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Selected AbstractsCuriosity and cure: Translational research strategies for neural repair-mediated rehabilitationDEVELOPMENTAL NEUROBIOLOGY, Issue 9 2007Bruce H. Dobkin Abstract Clinicians who seek interventions for neural repair in patients with paralysis and other impairments may extrapolate the results of cell culture and rodent experiments into the framework of a preclinical study. These experiments, however, must be interpreted within the context of the model and the highly constrained hypothesis and manipulation being tested. Rodent models of repair for stroke and spinal cord injury offer examples of potential pitfalls in the interpretation of results from developmental gene activation, transgenic mice, endogeneous neurogenesis, cellular transplantation, axon regeneration and remyelination, dendritic proliferation, activity-dependent adaptations, skills learning, and behavioral testing. Preclinical experiments that inform the design of human trials ideally include a lesion of etiology, volume and location that reflects the human disease; examine changes induced by injury and by repair procedures both near and remote from the lesion; distinguish between reactive molecular and histologic changes versus changes critical to repair cascades; employ explicit training paradigms for the reacquisition of testable skills; correlate morphologic and physiologic measures of repair with behavioral measures of task reacquisition; reproduce key results in more than one laboratory, in different strains or species of rodent, and in a larger mammal; and generalize the results across several disease models, such as axonal regeneration in a stroke and spinal cord injury platform. Collaborations between basic and clinical scientists in the development of translational animal models of injury and repair can propel experiments for ethical bench-to-bedside therapies to augment the rehabilitation of disabled patients. © 2007 Wiley Periodicals, Inc. Develop Neurobiol, 2007 [source] A Conscious and Inclusive Family StudiesJOURNAL OF MARRIAGE AND FAMILY, Issue 1 2000Katherine R. Allen I argue that family scholars must take bolder steps to engage the tensions between our heritage of positivist science and its postmodern challenges. I also argue that constructing theories, utilizing research methods, and examining substantive issues should be relevant to the diversity of the families we study and to ourselves as members of families. I offer examples of developing an informed reflexive consciousness to broaden the rationalist foundation that dominates family scholarship. For a more inclusive, balanced, and invigorated family studies, our subjective experiences and commitments as researchers should be acknowledged, confronted, and integrated. A family studies that is responsible to our readers, students, selves, and the people whose lives we study requires that we engage the critical intersections of race, class, gender, sexual orientation, and age as they define family diversity. [source] Lessons from Kipling and Rao: How to Re-Appropriate Another CultureORBIS LITERARUM, Issue 4 2002Ian Almond This brief study will examine Anglo-Indian Rudyard Kipling and Indo-Anglian Raja Rao's, attempts to re-appropriate a foreign culture in terms of their own wills. The novelist Rao's conviction of India's position as the origin of all Western culture, alongside Kipling's own curious tale of a tribe of distant "Englishmen" rediscovered in Northwest Afghanistan, both offer examples of attempts to re-describe and ultimately re-locate radically different cultures within the authors' own more familiar vocabularies. How does this cultural re-appropriation take place, and what happens to the author's parent culture when something as radically ,other' as an Afghan tribe or a medieval French heresy is suddenly and unexpectedly re-incorporated into the ,family'? The often unsettling consequences of this operation are considered as they manifest themselves in both texts in similar ways, advancing the possibility that cultural-appropriation affects the appropriator as much as the appropriated. And so strong is the inclination that is rooted in Mankind to the Love of their Country, that some learned and witty Men , have used great Art and Industry to represent them with such advantage to the World, as though Paradise were but another Name for their native Country. Bishop Stillingfleet1 [source] Origin of evolutionary novelty: Examples from limbsJOURNAL OF MORPHOLOGY, Issue 1 2002Neil H. Shubin Abstract Classic hypotheses of vertebrate morphology are being informed by new data and new methods. Long nascent issues, such as the origin of tetrapod limbs, are being explored by paleontologists, molecular biologists, and functional anatomists. Progress in this arena will ultimately come down to knowing how macroevolutionary differences between taxa emerge from the genetic and phenotypic variation that arises within populations. The assembly of limbs over developmental and evolutionary time offers examples of the major processes at work in the origin of novelties. Recent comparative developmental analyses demonstrate that many of the mechanisms used to pattern limbs are ancient. One of the major consequences of this phenomenon is parallelism in the evolution of anatomical structures. Studies of both the fossil record and intrapopulational variation of extant populations reveal regularities in the origin of variation. These examples reveal processes acting at the level of populations that directly affect the patterns of diversity observed at higher taxonomic levels. J. Morphol. 252:15,28, 2002. © 2002 Wiley-Liss, Inc. [source] | |||||||||||||