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Other Biological (other + biological)
Selected AbstractsBaseline cortisol measures and developmental pathways of anxiety in early adolescenceACTA PSYCHIATRICA SCANDINAVICA, Issue 3 2009K. Greaves-Lord Objective:, This study investigated whether baseline cortisol measures predicted future anxiety, and compared cortisol values of groups with different developmental pathways of anxiety. Method:, Cortisol levels were assessed in 1768 individuals (10,12 years). Anxiety levels were assessed at the same age and 2 years later. Results:, Cortisol measures did not predict future anxiety levels. Individuals with persistent anxiety problems did not show higher morning cortisol levels than those with persistently low, decreasing, or increasing anxiety levels. Instead, individuals with persistently high anxiety levels showed significantly lower evening cortisol levels than all other individuals. Further, participants with increasing anxiety levels showed higher morning cortisol levels (area under the curve; AUC) than individuals with persistently low anxiety levels. Conclusion:, The extent to which the HPA-axis , by itself , plays a role in the aetiology of anxiety is questionable. Interactions of the HPA-axis with other biological or environmental factors may be more important. [source] In situ on-line toxicity biomonitoring in water: Recent developmentsENVIRONMENTAL TOXICOLOGY & CHEMISTRY, Issue 9 2006Almut Gerhardt Abstract ,In situ on-line biomonitoring is an emerging branch of aquatic biomonitoring. On-line biomonitoring systems use behavioral and/or physiological stress responses of caged test organisms exposed in situ either in a bypass system or directly instream. Sudden pollution waves are detected by several existing single-species on-line biomonitors, which until now have been placed mostly in streamside laboratories. However, recent achievements have been multispecies biomonitors, mobile biomonitors for direct in-stream use, development of new instruments, new methods for data analysis and alarm generation, biomonitors for use in soil and sediment, and scientific research supporting responses as seen in on-line biomonitors by linking them to other biological and ecological effects. Mobile on-line monitoring platforms containing an array of biomonitors, biosensors, and chemical monitoring equipment might be the future trend, especially in monitoring transboundary rivers at country borders as well as in coastal zones. [source] Relationship between UVA protection and skin response to UV light: proposal for labelling UVA protectionINTERNATIONAL JOURNAL OF COSMETIC SCIENCE, Issue 4 2004M. Jean-Louis Refrégier Synopsis Definition and validation of a most relevant method to assess ultravoilet A (UVA) protection is a major concern for industry, authorities and consumers. However, due to the lack of knowledge about all the biological phenomena involved, the level of UVA protection needed, the ways to assess and label it, remain controversial. In order to overcome this situation, the paper deals with the outcomes of a mathematical model to calculate the distribution between ultravoilet B (UVB) and UVA components of skin responses to UV light. Mathematical calculations of UVB and UVA erythemal components of skin response to sunlight are developed from the well-known determination procedure to calculate the sunburn protection factor (SPF) of sunscreens. The model establishes the relationship between the UVA component of skin erythemal response to overall UV radiation received from sunlight and the ratio SPF/PFAe (erythemal protection factor) where SPF is the product and PFAe is related to the UVA part of the sunlight. Depending on the efficacy profile of sunscreens, the skin erythemal response may be mainly promoted by UVB rays as it normally occurs in unprotected skin or on contrary by UVA rays. Therefore, the efficacy profile of sunscreens defines the deepness where biological events induced by sunlight take place. This new relationship pinpoints the tremendous importance of the protection afforded by sunscreen products in the UVA range when erythema is taken as biological response. By extrapolation of the model to any other biological skin response it becomes possible to predict how to improve the efficiency of sunscreen products in the future. UVA protection afforded by sunscreens should be improved until reaching the same level as the SPF protection factor so that all UV-induced biological responses could be prevented or lowered at the same extend. To enforce this improvement, a proposal to classify sunscreen products in relation with their UVA protection is made. Résumé Bien que les méfaits du rayonnement UVA soient à présent reconnus et l'importance de s'en protéger au même titre que ceux du rayonnement UVB totalement admise, l'obtention d'un consensus au niveau international, sur les méthodes pour mesurer l'efficacité des produits solaires vis-à-vis des UVA et sur les niveaux d'efficacité souhaitables, semble impossible à atteindre. Afin de tenter de surmonter les obstacles actuels, nous présentons un modèle mathématique qui permet d'établir la relation qui dèfinit le poids relatif des rayonnements UVB et UVA dans l'initiation des phénomènes biologiques engendrés par le rayonnement solaire, en fonction des caractéristiques du produit solaire utilisé et en particulier de son efficacité protectrice vis-à-vis des UVA. Dans le cas de l'érythème nous établissons ainsi que la proportion des effets engendrés par le rayonnement UVA est définie par le rapport SPF/PFAe: le SPF étant le facteur de protection contre l'érythème vis-à-vis de l,ensemble du rayonnement UV, c'est l'indice de