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Distribution by Scientific Domains

Medical Sciences	64%
Life Sciences	9%
Psychology	6%
Education	6%
Business, Economics, Finance and Accounting	6%
2 Other Domains	9%

Distribution within Medical Sciences

Neurology	18%
Psychiatry	14%

Selected Abstracts

Internet networking for pharmacists: an evaluation of a mailing list for UK pharmacists

INTERNATIONAL JOURNAL OF PHARMACY PRACTICE, Issue 1 2003
Mr. Anthony R. Cox teaching fellow
Objective To analyse the content of messages to an internet mailing list for UK pharmacists and to ascertain if the list was performing a continuing professional development (CPD) function. Method For one month all messages to the main list were categorised by topic; details of the gender of the correspondent and their sector of the profession were noted. Members were surveyed using an internet questionnaire. Setting The population of subscribers to the mailing list at http:www.private-rx.com Key findings The top three categories of e-mails posted to the list were clinical pharmacy (20%), pharmacy politics (18%) and non-pharmacy chat (14%). Other subjects included legal issues, the Drug Tariff, government policy, business, risk management and e-mails of a personal and supportive nature. The survey obtained a 46% response rate. Ninety-eight per cent of respondents found the list valuable. Respondents reported increased face to face and Internet contact with other pharmacists after joining the list. Forty-four per cent of respondents said their practice had changed as a result of information gained from the mailing list. Qualitative data self-reported by respondents indicated increased self-perceived competence, confidence, knowledge and skills. Approaches to CPD had also been re-examined. Listening to peers' views and overcoming isolation was seen as important. Conclusion Private-Rx provided pharmacists with a rapid route for information gain, had perceived benefits and appeared to have brought about changes in practice. Internet discussion enables CPD without the restriction of time or place and reaches pharmacists who are under-represented in formal education programmes. [source]

Empfehlungen des Arbeitskreises 6.1 "Geotechnik der Deponiebauwerke" der Deutschen Gesellschaft für Geotechnik e. V. (DGGT)

BAUTECHNIK, Issue 9 2005
Karl Josef Witt
Der Arbeitskreis Geotechnik der Deponiebauwerke (früher Geotechnik der Deponien und Altlasten) hat in den Empfehlungsgruppen E1 bis E5 bisher 76 Empfehlungen veröffentlicht. Die jährliche Publikation wird fortgesetzt durch aktualisierte Fassungen der Empfehlungen E2-18 "Geotechnische Belange der Deponieentgasung" und durch die geotextilspezifischen Empfehlungen E2-9, E3-8 und E5-5. Auf weitere überarbeitete Empfehlungen wird hingewiesen. Recommendations of the DGGT Committee "Geotechnics of Landfill Structures". The Committee "Geotechnics of Landfill Structures", formerly "Geotechnics of Landfills and Contaminated Land", published up to now 75 recommendations. The series is continued by the revised recommendations E2-18 "Geotechnical aspects of gascollektion" and some more recommendations concerning the use and quality insurance of geosynthetics. Other subjects and recommendations revised during this year are reported. [source]

Nutritional factors affecting serum phenylalanine concentration during pregnancy for identical twin mothers with phenylketonuria

ACTA PAEDIATRICA, Issue 8 2000
C Fox
The effect of energy, protein, fat, and phenylalanine on serum phenylalanine concentrations during pregnancy for a set of identical twins with phenylketonuria (PKU) was examined. Blood samples were collected one to two times per week. The subjects completed a 3-d food record prior to each blood collection. The effect of the factors on serum phenylalanine levels was evaluated statistically using time-series analysis. Dietary intakes of the nutrients evaluated were similar for the subjects. For one subject, there were highly significant effects of energy, protein, and fat on serum phenylalanine levels. In contrast, these nutrients had no significant effect on serum phenylalanine for the other subject. Dietary phenylalanine had no significant effect on serum phenylalanine for either twin. Conclusions: There was no effect of phenylalanine intake and no consistent effect of energy, protein, or fat on serum phenylalanine. Other dietary or environmental factors or a combination of factors may impact serum phenylalanine levels of pregnant women with PKU. [source]

