Open Angle Glaucoma Patients (open + angle_glaucoma_patient)

Distribution by Scientific Domains

Selected Abstracts

Autonomic dysfunction in unselected and untreated primary open angle glaucoma patients: a pilot study

Doina Gherghel
Abstract Purpose:, To investigate the presence of silent cardiac ischaemic episodes and the status of autonomic function in consecutive, newly diagnosed and untreated primary open-angle glaucoma patients. Methods:, Twenty-four consecutively diagnosed glaucoma patients and 22 age-matched controls were subjected to ambulatory 24-h blood pressure (BP) and electrocardiogram (ECG) monitoring by using Cardiotens-01 (Meditech Ltd). Based on the ECG recordings, heart rate variability (HRV) frequency domain parameters [low-frequency (LF), high-frequency (HF) and LF/HF ratio] were calculated and analysed in the two study groups. Results:, Glaucoma patients demonstrated higher LF and LF/HF values than normal subjects for both the active period (p = 0.020 and 0.029) and the passive period (p = 0.044 and 0.049 respectively). HRV parameters were similar in patients and controls suffering from silent cardiac ischaemia (p > 0.05); however, glaucoma patients with normal ECG demonstrated higher LF and LF/HF values during the active period of the 24-h measurement period than control subjects characterized by the same cardiac activity (p = 0.010 and 0.021 respectively). Conclusion:, Independent of a history and/or clinical signs of cardiovascular disease, glaucoma patients exhibit abnormal autonomic function. [source]

A double masked placebo controlled study on the effect of nifedipine on optic nerve blood flow and visual field function in patients with open angle glaucoma

Georg Rainer
Aims, To investigate whether nifedipine affects ocular perfusion or visual fields in open angle glaucoma patients. Methods, In a parallel group study nifedipine or placebo was administered for 3 months (n = 30). Ocular fundus pulsation amplitude (FPA), cup blood flow (Flowcup) and visual field mean deviation (MD) were measured. Results, Five patients receiving nifedipine discontinued due to adverse events. Nifedipine did not affect FPA [difference: 0.3 Ám (95% CI ,0.3,0.9); P = 0.70], Flowcup: [difference: ,9 rel.units (95% CI ,133,114); P = 0.99], or MD [difference: 0.2dB (95% CI ,2.2,2.7); P = 0.51]vs placebo. Conclusions, Systemic nifedipine is not well tolerated in glaucoma patients and exerts no effect on visual fields or ocular perfusion. [source]

2127: Ghrelin concentration in the aqueous humour and plasma in open angle glaucoma patients

Purpose Ghrelin is a peptide hormone that exerts metabolic and smooth muscle-relaxant effects in ocular tissues. The aim of this study was to compare aqueous humor and plasma levels of ghrelin in patients with open angle glaucoma (OAG) and controls. Methods Twenty four OAG, including 7 pseudoexfoliation (PXG) and 17 primary open-angle glaucoma (POAG) patients, and 30 controls were included. All participants were patients scheduled for cataract or glaucoma surgery. Patients with other concomitant ocular disease, previous ocular surgery or diabetes were excluded. Blood samples were collected before cataract surgery. Aqueous humor was aspirated from the anterior chamber through a paracentesis with a 27 G needle under sterile conditions. Ghrelin levels in both samples were measured quantitatively with commercially available Radioimmunoassay (RIA) kits. Results Mean▒SD age was 71.0▒9.3 and 69.6▒6.6 years in the OAG and control groups, respectively (p=0.6). Plasma levels of ghrelin were 495.6▒157.7 pg/ml in the OAG and 482.2▒125.4 pg/ml in the control group, respectively (Mann-Whitney test, p=0.9). Aqueous humor levels of ghrelin were 85.5▒15.4 pg/ml and 123.4 ▒25.5 pg/ml in the OAG and control groups, respectively (Mann-Whitney test, p<0.01). The ratio of plasma/aqueous concentration in ghrelin was higher in the OAG versus the control group (5.82▒ 1.94 versus 4.00▒1.04, Mann-Whitney test, p<0.01). There was no difference neither in plasma nor in aqueous humor levels of ghrelin between POAG and PXG patients (p>0.5). Conclusion Aqueous humor levels of ghrelin were significantly lower in OAG patients. This difference may manifest a role of ghrelin in the disease process or a consequence of antiglaucoma treatment. [source]

2356: Diurnal variation of ocular pulse amplitude in primary open angle glaucoma patients

Purpose (1) to determine the diurnal behaviour of the ocular pulse amplitude (OPA) in primary open angle glaucoma (POAG) patients. (2) To identify any variables modulating OPA. Methods In this prospective study we included 22 POAG patients under topical intraocular pressure (IOP)-lowering treatment, who underwent contour dynamic tonometry measurements every three hours from 9am to 6pm for IOP and OPA readings. Heart rate (HR) and blood pressure (BP) were simultaneously recorded during the ocular measurements. Only the eye with greater glaucomatous damage was selected per patient. Results Both IOP and OPA did not change during the day (OPA: 3.0▒1.3, 3.2▒1.4, 2.9▒1.5, 3.0▒1.3; IOP: 19.3▒2.9, 20.0▒3.0, 19.1▒3.0, 19.8▒2.6; multiple comparisons p=0.21, p=0.27 respectively). Systolic, diastolic and did not present significant diurnal variation (p<0.05 all measurements). OPA was significantly correlated at all time-measurements with arterial pulse pressure, but not by IOP, median ocular pulse pressure(MOPP) nor median arterial pressure (p<0.05). Univariate analysis revealed HR to negatively correlate OPA at the 15h and 18h measurements (r= -0,42, p=0.049; r= -0,53, p=0.01; respectively). Multiple linear regression analysis identified blood pressure amplitude as an independent factor contributing to OPA (p<0.05 at all measurements). These observations were more pronounced in patients with high blood pressures. Conclusion OPA readings seem to be influenced by blood pressure amplitude in POAG patients. High blood pressure amplitude values may overcome the eye self-regulation mechanisms, resulting in the OPA becoming dependent on the blood pressure amplitude rather than of the IOP. [source]