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Of Strategies (of + strategy)
Kinds of Of Strategies Selected AbstractsXenopus, the next generation: X. Tropicalis genetics and genomicsDEVELOPMENTAL DYNAMICS, Issue 4 2002Nicolas Hirsch Abstract A small, fast-breeding, diploid relative of the frog Xenopus laevis, Xenopus tropicalis, has recently been adopted for research in developmental genetics and functional genomics. X. tropicalis shares advantages of X. laevis as a classic embryologic system, but its simpler genome and shorter generation time make it more convenient for multigenerational genetic, genomic, and transgenic approaches. Its embryos closely resemble those of X. laevis, except for their smaller size, and assays and molecular probes developed in X. laevis can be readily adapted for use in X. tropicalis. Genomic manipulation techniques such as gynogenesis facilitate genetic screens, because they permit the identification of recessive phenotypes after only one generation. Stable transgenic lines can be used both as in vivo reporters to streamline a variety of embryologic and molecular assays, or to experimentally manipulate gene expression through the use of binary constructs such as the GAL4/UAS system. Several mutations have been identified in wild-caught animals and during the course of generating inbred lines. A variety of strategies are discussed for conducting and managing genetic screens, obtaining mutations in specific sequences, achieving homologous recombination, and in developing and taking advantage of the genomic resources for Xenopus tropicalis. © 2002 Wiley-Liss, Inc. [source] Is the distribution of nitrogen-fixing cyanobacteria in the oceans related to temperature?ENVIRONMENTAL MICROBIOLOGY, Issue 7 2009Lucas J. Stal Summary Approximately 50% of the global natural fixation of nitrogen occurs in the oceans supporting a considerable part of the new primary production. Virtually all nitrogen fixation in the ocean occurs in the tropics and subtropics where the surface water temperature is 25°C or higher. It is attributed almost exclusively to cyanobacteria. This is remarkable firstly because diazotrophic cyanobacteria are found in other environments irrespective of temperature and secondly because primary production in temperate and cold oceans is generally limited by nitrogen. Cyanobacteria are oxygenic phototrophic organisms that evolved a variety of strategies protecting nitrogenase from oxygen inactivation. Free-living diazotrophic cyanobacteria in the ocean are of the non-heterocystous type, namely the filamentous Trichodesmium and the unicellular groups A,C. I will argue that warm water is a prerequisite for these diazotrophic organisms because of the low-oxygen solubility and high rates of respiration allowing the organism to maintain anoxic conditions in the nitrogen-fixing cell. Heterocystous cyanobacteria are abundant in freshwater and brackish environments in all climatic zones. The heterocyst cell envelope is a tuneable gas diffusion barrier that optimizes the influx of both oxygen and nitrogen, while maintaining anoxic conditions inside the cell. It is not known why heterocystous cyanobacteria are absent from the temperate and cold oceans and seas. [source] EXPLORING THE CONNECTIONS: LAND TENURE, SOCIAL IDENTITIES, AND AGROBIODIVERSITY PRACTICES IN GHANAGEOGRAFISKA ANNALER SERIES B: HUMAN GEOGRAPHY, Issue 2 2009Louis Awanyo ABSTRACT. This article employs qualitative and quantitative evidence from primary social research in Ghana to examine the link between land tenure security and social identities (of wealth/income and gender), and how they condition farmers' investments in practices that contribute to the rehabilitation of tree biodiversity (agrobiodiversity). Statistical analyses of the significance of the effects of farmers' de jure land tenure security regimes, and income and gender on agrobiodiversity practices were inconclusive. The conventional causation link between investments and more secure formal land tenure rights, for instance, was confirmed in investments in four out of eight agrobiodiversity practices. Testimonial-based evidence of farmers provided a clearer concept of land tenure security and an explanatory framework about the interacting and complex effects of income and gender on land tenure security. The theoretical and empirical argument developed from these testimonies portrays land tenure as embodying negotiated social processes, influenced by gender and income of individuals, whereby breadth of land rights, duration of rights over land, and assurance of rights are established, sustained, enhanced or changed through a variety of strategies to shape tenure security. These processes , tenure building and renewal processes , are critical because all farmers have lingering anxiety about land tenure rights, even among farmers with more secure formal rights. Investments are made in agrobiodiversity practices as a strategy to strengthen land tenure security and thereby minimize anxiety, leading to reverse causation