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Pyrimidinone Derivatives (pyrimidinone + derivative)

Distribution by Scientific Domains

Chemistry	100%

Selected Abstracts

Asymmetric Organocatalytic Tandem Reaction to Chiral Pyrimidinone Derivatives using Urea as Dinitrogen Source

ADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 11-12 2010
Zhao-Quan He
Abstract A facile method for the asymmetric synthesis of pyrimidinone derivatives was developed via an organocatalytic tandem aza-Michael addition,hemiaminal formation,dehydroxylation reaction, using N,N, -dialkyloxyurea as dinitrogen source (up to 97% ee). The transformations of hemiaminal intermediates to pyrimidinones with more complex structures have been also investigated. [source]

ChemInform Abstract: Tandem Sigmatropic Shifts in [4 + 2] Cycloaddition Reactions of 1,3-Diazabuta-1,3-dienes with Butadienylketene: Synthesis of Pyrimidinone Derivatives.

CHEMINFORM, Issue 33 2002
Arun K. Sharma
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source]

Synthesis and Metal-Complexation Properties of a New Hydroxypyrimidinone-Functionalized Sepharose

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, Issue 3 2005
M. Alexandra Esteves
Abstract The 1-hydroxy-2-(1H)-pyrimidinone derivative 4-(3-aminopropylamino)-1-hydroxy-2-(1H)-pyrimidinone (HOPY-PrN) was synthesized and its acid-base and complexation properties towards a set of metal ions (FeIII, AlIII, and ThIV) were studied by potentiometry and spectrophotometry. The ligand was further immobilized in an epoxy-activated sepharose by chemical coupling through the aminoalkyl pendent group with the aim of improving its sequestering capacity for residual amounts of metals. The new hydroxypyrimidinone-functionalized sepharose shows a high chelating capacity for metal ions in the pH range 3,8, thus suggesting good perspectives for potential environmental applications. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005) [source]

Asymmetric Organocatalytic Tandem Reaction to Chiral Pyrimidinone Derivatives using Urea as Dinitrogen Source

Promising antimicrobial agents: Synthetic approaches to novel tricyclic and tetracyclic pyrimidinones with antimicrobial properties

JOURNAL OF HETEROCYCLIC CHEMISTRY, Issue 5 2010
Hatem M. Gaber
New tricyclic pyrimidinone derivatives were obtained from the corresponding thiazolopyrimidinone or hydrazino systems. The annelation of tricyclic hydrazino compound with 1,2,4-triazole and tetrazole moieties gave novel tetracyclic condensed pyrimidinones. The investigation of the antimicrobial properties of tricyclic and tetracyclic pyrimidinones, by agar-well diffusion assay, was carried out against six pathogenic bacteria (Bacillus cereus, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Klebsiella spp, and Salmonella typhyrium) and four pathogenic fungi (Aspergillus flavus, Aspergillus niger, Aspergillus fumigatus, and Trichderma horozianum). Most of the compounds tested exhibited some degree of antimicrobial activity against microorganisms. Among these compounds, 4-benzylidenhydrazino-8-cyano-7-(furan-2-yl)thiazolo[3,2- a:4,5- d,]dipyrimidin-9-one (12) showed the most favorable antibacterial activity, while compound 17 showed the highest effect on fungi. Interestingly, tetrazole derivative 19 displayed a remarkable effect on fungi much more than the corresponding 3-substituted triazole derivatives on the one hand, whereas the lowest effect on bacteria on the other. J. Heterocyclic Chem., (2010). [source]