Effects of intensive harvesting on moose reproduction

JOURNAL OF APPLIED ECOLOGY, Issue 3 2000
Catherine Laurian
Summary 1.,It has been hypothesized that a balanced adult sex ratio is necessary for the full participation of ungulate females in reproduction and therefore high productivity. We tested this general hypothesis by combining two complementary approaches. 2.,First, using telemetry (n = 60) and annual aerial censuses between 1995 and 1998, we compared two moose Alces alces populations in Quebec, Canada, one non-harvested and the other subject to intensive sport harvesting from the end of September to mid-October. We tested the following predictions for the harvested population: (i) females increase movements and home ranges during the mating period; (ii) the mating system is modified, with the appearance of groups of one male and many females; (iii) subadult males participate in reproduction; (iv) the mating period extends over two to three oestrus cycles; (v) the calving period extends over several months; and (vi) productivity declines. 3.,Daily movements and home range sizes during the mating period did not differ between harvested and non-harvested populations. Most groups observed were male,female pairs. Subadult males (1·5,2·5 years old) were only observed with females in the harvested population. Mating and calving periods did not differ between populations. The proportion of females that gave birth and the number of calves produced were also comparable in the two populations. 4.,Secondly, we also assessed the existence of a relationship between population productivity and percentage of males in various management units of the province of Quebec that were characterized by a wide range in sex ratios. Contrary to prediction (vi), the number of calves per 100 adult females was not related to the percentage of adult males in the population. 5.,The participation of young adult males (subadults) in reproduction in our harvested population may have compensated for the lower percentage of adult males, and thus productivity was unaffected. We therefore reject the hypothesis that intensive harvesting, at least at the level we observed, affects reproduction and population productivity. 6.,As there are some uncertainties regarding the long-term effects of high hunting pressure, however, managers should favour sex ratios close to levels observed in non-harvested populations. [source]

The prevalence of mouse allergen in inner-city homes

PEDIATRIC ALLERGY AND IMMUNOLOGY, Issue 4 2002
Iwona Stelmach
Mouse allergen has not been studied in detail in the general population. It is common for patients from inner-city environments to report significant mouse infestation in their homes and neighborhoods. The aim of this study was to determine the prevalence of mouse allergen in the homes of inner-city children with asthma in relation to the demographic features of these children and their specific housing characteristics. Seventy-eight dust samples from 39 inner-city homes of Lodz, Poland, were analyzed for mouse allergen. Skin-prick tests (SPTs) to mouse allergen were performed in all patients. In addition, data regarding the demographics and housing of the subjects were related to the mouse allergen levels. Mouse allergen was detected in 22 of 78 dust samples (28%), and in 18 of 39 homes (46%), including 13 kitchen (33%) and nine bedroom (23%) samples. Mouse allergen levels did not correlate between different rooms in the same home. The levels detected ranged from 0.09 to 2.34 µg/g of dust. The highest levels were found in kitchens, with median levels of 0.2 µg/g, 95% confidence interval (CI): 0.12,0.85 (range: 0.1,2.34 µg/g); in bedrooms the mean levels were 0.23 µg/g, 95% CI: 0.1,0.97 (range: 0.09,1.62 µg/g). Eleven of 18 children with detectable mouse allergen in house dust, and three of 21 without detectable mouse allergen in house dust, had a positive SPT to mouse allergen. On home inspection, 18% of the homes had evidence of mice in one or two rooms and had higher levels of mouse allergen (p < 0.01). None of the other subject or housing variables evaluated were associated with higher mouse allergen levels. In Polish children, mouse allergen is an important factor of sensitivity and should be recognized in the diagnosis of allergic diseases as well as in allergen-reduction programmes. [source]

Re-entrainment of the circadian rhythms of plasma melatonin in an 11-h eastward bound flight

PSYCHIATRY AND CLINICAL NEUROSCIENCES, Issue 3 2001
Toshiharu Takahashi MD
Abstract We investigated the re-entrainment of melatonin rhythm in an 11-h eastward-bound flight. Eight male subjects participated in the present study. Blood sampling was carried out once before the flight and twice after the flight. During the daytime the subjects were exposed to natural zeitgeber outdoors on the day except the blood sampling. Seven of eight subjects showed antidromic re-entrainment, and the other subject showed orthodromic re-entrainment. The intensity of natural day light in New York amounted to 20 000 lx. As for the direction of the re-entrainment in New York the antidromic re-entrainment is naturally dominant. [source]

Peritoneal T Cell Responses Can Be Polarized Toward Th1 or Th2 in Children on Chronic Peritoneal Dialysis

ARTIFICIAL ORGANS, Issue 8 2004
Sabrina Chiesa
Abstract:, Peritoneal T cell responses can be polarized toward Th1 or Th2 in children on chronic peritoneal dialysis. Previous studies on the peritoneal immune system described the presence of activated T lymphocytes in peritoneal effluents from subjects on chronic peritoneal dialysis (CPD). Since Th1/Th2 polarized response can influence the outcome of specific infectious diseases, we investigated if activated Th1/Th2 cells can be detected in peritoneal effluents during peritoneal dialysis, in order to better understand the role of T cells in the mechanisms of peritoneal defense. We have studied 8 children (4 males, 4 females, mean age 5.8 ± 5.7 years, range 0.3,13.4) on CPD. Peritoneal cells have been isolated from peritoneal effluents by centrifugation. Immunofluorescent staining of intracellular cytokines for flow cytometric analysis was used to detect the percentage of T cells producing either IFN-, (Th1) or IL-4 (Th2). In the initial study 3 months after CPD initiation, high percentages of IFN-, positive peritoneal T cells (38% and 63%) were detected in two subjects; this finding is consistent with a Th1 polarization of peritoneal T cells. In another subject, high percentages of IL-4 positive T cells (31%) were detected, suggesting a Th2 polarization of peritoneal T cell response. Small amounts of either Th1 or Th2 T cells (2,4%) were also detected in the other subjects. At the 1 year follow-up, Th1 polarization persisted in one subject (18% IFN-, positive peritoneal T cells), in another a shift from Th1 to Th2 was observed, and in the other subject a down regulation of both T cell subsets occurred. The finding that a predominance of T cells producing either IFN-, or IL-4 was found in 3 out of 8 children strongly suggests that peritoneal T cell responses can be polarized toward Th1 or Th2. The decrease of Th1 and/or Th2 polarized T cells in the peritoneum of 4 out of 6 subjects (after 1 year) suggests that CPD can play an immunosuppressive role on T cell peritoneal responses. Further studies are needed in order to define whether different T helper activation patterns are associated with a higher risk of peritoneal infection or of peritoneal damage. [source]

