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Of Topics (of + topics)

Distribution by Scientific Domains
Life Sciences33%
Humanities and Social Sciences33%

Kinds of Of Topics

  • variety of topics
    		•

    Selected Abstracts

    Symposium on the musculoskeletal aspects of marfan syndrome: Meeting report and state of the science

    JOURNAL OF ORTHOPAEDIC RESEARCH, Issue 3 2007
    Kevin B. Jones
    Abstract The National Marfan Foundation sponsored a symposium in August 2005 to review recent progress in the area of Marfan-related musculoskeletal research. Orthopaedic surgeons, molecular geneticists, medical geneticists, and pain specialists met to review a variety of topics. This report reviews and summarizes the proceedings of the symposium, with emphasis on future directions for study that were identified in the course of the meeting. Areas covered include clinical detection, diagnosis, growth, spine deformity, molecular mechanisms, dural ectasia, protrusio acetabuli, and pain in Marfan syndrome. © 2006 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 2007 [source]

    Computer Simulation and the Philosophy of Science

    PHILOSOPHY COMPASS (ELECTRONIC), Issue 5 2009
    Eric Winsberg
    There are a variety of topics in the philosophy of science that need to be rethought, in varying degrees, after one pays careful attention to the ways in which computer simulations are used in the sciences. There are a number of conceptual issues internal to the practice of computer simulation that can benefit from the attention of philosophers. This essay surveys some of the recent literature on simulation from the perspective of the philosophy of science and argues that philosophers have a lot to learn by paying closer attention to the practice of simulation. [source]

    Protein Design and Evolution for Biocatalysis

    BIOTECHNOLOGY JOURNAL, Issue 4 2009
    Article first published online: 15 APR 200
    Cover illustration: Protein Design and Evolution for Biocatalysis. This special issue of Biotechnology Journal contains selected contributions from scientists participating to the ESF-EMBO Symposium which took place in October 2008 in San Feliu, Spain. Guest Editor is the chair and organizer of the meeting, Jiri Damborsky from Brno (Czech Republic). He highlights a variety of topics brought up in the meeting, ranging from new methods of rational design, directed evolution, metagenomics and single-molecule techniques, to construction of useful enzymes for industrial applications. Uwe Bornscheuer (Greifswald, Germany) authored a meeting report. Image colored pencils, © PhotoDisc, Inc.; Protein logo © ESF. [source]

    Increased postvoid residual volume after measuring the isovolumetric bladder pressure using the noninvasive condom catheter method

    BJU INTERNATIONAL, Issue 6 2007
    Sandra De Zeeuw
    The papers in this section cover a variety of topics, from urodynamics using a noninvasive method, the morbidity associated with long-term urinary catheters and attempts being made to lower this, the use of botulinum toxin in refractory idiopathic detrusor overactivity, and finally, a study into the effect of chronic prostatitis-like symptoms on the quality of life in a relatively large patient sample. OBJECTIVE To test, in an ongoing noninvasive longitudinal study in healthy men, whether the condom catheter method (a noninvasive urodynamic test to assess bladder function and bladder outlet obstruction) inhibits bladder function and whether this affects the reliability of the measured isovolumetric bladder pressure (Pves.iso). SUBJECTS AND METHODS Subjects (754, aged 40,79 years) voided three times, i.e. one free void and two condom measurements. The postvoid residual volume (PVR) was measured after each void using transabdominal ultrasonography. The statistical significance of differences was tested using Wilcoxon rank test and the Mann,Whitney U -test. RESULTS After free voiding the median (interquartile range) PVR was 18 (37) mL, and independent of the amount of fluid intake. In a subgroup of volunteers, when the free void was done last, the PVR was no different (P = 0.25), suggesting that the bladder did not become exhausted during the protocol. The PVR after two subsequent condom measurements was significantly higher than after free voiding, at 45 (78) and 57 (88) (both P < 0.05), independent of the number of interruptions in voiding. After supplementary fluid intake before the condom measurements, the PVR was double that with a normal fluid intake (P = 0.03). The median Pves.iso was 3 cmH2O higher in the second condom measurement than in the first (P < 0.05), although this small difference was not clinically relevant. CONCLUSIONS The condom measurement is associated with a significantly higher PVR, partly caused by supplementary fluid intake. This effect was only temporary and did not affect the measured Pves.iso. [source]

    Induction of potent antitumour natural-killer cells from peripheral blood of patients with advanced prostate cancer

    BJU INTERNATIONAL, Issue 9 2003
    T. Oikawa
    In this section there are four papers on a variety of topics. The subject of antitumour natural killer cells is addressed in patients with advanced prostate cancer. In another study, the authors describe their work into the effect of oestrogen and testosterone on the urethral seam of the developing male mouse genital tubercle. Another group of authors studied ion-channel currents of smooth muscle cells isolated from the prostate of the guinea pig, and the final paper describes how a novel pyrrole derivative, NS-8, suppresses the rat micturition reflex by inhibiting afferent pelvic nerve activity. OBJECTIVE To examine whether antitumour natural-killer (NK) cells can be induced from peripheral blood mononuclear cells (PBMCs) of patients with advanced prostate cancer, as cell therapy using antitumour immune cells is a promising candidate treatment but such patients generally have a suppressed immune response against cancer cells. PATIENTS AND METHODS PBMCs were obtained from 10 patients (four with stage D2 and six with stage B or C disease). For the NK cell expansion, PBMCs were co-cultured with irradiated HFWT cells, a cell line originating from Wilms' tumour, in RHAM , culture medium supplemented with 5% autologous plasma and interleukin-2 (200 U/mL) for 2 weeks. RESULTS When PBMCs were co-cultured with HFWT cells, lymphocytes from all patients had a 20- to 130-fold expansion after 2 weeks of culture. The CD16+ CD56+ cells constituted >,70% of the proliferated lymphocyte population. The induced NK cells had significantly greater cytotoxicity against a prostate cancer cell line (PC-3) than lymphocytes cultured with no HFWT cells. There was no significant difference in growth and phenotypes of lymphocytes and the induced NK cell activity between patients with stage D2, B or C. CONCLUSION NK cells with potent cytotoxic activity against prostate cancer cell lines from patients with advanced prostate cancer were selectively expanded. Further investigation is needed to determine whether this approach could be a candidate for cell therapy for advanced prostate cancer. [source]

    The Sociology of Space: A Use,Centered View

    CITY & COMMUNITY, Issue 4 2002
    Herbert J. Gans
    The revival of spatial sociology justifies a renewed exploration of the various connections between "space" and "society." I argue that sociologists must avoid both the reification of space and studies that mainly demonstrate that all social life exists in space. Instead, researchers should focus on the causal relations between space and society: (1) on the few but important ways in which natural space affects social life and collectivities; and (2) on the innumerable ways in which these collectivities turn natural space into social space and shape its uses. Treating use, users, and effects as primary concepts, the paper discusses a variety of topics in spatial sociology to illustrate my causal point and to suggest research and other questions that deserve answers. [source]