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Pain Research (pain + research)

Distribution by Scientific Domains
Medical Sciences78%

Kinds of Pain Research

  • in pain research
    		•

    Selected Abstracts

    The Child with Headache: Diagnosis and Treatment (Progress in Pain Research and Management, Vol.

    JOURNAL OF PAEDIATRICS AND CHILD HEALTH, Issue 6 2001

    [source]

    Biopsychosocial Pain Research in America: The Veterans Health System Leads the Way

    PAIN MEDICINE, Issue 7 2009
    Rollin M. Gallagher MD
    No abstract is available for this article. [source]

    The Role of Quasi-Experimental Designs in Pain Research

    PAIN MEDICINE, Issue 2 2004
    Edward Gracely PhD
    No abstract is available for this article. [source]

    Clinical Pain Research: Challenges Across Cancers, Cultures, and Disciplines

    PAIN MEDICINE, Issue 1 2001
    Article first published online: 21 DEC 200
    No abstract is available for this article. [source]

    Characterization of VR1 within the BMBF-Leitproject: ,Molecular Pain Research'

    JOURNAL OF NEUROCHEMISTRY, Issue 2003
    R. Jostock
    The vanilloid receptor VR1 is a ligand, heat and proton gated ion channel, expressed predominantly by primary sensory neurons. We show the molecular characterization of VR1 and its involvement in nociceptive behavior. Biochemical analysis of VR1 showed glycosylation at N604 and the predicted tetrameric structure. Reduced pH potentiated the gating of the receptor by NADA and anandamide in recombinant VR1. Acidification could sensitize VR1 and lead to hyperalgesia. Therefore, the VR1 antagonist capsazepine was tested in several animal models. Capsazepine reduced formalin induced nocifensive behavior and CFA induced mechanical hyperalgesia, and was antiallodynic and antihyperalgesic in animal models of neuropathic pain. VR1 antisense oligonucleotides inhibited VR1 expression in vitro and reduced tactile allodynia in vivo. In conclusion, we could provide evidence for a role of VR1 in inflammatory and neuropathic pain pathways. [source]

    Chest pain research; no more comparing apples with oranges

    EMERGENCY MEDICINE AUSTRALASIA, Issue 1 2010
    Anne-Maree Kelly
    No abstract is available for this article. [source]

    Involving users in low back pain research

    HEALTH EXPECTATIONS, Issue 4 2003
    Bie Nio Ong BA BEd MA PhD
    Abstract Objective, To involve users in the design of a research project that aims at describing a 12-month course of low back pain in an adult population sample (epidemiological strand), and to determine how patient and professional perceptions of low back pain and its treatment relate to the use of health-care and to subsequent outcome (qualitative strand). Design, Three focus groups were organized in the preparatory phase of the project with general practitioners, other health professionals and low back pain sufferers. Issues pertaining to the experience of living with, or treating low back pain were explored and users were asked to identify relevant research questions for consideration within the study. Findings, The focus groups revealed tensions between involving users as co-researchers for design issues and their role as sufferers and health professionals who want to share their narrative accounts of low back pain. The group discussions produced a wealth of material for analysis, but no explicitly stated research topics. Three key themes and the process of user involvement in the focus groups are discussed. Conclusions, The focus group format could be restrictive in that it allows for detailed exchange between participants, but is insufficiently geared towards the production of a research agenda. We draw conclusions as to possible approaches for user involvement in health services research design. [source]

    Nitric oxide and pain: ,Something old, something new'

