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Organization
Kinds of Organization Terms modified by Organization Selected AbstractsMEMORY ORGANIZATION AS THE MISSING LINK BETWEEN CASE-BASED REASONING AND INFORMATION RETRIEVAL IN BIOMEDICINECOMPUTATIONAL INTELLIGENCE, Issue 3-4 2006Isabelle Bichindaritz Mémoire proposes a general framework for reasoning from cases in biology and medicine. Part of this project is to propose a memory organization capable of handling large cases and case bases as occur in biomedical domains. This article presents the essential principles for an efficient memory organization based on pertinent work in information retrieval (IR). IR systems have been able to scale up to terabytes of data taking advantage of large databases research to build Internet search engines. They search for pertinent documents to answer a query using term-based ranking and/or global ranking schemes. Similarly, case-based reasoning (CBR) systems search for pertinent cases using a scoring function for ranking the cases. Mémoire proposes a memory organization based on inverted indexes which may be powered by databases to search and rank efficiently through large case bases. It can be seen as a first step toward large-scale CBR systems, and in addition provides a framework for tight cooperation between CBR and IR. [source] Immediate and Midterm Complications of Sclerotherapy: Report of a Prospective Multicenter Registry of 12,173 Sclerotherapy SessionsDERMATOLOGIC SURGERY, Issue 2 2005FACPH, Jean-Jérôme Guex MD Background Growing interest in sclerotherapy has emphasized the need for complete knowledge of all aspects of this method. Objective To precisely delineate the actual incidence of immediate and delayed untoward events of daily sclerotherapy. Methods A multicenter prospective registry was established in 22 phlebology clinics to report their activity and complications. Results During the study period, 12,173 sessions of sclerotherapy were carried out, 5,434 with liquid, 6,395 with foam, and 344 using both. Four thousand eighty-eight (33.9%) sessions were carried out with ultrasound guidance. Forty-nine incidents or accidents (0.4%) occurred, of which 12 were with liquid and 37 with foam. These were reported during the time of the study and an additional 1-month follow-up. Most numerous were 20 cases of visual disturbances (in 19 cases, foam or air block was used); all resolved shortly, without any after-effects. A femoral vein thrombosis was the only severe adverse event in this study. Conclusions This study demonstrates that sclerotherapy is a safe technique. FUNDING FOR RESEARCH WAS PROVIDED BY THE FRENCH SOCIETY OF PHLEBOLOGY, A NONPROFIT ORGANIZATION. [source] A CITY IN MOTION: TIME-SPACE ACTIVITY AND MOBILITY PATTERNS OF SUBURBAN INHABITANTS AND THE STRUCTURATION OF THE SPATIAL ORGANIZATION OF THE PRAGUE METROPOLITAN AREAGEOGRAFISKA ANNALER SERIES B: HUMAN GEOGRAPHY, Issue 2 2007Jakub Novák ABSTRACT. This contribution attempts to reveal the relations between new suburban areas and other parts of the Prague metropolitan area by investigating the time-space activity and mobility patterns of the inhabitants of newly built suburban districts. The focus on some aspects of the everyday life of people in new suburbs helps us to identify the impact of suburbanization on the changing geography of the metropolitan region and to better understand how the spatial organization of the Prague metropolitan area is produced, reproduced and transformed. We use several interrelated concepts, which serve the theoretical foundation of our work, namely time geography, structuration theory and the post-communist city. The empirical data utilized are primarily based on 262 diaries completed by eighty-eight individuals from thirty-eight households, accompanied by household questionnaires and interviews with the heads of households. The research confirmed the implicit, generally unspoken view that new suburbs in the Prague metropolitan region are heavily dependent on the core of the metropolitan area for the provision of jobs and services. However, newly built suburban shopping facilities to some extent disrupt this pattern, keeping some daily activities of inhabitants within the suburban zone. In addition to empirical observations, the key purpose of this contribution has been to discuss and apply time geography concepts and methods to the research of urban restructuring, and to understand the structuration of metropolitan spatial organization. [source] THE INFLUENCE OF MARITAL AND FAMILY THERAPY ON HEALTH CARE UTILIZATION IN A HEALTH-MAINTENANCE ORGANIZATIONJOURNAL OF MARITAL AND FAMILY THERAPY, Issue 3 2000David D. Law Research has shown that people reduce their use of health care after individual psychotherapy. However, little research has been done to learn if marital and family therapy has a similar effect. Subjects (n = 292) from a health-maintenance organization were randomly