Operative Results without Invasive Monitoring in Patients with Frontal Lobe Epileptogenic Lesions

EPILEPSIA, Issue 10 2001
A. Mariottini
Summary: ,Purpose: To further explore the still controversial issues regarding whether all or most candidates for epilepsy surgery should be investigated preoperatively with invasive long-term video-EEG monitoring techniques (ILTVE). Methods: We studied five patients with intractable seizures since early childhood using the same protocol: clinical evaluation, magnetic resonance imaging (MRI) with fluid-attenuated inversion recovery (FLAIR) sequences, long-term video-EEG (LTVE) monitoring with scalp electroencephalogram (EEG), interictal single photon emission computed tomography (SPECT), positron emission tomography (PET), and neuropsychological testing. The patients' seizures had clinical features suggesting a frontal lobe (FL) origin. MRI scans revealed focal cortical dysplasia (CD) in four patients and a probable gliotic lesion in the fifth. The findings in both PET and SPECT images were congruent with those of the MRI. Scalp LTVE failed to localize the ictal onset, although the data exhibited features suggestive of both CDs and FL seizures. On the basis of these results, surgery was performed with intraoperative corticography, and the cortical area exhibiting the greatest degree of spiking was ablated. Results: Histopathologic study of four of the resected specimens confirmed the presence of CD, whereas in the fifth, there were features consistent with a remote encephaloclastic lesion. There were no postoperative deficits. Seizures in three of the patients were completely controlled at 2,3.5 years of follow-up; a fourth patient is still having a few seizures, which have required reinstitution of pharmacotherapy, and the fifth has obtained 70% control. All patients have had significant improvement in psychosocial measures. For comparison, five patients with generally similar clinical and neuroradiologic features to the previous group underwent preoperative ILTVE monitoring. The surgical outcomes between the two groups have not differed significantly. Conclusions: We conclude that patients with FL epilepsies may be able to undergo successful surgery without preoperative ILTVE monitoring, provided there is high concordance between neuroimaging tests (MRI, SPECT, PET) and the seizure phenotypes, even when routine EEGs and scalp LVTE fail to localize ictal onset unambiguously. The surgical outcomes of these patients generally paralleled those of the other subjects who also had FL epilepsy but who were operated on only after standard ILTVE monitoring. [source]

Basic science knowledge of dental students on conventional and problem-based learning (PBL) courses at Liverpool

EUROPEAN JOURNAL OF DENTAL EDUCATION, Issue 4 2001
K. S. Last
This cross-sectional study investigated performances of two consecutive cohorts of second year dental students on completion of a conventional didactic course and two succeeding cohorts of second year dental students on a recently introduced problem-based learning (PBL) course at The University of Liverpool School of Dentistry. A 40 part true/false questionnaire tested recall of factual knowledge in anatomy, biochemistry, oral biology and physiology. The results showed no significant difference in the total scores when negatively marked between the conventional and PBL course groups but higher total scores in the PBL groups when positively marked. Performances in anatomy, oral biology and physiology did not differ between the groups when negatively marked but the scores of the conventional course groups in biochemistry were significantly lower than the others. With positive marking biochemistry scores were not significantly different but all other subjects were significantly higher in the PBL course groups. The PBL course groups offered fewer blank responses than the conventional course groups but the ratio of correct to incorrect responses, for both definite and intelligent guess responses, were similar in these groups. The compositional profile of the study groups was similar with respect to educational background but the PBL course groups included more females and more older students. The results of this study show that the overall knowledge recall in the basic sciences by dental students on PBL or conventional didactic courses does not differ and may be helpful to those considering the introduction of PBL into the curriculum. [source]

Relation of hypertension and glucose tolerance impairment in elderly people to the development of arteriosclerosis: Investigation using pulse wave velocity,

