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Other Candidates (other + candidate)

Distribution by Scientific Domains
Medical Sciences40%

Terms modified by Other Candidates

  • other candidate gene
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    Selected Abstracts

    Review article: investigational agents for chronic hepatitis C

    ALIMENTARY PHARMACOLOGY & THERAPEUTICS, Issue 7 2009
    A. J. V. THOMPSON
    Summary Background, The need for effective treatment for chronic hepatitis C infection has driven the development of novel antiviral agents that target specific steps in the viral replication cycle. Aim, To evaluate the current literature concerning investigational agents for chronic hepatitis C virus infection. Methods, Resources used included PubMed, conference proceedings from the American and European Liver Associations' meetings 2005,2008 and the National Institute of Health's clinical trials website (http://www.clinicaltrials.gov). The focus was restricted to investigational agents that have progressed beyond preclinical development. Results, Over 50 investigational agents for chronic hepatitis C infection are currently in clinical development. Specifically targeted anti-viral therapy for HCV (STAT-C) shows great promise with NS3/4a protease inhibitors now entering phase 3 programmes. New interferon-, and ribavirin formulations aim to optimize anti-viral efficacy yet limit toxicity. Other candidates include novel immunomodulators and therapeutic vaccines. Conclusions, A new era of therapy for chronic hepatitis C beckons, promising increased cure rates with shortened duration of therapy. However, the era will not be without challenges including viral resistance, drug toxicity and the need to optimize combination therapy in the face of a rapidly evolving therapeutic arsenal. [source]

    Identification of five chromosomal regions involved in predisposition to melanoma by genome-wide scan in the MeLiM swine model

    INTERNATIONAL JOURNAL OF CANCER, Issue 1 2004
    Claudine Geffrotin
    Abstract In human familial melanoma, 3 risk susceptibility genes are already known, CDKN2A, CDK4 and MC1R. However, various observations suggest that other melanoma susceptibility genes have not yet been identified. To search for new susceptibility loci, we used the MeLiM swine as an animal model of hereditary melanoma to perform a genome scan for linkage to melanoma. Founders of the affected MeLiM stock were crossed with each other and with healthy Duroc pigs, generating MeLiM, F1 and backcross families. As we had previously excluded the MeLiM CDKN2A gene, we paid special attention to CDK4 and MC1R, as well as to other candidates such as BRAF and the SLA complex, mapping them on the swine radiation hybrid map and/or isolating close microsatellite markers to introduce them into the genome scan. The results revealed, first, that swine melanoma was inherited as an autosomal dominant trait with incomplete penetrance, preferably in black animals. Second, 4 chromosomal regions potentially involved in melanoma susceptibility were identified on Sus Scrofa chromosomes (SSC) 1, 2, 7 and 8, respectively, in intervals 44,103, 1.9,18, 59,73 and 47,62 cM. A fifth region close to MC1R was revealed on SSC 6 by analyzing an individual marker located at position 7.5 cM. Lastly, CDK4 and BRAF were unlikely to be melanoma susceptibility genes in the MeLiM swine model. The 3 regions on SSC 1, 6 and 7, respectively, have counterparts on human chromosomes (HSA) 9p, 16q and 6p, harboring melanoma candidate loci. The 2 others, on SSC 2 and 8, have counterparts on HSA 11 and 4, which might therefore be of interest for human studies. © 2004 Wiley-Liss, Inc. [source]

    Local outbreaks of Operophtera brumata and Operophtera fagata cannot be explained by low vulnerability to pupal predation

    AGRICULTURAL AND FOREST ENTOMOLOGY, Issue 1 2010
    Annette Heisswolf
    1One of the unresolved questions in studies on population dynamics of forest Lepidoptera is why some populations at times reach outbreak densities, whereas others never do. Resolving this question is especially challenging if populations of the same species in different areas or of closely-related species in the same area are considered. 2The present study focused on three closely-related geometrid moth species, autumnal Epirrita autumnata, winter Operophtera brumata and northern winter moths Operophtera fagata, in southern Finland. There, winter and northern winter moth populations can reach outbreak densities, whereas autumnal moth densities stay relatively low. 3We tested the hypothesis that a lower vulnerability to pupal predation may explain the observed differences in population dynamics. The results obtained do not support this hypothesis because pupal predation probabilities were not significantly different between the two genera within or without the Operophtera outbreak area or in years with or without a current Operophtera outbreak. 4Overall, pupal predation was even higher in winter and northern winter moths than in autumnal moths. Differences in larval predation and parasitism, as well as in the reproductive capacities of the species, might be other candidates. [source]

