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Ongoing Debate (ongoing + debate)
Selected AbstractsD1 versus D2 lymphadenectomy and volume versus training: Ongoing debate in gastric cancer surgeryJOURNAL OF SURGICAL ONCOLOGY, Issue 5 2006Lloyd A. Mack No abstract is available for this article. [source] P-25 DOES THE PRESENCE OF KOILOCYTES IN A BNA SMEAR AFFECT CLINICAL OUTCOMES?CYTOPATHOLOGY, Issue 2006L. Alexander Introduction:, There is ongoing debate about the terminology used in the classification of dyskaryosis, including whether BNA smears should be classified according to whether koilocytes are present or not. We explored the effect of koilocytosis in the management experiences and clinical outcomes of women with a single BNA smear. Methods:, This study includes 410 women aged 20,59 years, resident in Tayside who had an ,baseline' BNA smear between 31/10/1999 and 31/10/2002 who were eligible for the TOMBOLA trial but who did not participate. Recommended follow-up for these women was a repeat smear in six months. Up to three-years follow-up data was collected on subsequent cytological smears, colposcopy examinations and any related histology. The baseline smear was re-read for the presence or absence of koilocytes. Women were classified according to their clinical outcomes during their three years. Results:, 47% (192/410) of women were classified as having koilocytosis at baseline. The mean age was lower among these women (25 years) compared to those without koilocytosis (35 years). 55% (105/192) of women with koilocytosis at baseline had one or more negative smears and no further abnormal smears, compared to 63% (137/218) of those without koilocytosis, the difference was not statistically significant. 28% (53/192) of women with koilocytosis at baseline were referred to colposcopy after subsequent low-grade or high-grade smears compared to 19% (42/218) of those without koilocytosis; the difference was statistically significant. 14% (27/192) of women with koilocytosis at baseline were diagnosed with CIN2/3 or worse during follow-up compared to 10% (21/218) of women without koilocytosis; the difference was not statistically significant. Discussion:, Our results suggest that the presence or absence of koilocytosis has little impact on the clinical outcomes of women with a BNA smear. [source] Aid and Fiscal Deficits: Lessons from Uganda on the Implications for Macroeconomic Management and Fiscal SustainabilityDEVELOPMENT POLICY REVIEW, Issue 2 2007Martin Brownbridge This article contributes to the ongoing debate on the macroeconomic management of large aid inflows to low-income countries by analysing lessons drawn from Uganda, where the fiscal deficit before grants, which was largely aid-funded, doubled to over 12% of GDP in the early 2000s. It focuses on the implications of the widening fiscal deficit for monetary policy, the real exchange rate, debt sustainability and the vulnerability of the budget to fiscal shocks, and argues that large fiscal deficits, even when funded predominantly by aid, risk undermining macroeconomic objectives and long-run fiscal sustainability. [source] The Good, the Bad and the Ugly: Discourse, Policy Controversies and the Role of Science in the Politics of Shrimp Farming DevelopmentDEVELOPMENT POLICY REVIEW, Issue 5 2005Christophe Béné This article revisits through a policy analysis the ongoing debate on shrimp farming aquaculture. It describes the changes in policy orientations that have taken place in recent years, and tries to relate them to the advocacy strategies developed by different networks and policy communities. The analysis reveals in particular the crucial contribution of the ,power of expertise' and shows how it has been instrumentalised by certain advocacy networks to depoliticise the debate. While this has allowed a number of key stakeholders to refocus the debate on technical solutions, it has prevented other groups concerned with more intractable social and political issues from engaging successfully in the policy process, thus leaving the long-term sustainability of aquaculture still a contentious issue. [source] Evolution of invertebrate nervous systems: the Chaetognatha as a case studyACTA ZOOLOGICA, Issue 1 2010Steffen Harzsch Abstract Harzsch, S. and Wanninger, A. 2010. Evolution of invertebrate nervous systems: the Chaetognatha as a case study. ,Acta Zoologica (Stockholm) 91: 35,43 Although recent molecular studies indicate that Chaetognatha may be one of the earliest Bilaterian offshoots, the phylogenetic position of this taxon still is a matter of ongoing debate. In this contribution, we review recent attempts to contribute phylogenetic information on the Chaetognatha by analysing structure and development of their nervous system (neurophylogeny). Analysing this group of organisms also has a major impact on our understanding of nervous system evolution in Bilateria. We review recent evidence from this