    ACTA ANAESTHESIOLOGICA SCANDINAVICA, Issue 9 2009
    A. MICLESCU
    Challenges have emerged following the revival of nitric oxide (NO) from ,something old', a simple gas derived from nitrogen and oxygen with a role in the early stages of evolution, into ,something new', an endogenously formed biological mediator regulating a wide variety of physiological functions. Although pain is a common sensation, it encompasses multiple neurobiologic components, of which NO is only one. In pain research, the study of NO is complicated by convoluted problems related mostly to the effects of NO, which are pro- or anti-nociceptive depending on the circumstances. This dual function reflects the multi-faceted roles of the NO molecule described in physiology. This review covers current information about NO and its implications in pain mechanisms. In addition, it follows the pain pathways, demonstrating the role of NO in peripheral nociceptive transmission as well in central sensitization. This knowledge may provide the scientific basis for developing new drugs that are indicated for different types of pain, drugs that may be related to the chemical links of NO. A comprehensive approach to understanding the effects of NO will help clinicians identify novel agents that combine the pharmacological profile of native drugs with a controllable manner of NO release. Inhibitors of NO synthesis may have analgesic effects and would be of interest for treating inflammatory and neuropathic pain. Unfortunately, only a few of these compounds have reached the stage of clinical pain trials. [source]

    RNA interference in pain research

    JOURNAL OF NEUROCHEMISTRY, Issue 2 2006
    Thomas Röhl
    Abstract Within the course of only the last few years, RNA interference (RNAi) has been established as a standard technology for investigation of protein function and target validation. The present review summarizes recent progress made in the application of RNAi in neurosciences with special emphasis on pain research. RNAi is a straightforward method to generate loss-of-function phenotypes for any gene of interest. In mammals, silencing is induced by small interfering RNAs (siRNAs), which have been shown to surpass traditional antisense molecules. Due to its high specificity, RNAi has the potential for subtype selective silencing of even closely related genes. One of the major challenges for in vivo investigations of RNAi remains efficient delivery of siRNA molecules to the relevant tissues and cells, particularly to the central nervous system. Various examples will be given to demonstrate that intrathecal application of siRNAs is a suitable approach to analyse the function of receptors or other proteins that are hypothesized to play an important role in pain signalling. Intensive efforts are currently ongoing to solve remaining problems such as the risk of off-target effects, the stability of siRNA molecules and their efficient delivery to the CNS. RNAi has thus demonstrated that it is an extremely valuable tool for the development of new analgesic drugs. [source]

    God Image and Happiness in Chronic Pain Patients: The Mediating Role of Disease Interpretation

    PAIN MEDICINE, Issue 5 2010
    Jessie Dezutter dra
    Abstract Objective., The present study explored the role of the emotional experience of God (i.e., positive and negative God images) in the happiness of chronic pain (CP) patients. Framed in the transactional model of stress, we tested a model in which God images would influence happiness partially through its influence on disease interpretation as a mediating mechanism. We expected God images to have both a direct and an indirect (through the interpretation of disease) effect on happiness. Design., A cross-sectional questionnaire design was adopted in order to measure demographics, pain condition, God images, disease interpretation, and happiness. One hundred thirty-six CP patients, all members of a national patients' association, completed the questionnaires. Results., Correlational analyses showed meaningful associations among God images, disease interpretation, and happiness. Path analyses from a structural equation modeling approach indicated that positive God images seemed to influence happiness, both directly and indirectly through the pathway of positive interpretation of the disease. Ancillary analyses showed that the negative influence of angry God images on happiness disappeared after controlling for pain severity. Conclusion., The results indicated that one's emotional experience of God has an influence on happiness in CP patients, both directly and indirectly through the pathway of positive disease interpretation. These findings can be framed within the transactional theory of stress and can stimulate further pain research investigating the possible effects of religion in the adaptation to CP. [source]

    Obtaining informed consent for clinical pain research: patients' concerns and informational needs. (University of Pennsylvania Center for Bioethics, Philadelphia, PA) Pain.

    PAIN PRACTICE, Issue 4 2001
    2001;92:7
    Investigators who conduct pain research are required to obtain voluntary informed consent from patients. However, little is known about what information patients expect when they decide whether to enroll in such studies. It is important that the investigators understand the need for information so that they can effectively and clearly describe the research risks and potential benefits that matter to the potential subjects. This study was designed to define information needs that patients have when they decide whether to participate in clinical pain research and identified clinical and demographic variables associate with specific needs. [source]