selected according to the type of therapy they had received. Subjects' medical records were examined for 6 months before, during, and after therapy. Those who received marital and family therapy significantly reduced their use of health care services by 21.5%. These results show an "offset effect" for marriage and family therapy. [source] SOCIAL ORGANIZATION AND HUMAN SPACE IN NORTH-EASTERN IBERIA DURING THE THIRD CENTURY BCOXFORD JOURNAL OF ARCHAEOLOGY, Issue 4 2008CARME RUESTES Summary By using GIS (Geographical Information System) visibility analysis, the visual surveillance of, and ways in which people engaged and experienced, an Iberian landscape north of Barcelona during the third century BC are explored. The study of visual surveillance from the hillforts that dominated the area is understood as a means to address issues of social structure and hierarchy. How Iberian people might have viewed and rationalized their world, which is an issue that has so far not been addressed within the theoretical approaches that currently characterize this area of Mediterranean archaeology, is explored here for the first time. Emphasis is placed on people's sense of place and on hillforts' prominence. Visibility analysis indicates a highly structured society, where each hillfort might have primarily controlled given zones of the landscape and might have informed others about events taking place there through an integrated visibility network. Whilst hillforts appear to have been sited according to the view that they offered, they do not seem to have been intended to maximize their own visual impact. Social and experiential approaches compellingly coincide to suggest a subdivision of this society between mountain and coastal communities in both practical and perceptual terms. [source] POWER IN SOCIAL ORGANIZATION AS THE SUBJECT OF JUSTICEPACIFIC PHILOSOPHICAL QUARTERLY, Issue 1 2005AARON JAMES This rationale for assessment of social justice equally applies to legally optional or informal social practices. But it does not apply to individual conduct. Indeed, it follows that principles of social justice cannot provide a basis for the assessment and guidance of individual choice. The paper develops this practice-based conception of the subject of justice by rejoining G. A. Cohen's influential critique of Rawls' focus on the "basic structure" of society. [source] THE ROLE OF JOB EMBEDDEDNESS ON EMPLOYEE PERFORMANCE: THE INTERACTIVE EFFECTS WITH LEADER,MEMBER EXCHANGE AND ORGANIZATION-BASED SELF-ESTEEMPERSONNEL PSYCHOLOGY, Issue 4 2008TOMOKI SEKIGUCHI Although job embeddedness was originally conceptualized to explain job stability or "why people stay" in their organizations, this investigation examines the role of job embeddedness as a hypothesized moderator of relationships among leader,member exchange (LMX), organization-based self-esteem (OBSE), organizational citizenship behaviors (OCBs), and task performance. Findings from 2 studies involving 367 employees and 41 supervisors, 1 in a telecommunications company and another in a manufacturing setting, support hypotheses concerning job embeddedness as a moderator of the relationship between (a) LMX and task performance within a telecommunication sample and LMX and OCBs in a sample of manufacturing employees, and (b) OBSE and OCBs in a manufacturing sample. Further, a hypothesized 3-way interaction involving job embeddedness, LMX, and OBSE on task performance was found in a sample of manufacturing employees. The implications of these findings for studying and managing job embeddedness in relation to employee performance are discussed. [source] DIAGNOSING ORDER PLANNING PERFORMANCE AT A NAVY MAINTENANCE AND REPAIR ORGANIZATION, USING LOGISTIC REGRESSIONPRODUCTION AND OPERATIONS MANAGEMENT, Issue 4 2003JORIS M. KEIZERS We present a tool to diagnose the behavior of planners in complex production processes and to establish improvement potential for the delivery performance by changing the planning behavior. Scientific literature on production control offers valuable knowledge, but the complexity of real-life processes makes it impossible to directly apply this knowledge in real-life. The presented tool identifies possible deficiencies in the current way of managing the business processes, by matching the scientific knowledge on order planning with data reflecting the real-life processes via logistic regression. A case study at a maintenance organization illustrates the diagnosis tool. [source] PUBLIC MANAGEMENT REFORM IN THE UK AND ITS CONSEQUENCES FOR PROFESSIONAL ORGANIZATION: A COMPARATIVE ANALYSISPUBLIC ADMINISTRATION, Issue 1 2007STEPHEN ACKROYD It is often assumed in the literature on public management reforms that radical changes in values, work and organization have occurred or are under way. In this paper our aim is to raise questions about this account. Focusing on three services in the UK, each dominated by organized professions , health