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Partial Displacement (partial + displacement)

Distribution by Scientific Domains

Medical Sciences	50%

Selected Abstracts

Patient safety incidents associated with airway devices in critical care: a review of reports to the UK National Patient Safety Agency

ANAESTHESIA, Issue 4 2009
A. N. Thomas
Summary We used key words and letter sequences to identify airway-associated patient safety incidents submitted to the UK National Patient Safety Agency from critical care units in England and Wales. We identified 1085 such airway incidents submitted in the two years from October 2005 to September 2007. Three hundred and twelve incidents (28.8%) involved neonates or babies. Of the total 1085 incidents, 200 (18.4%) were associated with tracheal intubation, 53 (4.9%) with tracheostomy and 893 (82.3%) were post-procedure problems. One hundred and ten incidents (10.1%) were associated with more than temporary harm. Eighty-eight intubation incidents were associated with equipment problems. Partial displacement of tubes resulted in more than temporary harm to the patient more frequently than complete tube displacement (15.7% vs 3.8%). Capnography was not described in any cases of displacement or blockage of tracheal or tracheostomy tubes. Recommendations concerning minimum standards for capnography, availability and checking of equipment and tracheostomy placement are made. [source]

Present and future therapeutic strategies for idiopathic oligozoospermia

INTERNATIONAL JOURNAL OF ANDROLOGY, Issue 6 2000
Dimitrios A. Adamopoulos
The effectiveness of medical treatment for idiopathic oligozoospermia (IO) has been at best doubtful until now and a logical consequence of this unsatisfactory situation has been the partial displacement of this approach by assisted reproduction techniques. This state of affairs has resulted from insufficient investigation, inappropriately designed clinical trials and consistent disregard for the principles of evidence-based medicine. Protocol-related shortcomings and wrong interpretation of the data available have also been some of the all too frequent problems encountered in this therapeutic approach. In this rather misty situation, it appears that, of the therapeutic agents used so far, follicle stimulating hormone (FSH) (mainly FSH-secretagogues) may exert some beneficial effects on a number of biological endpoints related to spermatogenesis and sperm maturation. The short and medium term prospects of medical treatment for IO rest mainly with improvement of investigative procedures to a higher degree of sophistication, with emphasis placed on identifying the causes rather than the results of dysfunction so that a better selection of candidates can be made. Moreover, the introduction of prognostic indices for evaluation of the beneficial effects of a therapeutic agent may be of paramount importance. Finally, a better assessment of the preparations available and, possibly, the introduction of new more specific agents may also be an important step forward in this field. This type of large-scale effort should not be left to individual investigators or special centres working independently, but it may come under the auspices of a central regulating agency so that undisputed results from large, multicentre and uniform studies might be obtained, if medical treatment is to remain a good option. In this context, it may also be emphasized that andrology's main task should always be to treat the male with the problem rather than his healthy female partner, whenever this is possible. [source]

A missense mutation in the vacuolar protein GOLD36 causes organizational defects in the ER and aberrant protein trafficking in the plant secretory pathway

THE PLANT JOURNAL, Issue 6 2010
Lucia Marti
Summary A central question in cell biology is how the identity of organelles is established and maintained. Here, we report on GOLD36, an EMS mutant identified through a screen for partial displacement of the Golgi marker, ST-GFP, to other organelles. GOLD36 showed partial distribution of ST-GFP into a modified endoplasmic reticulum (ER) network, which formed bulges and large skein-like structures entangling Golgi stacks. GOLD36 showed defects in ER protein export as evidenced by our observations that, besides the partial retention of Golgi markers in the ER, the trafficking of a soluble bulk-flow marker to the cell surface was also compromised. Using a combination of classical mapping and next-generation DNA sequencing approaches, we linked the mutant phenotype to a missense mutation of a proline residue in position 80 to a leucine residue in a small endomembrane protein encoded by the gold36 locus (At1g54030). Subcellular localization analyses indicated that GOLD36 is a vacuolar protein and that its mutated form is retained in the ER. Interestingly also, a gold36 knock-out mutant mirrored the GOLD36 subcellular phenotype. These data indicate that GOLD36 is a protein destined to post-ER compartments and suggest that its export from the ER is a requirement to ensure steady-state maintenance of the organelle's organization and functional activity in relation to other secretory compartments. We speculate that GOLD36 may be a factor that is necessary for ER integrity because of its ability to limit deleterious effects of other secretory proteins on the ER. [source]

Synthesis and Supramolecular Association of Immobilized NCN-Pincer Platinum(II) Complexes on Hyperbranched Polyglycerol Supports

CHEMISTRY - A EUROPEAN JOURNAL, Issue 5 2004
Salah-Eddine Stiriba Dr.
Abstract Pertosylation of hyperbranched polyglycerol (Mn=2000; Mw/Mn=1.3) followed by partial displacement of the tosyl groups with carboxylic acid functionalized NCN-pincer platinum(II) complexes [PtI-2,6-(NMe2CH2)2C6H2 -4-COOH], resulted in covalent attachment of the NCN-pincer complexes to the polyglycerol. These functionalized hyperbranched macromolecules have been characterized by 1H, 13C, and 195Pt NMR, UV-visible, and IR spectroscopy. The presence of Pt and I atoms renders them directly visible by transmission electron microscopy (TEM) without staining procedures, which offers images of associated hyperbranched macromolecules. TEM micrographs show disk-shaped structures with a small size-distribution (15,20 nm), and characteristic core-shell ring structures. The thickness of the corona observed in TEM could be correlated with the substitution degree with pincer platinum moieties. [source]