    Continuous screening system for inhibited enzyme catalysis: A membrane reactor approach

    BIOTECHNOLOGY JOURNAL, Issue 8 2010
    Evgenij Lyagin
    Abstract The screening of catalysts, substrates or conditions in the early stages of bioprocess development requires an enormous number of experiments and is a tedious, expensive and time-consuming task. Currently available screening systems can only be operated in batch or fed-batch mode, which can lead to severe misinterpretations of screening results. For example, catalysts that are inhibited by substrates or accumulating products will be excluded from further investigations in the early stages of process development despite the fact that they might be superior to other candidates in a different operational mode. Important and advantageous properties such as turnover stability can also be overshadowed by product inhibition. The aim of this study was to develop a novel screening system that enables continuous feeding of substrates and continuous removal of products. A prototype based on the membrane reactor concept was designed and operated for a model reaction, the hydrolysis of cellulose. [source]

    The Role of Indigenous Peoples in Guatemalan Political Advertisements: An Ethnographic Content Analysis

    COMMUNICATION, CULTURE & CRITIQUE, Issue 3 2010
    Colleen Connolly-Ahern
    This study investigates the current status of indigenous peoples within Guatemalan society, as articulated in one of the most relevant forms of modern communication, political advertising, and defined by one of the most relevant forms of self-expression to the indigenous peoples of Guatemala, the traje. Using ethnographic content analysis, the study examines the roles and characterizations of indigenous people in 67 television commercials from across the Guatemalan political spectrum. Results indicate that indigenous people are most often seen as "crowd members," and are never given important roles, such as "candidate endorser" or "undecided voter." Overall, wearing traje is associated with helplessness and separateness. The commercials of Q'iché Maya candidate Rigoberta Menchú exhibited many of the same characteristics of other candidates. Le rôle des peuples autochtones dans les publicités politiques guatémaltèques : une analyse de contenu ethnographique Colleen Connolly-Ahern & Antoni Castells i Talens Cette étude explore le statut actuel des peuples autochtones dans la société guatémaltèque, telle qu'elle est articulée dans l'une des formes les plus appropriées de communication moderne, les publicités politiques, et telle que définie par l'une des formes d'expression des peuples autochtones du Guatemala les plus pertinentes, le «traje». Par une analyse de contenu ethnographique, l'étude explore les rôles et les représentations des peuples autochtones dans 67 publicités télévisées couvrant le spectre politique du Guatemala. Les résultats indiquent que les peuples autochtones sont le plus souvent vus comme des «membres de la foule». Ils n'ont jamais de rôles importants comme celui de «partisan d'un candidat» ou d'«électeur indécis'. Dans l'ensemble, le port du «traje» est associéà l'impuissance et à la différence. Les publicités de la candidate maya k'iche' Rigoberta Menchú présentaient plusieurs des mêmes caractéristiques que celles des autres candidats. El Rol de las Personas Indígenas en la Publicidad Política de Guatemala: Un Análisis de Contenido Etnográfico Colleen Connolly-Ahern & Antoni Castells i Talens Advertising and Public Relations College of Communications, Penn State University, State College, PA 16802, USA Resumen Este estudio investiga el estado corriente de las personas indígenas dentro de la sociedad Guatemalteca, articulado en una de las formas más relevantes de la comunicación moderna, la publicidad política, y definido por una de las formas más relevantes de auto expresión de las personas Indígenas de Guatemala, el traje. Usando un análisis de contenido etnográfico, este estudio examina los roles y las caracterizaciones de las personas indígenas en 67 comerciales de televisión a través del espectro político Guatemalteco. Los resultados indican que las personas indígenas son vistas más a menudo como "miembros de la multitud'' y nunca se les da roles importantes tales como ,,el candidato de la representación'' o ,,el votante indeciso. '' En general, el uso del traje está asociado con la impotencia y la separación. Los comerciales de la candidata Q'ich,e Maya Rigoberta Menchú exhibieron muchas de las mismas características de los otros candidatos. [source]