care, housing, and social services , significant variations in the effectiveness of reforms are noted. The available research also suggests that these outcomes have been inversely proportional to the efforts expended on introducing new management practices. The most radical changes have been in housing, where, paradoxically, successive UK governments focused least attention. By contrast, in health and social services, management restructuring has been less effective, despite the greater resources devoted to it. This variation is attributed to professional values and institutions, against which reforms were directed, and the extent to which different groups became locked either into strategies of resistance or accommodation. [source] MANAGERIAL STRUCTURE OF BUSINESS GROUPS IN TAIWAN: THE INNER CIRCLE SYSTEM AND ITS SOCIAL ORGANIZATIONTHE DEVELOPING ECONOMIES, Issue 1 2003CHI-NIEN CHUNG This paper examined the management structure of Taiwan's business groups. The objective was to determine how independent group firms coordinate their business. Employing longitudinal data of the top 100 groups, I investigated the "inner circle" system and its evolution. I found that group leaders occupied overlapped positions at the director rather than at the manager level, which implied a separation of strategic planning and routine administration. Secondly, the dynamics of inner circle management did not hinge upon the group president as in the Korean chaebol, nor on the norm of corporate community as in the Japanese keiretsu, but on the social ties in the inner circle. Analyzing the background of the leaders indicated that family never dominated the scene even in the early years, and their significance decreased along with environmental changes. The transition in Taiwan in the late 1980s motivated business groups to introduce more "outside" talent into decision-making. [source] THE COMBINED EFFECT OF DONATION PRICE AND ADMINISTRATIVE INEFFICIENCY ON DONATIONS TO US NONPROFIT ORGANIZATIONSFINANCIAL ACCOUNTABILITY & MANAGEMENT, Issue 1 2009Fred A. Jacobs We examine the effects that two accounting measures of nonprofit organization (NPO) inefficiency, administrative inefficiency and donation price, have on donations to US NPOs using a better-specified model and industry-specific samples. Although numerous studies examine the effect that donation price has on donations (e.g., Marudas and Jacobs, 2006; Marudas, 2004; Khanna and Sandler, 2000; and Tinkelman, 1999), only three studies examine the effect of administrative inefficiency on donations (Tinkelman and Mankaney, 2007; Frumkin and Kim, 2001; and Greenlee and Brown, 1999). However, none of these studies tests donation price and administrative inefficiency in one model and only two test industry-specific samples of NPOs. We find that misspecifying the model by including only one of these two inefficiency measures creates substantial bias and the effect of administrative inefficiency on donations varies substantially across industries. Administrative inefficiency has a significantly negative effect on donations to NPOs in the full sample and the philanthropy sample, but no significant effect on donations to NPOs in the arts, education, health, or human services samples. Furthermore, donation price has a significantly negative effect on donations to NPOs in the full sample and the education, health and human services samples, but not in the arts or philanthropy samples. Results are also reported for the other variables in the model , government support, program service revenue, fundraising and organizational age, wealth and size. [source] NETWORKING, KNOWLEDGE ORGANIZATIONS AND AEROMOBILITYGEOGRAFISKA ANNALER SERIES B: HUMAN GEOGRAPHY, Issue 3 2009Claus Lassen ABSTRACT. This article explores networking and travel in two international knowledge organizations located in Denmark. It shows that these knowledge organizations are organized in various ways through different types of network on different scales. Therefore the individual employees in both organizations are dependent on their ability to create and maintain relations within networks. The article argues that such networking activities cannot be understood separately from air travel. However, work and travel decisions are also highly individualized, meaning that a number of more individual and non-work rationalities are also significant in employees deciding whether to travel or not. Therefore the article concludes that, in a number of social situations, individual rationalities function as a barrier to the increased use of video technology. It is therefore necessary to create new mechanisms to support the increased use of virtual communications in order to reduce the environmental impact of air travel in knowledge organizations. [source] WICKED WATER PROBLEMS: SOCIOLOGY AND LOCAL WATER ORGANIZATIONS IN ADDRESSING WATER RESOURCES POLICY,JOURNAL OF THE AMERICAN WATER RESOURCES