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Outline Strategies (outline + strategy)

Distribution by Scientific Domains
Mathematics and Statistics50%

Selected Abstracts

A non-linear and non-Gaussian state-space model for censored air pollution data

ENVIRONMETRICS, Issue 2 2005
Craig J. Johns
Abstract Lidar technology is used to quantify airborne particulate matter less than 10,,m in diameter (PM10). These spatio-temporal lidar data on PM10 are subject to censoring due to detection limits. A non-linear and non-Gaussian state-space model is modified to accommodate data subject to detection limits and outline strategies for Markov-chain Monte Carlo estimation and filtering. The methods are applied to spatio-temporal lidar measurements of dust particle concentrations. Copyright © 2004 John Wiley & Sons, Ltd. [source]

Climate change: the science and the policy

JOURNAL OF APPLIED ECOLOGY, Issue 5 2005
DAVID KING
Summary Globally we face serious challenges from the effects of climate change. The causal link between global warming and increased greenhouse gas emissions is well established. Carbon dioxide levels are at a higher level than at any time in the past 750 000 years at least, and it is too late to stop further warming and consequent impacts on UK and global societies. Here I summarize the latest scientific evidence for anthropogenic global warming and outline strategies for adapting to its impacts and mitigating the effects in the longer term. [source]

Making Efficient Use of Patients in Designing Phase III Trials Investigating Simultaneously a Set of Targeted Therapies with Different Targets

BIOMETRICAL JOURNAL, Issue 6 2006
Werner Vach
Abstract Targeted therapies are a recent development in cancer treatment research. As these therapies can only be administered to patients with certain individual characteristics, it is a straightforward idea to investigate several of such therapies simultaneously in a given patient population in order to compare each targeted therapy with the current standard therapy. This raises the question how patients satisfying several characteristics should be handled. We consider in this paper several designs to allocate treatments in a random manner to these patients, such that the evaluation of each single targeted therapy can be based on a simple comparison of patients receiving the targeted therapies versus those receiving the standard therapy within a well defined subgroup of patients satisfying the corresponding characteristic. We show how one can ensure that patients with several characteristics can contribute simultaneously to the evaluation of several targeted therapies and that this is the key point for an efficient use of the patients available. We further discuss some ethical and practical issues in applying the new designs and outline strategies to evaluate the overall effect of all targeted therapies together. (© 2006 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source]

Innovation,What's Design Got to Do with It?

DESIGN MANAGEMENT REVIEW, Issue 1 2004
Bettina von Stamm
If the goal is innovation, then Bettina von Stamm is sure design is an essential component in realizing that goal. She celebrates the differences between designers and other functions and documents how their unique perspectives can improve business performance, help expand market share, and leverage bottom-line results. She believes design must be an in-house expertise and outlines strategies to integrate design and designers into the innovation effort. [source]