field and suggest that Urbilateria already was equipped with the genetic toolkit required to build a complex, concentrated central nervous system (CNS), although this was not expressed phenotypically so that Urbilateria was equipped with a nerve plexus and not a CNS. This implies that in the deep metazoan nodes, concentration of the ancestral plexus occurred twice independently, namely once after the protostome,deuterostome split on the branch leading to the protostomes (resulting in a ventrally positioned nerve cord) and once along the chordate line (with a dorsal nerve cord). [source] Matching Response to Context in Complex Political Emergencies: ,Relief', ,Development', ,Peace-building' or Something In-between?DISASTERS, Issue 4 2000Philip White There is an ongoing debate over the value and pitfalls of the policy and practice of ,linking relief and development' or ,developmental relief' in aid responses to complex political emergencies (CPEs). Driven by concerns about relief creating dependence, sometimes doing harm and failing to address root causes of emergencies despite its high cost, pursuit of both relief and development has become a dominant paradigm among international aid agencies in CPEs as in ,natural' disasters. In CPEs a third objective of ,peace-building' has emerged, along with the logic that development can itself help prevent or resolve conflict and sustain peace. However, this broadening of relief objectives in ongoing CPEs has recently been criticised on a number of counts, central concerns being that it leads to a dilution of commitment to core humanitarian principles and is overly optimistic. This paper addresses these issues in the light of two of the CPEs studied by the COPE project: Eritrea and Somalia/Somaliland. It is argued that the debate has so far suffered from lack of clarity about what we mean by ,relief', ,development' and, for that matter, ,rehabilitation' and ,peace-building'. The wide spectrum of possible aid outcomes does not divide neatly into these categories. The relief,development divide is not always as clear-cut, technically or politically, as the critics claim. Moreover such distinctions, constructed from the point of view of aid programmers, are often of little relevance to the concerns of intended beneficiaries. Second, there has been insufficient attention to context: rather than attempting to generalise within and across CPE cases, a more productive approach would be to examine more closely the conditions under which forms of aid other than basic life support can fruitfully be pursued. This leads to consideration of collective agency capacity to respond effectively to diverse needs in different and changing circumstances. [source] Effects of terrain smoothing on topographic shielding correction factors for cosmogenic nuclide-derived estimates of basin-averaged denudation ratesEARTH SURFACE PROCESSES AND LANDFORMS, Issue 1 2009Kevin P. Norton Abstract Estimation of spatially averaged denudation rates from cosmogenic nuclide concentrations in sediments depends on the surface production rates, the scaling methods of cosmic ray intensities, and the correction algorithms for skyline, snow and vegetation shielding used to calculate terrestrial cosmogenic nuclide production. While the calculation of surface nuclide production and application of latitude, altitude and palaeointensity scaling algorithms are subjects of active research, the importance of additional correction for shielding by topographic obstructions, snow and vegetation is the subject of ongoing debate. The derivation of an additional correction factor for skyline shielding for large areas is still problematic. One important issue that has yet to be addressed is the effect of the accuracy and resolution of terrain representation by a digital elevation model (DEM) on topographic shielding correction factors. Topographic metrics scale with the resolution of the elevation data, and terrain smoothing has a potentially large effect on the correction of terrestrial cosmogenic nuclide production rates for skyline shielding. For rough, high-relief landscapes, the effect of terrain smoothing can easily exceed analytical errors, and should be taken into account. Here we demonstrate the effect of terrain smoothing on topographic shielding correction factors for various topographic settings, and introduce an empirical model for the estimation of topographic shielding factors based on landscape metrics. Copyright © 2008 John Wiley and Sons, Ltd. [source] The Epidemiology of Convulsive Status Epilepticus in Children: A Critical ReviewEPILEPSIA, Issue 9 2007Miquel Raspall-Chaure Summary:, There is ongoing debate regarding the most appropriate definition of status epilepticus. This depends upon the research question being asked. Based on the most widely used "30 min definition," the incidence of childhood convulsive status epilepticus (CSE) in developed countries is approximately 