ASSOCIATION, Issue 3 2000David M. Freeman ABSTRACT: Water policy problems are wicked, not in an ethically deplorable sense, but in the sense that they present us with especially difficult challenges of becoming more effective in our interdisciplinary collaboration, of integrating two very different types of knowledge, of working across several socio-political units of analysis simultaneously, and of better organizing water as a common property resource. Sociology, as a discipline, does not have a particularly rich history of successful interdisciplinary collaboration on water resources research and teaching, but it potentially has a most useful contribution to make by focusing on the analysis of local common property resource organizations that operate in the interface between individual resource users and State-Federal entities. These organizations (e.g., water user associations, mutual companies, irrigation districts, acequias, conservancy districts) have been the orphans of water policy discourse but their operations are critical to undertaking more effective 21st century social analysis, research work, and action programs. Sociologists who work to better comprehend the operations of, and constraints upon, these organizations build a sociology that can better collaborate with other water-related disciplines in addressing the challenges posed by the wickedness of our water problems. [source] POWER, RATIONALITY AND LEGITIMACY IN PUBLIC ORGANIZATIONSPUBLIC ADMINISTRATION, Issue 1 2009RAY GORDON In this paper we propose answers to the research question: how does power shape the construction of legitimacy in the context of public organizations? We suggest that while organizational structures of dominancy will be embedded, not all structures of dominancy align with those that are normatively presented as legitimate and authoritative. Such situations make the creation and sustenance of legitimacy problematic for organizational action. This paper advances our understanding of the relation between power, rationality and legitimacy by showing how structures of domination recursively constitute, and are constituted by, legitimacy that may not be authoritative. We show, empirically, how these relations prevented a police organization from reforming by breaking the recursive patterns of domination and legitimization. Theoretically, we argue that understanding organizational change must be connected to issues of power and legitimacy. [source] DISPARATE POWER AND DISPARATE RESOURCES: COLLABORATION BETWEEN FAITH-BASED AND ACTIVIST ORGANIZATIONS FOR CENTRAL FLORIDA FARMWORKERSANNALS OF ANTHROPOLOGICAL PRACTICE, Issue 1 2010Nolan Kline This article highlights the collaboration between an evangelical faith-based organization and secular activist organization to address the oral health needs of African American former farmworkers in Central Florida. Highlighting the FBO's evangelistic agenda, I discuss one FBO as a charitable health care provider filling a service gap within the broader health care system. In addition, I discuss the organizations' different levels of access to powerful agents of change, and the role of the anthropologist as an intermediary between the FBO and secular organization. This article first details the health concerns of the former farmworker population in Central Florida as they relate to farm labor and living in an environmentally harmful area. It then sheds light on systematic health care constraints in the United States that necessitate intervention from faith-based organizations and secular activist organizations. Last, this article provides a case study of how an anthropologist, acting as an intermediary to connect a faith-based group with an activist group, helped address one specific health need for former migrant farmworkers. [source] PRACTICING WHAT WE PREACH: THE POSSIBILITIES OF PARTICIPATORY ACTION RESEARCH WITH FAITH-BASED ORGANIZATIONSANNALS OF ANTHROPOLOGICAL PRACTICE, Issue 1 2010Katherine Lambert-Pennington This article examines the role and methodologies of the anthropologist as practitioner working in faith-based development initiatives. In particular, the author discusses attempts to use a participatory action research (PAR) model to examine the current programs, congregational participation, and future community development activities of Saint Andrew African Methodist Episcopal (AME) Church. The article examines how the FBO's traditional model of community development interfaced with the university research team's participatory approach and shaped the way that research was carried out. Additionally, the author discusses the varying ways that she, as an anthropologist, and her methods were positioned and the process of negotiating a mutually acceptable methodology. This FBO-university partnership revealed several key issues that have relevance for anthropologists engaged in work with FBOs and beyond. First, the model of faith-based community development