,and of most interest to historians,the things and events of their past. [source] Using ancient DNA analysis in palaeopathology: a critical analysis of published papers, with recommendations for future workINTERNATIONAL JOURNAL OF OSTEOARCHAEOLOGY, Issue 6 2008C. Roberts Abstract Despite an observable increase in the number of studies using ancient DNA analysis to diagnose disease in human remains, there remain issues to be addressed about the quality of the resulting publications. This paper describes the qualitative analysis of published papers that describe the detection of pathogenic DNA in human skeletal and mummified remains from archaeological sites. Its ultimate goal is to provide an overview of the main problematic issues in relationship to standards developed in molecular biology and to make recommendations for future work. Sixty-five papers published between 1993 and 2006 were surveyed and the quality of each was assessed using 15 criteria. Interesting results emerged. Of particular note was the high number of papers that did not acknowledge the use of even basic contamination control (90%) or procedures to validate results independently (85%). This study illustrates that attention to contamination control and authentication of results is needed in future research, if confidence in aDNA analysis in palaeopathology is to be increased. Additionally, methods of analysis must be described in published papers to ensure transparency in processes utilised to generate the data. Copyright © 2008 John Wiley & Sons, Ltd. [source] Do Expert Informational Intermediaries Add Value?JOURNAL OF ACCOUNTING RESEARCH, Issue 4 2003Evidence from Auditors in Microcap Initial Public Offerings Do expert informational intermediaries add value? We address this question by examining the informativeness of the audit report contained in the prospectus associated with a firm's initial public offering (IPO). At the time of the IPO, there is a relative lack of information to facilitate the establishment of equity values, suggesting that the information provided by outside "experts" (e.g., auditors, underwriters) is particularly important. In this article we study small, non-venture-backed IPOs, a segment of the market with the poorest long-run performance and where the prestigious audit firm is often the sole (if any) expert present. We find that the pre-IPO opinions of larger auditors are more predictive of post-IPO negative stock delistings. Of particular note, the opinions of the national-tiered firms are comparably predictive to those of the Big 6, though this finding emerges only after we consider the selectivity-based differences in the clients that hire these national firms. Our findings also indicate that, for larger auditors the presence of a pre-IPO going-concern opinion is more strongly associated with first-year stock returns and that larger auditors are more likely to give such opinions to their distressed clients. Overall, we address a deficiency in the literature relating to "the paucity of evidence on the value of auditor opinions to investors" (Healy and Palepu [ 2001 p. 415]). [source] Children with physical disability: Gaps in service provision, problems joining inJOURNAL OF PAEDIATRICS AND CHILD HEALTH, Issue 7-8 2008Phillipa Clark Aim: To describe the reported experiences of the estimated 14 500 New Zealand children with a physical disability and those of their families and whanau (extended families). Method: We have used data from the Household Disability Survey conducted in 2002 to obtain this information. Results: These children and their carers reported a number of perceived unmet needs in all areas covered in the survey: service and assistance, transport, accommodation and education. Thus an estimated 24% reported an unmet need for equipment, and 10% an unmet need for home modification. Around 9% reported having to fund respite care themselves. Of particular note was the proportion of children who had difficulties joining in games and sport at school (59%), going on school outings or camps (28%), playing at school (47%), and or making friends (35%). In all, an estimated 67% of children had one or more problems taking part at school. Conclusion: More could be done to help such families and to facilitate the full participation of these children. [source] General and specific host responses to bacterial infection in Peyer's patches: a role for stromelysin-1 (matrix metalloproteinase-3) during Salmonella enterica infectionMOLECULAR MICROBIOLOGY, Issue 1 2007Scott A. Handley Summary Salmonella enterica serovar Typhimurium (S. typhimurium) and Yersinia enterocolitica are enteric pathogens capable of colonizing and inducing inflammatory responses in Peyer's patches (PPs) and mesenteric lymph nodes (MLNs). Although the tissue colonization pattern is similar between these two pathogens, their pathogenic lifestyles are quite different. For example, while S. typhimurium is primarily an intracellular pathogen, Y. enterocolitica survives primarily extracellularly. We determined and compared the transcriptional changes occurring in response to S. typhimurium and Y. enterocolitica colonization of PP using Affymetrix GeneChip technology. Both pathogens elicited a general inflammatory response indicated by the upregulation of cytokines and chemokines. However, specific differences were also observed, most notably in the transcriptional regulation of gamma interferon (IFN-,) and IFN-,-regulated genes in response to S. typhimurium but not Y. enterocolitica. Of particular note, a group of genes encoding matrix metalloproteinases (MMPs) had increased transcript numbers in the PPs following infection with both pathogens. The experiments described here compare oral S. typhimurium or Y. enterocolitica infection in stromelysin-1 (MMP-3)-deficient mice (mmp-3,/,) with mice possessing functional MMP-3 (mmp-3+/+). There was little difference in the survival of MMP-3-deficient mice infected with Y. enterocolitica when compared with littermate controls. Surprisingly though, mmp-3,/, mice were markedly more resistant to S. typhimurium infection than the control mice. S. typhimurium was able to colonize mmp-3,/, mice, albeit in a delayed fashion, to equivalent levels as mmp-3+/+ mice. Nevertheless, significantly lower levels of inflammatory cytokines were detected in tissues and