20/100,000/year, but will vary depending, among others, on socioeconomic and ethnic characteristics of the population. Age is a main determinant of the epidemiology of CSE and, even within the pediatric population there are substantial differences between older and younger children in terms of incidence, etiology, and frequency of prior neurological abnormalities or prior seizures. Overall, incidence is highest during the first year of life, febrile CSE is the single most common cause, around 40% of children will have previous neurological abnormalities and less than 15% will have a prior history of epilepsy. Outcome is mainly a function of etiology. However, the causative role of CSE itself on mesial temporal sclerosis and subsequent epilepsy or the influence of age, duration, or treatment on outcome of CSE remains largely unknown. Future studies should aim at clarifying these issues and identifying specific ethnic, genetic, or socioeconomic factors associated with CSE to pinpoint potential targets for its primary and secondary prevention. [source] In Search of Causality: A Regional Approach to Urban Growth in Eighteenth-century EnglandGEOGRAFISKA ANNALER SERIES B: HUMAN GEOGRAPHY, Issue 3 2000Jon Stobart The simple equation of industrialisation and urbanisation contains much truth: recent national surveys confirm that rapid coal-based industrial growth spawned massive urban development in Britain. And yet at the local level a wide diversity of growth experiences reflect a complex and overlapping nexus of growth stimuli which defy attempts at generalisation. In taking a regional perspective, this paper seeks to occupy a productive middle ground in this ongoing debate. Placing urban growth in north-west England into its real economic and geographical context, it recognises the complexities of urban growth but transcends the narrowness of the particular. In so doing, it challenges some of the certainties of industrial urbanisation, emphasising instead the importance of rural industry, urban commercial functions and inter-place linkages. Most fundamentally, it argues for a more nuanced understanding of the geography of causality. [source] MOVING VIOLATIONS: DATA PRIVACY IN PUBLIC TRANSITGEOGRAPHICAL REVIEW, Issue 3 2007NANCY J. OBERMEYER ABSTRACT. This article draws from the foundation provided by the ongoing debate about geosurveillance to frame a discussion of the use of tracking technologies in public transit. Specifically, it uses the case of public transit to illustrate the uncomfortable debate about compromises that come with increased surveillance to enhance public safety and security. The article begins with a discussion of the evolution of the debate about geosurveillance, casting the use of surveillance technologies in public transit within this framework. Next, it describes and discusses the implementation of automatic vehicle locators and closed-circuit television in public transit. The following sections focus on the risks to individual privacy that accompany implementation of these technologies, then describe an unusual effort to draw attention to the prevalence of increased surveillance in public spaces in an effort to expose the risks. The article concludes by making the case that public transit is a place where surveillance provides clear benefits but where the humans who review the surveillance data must interpret and use them responsibly to minimize the risks to individual privacy. [source] The seismic anomaly beneath Iceland extends down to the mantle transition zone and no deeperGEOPHYSICAL JOURNAL INTERNATIONAL, Issue 3 2000G. R. Foulger A 3-D teleseismic tomography image of the upper mantle beneath Iceland of unprecedented resolution reveals a subvertical low wave speed anomaly that is cylindrical in the upper 250 km but tabular below this. Such a morphological transition is expected towards the bottom of a buoyant upwelling. Our observations thus suggest that magmatism at the Iceland hotspot is fed by flow rising from the mantle transition zone. This result contributes to the ongoing debate about whether the upper and lower mantles convect separately or as one. The image also suggests that material flows outwards from Iceland along the Reykjanes Ridge in the upper 200 km, but is blocked in the upper 150 km beneath the Tjornes Fracture Zone. This provides direct observational support for the theory that fracture zones dam lateral flow along ridges. [source] Rafts in oligodendrocytes: Evidence and structure,function relationshipGLIA, Issue 6 2006Ellen Gielen Abstract The plasma membrane of eukaryotic cells exhibits lateral inhomogeneities, mainly containing cholesterol and sphingomyelin, which provide liquid-ordered microdomains (lipid "rafts") that segregate membrane components. Rafts are thought to modulate the biological functions of molecules that become associated with them, and as such, they appear to be involved in a variety of processes, including