shapes the possibilities of the work. Second, it shows how the anthropologist, and university partners more generally, are positioned by the organization, informs how and by whom the data is collected, what data is collected, and how it is used. Finally, there is no longer room for anthropologists to work alone; community issues and agency demands are complex and require interdisciplinary collaborative responses. [source] COMMERCIAL ACTIVITY AS INSURANCE: THE INVESTMENT BEHAVIOUR OF NON-PROFIT ORGANIZATIONSANNALS OF PUBLIC AND COOPERATIVE ECONOMICS, Issue 3 2010John Bennett ABSTRACT,:,We provide a new explanation for commercial activities by non-profit organizations whose primary concern is to supply mission output. Starting from the observation that donations to individual non-profits are often highly volatile, we show how investment in commercial activity can constitute a form of insurance for mission activity. Although investment in commercial activity has an opportunity cost in terms of capacity to produce mission output, if donations turn out to be low the commercial revenue will enable cross-subsidization of mission output. The equilibrium commercial investment is (weakly) positively related to the degree of risk aversion. [source] Cross-domain authorization for federated virtual organizations using the myVocs collaboration environmentCONCURRENCY AND COMPUTATION: PRACTICE & EXPERIENCE, Issue 4 2009Jill Gemmill Abstract This paper describes our experiences building and working with the reference implementation of myVocs (my Virtual Organization Collaboration System). myVocs provides a flexible environment for exploring new approaches to security, application development, and access control built from Internet services without a central identity repository. The myVocs framework enables virtual organization (VO) self-management across unrelated security domains for multiple, unrelated VOs. By leveraging the emerging distributed identity management infrastructure. myVocs provides an accessible, secure collaborative environment using standards for federated identity management and open-source software developed through the National Science Foundation Middleware Initiative. The Shibboleth software, an early implementation of the Organization for the Advancement of Structured Information Standards Security Assertion Markup Language standard for browser single sign-on, provides the middleware needed to assert identity and attributes across domains so that access control decisions can be determined at each resource based on local policy. The eduPerson object class for lightweight directory access protocol (LDAP) provides standardized naming, format, and semantics for a global identifier. We have found that a Shibboleth deployment supporting VOs requires the addition of a new VO service component allowing VOs to manage their own membership and control access to their distributed resources. The myVocs system can be integrated with Grid authentication and authorization using GridShib. Copyright © 2008 John Wiley & Sons, Ltd. [source] InterGrid: a case for internetworking islands of GridsCONCURRENCY AND COMPUTATION: PRACTICE & EXPERIENCE, Issue 8 2008Marcos Dias de Assunção Abstract Over the last few years, several nations around the world have set up Grids to share resources such as computers, data, and instruments to enable collaborative science, engineering, and business applications. These Grids follow a restricted organizational model wherein a Virtual Organization (VO) is created for a specific collaboration and all interactions such as resource sharing are limited to within the VO. Therefore, dispersed Grid initiatives have led to the creation of disparate Grids with little or no interaction between them. In this paper, we propose a model that: (a) promotes interlinking of islands of Grids through peering arrangements to enable InterGrid resource sharing; (b) provides a scalable structure for Grids that allow them to interconnect with one another and grow in a sustainable way; (c) creates a global Cyberinfrastructure to support e-Science and e-Business applications. This work identifies and proposes architecture, mechanisms, and policies that allow the internetworking of Grids and allows Grids to grow in a similar manner as the Internet. We term the structure resulting from such internetworking between Grids as the InterGrid. The proposed InterGrid architecture is composed of InterGrid Gateways responsible for managing peering arrangements between Grids. We discuss the main components of the architecture and present a research agenda to enable the InterGrid vision. Copyright © 2007 John Wiley & Sons, Ltd. [source] Optimization of integrated Earth System Model components using Grid-enabled data management and computationCONCURRENCY AND COMPUTATION: PRACTICE & EXPERIENCE, Issue 2 2007A. R. Price Abstract In this paper, we present the Grid enabled data management system that