GERIATRICS & GERONTOLOGY INTERNATIONAL, Issue 1 2005
Takeshi Isobe
Background: The aim of the present study was to determine the correlation between the combination of hypertension and diabetes mellitus and arteriosclerosis using pulse wave velocity (PWV). Methods: The subjects were 186 men over the age of 60 years (mean age: 68.8 ± 5.8 years). PWV, systolic blood pressure (SBP), diastolic blood pressure, body mass index, fasting blood sugar (FBS), total cholesterol, triglyceride and HDL cholesterol were measured in all subjects. The subjects were divided into three groups on the basis of FBS level: a normal group (FBS < 110 mg/dL), an impaired fasting glucose group (110 , FBS < 126 mg/dL) and a diabetes mellitus group (FBS , 126 mg/dL or taking antidiabetics). The subjects were also divided into two groups on the basis of blood pressure level: a hypertension (HT) group (SBP , 140 mmHg and/or diastolic blood pressure , 90 mmHg or taking antihypertensives) and a normotension group (other subjects). Results: PWV showed positive correlations with SBP and FBS (r = 0.499 and r = 0.300, respectively). In all three groups classified by FBS level, PWV was higher in subjects with HT than in subjects with normotension (P < 0.01 in all three groups). In the HT group, PWV had already increased at the stage of impaired fasting glucose and was significantly higher in the diabetes mellitus group than in the normal FBS group (P = 0.002). In multiple regression analysis using PWV as a dependent variable, SBP and FBS were selected as independent variables. Conclusions: Even in the elderly, strict control of blood pressure and blood sugar level may be necessary in order to prevent the development of arteriosclerotic diseases. [source]

CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease

HEPATOLOGY, Issue 2 2003
Maurice G. Emery
Previous studies suggest that hepatic cytochrome P450 2E1 (CYP2E1) activity is increased in individuals with chronic alcoholism, nonalcoholic steatohepatitis (NASH), and morbid obesity, and may contribute to liver disease. We studied 16 morbidly obese subjects with varying degrees of hepatic steatosis and 16 normal-weight controls. Obese subjects were evaluated at baseline, 6 weeks, and 1 year after gastroplasty, a procedure that leads to weight loss. Hepatic CYP2E1 activity was assessed by determination of the clearance of chlorzoxazone (CLZ), an in vivo CYP2E1-selective probe. Liver biopsy tissue was obtained during surgery for histopathology. Both the total and unbound oral CLZ clearance (Clu/F) was elevated approximately threefold in morbidly obese subjects compared with controls (P < .001). The Clu/F was significantly higher among subjects with steatosis involving >50% of hepatocytes, compared with those with steatosis in ,50% of hepatocytes (P = .02). At postoperative week 6 and year 1, the median body mass index (BMI) of subjects who underwent gastroplasty decreased by 11% and 33%, total oral CLZ clearance declined by 16% (P < .01) and 46% (P < .05), and Clu/F decreased by 18% (P < .05) and 35% (P = .16), respectively. Moreover, those subjects with a year 1 BMI <30 kg/m2 exhibited a median Clu/F that was 63% lower (P = .02) than the respective clearance for all other subjects. In conclusion, hepatic CYP2E1 activity is up-regulated in morbidly obese subjects. A positive association between the degree of steatosis and CYP2E1 activity preoperatively and between the extent of obesity and CYP2E1 activity postoperatively, suggests that CYP2E1 induction is related to or caused by hepatic pathology that results from morbid obesity. [source]

Determinants of performance in advanced undergraduate management accounting: An empirical investigation

ACCOUNTING & FINANCE, Issue 1 2002
L. G. Drennan
This exploratory study empirically investigates the performance of students in advanced management accounting. Findings are that English language as the first or subsequent language has no differential impact on introductory level performance. However, at advanced levels and in other subjects requiring the application of concepts to unfamiliar situations, students whose first language was English outperformed others. Similarly, students who had studied prerequisite subjects at the same university outperformed their exempted colleagues (both overseas and local) in advanced management accounting. These findings indicate that the difference due to language differences may not actually be due to language, but rather that language may simply be proxying for something else such as a different learning style. [source]

Effects of reminiscence and life review on late-life depression: a meta-analysis

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, Issue 12 2003
Ernst Bohlmeijer
Abstract Aim To assess the effectiveness of reminiscence and life review on late-life depression across different target groups and treatment modalities. Method Twenty controlled outcome studies were retrieved from Psychlit, Medline and Dissertation Abstracts. For each study a standardised effect size, d, was calculated and a random-effects meta-analysis was conducted. Results An overall effect size of 0.84 (95% Confidence Intervals (CI)=0.31,1.37) was found, indicating a statistically and clinically significant effect of reminiscence and life review on depressive symptomatology in elderly people. This effect is comparable to the effects commonly found for pharmacotherapy and psychological treatments. The effect was larger in subjects with elevated depressive symptomatology (d=1.23) as compared to other subjects (d=0.37). Other characteristics of the subjects or interventions were not found to be related to increased or decreased effect sizes. Discussion Reminiscence and life review are potentially effective treatments for depressive symptoms in the elderly and may thus offer a valuable alternative to psychotherapy or pharmacotherapy. Especially in non-institutionalised elderly people,who often have untreated depression,it may prove to be an effective, safe and acceptable form of treatment. Randomized trials with sufficient statistical power are necessary to confirm the results of this study. Copyright © 2003 John Wiley & Sons, Ltd. [source]