signal transduction, membrane sorting, cell adhesion and pathogen entry. Although still a matter of ongoing debate, evidence in favor of the presence of these microdomains is gradually accumulating but a consensus on issues like their size, lifetime, composition, and biological significance has yet to be reached. Here, we provide an overview of the evidence supporting the presence of rafts in oligodendrocytes, the myelin-producing cells of the central nervous system, and discuss their functional significance. The myelin membrane differs fundamentally from the plasma membrane, both in lipid and protein composition. Moreover, since myelin membranes are unusually enriched in glycosphingolipids, questions concerning the biogenesis and functional relevance of microdomains thus appear of special interest in oligodendrocytes. The current picture of rafts in oligodendrocytes is mainly based on detergent methods. The robustness of such data is discussed and alternative methods that may provide complementary data are indicated. © 2006 Wiley-Liss, Inc. [source] Stochastic Study of Solute Transport in a Nonstationary MediumGROUND WATER, Issue 2 2006Bill X. Hu A Lagrangian stochastic approach is applied to develop a method of moment for solute transport in a physically and chemically nonstationary medium. Stochastic governing equations for mean solute flux and solute covariance are analytically obtained in the first-order accuracy of log conductivity and/or chemical sorption variances and solved numerically using the finite-difference method. The developed method, the numerical method of moments (NMM), is used to predict radionuclide solute transport processes in the saturated zone below the Yucca Mountain project area. The mean, variance, and upper bound of the radionuclide mass flux through a control plane 5 km downstream of the footprint of the repository are calculated. According to their chemical sorption capacities, the various radionuclear chemicals are grouped as nonreactive, weakly sorbing, and strongly sorbing chemicals. The NMM method is used to study their transport processes and influence factors. To verify the method of moments, a Monte Carlo simulation is conducted for nonreactive chemical transport. Results indicate the results from the two methods are consistent, but the NMM method is computationally more efficient than the Monte Carlo method. This study adds to the ongoing debate in the literature on the effect of heterogeneity on solute transport prediction, especially on prediction uncertainty, by showing that the standard derivation of solute flux is larger than the mean solute flux even when the hydraulic conductivity within each geological layer is mild. This study provides a method that may become an efficient calculation tool for many environmental projects. [source] Cytomegalovirus in inflammatory bowel disease: Pathogen or innocent bystander?INFLAMMATORY BOWEL DISEASES, Issue 9 2010Garrett Lawlor MD Abstract The role of cytomegalovirus (CMV) in exacerbations of inflammatory bowel disease (IBD) remains a topic of ongoing debate. Current data are conflicting as to whether CMV worsens inflammation in those with severe colitis, or is merely a surrogate marker for severe disease. The interpretation of existing results is limited by mostly small, retrospective studies, with varying definitions of disease severity and CMV disease. CMV colitis is rare in patients with Crohn's disease or mild-moderate ulcerative colitis. In patients with severe and/or steroid-refractory ulcerative colitis, local reactivation of CMV can be detected in actively inflamed colonic tissue in about 30% of cases. Where comparisons between CMV+ and CMV, steroid-refractory patients can be made, most, but not all, studies show no difference in outcomes according to CMV status. Treatment with antiviral therapy has allowed some patients with severe colitis to avoid colectomy despite poor response to conventional IBD therapies. This article reviews the immunobiology of CMV disease, the evidence for CMV's role in disease severity, and discusses the outcomes with antiviral therapy. (Inflamm Bowel Dis 2010) [source] Duloxetine 60 mg once daily in the treatment of milder major depressive disorderINTERNATIONAL JOURNAL OF CLINICAL PRACTICE, Issue 5 2006D. G. S. Perahia Summary There is ongoing debate regarding the effectiveness of antidepressants in patients with milder major depressive disorder (MDD). This post-hoc analysis evaluated the efficacy and tolerability of duloxetine in the subset of 159 (75 duloxetine and 84 placebo) patients with milder MDD (baseline HAMD17 total score ,15 and ,18) who were treated once daily with duloxetine 60 mg or placebo in two identical, 9-week, randomised, double-blind trials. At endpoint, change from baseline on HAMD17 was greater in the duloxetine group (,7.0) than in the placebo group (,4.1) (p = 0.005). Response and remission rates, and improvement on