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Parallel Synthesis (parallel + synthesis)

Distribution by Scientific Domains
Chemistry95%

Kinds of Parallel Synthesis

  • solution-phase parallel synthesis
    		•

    Selected Abstracts

    ChemInform Abstract: Microwave-Assisted, Solvent-Free, Parallel Syntheses and Elucidation of Reaction Mechanism for the Formation of Some Novel Tetraaryl Imidazoles of Biological Interest.

    CHEMINFORM, Issue 37 2009
    B. R. Prashantha Kumar
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

    Microwave Induced Synthesis of the Thiazolidine-2,4-dione Motif and the Efficient Solvent Free-Solid Phase Parallel Syntheses of 5-Benzylidene-thiazolidine-2,4-dione and 5-Benzylidene-2-thioxo-thiazolidine-4-one Compounds.

    CHEMINFORM, Issue 51 2006
    B. R. Prashantha Kumar
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]

    A Straightforward Protocol for the Solution-Phase Parallel Synthesis of Ceramide Analogues

    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 1 2008
    Santiago Grijalvo
    Abstract A simple solution-phase protocol for the synthesis of ceramide analogues from easily accessible enantiopure scaffolds is disclosed. The method relies on the use of nucleophilic thiolates or phenoxides and appropriate supported reagents or scavengers to give the target compounds in good overall yields. The method is easily adaptable to combinatorial protocols and also amenable to automated processes for the generation of small-to-medium-sized libraries for further screening.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008) [source]

    Parallel Synthesis of O -Phenoxyethyl and O -Adamantyl N- acyl Thiocarbamates Endowed with Antiproliferative Activity

    ARCHIV DER PHARMAZIE, Issue 6 2009
    Andrea Spallarossa
    Abstract In order to further explore the antiproliferative properties of O -phenoxyethyl and O -adamantyl acylthiocarbamates (ATCs), a series of 14 derivatives was prepared by a parallel adaptation of a highly convergent one-pot three-step procedure. Ten acylthiocarbamates were selected by the National Cancer Institute drug evaluation program and screened against a panel of 55 to 58 cell lines derived from nine different types of human cancers. In general, the tested compounds showed a widespread micromolar activity with some specificity against leukemia, renal UO-31, central nervous system (CNS) SNB-75, and non-small cell lung HOP-92 cancer cell lines. Bioinformatic COMPARE analyses were carried out to identify possible mechanism(s) of action for acylthiocarbamate antiproliferative activity. [source]

    ChemInform Abstract: Microwave-Assisted Parallel Synthesis of Fused Heterocycles in a Novel Parallel Multimode Reactor.

    CHEMINFORM, Issue 13 2009
    Matthias Treu
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

    ChemInform Abstract: Scaffold Preparation and Parallel Synthesis of Arrays of 5,6,7,8-Tetrahydropyrrolo-azepinones in the Solution Phase.

    CHEMINFORM, Issue 40 2008
    Leonarda Piras
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

    ChemInform Abstract: Solution-Phase Parallel Synthesis of Novel 1,2,3,4-Tetrahydroisoquinolin-1-ones as Anticonvulsant Agents.

    CHEMINFORM, Issue 29 2008
    Rosaria Gitto
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

    An Efficient Method for Solution-Phase Parallel Synthesis of 2-Quinoxalinol Salen Schiff-Base Ligands.

    CHEMINFORM, Issue 48 2007
    Xianghong Wu
    Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source]

    Parallel Synthesis of a Library of Acylsemicarbazides Using a Solution-Phase One-Pot Method and Their Evaluation as Crop-Protection Agents.

    CHEMINFORM, Issue 4 2006
    Justyna A. Grzyb
    Abstract For Abstract see ChemInform Abstract in Full Text. [source]

    Discovery of 2-Aminothiazole-4-carboxamides, a Novel Class of Muscarinic M3 Selective Antagonists, Through Solution-Phase Parallel Synthesis.

    CHEMINFORM, Issue 39 2005
    Yufu Sagara
    Abstract For Abstract see ChemInform Abstract in Full Text. [source]

    Solution-Phase Parallel Synthesis of an N-Alkylated Dihydropteridinone Library from Fluorous Amino Acids.

    CHEMINFORM, Issue 12 2005
    Tadamichi Nagashima
    Abstract For Abstract see ChemInform Abstract in Full Text. [source]

    Standardization Protocols and Optimized Precursor Sets for the Efficient Application of Automated Parallel Synthesis to Lead Optimization: A Mitsunobu Example.

    CHEMINFORM, Issue 5 2003
    Robert G. Gentles
    Abstract For Abstract see ChemInform Abstract in Full Text. [source]

    A General Staudinger Protocol for Solution-Phase Parallel Synthesis.

