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Organic Synthesis (organic + synthesis)
Selected AbstractsChemInform Abstract: "Cation Flow" Method: A New Approach to Conventional and Combinatorial Organic Syntheses Using Electrochemical Microflow Systems.CHEMINFORM, Issue 50 2001Seiji Suga Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] Rhodium-Catalyzed Asymmetric Nitroallylation of Arylmetallics with Cyclic Nitroallyl Acetates and Applications in Organic SynthesisEUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 18 2006Lin Dong Abstract Highly enantioselective rhodium-catalyzed nitroallylations of arylboronic acids and arylzinc chlorides with cyclic nitroallyl acetates are described. Catalyst screening indicated that the rhodium complex of [Rh(OH)(COD)]2 and optically pure binap is the optimal catalyst for the nitroallylation of arylboronic acids with 2-nitrocyclohex-2-enyl esters, providing good yields and high enantioselectivities of up to 99,% ee. The rhodium complex prepared from Rh(acac)(C2H4)2 and (R)-binap efficiently catalyzed the nitroallylation of arylzinc chlorides with 2-nitrocyclohex-2-enyl acetate at 0 °C in high yields of up to 93,% and with high enantioselectivities of up to 96,% ee. A number of synthetically useful intermediates with high optical purity were prepared with this reaction as starting point: concise total syntheses of optically pure (+)-,-lycorane in 53,% overall yield and of (+)-,-lycorane in 52,% overall yield were achieved by commencing with the asymmetric nitroallylation of 3,4-methylenedioxyphenylzinc chloride with 2-nitrocyclohex-2-enyl acetate. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006) [source] Highly Efficient Asymmetric Epoxidation of Electron-Deficient ,,,-Enones and Related Applications to Organic SynthesisADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 10 2009Changwu Zheng Abstract The asymmetric epoxidation of electron-deficient olefins has been achieved using inexpensive and readily available prolinols as catalysts with good to excellent yields and enantioselectivities. The utility of the resulting chiral epoxides was illustrated by elaboration to several synthetically useful compounds featuring a concise synthesis of (,)-(5R,6S)-balasubramide. [source] Cyclopropyl Building Blocks for Organic Synthesis, 131.ADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 15 2006Palladium-Catalyzed Bicyclization with Carbonyl Insertion of Alkenyl-Tethered Propargyl Carbonates Towards a Scalable Synthesis of Various 2-(Bicyclo[3.1.0]hex-1-yl)acrylates Abstract The Pd-catalyzed 5- exo-trig- 3 -exo-trig cascade cyclization of 1,6-enynes with a propargyl carbonate terminus offers the shortest synthetic route to variously substituted 2-(bicyclo[3.1.0]hex-1-yl)acrylates, a novel class of prospective monomers for low-shrinkage polymers. To apply this reaction to large-scale preparations of the said bicyclic acrylates, a flexible Pd catalyst system with tunable reactivity has been developed. The dependence of the product and diastereomer distribution on both the reaction conditions, including the type of palladium catalyst used, and on the nature of the substrate has been investigated. A variety of methyl 2-(bicyclo[3.1.0]hex-1-yl)acrylates and parent carboxylic acids as well as some of their derivatives of potential interest towards a technical application were prepared on a multigram scale. A general large-scale synthesis of the cyclization precursors bearing one or two carbonyl groups in the tether is also disclosed. [source] Transition Metal Arene ,-Complexes in Organic Synthesis and Catalysis.ADVANCED SYNTHESIS & CATALYSIS (PREVIOUSLY: JOURNAL FUER PRAKTISCHE CHEMIE), Issue 9 2005Edited by E. Peter Kündig No abstract is available for this article. [source] Crosslinked Polyacrolein Microspheres with High Loading of Aldehyde Groups for Use as Scavenger Resins in Organic Synthesis,MACROMOLECULAR RAPID COMMUNICATIONS, Issue 19 2004Chao Lin Abstract Summary: Suspension polymerization yielded microspheres (40,50 ,m) of polyacrolein. Smooth and rugged surfaces can be created by varying the polymerization procedure. We have shown that the polyacrolein resins with a high loading of aldehyde groups serve as effective scavengers for primary amines and may be used to remove compounds bearing amino groups in the combinatorial synthesis of compound libraries. Copolymerization with styrene can help to separate the adjacent aldehyde groups, thus making the functional groups more available in organic reactions. The polyacrolein resins in the aldehyde form or after appropriate chemical modifications may also be useful as support materials in solid-phase synthesis. The SEM image of macroporous polyacrolein microspheres with toluene as porogen prepared by free radical polymerization. [source] Superbases for Organic Synthesis.ANGEWANDTE CHEMIE, Issue 49 2009Amidines, Guanidines, Phosphazenes, Related Organocatalysts. John Wiley & Sons, Hoboken 2009. 336,S., geb., 119.00,,.,ISBN 978-0470518007 [source] Reagents for Radical and Radical Ion Chemistry.Handbook of Reagents for Organic Synthesis.ANGEWANDTE CHEMIE, Issue 32 2009Herausgegeben von David Crich. John Wiley & Sons, Hoboken 2008. 