effects between land tenure, social identities, and investments. [source] The Impact of Fair Trade on Social and Economic Development: A Review of the LiteratureGEOGRAPHY COMPASS (ELECTRONIC), Issue 6 2008Ann Le Mare This article explores the outcomes of Fair Trade for producers, artisans and their organisations. It asks the question, ,what happens to people who are involved in Fair Trade?', and reviews the case studies and empirical research conducted on Fair Trade for a range of products in different countries. The article is organised around important aspects of development which Fair Trade seeks to influence, including market relations, institutional development, economic development and reductions in poverty, social development, gender equity and sustainable development. The outcomes are diverse and complex, though, most studies found significant impact on social and economic aspects of development, contributing to the capacity to improve and diversify livelihoods. Fostering sustainable commercial organisations is an important contribution of Fair Trade networks. However, there appears to be less success in achieving gender equality and dealing with issues of importance to women. Both the enactment of partnership and the achievement of development goals require continuous commitment, a variety of strategies and cooperation with other actors, such as government and non-governmental organisations. [source] Functional polymorphisms in dopamine and serotonin pathway genes,HUMAN MUTATION, Issue 1 2006Ursula M. D'Souza Abstract There is mounting evidence on the functional significance of single nucleotide and simple repeat sequence polymorphisms in both the coding and regulatory regions of genes in the monoamine neurotransmitter pathways. Many of these gene variants have been associated with human behavioral disorders and traits, and thus have important clinical relevance. This review summarizes the literature on the published functional studies from a molecular, cellular, and neurobiological perspective, and notes their possible behavioral consequences. Functional studies have adopted a variety of strategies. Pharmacological studies have focused on the effects of gene variation at the protein level in terms of binding to ligands or drugs. Other key investigations have determined effects on gene expression at the level of transcription in mammalian cell cultures, lymphoblasts, and/or human postmortem brain tissue. This has enabled the comparison of in vitro and in vivo data, and furthermore provides an improved perceptive of their respective advantages. Additionally, molecular biological approaches have identified transcription factors (DNA-binding proteins) that interact with the motifs within the polymorphisms themselves. Various neuroimaging studies have further determined the relationship of genotype with protein availability in the brain, and thus have contributed to our understanding of the in vivo functional significance of gene variants. Finally, there is growing evidence from both human and animal studies on the interaction of functional polymorphisms with the environment in determining a behavioral outcome. Taken together, these findings have contributed to a greater understanding of the plausible molecular mechanisms that underpin the functional significance of polymorphisms in monoamine neurotransmitter pathway genes, and how they may influence behavioral phenotypes. Hum Mutat 27(1), 1,13, 2006. © 2005 Wiley-Liss, Inc. [source] Formation and applications of stable 10 nm to 500 nm supramolecular porphyrinic materialsISRAEL JOURNAL OF CHEMISTRY, Issue 3 2005Charles Michael Drain Nanoscaled materials of organic dyes are of interest for a variety of potential applications because of the rich photonic properties that this class of molecules can impart. One mode to form such nanoscaled materials is via self-organization and self-assembly, using reasonably well understood methods in supramolecular chemistry. But there are inherent complexities that arise from the use of organic-based supramolecular materials, including stability toward dioxygen, structural stability, and nanoarchitectures that may change with environmental conditions. Porphyrinoids have rich photonic properties yet are remarkably stable, have a rigid core, are readily functionalized, and metalation of the macrocycle can impart a plethora of optical, electronic, and magnetic properties. While there are many <10 nm porphyrinic assemblies, which may or may not self-organize into crystals, there is a paucity of 10,500 nm porphyrinic materials that can be isolated and stored. A variety of strategies towards the latter nanoscopic porphyrinic materials are discussed in terms of design, construction, and nanoarchitecture. The hierarchical structures include colloids, nanorods, nanotubes, nanorings, and nano-crystalline materials. This prolegomenon emphasizes the supramolecular chemistry, structure-stability, and structure-function relationships. The goal herein is to examine general trends and delineate