the Clinical Global Impressions-Severity (CGI-S) scale, the Patient Global Impressions-Improvement (PGI-I) scale, and measures of painful symptoms were also significantly better in the duloxetine group (p < 0.05). Tolerability was consistent with that seen in previous studies of duloxetine in patients with more severe depression. In conclusion, duloxetine 60 mg/day is effective and well tolerated in milder MDD. [source] Don't seize the day hospital!INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, Issue 7 2005Recent research on the effectiveness of day hospitals for older people with mental health problems Abstract Background Day hospital (DH) care remains a core component of mental health services for older people. However, there has been an ongoing debate about the effectiveness and value for money of DHs in comparison to day centres (DC). Aim The aim was to review the recent research on the effectiveness of day hospitals for older people with mental health problems. Method A systematic search of relevant research literature over the last decade using the major electronic healthcare databases examining the quality and effectiveness of mental health DHs for older people. Results In the last decade the evidence for the effectiveness of DHs has continued to increase, but still lags behind research on DHs in general adult psychiatry and geriatric medicine. The review found that DHs appear effective at assessing and meeting needs and that a systematic approach to evaluating quality can be used to improve services. Conclusion Recent research supports the effectiveness of day hospitals, but further studies are needed in order to provide a more robust evidence base. Copyright © 2005 John Wiley & Sons, Ltd. [source] Positively negative: the impact of negativity upon the political consumerINTERNATIONAL JOURNAL OF NONPROFIT & VOLUNTARY SECTOR MARKETING, Issue 4 2008Jenny LloydArticle first published online: 15 OCT 200 For years there has been an ongoing debate as to the role and impact that ,marketing' has had on politics. Yet, it is the case that many of the concepts associated with the field of marketing have real relevance and have, in fact, been employed within the field of political campaigning for many decades. This is an empirical paper that focuses upon the concept of political brands and the impact that current trends in campaign strategy, and in particular the growth and continued use of negative campaigning, have upon them. Using a constructivist grounded theory approach, the implications associated with such activity are examined and, in particular, its effect upon the consumer/brand relationship. Within the consideration of the results, it becomes clear that political brands' use of negative campaigning is somewhat shortsighted; offering short-term gains but at the cost of long-term damage not only to their brand image but also to the wider democratic system as it stands. In a search for political ,brands' that more effectively meet their needs, there appears a tendency for political consumers to now look outside of the conventional political sector. The emergent concept of the ,negative brand' is explored together with the implications for political consumers, political brands and the wider field of conventional party politics. Copyright © 2007 John Wiley & Sons, Ltd. [source] Analysis and interpretation of flint toolmarks found on bones from West Tump long barrow, GloucestershireINTERNATIONAL JOURNAL OF OSTEOARCHAEOLOGY, Issue 1 2004M. J. Smith Abstract West Tump is a Neolithic chambered tomb originally excavated in 1880. The mound was found to contain a mixed skeletal assemblage, the majority of which was disarticulated. Between 2000 and 2001 material from the site including human bone was re-examined with a portion of this project focused on taphonomic evidence observed on the human skeletal material. Amongst the factors selected for investigation were deliberate toolmarks. Three specimens were identified as exhibiting toolmarks. Analysis demonstrated that the observed features were cutmarks, consistent with the use of flint tools. However those on two of the specimens were found to be both post-mortem and recent. The cutmarks observed on the remaining specimen, a right clavicle, were identified as having been inflicted during the peri-mortem period and consistent with decapitation. British Neolithic mortuary practice has been the subject of ongoing debate since the earliest excavations of relevant sites, but until very recently few assemblages from such contexts have been re-examined and much of the data in use has derived from sources of considerable age and questionable reliability. The selective removal of specific skeletal elements (particularly skulls) has repeatedly been described in the literature regarding the collective funerary monuments of this period. It has often been assumed that such practices took place after the soft tissues had