has been deployed for the Grid ENabled Integrated Earth system model (GENIE) project. The database system is an augmented version of the Geodise Database Toolbox and provides a repository for scripts, binaries and output data in the GENIE framework. By exploiting the functionality available in the Geodise toolboxes we demonstrate how the database can be employed to tune parameters of coupled GENIE Earth System Model components to improve their match with observational data. A Matlab client provides a common environment for the project Virtual Organization and allows the scripting of bespoke tuning studies that can exploit multiple heterogeneous computational resources. We present the results of a number of tuning exercises performed on GENIE model components using multi-dimensional optimization methods. In particular, we find that it is possible to successfully tune models with up to 30 free parameters using Kriging and Genetic Algorithm methods. Copyright © 2006 John Wiley & Sons, Ltd. [source] EXECUTING THE INNOCENT AND SUPPORT FOR CAPITAL PUNISHMENT: IMPLICATIONS FOR PUBLIC POLICYCRIMINOLOGY AND PUBLIC POLICY, Issue 1 2005JAMES D. UNNEVER Research Summary: The issue of whether innocent people have been executed is now at the center of the debate concerning the legitimacy of capital punishment. The purpose of this research was to use data collected by the Gallup Organization in 2003 to investigate whether Americans who believed that an innocent person had been executed were less likely to support capital punishment. We also explored whether the association varied by race, given that African Americans are disproportionately affected by the death penalty. Our results indicated that three-quarters of Americans believed that an innocent person had been executed for a crime they did not commit within the last five years and that this belief was associated with lower levels of support for capital punishment, especially among those who thought this sanction was applied unfairly. In addition, our analyses revealed that believing an innocent person had been executed had a stronger association with altering African American than white support for the death penalty. Policy Implications: A key claim of death penalty advocates is that a high proportion of the public supports capital punishment. In this context, scholars opposing this sanction have understood the importance of showing that the public's support for executing offenders is contingent and shallower than portrayed by typical opinion polls. The current research joins this effort by arguing that the prospect of executing innocents potentially impacts public support for the death penalty and, in the least, creates ideological space for a reconsideration of the legitimacy of capital punishment. [source] THE CITY AS BARRACKS: Freetown, Monrovia, and the Organization of Violence in Postcolonial African CitiesCULTURAL ANTHROPOLOGY, Issue 3 2007DANNY HOFFMAN Responding to characterizations of the postcolonial African city as a negative space, theorists of African urban processes have begun to focus on the city's unique modes of production. But what does this emphasis on productive capacity mean if "the city" is not Johannesburg or Nairobi but the West African urban warscape of Freetown or Monrovia? I explore that question by examining how the labor of male urban youth is organized according to the logic of the barracks. I suggest that these West African capitals make labor simultaneously available for use on regional battlefields or mines, logging camps, or rubber plantations. Focusing on the Brookfields Hotel in central Freetown and Monrovia's Duala neighborhood underscores how urban spaces are increasingly configured by the structure and function of the barracks: as spaces for the organization and deployment of violent labor. [source] Dental injury among Brazilian schoolchildren in the state of São PauloDENTAL TRAUMATOLOGY, Issue 3 2004Sylvia Grimm Abstract ,,,To describe the distribution of dental trauma in Brazilian schoolchildren and its association with demographic, environmental and clinical factors. A random sample of 73 243 schoolchildren's oral examination records from private and public units, selected from 131 cities within the state of São Paulo, Brazil, was analysed. Trauma was assessed based on international methodological standards prescribed by the World Health Organization for Oral Health Surveys (1997). Proportions obtained were compared between urban and rural schools, as well as between private and public units. Oral health status indices were estimated based on the decayed, missing and filled teeth (DMFT) index , the average number of decayed, missing and filled teeth; the proportion of caries-free 5-year-old schoolchildren and anterior maxillary overjet among 12-year-old schoolchildren. The prevalence of dental trauma in anterior dentition was of 2.4, enrolling average 1.2 teeth per child. A rate of 2.4 