general principles. [source] Innovations in United States genetics nursing: Practice and researchJAPAN JOURNAL OF NURSING SCIENCE, Issue 2 2005Dale H. LEA Abstract Aim:, Clinical and research applications from human genome discoveries are growing and creating both opportunities and challenges to the integration of genetic concepts into practice and research. Nurses have a long history of caring for individuals, families, and groups with genetic conditions. In the past two decades, a small group of nurses in the USA have used a variety of strategies to further develop the field of genetics nursing. In this paper we identify innovative approaches to identifying genetics-related nursing roles and opportunities, as well as successful collaborative efforts beyond nursing to address the emerging health and societal challenges related to human genetics discoveries. Methods:, The information presented here comes from a variety of sources where the authors or genetics nurses directly participated, including: (i) a systematic literature review of genetics nursing; (ii) a comprehensive research study of models of delivering clinical genetics services and the roles of health professionals; and (iii) participation in numerous national research, planning, programmatic, and advisory groups involved with clinical genetics-related health services, research, education, and public policy. Results:, Genetics nurses in the US have developed innovative responses to genetics-related challenges within and beyond the profession of nursing. These include: (i) establishing an organization for nurses in genetics and gaining formal recognition of genetics as a specialty of nursing; (ii) defining the scope of genetics nursing practice and developing a new genetics nursing credential; (iii) establishing a multiprofessional genetics education coalition and defining genetic competency for health-care practice; (iv) creating new clinical practice roles for nurses that integrate emerging genetics concepts and skills into diverse clinical practice areas; (v) expanding nursing involvement in genetics-related research; and (vi) participation in high-level genetics advisory groups. Conclusions:, The US experience shows that nurses have made substantial progress in expanding their involvement in genetic services through visionary leadership, innovative approaches to challenges, establishing support with nurse colleagues, and engaging in multiprofessional efforts. The most important first step is developing a supportive environment for nurse advancement. In the US, the genetics nurses' organization known as the International Society of Nurses in Genetics (ISONG) has provided this base. [source] Viral appropriation of apoptotic and NF-,B signaling pathwaysJOURNAL OF CELLULAR BIOCHEMISTRY, Issue 6 2004Andrew G. Bowie Abstract Viruses utilize a variety of strategies to evade the host immune response and replicate in the cells they infect. The comparatively large genomes of the Orthopoxviruses and gammaherpesviruses encode several immunomodulatory proteins that are homologous to component of the innate immune system of host cells, which are reviewed here. However, the viral mechanisms used to survive host responses are quite distinct between these two virus families. Poxviruses undergo continuous lytic replication in the host cytoplasm while expressing many genes that inhibit innate immune responses. In contrast, herpesviruses persist in a latent state during much of their lifecycle while expressing only a limited number of relatively non-immunogenic viral proteins, thereby avoiding the adaptive immune response. Poxviruses suppress, whereas latent gammaherpesviruses activate, signaling by NF-,B, yet both viruses target similar host signaling pathways to suppress the apoptotic response. Here, modulation of apoptotic and NF-,B signal transduction pathways are examined as examples of common pathways appropriated in contrasting ways by herpesviruses and poxviruses. © 2004 Wiley-Liss, Inc. [source] Managing infant feeding practices: the competing needs of bulimic mothers and their childrenJOURNAL OF CLINICAL NURSING, Issue 6 2009Helen Stapleton Aim., This paper seeks to explain how bulimic mothers accommodated infant feeding demands in conjunction with managing their disordered eating practices. Background., Eating disorders are chronic and disabling illnesses primarily affecting women. There are few qualitative studies describing bulimia in the context of motherhood. Design., The study employed an inductive qualitative approach. Methods., A purposive sample of childbearing women (n = 16), who self-defined as living with an eating disorder, were recruited. Data were generated from one-to-one interviews; a thematic analysis identified key issues. Results., Participants were primarily responsible for ensuring child/ren's socialisation processes, including modelling appropriate dietary behaviours and these demands often conflicted with their personal needs for food restraint. Pressures to participate in social activities with