decayed. One of the examples discussed, suggests this may not always have been the case and the potential significance of this finding is discussed in addition to a possible interpretation of the cutmarks seen on the remaining specimens. Copyright © 2004 John Wiley & Sons, Ltd. [source] Promoting sustainable compliance: Styles of labour inspection and compliance outcomes in BrazilINTERNATIONAL LABOUR REVIEW, Issue 2-3 2008Roberto PIRES Abstract. Can workers' rights and social protections be reconciled with firms' competitiveness and productivity? In contrast to current development policy advice, which emphasizes the "flexibilization" of labour laws, this article contributes to an ongoing debate about styles of inspection by exploring the causal links between different regulatory practices and economic development and compliance outcomes. Findings from subnational comparisons in Brazil challenge established theories about the behaviours of firms and regulatory agencies, and indicate that labour inspectors have been able to promote sustainable compliance (legal and technical solutions linking up workers' rights with firms' performance) by combining punitive and pedagogical inspection practices. [source] Application of labour and employment law beyond the contract of employmentINTERNATIONAL LABOUR REVIEW, Issue 1-2 2007Mark FREEDLAND The personal scope of employment law is the subject of much ongoing debate. Arguing that an exclusively contractual analysis of this domain is unsatisfactory, the author constructs a European-based empirical typology distinguishing the personal work relations of "standard employees", public officials, "liberal professions", individual entrepreneurial workers, marginal workers, and labour market entrants. These categories and their inter-relationships are then analysed dynamically in terms of "personal work nexuses" - a concept encompassing complex legal ramifications beyond the contractual framework. The conclusions highlight the value of this analytical approach to recent efforts by the ILO and the European Commission to "modernize" labour law. [source] Secularism as a Barrier to Integration?INTERNATIONAL MIGRATION, Issue 3 2004The French Dilemma ABSTRACT This article focuses on the secularism debate currently taking place in France by examining how this issue impacts the integration of immigrants, particularly Muslim immigrants. Secularism is one of the key values of French Republicanism, but one which has been challenged by the establishment of a settled population of Muslim immigrants in France. The issue has been particularly highlighted by the affaire des foulards (headscarf affair), an ongoing debate over the rights of Muslim girls to wear a headscarf to secular French schools. Discussions of the principle of secularism and of its application have been even more intense in recent months with the publication in December 2003 of a report by the Stasi Commission, a commission set up by President Chirac to investigate the application of the principle of secularism, and by the passage of legislation intended to outlaw the wearing of any "overt" religious insignia in French schools. This article examines these recent developments in the context of the long-running debate over Muslim women's right to wear a headscarf in French schools. It argues that the current focus on secularism provides evidence of the return of assimilation as a primary objective of public policy (Brubaker, 2001) and the decreasing strength of the movement in favour of the droit à la différence (right to difference). Finally, the paper argues that this has provided important obstacles to the integration of certain groups of immigrants, particularly Muslim immigrants. [source] The War against Iraq and International Order: From Bull to Bush,INTERNATIONAL STUDIES REVIEW, Issue 2 2004Galia Press-Barnathan This essay has two goals: (1) to examine US foreign policy leading to the war in Iraq through the lens of Bull's (1977) classic book, The Anarchical Society, and (2) to explore in a unipolar, hegemonic system the relevance and power of the institutional mechanisms that are supposed to preserve international society according to Bull. It also addresses the implications of the events from September 11, 2001, through the war in Iraq for the ongoing debate within the Grotian school regarding the limits of international society and the international society,world society divide. [source] Test of an adaptive hypothesis for egg speckling along an elevational gradient in a population of Mexican jays Aphelocoma ultramarinaJOURNAL OF AVIAN BIOLOGY, Issue 4 2009Elena C. Berg The adaptive significance of avian egg speckling patterns has been a subject of ongoing debate. We examined speckling in a population of Mexican jays Aphelocoma ultramarina exhibiting extreme eggshell variability. We sampled 167 eggs at 55 nests from sites ranging across a steep elevation gradient within the Sierra