protection affiché sur les produits; et, PFAe étant le facteur de protection du produit vis-à-vis du seul rayonnement UVA. L'extrapolation possible de ce modèle à l'ensemble des phénomènes biologiques met en évidence que le facteur de proportionnalité entre la protection globale et celle apportée vis-à-vis des UVA (SPF/PFAe) permet d'établir une classification de la qualité des systèmes filtrants en fonction de leur aptitude à prèvenir l'ensemble des méfaits du rayonnement solaire. Ce modèle démontre l'importance d'évaluer l,efficacité protectrice des produits solaires vis-à-vis du rayonnement UVA et son enseignement plus pertinent que celle de seulement évaluer l'allure des spectres d'absorption. Nous jugeons que l'application directe de ce modèle, au même titre que les méthodes d'évaluation de l,allure des spectres d'absorption, n'est aujourd'hui pas souhaitable en raison des connaissances et donc de la validation insuffisantes des méthodes in vitro en particulier pour évaluer les produits non parfaitement photostables. En conséquence, nous proposons de mettre en place une qualification qui repose sur l'évaluation de la protection UVA par les mèthodes in vivo dûment étudiées et validées telles que les méthodes PPD ou PFA. La mise en place du système proposé de qualification des produits solaires, permettrait d'apporter rapidement aux consommateurs une meilleure information sur la qualité des produits et permettrait de créer une dynamique d'amélioration de la qualité de l'ensemble des produits commercialisés. [source] In silico mining of EST databases for novel pre-implantation embryo-specific zinc finger protein genes,MOLECULAR REPRODUCTION & DEVELOPMENT, Issue 3 2001Kong-Bung Choo Abstract Progress in the understanding of early mammalian embryo development has been severely hampered by scarcity of study materials. To circumvent such a constraint, we have developed a strategy that involves a combination of in silico mining of new genes from expressed sequence tags (EST) databases and rapid determination of expression profiles of the dbEST-derived genes using a PCR-based assay and a panel of cDNA libraries derived from different developmental stages and somatic tissues. We demonstrate that in a random sample of 49 independent dbEST-derived zinc finger protein genes mined from a mouse embryonic 2-cell cDNA library, more than three-quarters of these genes are novel. Examination of characteristics of the human orthologues derived from these mouse genes reveals that many of them are associated with human malignancies. Expression studies have further led to the identification of three novel genes that are exclusively expressed in mouse embryos before or up to the 8-cell stage. Two of the genes, designated 2czf45 and 2czf48 (2czf for 2 -cell zinc finger), are zinc finger protein genes coding for a RBCC protein with a RFP domain and a protein with three C2H2 fingers, respectively. The third gene, designated 2cpoz56, codes for a protein with a POZ domain that is often associated with zinc finger proteins. These three genes are candidate genes for regulatory or other functions in early embryogenesis. The strategy described in this report should generally be applicable to rapid and large-scale mining of other classes of rare genes involved in other biological and pathological processes. Mol. Reprod. Dev. 59:249,255, 2001. © 2001 Wiley-Liss, Inc. [source] New advancements for in situ treatment using electrical resistance heatingREMEDIATION, Issue 2 2007Thomas Powell Electrical resistance heating (ERH) is proving to be an effective technology to rapidly heat the subsurface and, in doing so, removing volatile organic compounds. Practitioners of this technology have observed that other processes (biodegradation, abiotic degradation, hydrolysis, and possibly others) occur to break down the chemicals of concern, and remediation is not solely accomplished through vaporization. Few sites treated using ERH have been monitored during and after treatment to identify and evaluate the processes occurring and assess the contribution of these other biological and chemical processes in the remediation effort so that they may be incorporated in the remediation design. At Fort Lewis, Washington, a landfill has been undergoing ERH treatment in three phases, where chlorinated volatile organic compounds represent the primary chemicals of concern in soil and groundwater. Other chemicals of concern include petroleum products, oils, and lubricants. The Fort Lewis remediation projects provided an opportunity to observe the reactions occurring in the subsurface during ERH and fine-tune the study with each phase of operation. This study is still under way. However, the data gathered to date, which focuses on biodegradation, provides insights into the processes that have been observed. For the Fort Lewis site, biotic and abiotic degradation processes have been observed throughout the range of operating temperatures. At the lower temperature ranges (up to 70°C), biological processes appear to predominate. Above 70°C, abiotic processes become much more active. The goal of this work is to eventually optimize the use of these intrinsic processes in ERH remediation to reduce energy requirements and costs. © 2007 Wiley Periodicals, Inc. [source] Bioassay Labels Based on Apoferritin NanovehiclesCHEMBIOCHEM, Issue 9 2006Guodong Liu Dr. A simpler label. Various redox and optical markers have been easily loaded in the cavity of apoferritin to develop novel and versatile nanoparticle labels for optical and electrochemical bioassays. Such use of apoferritin nanovehicles offers convenient loading and releasing of the markers of interest by pH control instead of harsher