The multi-chain Markov switching model

JOURNAL OF FORECASTING, Issue 7 2005
Edoardo Otranto
Abstract In many real phenomena the behaviour of a certain variable, subject to different regimes, depends on the state of other variables or the same variable observed in other subjects, so the knowledge of the state of the latter could be important to forecast the state of the former. In this paper a particular multivariate Markov switching model is developed to represent this case. The transition probabilities of this model are characterized by the dependence on the regime of the other variables. The estimation of the transition probabilities provides useful information for the researcher to forecast the regime of the variables analysed. Theoretical background and an application are shown. Copyright © 2005 John Wiley & Sons, Ltd. [source]

Levels of HSP70 in HIV+ patients in different viroimmunological states

JOURNAL OF MEDICAL VIROLOGY, Issue 3 2006
E. Espigares
Abstract The aim of the study was to establish an association between the viroimmunological status of HIV positive patients and their levels of the 70-kD heat shock protein (Hsp70). The longitudinal retrospective case study involved 61 patients at the University Hospital in Granada (Spain) from 1999 to 2002. Twenty-five patients were viroimmunologically stable, while the other 36 patients had suffered virological failure. A minimum of three blood samples were taken at intervals of at least 3 months for the patients who were stable virologically and immunologically, whereas four samples were taken for the virological failure group: two previous to the onset of virological failure, a third corresponding to the time of virological failure, and a fourth at least 3 months after remission of virological failure. Blood samples were also obtained from 20 healthy control subjects; Hsp70 levels in all were determined by enzyme immunoassay. The mean concentration of Hsp70 was 145.4 ng/ml in the HIV-infected patients as opposed to 72.1 ng/ml in the controls. While the viroimmunologically stable group showed levels similar to those of the controls (66.5 ng/ml), the mean value of Hsp70 in the virological failure group was nearly four times as high (249.1 ng/ml), yet this difference was not statistically significant. The patients treated with reverse transcriptase inhibitors were found to have significantly higher levels of Hsp70 than the other subjects. The transformed variable Hsp70/CD4+ presents less variability than the Hsp70 value itself, giving a higher degree of statistical significance, and may be considered a useful parameter for diagnostic, prognostic, and therapeutic management of HIV positive patients. J. Med. Virol. 78:318,323, 2006. © 2006 Wiley-Liss, Inc. [source]

Progress in International Reading Literacy Study 2006 (PIRLS): pedagogical correlates of fourth-grade students in Hong Kong

JOURNAL OF RESEARCH IN READING, Issue 3 2009
Wai Ming Cheung
Reading literacy of fourth-grade students in Hong Kong showed a remarkable improvement from 2001 to 2006 as shown by international PIRLS studies. This study identified various aspects of the teacher factor contributing to the significant improvement among students. A total of 4,712 students and 144 teachers from 144 schools were randomly selected using probability proportional-to-size technique to receive the Reading Assessment Test and complete the Teacher's Questionnaire, respectively. A number of items pertaining to teachers' instructional strategies and activities, opportunities for students to read various types of materials, practices on assessment, and professional preparation and perception, were found to be significantly correlated with the outcome of students' reading literacy. Stepwise regression procedure revealed four significant predictors for students' overall reading achievement. The most powerful predictor was the use of materials from other subjects as reading resources. Suggestions to improve quality of teaching of reading and further studies are made. [source]

MEASUREMENT OF BITING VELOCITIES, AND PREDETERMINED AND INDIVIDUAL CROSSHEAD SPEED INSTRUMENTAL IMITATIVE TESTS FOR PREDICTING CHEESE HARDNESS

JOURNAL OF TEXTURE STUDIES, Issue 1 2002
J.-F. MEULLENET
ABSTRACT Average first bite velocities of ten cheeses were measured for seven subjects trained in descriptive analysis using an electrognathograph. The effectiveness of instrumental imitative tests performed at predefined and individual crosshead speeds (matching velocities measured in vivo) to predict hardness perception of cheeses were assessed. For five of the seven subjects, the perception of hardness was adequately described by imitative instrumental tests performed with dental replicas of individual subjects. For some of the subjects (2 of 5), individual crosshead speed testing significantly improved the instrumental prediction of hardness. For other subjects, the instrumental test method did not seem to greatly influence the results. [source]