del Carmen mountain range in Coahuila, Mexico, in order to test the recent hypothesis that egg speckling lends structural support to eggs and should therefore be more prevalent in females subject to reduced environmental calcium. Although we documented high variation in the amount and distribution of eggshell speckling within the Sierra del Carmen jays, we found no relationship between local soil calcium levels and the pattern of speckling. Our results indicate that explanations in addition to soil calcium levels are necessary to explain extreme variation in eggshell speckling in birds. [source] Cancer stem cells: Cell culture, markers, and targets for new therapiesJOURNAL OF CELLULAR BIOCHEMISTRY, Issue 5 2009Candace A. Gilbert Abstract A cancer stem cell (CSC) is defined as an undifferentiated cell with the ability to self-renew, differentiate to multiple lineages and initiate tumors that mimic the parent tumor. In this review, we focus on glioblastomas, describing recent progress and problems in characterizing these cells. There have been advances in CSC culture, but tumor cell heterogeneity has made purification of CSCs difficult. Indeed, it may be that CSCs significantly vary from tumor to tumor. We also discuss the proposal that CSCs are resistant to radiotherapy and chemotherapy and play a major role in repopulating tumors following treatment. To overcome their resistance to conventional therapies, we may be able to use our extensive knowledge of the signaling pathways essential for stem cells during development. These pathways have potential as targets for new glioblastoma therapies. Hence, although there is an ongoing debate on the nature of CSCs, the theory continues to suggest new ideas for both the lab and the clinic. J. Cell. Biochem. 108: 1031,1038, 2009. © 2009 Wiley-Liss, Inc. [source] Managing new-style currency crises: the swan diagram approach revisited,JOURNAL OF INTERNATIONAL DEVELOPMENT, Issue 5 2007Ramkishen S. Rajan Abstract The new-style currency crises that have afflicted a number of developing and emerging economies of late are characterised by sudden stops in capital inflows and adverse balance sheet effects. Given the potential high costs of these crises, there remains an ongoing debate on how they might best be managed when they do arise. This paper argues that the age-old Swan diagram, appropriately modified, is able to provide useful insights into how a country might manage a new-style crisis via a combination of adjustment (which involves expenditure switching and reducing polices) and financing. Copyright © 2006 John Wiley & Sons, Ltd. [source] International health electives: thematic results of student and professional interviewsMEDICAL EDUCATION, Issue 7 2010Andrew Petrosoniak Medical Education 2010: 44: 683,689 Objectives, The purpose of this study was to explore the complexities (including harms and benefits) of international health electives (IHEs) involving medical trainees. This exploration contributes to the ongoing debate about the goals and implications of IHEs for medical trainees. Methods, This qualitative study used anonymous, one-to-one, semi-structured interviews. All participants had previous international health experiences. Between September 2007 and March 2008, we interviewed a convenience sample of health care professionals (n = 10) and medical trainees (n = 10). Using a modified grounded theory methodology, we carried out cycles of data analysis in conjunction with data collection in an iterative and constant comparison process. The study's thematic structure was finalised when theme saturation was achieved. Results, Participants described IHEs in both negative and positive terms. IHEs were described as unsustained short-term contributions that lacked clear educational objectives and failed to address local community needs. Ethical dilemmas were described as IHE challenges. Participants reflected that many IHEs included aspects of medical tourism and the majority of participants described the IHE in negative terms. However, a few participants acknowledged the benefits of the IHE. Specifically, it was seen as an introduction to a career in global health and as a potential foundation for more sustainable projects with positive host community impacts. Finally, despite similar understandings among participants, self-awareness of medical tourism was low. Conclusions, International health electives may include potential harms and benefits for both the trainee and the host community. Educational institutions should encourage and support structured IHEs for trainee participation. We recommend that faculties of medicine and global health educators establish pre-departure training courses for trainees and that IHE opportunities have sufficient structures in place to mitigate the negative effects of medical tourism. We also recommend that trainees be provided with opportunities to conduct self-reflection and critically assess