impaired anterior teeth per thousand was obtained, upper central incisors being those that were most affected , 7.7 in every 10. Among 8- to 11-year-old children, the rates grew regularly. The proportion of dental trauma was significantly higher in boys than in girls (P < 0.01), and gender prevalence ratio was of 1.58 for boys. The results showed positive associations between dental trauma and caries-free 5-year-old schoolchildren (P = 0.003), anterior maxillary overjet,3 mm (P < 0.001), and private school as a socio-economic proxy indicator (P = 0.048). [source] Classification of Anxiety and Depressive disorders: problems and solutionsDEPRESSION AND ANXIETY, Issue 4 2008G. Andrews MD Abstract The American Psychiatric Association and the World Health Organization have begun to revise their classifications of mental disorders. Four issues related to these revisions are discussed in this study: the structure of the classifications, the relationship between categories and dimensions, the sensitivity of categorical thresholds to definitions, and maximizing the utility and validity of the diagnostic process. There is now sufficient evidence to consider replacing the present groupings of disorders with an empirically based structure that reflects the actual similarities among disorders. For example, perhaps the present depression and anxiety disorders would be best grouped as internalizing disorders. Most mental disorders exist on a severity dimension. The reliability and validity of the classification might be improved if we accepted the dimensional nature of disorders while retaining the use of categorical diagnoses to enhance clinical utility. Definitions of the thresholds that define categories are very susceptible to detail. In International Classification of Diseases-11(ICD-11) and Diagnostic and Statistical Manual of Mental Disorders-V (DSM-V), disorders about which there is agreement should be identically defined, and disorders in which there is disagreement should be defined differently, so that research can identify which definition is more valid. The present diagnostic criteria are too complex to have acceptable clinical utility. We propose a reduced criterion set that can be remembered by clinicians and an enhanced criterion set for use with decision support tools. Depression and Anxiety 25:274,281, 2008. © 2008 Wiley-Liss, Inc. [source] January 31, 2003 Editorial Announcement of New Organization: The International Transplant-Skin Cancer CollaborativeDERMATOLOGIC SURGERY, Issue 8 2003Article first published online: 22 JUL 200 No abstract is available for this article. [source] Filariasis: diagnosis and treatmentDERMATOLOGIC THERAPY, Issue 6 2009Natalia Mendoza ABSTRACT Filariasis is an infectious disease of the lymphatics and subcutaneous tissues caused by nematodes or filariae. Carried by mosquito vectors, this disease causes millions of people to suffer from lymphedema and elephantiasis, characteristics of filariasis infection. This disease can be diagnosed through the identification of microfilariae in blood or skin samples, antigen detection, radiographic imaging, or polymerase chain reaction. Mass drug administration by the World Health Organization has helped to diminish the incidence of filariasis. However, continued research on new drugs and vaccinations will be needed to control and reduce the microfilarial levels in the human population. [source] Treat Your Organization as a Prototype: The Essence of Evidence-Based ManagementDESIGN MANAGEMENT REVIEW, Issue 3 2006Jeffrey Pfeffer Professor First page of article [source] Antidiabetic and toxicological evaluations of naringenin in normoglycaemic and NIDDM rat models and its implications on extra-pancreatic glucose regulationDIABETES OBESITY & METABOLISM, Issue 11 2008R. R Ortiz-Andrade Aim:, The present investigation was designed to determine the in vivo antidiabetic effect of naringenin (NG) in normoglycaemic and diabetic rat models through blood glucose (GLU) measurements following acute and subchronic time periods. Possible modes of action of NG were investigated and its acute toxicity determined. Methods:, Normoglycaemic and non-insulin-dependent diabetes mellitus (NIDDM) rat models were treated for acute and subchronic (5 days) time periods with 50 mg/kg/day of NG. Blood biochemical profiles were determined after 5 days of the treatment in normoglycaemic and NIDDM rats using commercial kits for GLU, triglycerides (TG), total cholesterol (CHOL) and high-density lipoprotein (HDL). In order to elucidate its antidiabetic mode of action, NG was administered intragastrically and an oral glucose tolerance test performed using GLU and sucrose (2 g/kg) as substrates. The inhibitory effect of a single concentration of NG (10 ,M) on 11,-hydroxysteroid dehydrogenase type 1 (11,-HSD1) activity in vitro was determined. Finally, the preclinical safety and tolerability of NG was determined by toxicological evaluation in mice