    CHEMINFORM, Issue 38 2002
    Craig W. Lindsley
    Abstract For Abstract see ChemInform Abstract in Full Text. [source]

    Facile, microwave-assisted parallel syntheses of N -substituted 1,4-dihydropyridines of biological interest

    JOURNAL OF HETEROCYCLIC CHEMISTRY, Issue 2 2009
    B. R. Prashantha Kumar
    A solventless parallel synthesis of some novel, N -substituted dihydropyridines by the application of microwaves is reported. The synthetic methodology adopted to synthesize the titled compounds and their antioxidant activity is described. J. Heterocyclic Chem., 46, 336 (2009). [source]

    D -Glucose as a Pentavalent Chiral Scaffold

    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 8 2003
    Till Opatz
    Abstract A novel carbohydrate-based scaffold for combinatorial chemistry has been developed. This scaffold allows the selective attachment of five different side chains, giving rise to products of enormous structural diversity. As a demonstration of its usefulness, a series of model compounds has been prepared in high purity and yield by multistep parallel synthesis on a solid phase. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003) [source]

    Synthesis of Biaryls and Aryl Ketones via Microwave-Assisted Decarboxylative Cross-Couplings

    ADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 16 2009
    Lukas
    Abstract A protocol for the microwave-assisted decarboxylative cross-couplings of carboxylic acid salts with aryl halides has been developed that allows the synthesis of various biaryls and aryl ketones in high yields. After careful adaptation of the bimetallic catalyst system and reaction conditions, these mechanistically complex transformations can now be performed within only five minutes in concentrated solution in a sealed vessel. This greatly simplified reaction protocol is ideally suited for applications in parallel synthesis and drug discovery. [source]

    Facile, microwave-assisted parallel syntheses of N -substituted 1,4-dihydropyridines of biological interest

    JOURNAL OF HETEROCYCLIC CHEMISTRY, Issue 2 2009
    B. R. Prashantha Kumar
    A solventless parallel synthesis of some novel, N -substituted dihydropyridines by the application of microwaves is reported. The synthetic methodology adopted to synthesize the titled compounds and their antioxidant activity is described. J. Heterocyclic Chem., 46, 336 (2009). [source]

    Towards the automatic analysis of 1H NMR spectra: Part 4,Additional requirements of flow-NMR

    MAGNETIC RESONANCE IN CHEMISTRY, Issue 12 2004
    Lee Griffiths
    Abstract Flow-NMR allows more rapid and convenient acquisition of NMR spectra. Its main application area has therefore been in multiple parallel synthesis or combinatorial chemistry. At the same time, there is a significant need to automate the analysis of the resultant spectra. However, flow-NMR brings spectral imperfections, which compromise attempts to automate this analysis. This study proposes experimental and computational expedients to accommodate the effects of residual solvent peaks, 13C satellites, finite signal-to-noise ratio, impurities, presaturation on integral calculations, the ,silent' region and how multiplet areas can be scaled to numbers of protons in this environment. Copyright © 2004 John Wiley & Sons, Ltd. [source]

    Polymer-Supported Copper(I) Catalysts for the Experimentally Simplified Azide,Alkyne Cycloaddition

    MOLECULAR INFORMATICS, Issue 11-12 2007
    Timothy
    Abstract Tris-(benzyltriazolylmethyl)amine (TBTA), a widely used ligand for the copper-catalyzed azide-alkyne cycloaddition, has been immobilized on a TentaGel resin. Once loaded with copper(I), the resulting air-stable complex acts as an efficient catalyst for the azide-alkyne cycloaddition reaction and prevents contamination of products by copper salts. The immobilized TBTA ligand should find immediate use in the parallel synthesis of compounds for direct screening. [source]

    De novo synthesis and assembly of multiplex riboswitches in vitro

    BIOTECHNOLOGY PROGRESS, Issue 5 2009
    Hao-Hua Sun
    Abstract Pools of short synthetic oligonucleotides (oligos) are required in the multiplex and parallel DNA construction. Microarray technology provides a fast and economical mean for massive parallel synthesis of oligos. The method of oligo synthesis with the programmable microfluidic PicoArray could simultaneously synthesize the designed oligos for multiple riboswitch genes. The synthetic oligos were recovered and purified as a pool of oligo mixture (OligoMix). Three temperature steps were employed to denature, anneal and extend the designed OligoMix until, after multiple rounds of thermocycling, the riboswitches with the desired length are obtained. The OligoMix was amplified using this PCR-based technique and the flanking adapter segments were cleaved for following assembly. Based on these oligos derived from 197 riboswitch sequences, the method of simultaneous assembling multiplex riboswitches (SAMRs) showed high fidelity by sequence identification. The resultant error rate was determined to be 2.78,. With the templates from SAMRs, in vitro transcription was applied to produce milligram amounts of biologically active riboswitches. With the verification of biological activity based on the high specificity of recognizing small-molecule metabolites as well as the DNA sequence redivivus by RT-PCR, the assembled riboswitches can be used for further gene operation and biological application. © 2009 American Institute of Chemical Engineers Biotechnol. Prog., 2009 [source]