The effect of perceived length on visuomotor localization

OPHTHALMIC AND PHYSIOLOGICAL OPTICS, Issue 3 2001
Nick Fogt
Summary Purpose: The purpose of this experiment was to study visuomotor localization in the presence of either a horizontal array of equally spaced dots or a thin horizontal line. Methods: Pointing behavior was used to assess directional localization. In experiment 1, subjects were made myopic using a contact lens and then corrected with a spectacle lens. Subjects were tested in the presence and absence of a regularly spaced, horizontal array of dots with and without the contact lens/spectacle combination. In experiment 2, subjects wore the contact lens/spectacle in all cases. Some subjects were tested in the presence and then in the absence of a regularly spaced, horizontal array of dots while the order of conditions was reversed for other subjects. In experiments 3 and 4, subjects were tested without the contact lens/spectacle combination. In experiment 3, subjects were tested in the absence and then in the presence of a regularly spaced, horizontal arrays of dots. In experiment 4, subjects were tested in the absence and then in the presence of a thin horizontal line. Results: In experiment 1, in the absence of the array of dots, subjects undershot targets with the contact lens/spectacle combination. When the array was present, pointing with the contact lens/spectacle combination was accurate. In experiment 2, subjects undershot targets in the absence of the array of dots if this condition was performed first. If the array was present in the initial condition, the pointing undershoot in the second condition (array absent) was reduced. In all cases, the pointing undershoot was reduced in the presence of the array. In experiments 3 and 4, a pointing overshoot was found in the presence of an array of dots or a thin line. Conclusions: It is concluded that extraretinal eye position information is not the primary determinant of visuomotor localization in the presence of a horizontal contour. The overshoot produced by a horizontal contour may be related to a length illusion brought about by spatial filtering in the visual system or inaccurate distance judgments. [source]

Distribution of 10 periodontal bacterial species in children and adolescents over a 7-year period

ORAL DISEASES, Issue 7 2008
K Nakano
Objective:, There is scant information available regarding the distribution of periodontal bacterial species in children and adolescents over an extended period. The purpose of this study was to compare bacterial profiles in the same individuals over a period of 7 years. Subject and methods:, Twenty-six children and adolescents from whom dental plaque and saliva specimens were obtained during both the first (1999,2000) and second (2006,2007) periods, were analyzed. Bacterial DNA was extracted from each specimen and the presence of 10 periodontal bacterial species was determined using a PCR method, with a focus on the red complex species of Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia. Results:, Subjects with red complex species in saliva specimens obtained during the second collection possessed a significantly higher number of total bacterial species than those without. The detection rate of the red complex species in the second collection period samples was significantly greater in subjects who had two or more species detected in samples taken during the first collection compared with the other subjects. Conclusion:, Subjects possessing red complex species may be at possible risk for infection with a high number of periodontal bacterial species during adolescent and younger adult years. [source]

Beryllium-stimulated neopterin as a diagnostic adjunct in chronic beryllium disease

AMERICAN JOURNAL OF INDUSTRIAL MEDICINE, Issue 6 2003
Lisa A. Maier MD, MSPH
Abstract Background The diagnosis of chronic beryllium disease (CBD) relies on the beryllium lymphocyte proliferation test (BeLPT) to demonstrate a Be specific immune response. This test has improved early diagnosis, but cannot discriminate beryllium sensitization (BeS) from CBD. We previously found high neopterin levels in CBD patients' serum and questioned whether Be-stimulated neopterin production by peripheral blood cells in vitro might be useful in the diagnosis of CBD. Methods CBD, BeS, Be exposed workers without disease (Be-exp) normal controls and sarcoidosis subjects were enrolled. Peripheral blood mononuclear cells (PBMN) were cultured in the presence and absence of beryllium sulfate. Neopterin levels were determined from cell supernatants by enzyme linked immunosorbent assay (ELISA). Clinical evaluation of CBD subjects included chest radiography, pulmonary function testing, exercise testing, and the BeLPT. Results CBD patients produced higher levels of neopterin in both unstimulated and Be-stimulated conditions compared to all other subjects (P,<,0.0001). Unstimulated neopterin mononuclear cell levels overlapped among groups, however, Be-stimulated neopterin levels in CBD showed little overlap. Using a neopterin concentration of 2.5 ng/ml as a cutoff, Be-stimulated neopterin had a sensitivity of 80% and specificity of 100% for CBD and was able to differentiate CBD from BeS. Be-stimulated neopterin was inversely related to measures of pulmonary function, exercise capacity, and gas exchange. Conclusions Neopterin may be a useful diagnostic adjunct in the non-invasive assessment of CBD, differentiating CBD from BeS. Further studies will be required to determine how it performs in workplace screening. Am. J. Ind. Med. 43:592,601, 2003. © 2003 Wiley-Liss, Inc. [source]

Bone marrow transplantation in subjects with mental disorders

PSYCHIATRY AND CLINICAL NEUROSCIENCES, Issue 3 2003
Rie Akaho
Abstract Bone marrow transplantation (BMT) is a critical treatment of malignant illnesses including leukemia and others. Successful achievement of BMT requires the patients to tolerate isolation for several weeks to avoid infections. They are also required to follow several regulations and instructions to survive the treatment because the patients' physical condition is complicated due to the malignant illness, preparatory treatment and transplant of bone marrow from other subjects. These could be a significant challenge for patients with mental disorders. Here the cases are reported of seven leukemia patients who were referred to the Metropolitan Komagome Hospital for BMT from April 1996 through May 2000, who had been suffering from mental disorders, including schizophrenia, bipolar I mood disorder, panic disorder, dysthymic disorder, autistic disorder, and borderline personality disorder, prior to the treatment. The BMT was achieved in six out of the seven subjects; the exception was a subject with borderline personality disorder. Psychiatric treatments, including medication, to improve and maintain mental status appeared to be critical for the achievement of BMT in several patients. Understanding of the status of the malignant disease and the role of BMT was another significant issue. Test admission seemed to be helpful to reduce concerns and anxiety both in the patients and hospital staff. [source]