and rats using Organization for Economic Cooperation and Development (OECD) protocols. Results:, Intragastrically administered NG (50 mg/kg) induced a significant decrease in plasma GLU in normoglycaemic and NIDDM rat models (p < 0.05) following acute and subchronic time periods. After 5 days of administration, NG produced significant diminished blood GLU and TG levels in streptozotocin,nicotinamide,induced diabetic rats. The administration of NG to normal rats significantly increased the levels of TG, CHOL and HDL (p < 0.05). NG (5 and 50 mg/kg) induced a total suppression in the increase of plasma GLU levels after administration of substrates (p < 0.01), but NG did not produce inhibition of ,-glucosidase activity in vitro. However, NG (10 ,M) was shown to inhibit 11,-HSD1 activity by 39.49% in a cellular enzyme assay. Finally, NG showed a Medium Lethal Dose LD50 > 5000 mg/kg and ranking at level five based on OECD protocols. Conclusion:, Our findings suggest that NG may exert its antidiabetic effect by extra-pancreatic action and by suppressing carbohydrate absorption from intestine, thereby reducing the postprandial increase in blood GLU levels. [source] Prediction of cardiovascular and total mortality in Chinese type 2 diabetic patients by the WHO definition for the metabolic syndromeDIABETES OBESITY & METABOLISM, Issue 1 2006G. T.-C. Aim:, The aim of this study is to investigate the prevalence of metabolic syndrome (MES) in type 2 diabetic patients and the predictive values of the World Health Organization (WHO) and National Cholesterol Education Programme (NCEP) definitions and the individual components of the MES on total and cardiovascular mortality. Methods:, A prospective analysis of a consecutive cohort of 5202 Chinese type 2 diabetic patients recruited between July 1994 and April 2001. Results:, The prevalence of the MES was 49.2,58.1% depending on the use of various criteria. There were 189 deaths (men: 100 and women: 89) in these 5205 patients during a median (interquartile range) follow-up period of 2.1 (0.3,3.6 years). Of these, 164 (87%) were classified as cardiovascular deaths. Using the NCEP criterion, patients with MES had a death rate similar to those without (3.51 vs. 3.85%). By contrast, based on the WHO criteria, patients with MES had a higher mortality rate than those without (4.3 vs. 2.4%, p = 0.002). Compared to patients with neither NCEP- nor WHO-defined MES, only the group with MES defined by the WHO, but not NCEP, criterion had significantly higher mortality rate (2.6 vs. 6.8%, p < 0.001). Using Cox regression analysis, only age, duration of diabetes and smoking were identified as independent factors for cardiovascular or total death. Among the various components of MES, hypertension, low BMI and albuminuria were the key predictors for these adverse events. Conclusions:, In Chinese type 2 diabetic patients, the WHO criterion has a better discriminative power over the NCEP criterion for predicting death. Among the various components of the MES defined either by WHO or NCEP, hypertension, albuminuria and low BMI were the main predictors of cardiovascular and total mortality. [source] Increased prevalence of cardiovascular disease in Type 2 diabetic patients with non-alcoholic fatty liver diseaseDIABETIC MEDICINE, Issue 4 2006G. Targher Abstract Aims, To estimate the prevalence of cardiovascular disease (CVD) in Type 2 diabetic patients with and without non-alcoholic fatty liver disease (NAFLD), and to assess whether NAFLD is independently related to prevalent CVD. Methods, We studied 400 Type 2 diabetic patients with NAFLD and 400 diabetic patients without NAFLD who were matched for age and sex. Main outcome measures were prevalent CVD (as ascertained by medical history, physical examination, electrocardiogram and echo-Doppler scanning of carotid and lower limb arteries), NAFLD (by ultrasonography) and presence of the metabolic syndrome (MetS) as defined by the World Health Organization or Adult Treatment Panel III criteria. Results, The prevalences of coronary (23.0 vs. 15.5%), cerebrovascular (17.2 vs. 10.2%) and peripheral (12.8 vs. 7.0%) vascular disease were significantly increased in those with NAFLD as compared with those without NAFLD (P < 0.001), with no differences between sexes. The MetS (by any criteria) and all its individual components were more frequent in NAFLD patients (P < 0.001). In logistic regression analysis, male sex, age, smoking history and MetS were independently related to prevalent CVD, whereas NAFLD was not. Conclusions, The prevalence of CVD is increased in patients with Type 2 diabetes and NAFLD in association with an increased prevalence of MetS as compared with diabetic patients without NAFLD. Follow-up studies are necessary to determine whether this higher prevalence of CVD among diabetic patients with NAFLD affects long-term mortality. Diabet. Med. (2006) [source] | ||||||||||||||||||||||||||||||||||||||||||||||