conditions and avoids complicated nanoparticle syntheses. The new nanoparticle labels could be applicable to other biological assays, particularly immunoassays. [source] Digital Imaging: A Promising Tool for Mushroom IdentificationACADEMIC EMERGENCY MEDICINE, Issue 7 2003Connie B. Fischbein BA Mushroom poisoning is a diagnostic and treatment dilemma for health care professionals. Decisions regarding treatment following ingestions are usually made without a firm identification of the fungus and tend to be more aggressive than necessary. The identification of mushrooms is beyond the scope of health care professionals, and a mycologist is essential to make an accurate identification. Telemedicine and digital imaging is an emerging technology that can assist in mushroom identification and facilitate patient care. The efficacy of using digital images sent over the Internet was tested in a pilot project. This article describes three cases in which digital images and verbal descriptions assisted in mushroom identification. When the actual specimen was sent to a mycologist, a definitive identification was obtained and compared with the presumptive identification. Digital images alone do not permit definitive identification; however, they often contain sufficient information to help the clinician rule out the possibility of a severely toxic species. Data accumulated to date indicate that digital imaging can be an important tool in the diagnosis and treatment of mushroom ingestion, and possibly other biologicals such as plants, insects, and reptiles. [source] Ethical issues in biotechnologies and international tradeJOURNAL OF CHEMICAL TECHNOLOGY & BIOTECHNOLOGY, Issue 5 2002Joseph H Hulse Natural and physical sciences are based on determinable facts. What is ethical, as distinct from illegal, is largely a matter of opinion. Scientific and industrial activities related to ancient and modern biotechnologies are among the most critically scrutinised for ethical probity by social activists and journalists. The practices and products of biotechnologies should be judged both deontologically , by motivation and intention, and teleologically , by determinable consequence. Bioethical criteria have been proposed by governments, medical practitioners and philosophers for many centuries. During the past decade, various scientifically competent organisations, national and international, have formulated comprehensive protocols by which to determine effectiveness and safety of novel foods, pharmaceuticals and other biologicals, including those derived from genetically modified organisms. Means and opportunities by which to satisfy the health and nutritional needs of impoverished nations and communities differ significantly from those who enjoy greater affluence. It is distinctly unethical for Europeans and North Americans, whose food and health securities are not at risk, to impose their ethical predilections on poorer nations. Equally reprehensible are the diverse tariff and non-tariff barriers to equitable international trade, and acts of biopiracy inflicted upon poorer nations. As a wise Asian sage has observed, the planet's resources and scientific ingenuity are sufficient to satisfy everyone's need, but not everyone's greed. Present and predictable world-wide demand for bioscientists and bioengineers exceeds best estimates of supply. Systematically planned, long-term investments by governments and bioindustries to generate adequate qualified men and women are urgently needed. © 2002 Society of Chemical Industry. [source] Guidelines for submitting adverse event reports for publication,,PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, Issue 5 2007FISPE (Chair), William N. Kelly Pharm D Publication of case reports describing suspected adverse effects of drugs and medical products that include herbal and complementary medicines, vaccines, and other biologicals and devices is important for postmarketing surveillance. Publication lends credence to important signals raised in these adverse event reports. Unfortunately, deficiencies in vital information in published cases can often limit the value of such reports by failing to provide sufficient details for either (i) a differential diagnosis or provisional assessment of cause-effect association, or (ii) a reasonable pharmacological or biological explanation. Properly described, a published report of one or more adverse events can provide a useful signal of possible risks associated with the use of a drug or medical product which might warrant further exploration. A review conducted by the Task Force authors found that many major journals have minimal requirements for publishing adverse event reports, and some have none at all. Based on a literature review and our collective experience in reviewing adverse event case reports in regulatory, academic, and industry settings, we have identified information that we propose should always be considered for inclusion in a report submitted for publication. These guidelines have been endorsed by the International Society for Pharmacoepidemiology (ISPE) and the International Society of Pharmacovigilance (ISoP) and are freely available on the societies' web sites. Their widespread distribution is encouraged. ISPE and ISoP urge biomedical journals to adopt these guidelines and apply them to case reports submitted for publication. They also encourage schools of medicine, pharmacy, and nursing to incorporate them into the relevant curricula that address the detection, evaluation, and reporting of suspected drug or other medical product adverse events. Copyright © 2007 Kelly et al. Reproduced with permission by John Wiley & Sons, Ltd. [source] | ||||||||||||||||