Between private and public: Towards a conception of the transitional subject

THE INTERNATIONAL JOURNAL OF PSYCHOANALYSIS, Issue 5 2008
Jill Gentile
Elaborating upon Winnicott's seminal contributions on the transitional object, the author proposes a conception of a transitional subject in which the patient comes into being simultaneously between private and public, subjective creation and material life, me and not-me. By anchoring subjective creation in the real world (including the body), the patient creates a basis for authentic psychesoma as well as for both personal and symbolic contributions to the world beyond omnipotence, including the world of other subjects. In this sense, intersubjective life is seen as predicated upon transitionality, with the patient seen as simultaneously coming into being as a distinctly personal subject and, in part, as a symbol. Clinical phenomenology is described and is interpreted with respect to the need within psychoanalysis itself for a third, and for a realm of meaning-creation that lies beyond privacy, omnipotence, and the dyad. [source]

Changes in cerebral oxygenation in children undergoing surgical repair of ventricular septal defects

ANAESTHESIA, Issue 1 2003
Y. Morimoto
Summary There have been few published studies on changes in cerebral oxygenation during paediatric cardiac surgery as measured by conventional near-infrared spectroscopy. We studied changes in cerebral oxygenation in 16 children undergoing surgical repair of ventricular septal defects. Fifteen of the patients showed similar patterns of changes: brain tissue concentrations of oxyhaemoglobin decreased significantly during cardiopulmonary bypass, whereas there was no significant change in brain tissue concentrations of deoxyhaemoglobin. In the remaining patient, who suffered decreased blood flow to the lower body during surgery, the pattern of changes was different to that of the other subjects. This patient suffered postoperative respiratory and renal failure. This study suggests that conventional near-infrared spectroscopy may be useful for clinical monitoring during ventricular septal defect repair. [source]

Die Mittlere Lebensdauer Der Veterinäranatomen an Deutschsprachigen, Tierärztlichen Bildungsstätten

ANATOMIA, HISTOLOGIA, EMBRYOLOGIA, Issue 2 2009
B. Vollmerhaus
Summary The average lifespan of veterinary anatomists was statistically analysed. All teachers who ever taught veterinary anatomy (formerly ,zootomy') and histology/embryology separately or in combination with other subjects in Germany, Austria and Switzerland were included in that circle. The observation period was from the foundation of the veterinary schools up to the present. We find that the average lifespan of this specific group is not different from that of the general population. Comparable previous opinions on the lifespan of anatomists, estimated as shorter than that of the general population by Hyrtl, and longer by Voss, are incorrect. This opportunity is also used to mention our time-honored; especially the early completed and aged colleagues. Zusammenfassung Die Lebensdauer der Veterinäranatomen wird statistisch untersucht. In den Personenkreis sind alle Lehrer einbezogen, die die Fächer Veterinäranatomie (früher Zootomie) und Histologie/Embryologie separat oder in Verbindung mit anderen Fächern jemals in Deutschland, Österreich und der Schweiz gelehrt haben. Der Beobachtungszeitraum reicht von der Gründung von Tierarzneischulen bis zur Gegenwart. Das Fazit lautet, daß sich die mittlere Lebensdauer dieser spezifischen Berufsgruppe nicht von derjenigen der allgemeinen Bevölkerung unterscheidet. Vergleichbare ältere Ansichten über die Lebensdauer der Anatomen , von Hyrtl als kürzer vermutet, von Voss als weit länger berechnet , sind unzutreffend. Die Gelegenheit wird genutzt, unserer Altvorderen, insbesondere der Frühvollendeten und Hochbetagten, zu gedenken. [source]

Pilot trial of low-dose naltrexone and quality of life in multiple sclerosis,

ANNALS OF NEUROLOGY, Issue 2 2010
Bruce A. C. Cree MD
Objective To evaluate the efficacy of 4.5mg nightly naltrexone on the quality of life of multiple sclerosis (MS) patients. Methods This single-center, double-masked, placebo-controlled, crossover study evaluated the efficacy of 8 weeks of treatment with 4.5mg nightly naltrexone (low-dose naltrexone, LDN) on self-reported quality of life of MS patients. Results Eighty subjects with clinically definite MS were enrolled, and 60 subjects completed the trial. Ten withdrew before completing the first trial period: 8 for personal reasons, 1 for a non,MS-related adverse event, and 1 for perceived benefit. Database management errors occurred in 4 other subjects, and quality of life surveys were incomplete in 6 subjects for unknown reasons. The high rate of subject dropout and data management errors substantially reduced the trial's statistical power. LDN was well tolerated, and serious adverse events did not occur. LDN was associated with significant improvement on the following mental health quality of life measures: a 3.3-point improvement on the Mental Component Summary score of the Short Form-36 General Health Survey (p = 0.04), a 6-point improvement on the Mental Health Inventory (p < 0.01), a 1.6-point improvement on the Pain Effects Scale (p =.04), and a 2.4-point improvement on the Perceived Deficits Questionnaire (p = 0.05). Interpretation LDN significantly improved mental health quality of life indices. Further studies with LDN in MS are warranted. ANN NEUROL 2010 [source]