their IHE experiences. [source] SOSA'S MOORE AND THE NEW DOGMATISTSMETAPHILOSOPHY, Issue 2 2009SUSANA NUCCETELLI Abstract: Some seventy years ago, G. E. Moore invoked his own sensory experience (as of a hand before him in the right circumstances), added some philosophical analysis about externality, and took himself to have offered his "Proof" of the existence of an external world. Current neo-Mooreans either reject completely the standard negative assessment of the Proof or qualify it substantially. For Sosa, the Proof can be persuasive, but only when read literally as offering reasons for the conclusion that there is at least one external object,rather than that the prover is justified in believing, or even knowing, that there is at least one external object. Sosa, then, is a neo-Moorean,though not of the sort we might expect in light of the ongoing debate about the Proof. I argue that Sosa needs to say more about the circularity often thought to vitiate the Proof before we can accept his view. [source] Sequence diversity and haplotype associations with phenotypic responses to crowding: GIGANTEA affects fruit set in Arabidopsis thalianaMOLECULAR ECOLOGY, Issue 14 2007MARCUS T. BROCK Abstract Identifying the molecular genetic basis of intraspecific variation in quantitative traits promises to provide novel insight into their evolutionary history as well as genetic mechanisms of adaptation. In an attempt to identify genes responsible for natural variation in competitive responses in Arabidopsis thaliana, we examined DNA sequence diversity at seven loci previously identified as members of the phytochrome B signalling network. For one gene, GIGANTEA (GI), we detected significant haplotype structure. To test for GI haplogroup,phenotype associations, we genotyped 161 A. thaliana accessions at GI and censused the same accessions for total fruit set and the expression of three phenotypic traits (days to flowering, petiole length, and inflorescence height) in a greenhouse experiment where plants were grown in crowded and uncrowded environments. We detected a significant association between GI and total fruit set that resulted in a 14% difference in average fruit set among GI haplogroups. Given that fruit set is an important component of fitness in this species and given the magnitude of the effect, the question arises as to how variation at this locus is maintained. Our observation of frequent and significant epistasis between GI and background single nucleotide polymorphisms (SNP), where the fitness ranking of the GI allele either reverses or does not differ depending on the allele at the interacting SNP, suggests that epistatic selection may actively maintain or at least slow the loss of variation at GI. This result is particularly noteworthy in the light of the ongoing debate regarding the genetic underpinnings of phenotypic evolution and recent observations that epistasis for phenotypic traits and components of fitness is common in A. thaliana. [source] Lack of mitochondrial genetic structure in hamlets (Hypoplectrus spp.): recent speciation or ongoing hybridization?MOLECULAR ECOLOGY, Issue 11 2003Marina L. Ramon Abstract Species in the genus Hypoplectrus (hamlet fish) have been recognized primarily on the basis of colour morphology, which varies substantially. Limited differentiation in other morphological characters, however, has led to ongoing debate about their taxonomy. Our analysis of mtDNA sequences demonstrates neither reciprocal monophyly nor significant genetic differentiation among hamlet colour morphs. These data are potentially consistent with a model of recent speciation due to sexual selection on colour morphology. The presence within hamlets of two divergent mtDNA clades, however, suggests a longer history during which hybridization and gene flow have prevented the differentiation of hamlet colour morphs, at least in neutral genetic markers. [source] Déjà Vu all over again: Charter reform fails in St. LouisNATIONAL CIVIC REVIEW, Issue 3 2005Robert A. Cropf Editor's note: There is a lively ongoing debate in this country over the forms of organization and the distribution of powers within local government, especially when it comes to the critical question of mayoral leadership. The following essay is an account of a failed attempt to change St. Louis's city charter. Because the National Civic League's Community Services program played a role in facilitating the discussion leading up to the proposal of charter amendments, we would like to emphasize that as with most essays and reports published in this journal, the analysis and conclusions herein represent the perspectives of the authors, or in some cases the participants they interviewed, and not necessarily those of National Civic League staff. We hope this essay will stimulate further discussion and debate on these critical issues of concern. [source] | ||||||||||||||||||||||||||||||||||||||||||||||||||||