722,S., geb., 129.00,,.,ISBN 978-0470065365 [source] Effect of new and known 1,4-dihydropyridine derivatives on blood glucose levels in normal and streptozotocin-induced diabetic ratsCELL BIOCHEMISTRY AND FUNCTION, Issue 4 2004na Briede Abstract Analysis of the effect of several 1,4-DHP Ca2+ channel antagonists on experimental and clinical diabetes shows that structurally similar Ca2+ channel antagonists can exert opposite effects on Ca2+ influx, glucose homeostasis and insulin secretion. The influence of the Ca2+ channel antagonists on pancreatic , cell functions is dependent on lipophilicity, interactions with the cell membrane lipid bilayer, with SNAREs protein complexes in cell and vesicle membranes, with intracellular receptors, bioavailability and time of elimination from several organs and the bloodstream. In the present work we studied the effect at several doses of new compounds synthesized in the Latvian Institute of Organic Synthesis on blood glucose levels in normal and STZ-induced diabetic rats. The compounds tested were: 1,4-DHP derivatives cerebrocrast (1), etaftoron (2), OSI-1190 (3), OSI-3802 (4), OSI-2954 (5) and known 1,4-DHP derivatives: niludipine (6), nimodipine (7) and nicardipine (8) which possess different lipophilicities. Analysis of the structure,function relationships of the effect of 1,4-DHP derivatives on glucose metabolism showed that cerebrocrast could evoke qualitative differences in activity. Insertion of an OCHF2 group in position 2 of the 4-phenylsubstituent and propoxyethylgroup R in ester moieties in positions 3 and 5 of the DHP structure, as well as an increase in the number of carbon atoms in the ester moiety, significantly modified the properties of the compound. Thereby cerebrocrast acquired high lipophilicity and membranotropic properties. Cerebrocrast, in a single administration at low doses (0.05 and 0.5,mg,kg,1, p.o.), significantly decreased the plasma level of glucose in normal rats and in STZ-induced diabetic rats returned plasma glucose to basal levels. This effect was characterized by a slow onset and a powerful long-lasting influence on glucose metabolism, especially in STZ-induced diabetic rats. Copyright © 2004 John Wiley & Sons, Ltd. [source] ChemInform Abstract: A Microfluidic Flow Chemistry Platform for Organic Synthesis: The Hofmann Rearrangement.CHEMINFORM, Issue 40 2009Alessandro Palmieri Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Cyclopropyl Building Blocks in Organic Synthesis.CHEMINFORM, Issue 32 2009Part 151. Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Benzothiazines in Organic Synthesis.CHEMINFORM, Issue 22 2009An Approach to the Synthesis of seco-Pseudopteroxazole. Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Ionic Liquid Phase Organic Synthesis (IoLiPOS) Methodology Applied to the Preparation of New 3,4-Dihydropyrimidine-2(1H)-ones Bearing Bioisostere Group in N-3 Position.CHEMINFORM, Issue 42 2008Jean Christophe Legeay Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Cyclopropyl Building Blocks for Organic Synthesis.CHEMINFORM, Issue 14 2008Part 145. Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Cyclopropyl Building Blocks for Organic Synthesis.CHEMINFORM, Issue 14 2008Part 145. Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Cyclopropyl Building Blocks in Organic Synthesis.CHEMINFORM, Issue 6 2008Part 141. Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: A Simple and Convenient Method for the Preparation of Diborane from Tetrabutylammonium Borohydride and Benzyl Chloride for Application in Organic Synthesis.CHEMINFORM, Issue 3 2008Mariappan Periasamy Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] Benzothiazines in Organic Synthesis.CHEMINFORM, Issue 44 2007The Preparation of Enantiomerically Pure 4-Substituted Quinolones. Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] Cyclopropyl Building Blocks for Organic Synthesis.CHEMINFORM, Issue 22 2007Part 138. Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] Cyclopropyl Building Blocks for Organic Synthesis.CHEMINFORM, Issue 22 2007Part 138. Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] Multicomponent Reactions to Form Heterocycles by Microwave-Assisted Continuous Flow Organic Synthesis.CHEMINFORM, Issue 20 2007W. Stacy Bremner Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] Cyclopropyl Building Blocks for Organic Synthesis.CHEMINFORM, Issue 14 2007Part 127. Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] Ionic Liquid in Organic Synthesis: The Pictet,Spengler Reaction.CHEMINFORM, Issue 50 2006Huey-Min Wang Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] Propionic Acids in Organic Synthesis: Novel Synthesis of Benzimidazole, 3,1-Benzoxazine, 3-Aminoquinazoline and 3-Aminothieno[2,3-d]pyrimidine Derivatives Containing 2-Naphthyl Propionyl Moiety.CHEMINFORM, Issue 21 2006Abdullah G. M. Al-Sehemi Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] 1-Bromo-1-lithioethene: A Practical Reagent in Organic Synthesis.CHEMINFORM, Issue 18 2006Yehor Y. Novikov Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] Combining Enabling Techniques in Organic Synthesis: Solid Phase Assisted Catalysis under Microwave Conditions Using a Stable Pd(II)-Precatalyst.CHEMINFORM, Issue 13 2006Kamal M. Dawood Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] Cyclopropyl Building Blocks for Organic Synthesis.CHEMINFORM, Issue 7 2006Other Vinylcyclopropanes with Carbon Monoxide Catalyzed by Octacarbonyldicobalt., Part 120. [5 + 1] Cocyclization of (Cyclopropylmethylene)cyclopropanes Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access the actual ChemInform Abstract, please click on HTML or PDF. [source] Unexpected Isolation of 4-Isothiocyanatomethylene-4H-pyridine-1-carboxylic Acid Ethyl Ester as Potential Template in Organic Synthesis.CHEMINFORM, Issue 5 2006Aladdin E. Sarhan Abstract For Abstract see ChemInform Abstract in Full Text. [source] Organic Synthesis Using Phosphorus Oxychloride.CHEMINFORM, Issue 49 2005Part 3. No abstract is available for this article. [source] A Microreactor for Microwave-Assisted Capillary (Continuous Flow) Organic Synthesis.CHEMINFORM, Issue 42 2005Eamon Comer Abstract For Abstract see ChemInform Abstract in Full Text. [source] | ||||||||||||||||||||||||||||||||||