Decreased ventilatory response to hypercapnia in dementia with Lewy bodies,

ANNALS OF NEUROLOGY, Issue 5 2009
Katsuyoshi Mizukami MD
A systematic autonomic dysfunction observed among patients with dementia with Lewy bodies (DLB) has recently attracted close attention. Here, we compare cardiovascular and pulmonary autonomic functions among patients with DLB, patients with Alzheimer's disease, and healthy control subjects. All 15 DLB patients demonstrated severely low ventilatory response to hypercapnia, whereas none of the other subjects demonstrated abnormal results. The majority of the DLB patients showed impaired heart rate variability, low uptake on 123I-metaiodobenzylguanidine myocardial scintigraphy, and orthostatic hypotension. Ventilatory response to hypercapnia as a marker of respiratory autonomic function is a promising diagnostic tool for DLB. Ann Neurol 2009;65:614,617 [source]

Mild-onset presentation of Canavan's disease associated with novel G212A point mutation in aspartoacylase gene

ANNALS OF NEUROLOGY, Issue 2 2006
Christopher G. Janson MD
We describe two sisters with a mild-onset variant of Canavan's disease who presented at age 50 and 19 months with developmental delay but without macrocephaly, hypotonia, spasticity, or seizures. Remarkably, both patients had age-appropriate head control, gross motor development, and muscle tone. There were very mild deficits in fine motor skills, coordination, and gait. Both sisters had a history of strabismus, but otherwise vision was normal. The older child showed evidence of mild cognitive and social impairment, whereas language and behavior were normal for age in the infant. Both patients were found to be compound heterozygotes for C914A (A305E) and G212A (R71H) mutations in ASPA. Like all other known ASPA mutations, this previously unknown G212A mutation appears to have low absolute enzyme activity. Nevertheless, it is associated in these patients with an extremely benign phenotype that is highly atypical of Canavan's disease. Biochemical and clinical data were evaluated using a generalized linear mixed model generated from 25 other subjects with Canavan's disease. There were statistically significant differences in brain chemistry and clinical evaluations, supporting a distinct variant of Canavan's disease. Future studies of ASPA enzyme structure and gene regulation in these subjects could lead to a better understanding of Canavan's pathophysiology and improvements in ASPA gene therapy Ann Neurol 2006;59:428,431 [source]

Peritoneal T Cell Responses Can Be Polarized Toward Th1 or Th2 in Children on Chronic Peritoneal Dialysis

Teaching of biochemistry in medical school

BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION, Issue 6 2008
A well-trodden pathway?
Abstract Biochemistry and molecular biology occupy a unique place in the medical school curriculum. They are frequently studied prior to medical school and are fundamental to the teaching of biomedical sciences in undergraduate medical education. These two circumstances, and the trend toward increased integration among the disciplines, have led to reconsideration of biochemistry instruction in many medical schools. We conducted a survey to explore the evolving trends in biochemistry education. A broad diversity was evident in parameters including course content, faculty, governance, prerequisites, and teaching methods. Notably, sharp differences were apparent between freestanding biochemistry courses and those in which biochemistry is integrated with other subjects. Furthermore, the data imply a likely trend toward increased integration of biochemistry with other disciplines in the medical school curriculum. [source]

Late effects of early growth hormone treatment in Down syndrome

ACTA PAEDIATRICA, Issue 5 2010
Å Myrelid
Abstract Objective:, Down syndrome (DS) is associated with short stature and psychomotor delay. We have previously shown that growth hormone (GH) treatment during infancy and childhood normalizes growth velocity and improves fine motor skill performance in DS. The aim of this study was to investigate late effects of early GH treatment on growth and psychomotor development in the DS subjects from the previous trial. Design:, Twelve of 15 adolescents with DS (3 F) from the GH group and 10 of 15 controls (5 F) participated in this follow-up study. Fifteen other subjects with DS (6 F) were included as controls in anthropometric analyses. Cognitive function was assessed with the Leiter International Performance Scale-Revised (Leiter-R) and selected subtests of the Wechsler Intelligence Scale for Children, Third edition (WISC-III). The Bruininks-Oseretsky Test of Motor Proficiency, Second edition (BOT-2), was used to assess general motor ability. Results:, Although early GH treatment had no effect on final height, the treated subjects had a greater head circumference standard deviation score (SDS) than the controls (,1.6 SDS vs. ,2.2 SDS). The adolescents previously treated with GH had scores above those of the controls in all subtests of Leiter-R and WISC-III, but no difference in Brief IQ-score was seen between the groups. The age-adjusted motor performance of all subjects was below ,2 SD, but the GH-treated subjects performed better than the controls in all but one subtest. Conclusion:, The combined finding of a greater head circumference SDS and better psychomotor performance indicates that DS subjects may benefit from early GH treatment. [source]