serum in the mmp-3,/, mice in comparison with mmp-3+/+ mice. We hypothesize that MMP-3 is involved in initiating an early and lethal cytokine response to S. typhimurium colonization. [source] Television Characterizations of Homeless People in the United KingdomANALYSES OF SOCIAL ISSUES & PUBLIC POLICY, Issue 1 2005Darrin Hodgetts Media link events in society into meaningful plotlines for public consumption. For social issues such as homelessness this storytelling process continues until an issue is resolved or another concern takes precedence. This article investigates British Independent Television News1 (ITN) portrayals of homelessness from January 1993 to December 2002 (n= 99). News items are explored as instalments in a larger news narrative through which the public is offered engagements with homeless characters. A quantitative content analysis was used to establish the general prevalence of items throughout the year, story locations, causes and solutions offered for homelessness, and character roles. A qualitative narrative analysis was used to explore the function of these story elements in the overall patterning of the ITN story of homelessness. Of particular note was the promotion of a philanthropic approach to service delivery through the characterization of homeless people as needy victims and the maintenance of estranged relationships between the viewing public and homeless people. The significance of ITN's exclusion of homeless people from public deliberations regarding their needs is discussed in relation to the failure of this wealthy nation to resolve homelessness. [source] Anthropology and the military: AFRICOM, ,culture' and future of Human Terrain Analysis (Respond to this article at http://www.therai.org.uk/at/debate)ANTHROPOLOGY TODAY, Issue 1 2010Robert Albro This article updates new developments in the evolution of the US Army's controversial Human Terrain System program (HTS). Building upon the recent report on the HTS program by the American Anthropological Association's Commission on the Engagement of Anthropology with the Security and Intelligence Communities, this article discusses how HTS-type arrangements are becoming part of the US Department of Defense's (DoD's) newest Combatant Command for the continent of Africa, or AFRICOM. Of particular note is the way "human terrain" no longer refers simply to the HTS program, but has acquired expanded reference to describe a broader array of approaches to the leveraging of socio-cultural knowledge within DoD. Most notably for AFRICOM, this includes moving beyond rapid assessment ethnography to incorporate cultural data into the predictive work of cultural modelling, as this informs the implementation both of counterinsurgency doctrine as well as military humanitarianism in Africa and elsewhere. This article explores the ethical, practical and cultural implications of such a turn. [source] Trypanosoma brucei UDP-galactose-4,-epimerase in ternary complex with NAD+ and the substrate analogue UDP-4-deoxy-4-fluoro-,- d -galactoseACTA CRYSTALLOGRAPHICA SECTION F (ELECTRONIC), Issue 9 2006Magnus S. Alphey The structure of the NAD-dependent oxidoreductase UDP-galactose-4,-epimerase from Trypanosoma brucei in complex with cofactor and the substrate analogue UDP-4-deoxy-4-fluoro-,- d -galactose has been determined using diffraction data to 2.7,Å resolution. Despite the high level of sequence and structure conservation between the trypanosomatid enzyme and those from humans, yeast and bacteria, the binding of the 4-fluoro-,- d -galactose moiety is distinct from previously reported structures. Of particular note is the observation that when bound to the T. brucei enzyme, the galactose moiety of this fluoro-derivative is rotated approximately 180° with respect to the orientation of the hexose component of UDP-glucose when in complex with the human enzyme. The architecture of the catalytic centre is designed to effectively bind different orientations of the hexose, a finding that is consistent with a mechanism that requires the sugar to maintain a degree of flexibility within the active site. [source] Corporate environmental non-reporting , a UK FTSE 350 perspectiveBUSINESS STRATEGY AND THE ENVIRONMENT, Issue 4 2008A. D. Martin Abstract Until relatively recently the majority of large publicly listed UK companies have not produced annual environmental reports. Of particular note is the slow take-up of environmental reporting amongst the UK's top 350 companies, the FTSE 350. Using the results of a postal questionnaire, the reluctance of a majority of the FTSE 350 to voluntarily report is linked to 13 drawbacks. Results from non-reporting respondents to the questionnaire allowed the relative importance of these drawbacks to be placed in a ranked order. Senior management doubt over the advantages of reporting was shown to be the most important drawback, closely followed by the effort required for data collection. A comparison in the uptake of corporate environmental management practices (other than reporting) was also made amongst reporters and non-reporters. Reporters were shown to have a generally higher level of uptake, although company sector type and size was influential on environmental engagement overall. Copyright © 2006 John Wiley & Sons, Ltd and ERP Environment. [source] Linked Lives: Stability and Change in Maternal Circumstances and Trajectories of Antisocial Behavior in ChildrenCHILD DEVELOPMENT, Issue 1 2004Ross Macmillan Drawing on the notion of linked lives, this study examined the effects of stability and change in maternal circumstance on developmental trajectories of antisocial behavior in children 4 to 7 years of age. Using data from a national sample of young mothers and growth curve analysis, the study demonstrated that early maternal circumstances influences early antisocial behavior, whereas stability and change in these circumstances both exacerbate and ameliorate behavior problems. Of particular note, meaningful escape from poverty attenuates antisocial behavior whereas persistence in poverty or long-term movement into poverty intensifies such problems. These findings highlight the importance of structural context for parenting practices and the need to consider child development in light of dynamic and changing life-course fortunes of parents. [source] | |||||||||||||||||||