children were widely experienced as stressful especially when these events focused on food. Participants viewed early and repeated exposure to ,healthy' eating as protective against their children acquiring an eating disorder and in this respect commercial child-care facilities provided alternative environments for children to explore food-related activities. Conclusions., Participants employed a variety of strategies to ensure children's exposure to normalising influences and socialising processes. Concerns about personal competencies with respect to food preparation and storage were articulated by all participants. Relevance to clinical practice., Professionals involved with providing care to mothers and their infants are well placed to support bulimic clients and to foster confidence in their mothering skills. Early and appropriate intervention is key to effecting positive changes in bulimic patterns, with potential benefits to women's future health and well-being and that of their children. [source] Strategies reported used by instructors to address student alternate conceptions in chemical equilibriumJOURNAL OF RESEARCH IN SCIENCE TEACHING, Issue 10 2005Jeff S. Piquette This study explores general-chemistry instructors' awareness of and ability to identify and address common student learning obstacles in chemical equilibrium. Reported instructor strategies directed at remediating student alternate conceptions were investigated and compared with successful, literature-based conceptual change methods. Fifty-two volunteer general chemistry instructors from 50 U.S. colleges and universities completed an interactive web-based instrument consisting of open-ended questions, a rating scale, classroom scenarios, and a demographic form. Survey respondents who provided responses or described remediation strategies requiring further clarification were identified (n,=,6); these respondents amplified their views in separate, researcher-led semistructured phone interviews. All 52 responding chemistry instructors reported and identified common student areas of difficulty in chemical equilibrium. They reported employing a variety of strategies to address and attempt to remediate students' alternate conceptions; however, these self-reported strategies rarely included all four necessary conditions specified by Posner, Strike, Hewson, and Gertzog (Science Education, 66, 211,217, 1982) to stimulate conceptual change. Instructor-identified student alternate conceptions were congruent with literature-reported alternate conceptions of chemical equilibrium, thus providing validation support for these compilations. Implications for teaching and further research are also highlighted. © 2005 Wiley Periodicals, Inc. J Res Sci Teach 42: 1112,1134, 2005 [source] Tales of Deviance and Control: On Space, Rules, and Law in Squatter SettlementsLAW & SOCIETY REVIEW, Issue 2 2010Jean-Louis Van Gelder In Latin American cities, around a third of the urban population lives in tenure situations that can be designated as informal, yet variation in the ways and extent to which these arrangements do not comply with law is extensive. Furthermore, informal dwellers often employ a variety of strategies to legitimize and ultimately legalize their tenure, implying a dynamic rather than a static relationship between illegality and legality. Conceiving of land tenure in dichotomous terms, as simply being either legal or illegal, therefore, fails to reflect this diversity, nor does it capture the evolving nature of the relationship between informal settlements and the state system. Drawing from the development of squatter settlements in Buenos Aires, this article proposes an alternative perspective and shows how settlements alternate strategies of noncompliance with adaptation to the state legal system to gradually increase their legality. [source] Gene-based treatment of motor neuron diseases,MUSCLE AND NERVE, Issue 3 2006Thais Federici PhD Abstract Motor neuron diseases (MND), such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA), are progressive neurodegenerative diseases that share the common characteristic of upper and/or lower motor neuron degeneration. Therapeutic strategies for MND are designed to confer neuroprotection, using trophic factors, anti-apoptotic proteins, as well as antioxidants and anti-excitotoxicity agents. Although a large number of therapeutic clinical trials have been attempted, none has been shown satisfactory for MND at this time. A variety of strategies have emerged for motor neuron gene transfer. Application of these approaches has yielded therapeutic results in cell culture and animal models, including the SOD1 models of ALS. In this study we describe the gene-based treatment of MND in general, examining the potential viral vector candidates, gene delivery strategies, and main therapeutic approaches currently attempted. Finally, we discuss future directions and potential strategies for more effective motor neuron gene delivery and clinical translation. Muscle Nerve, 2005 [source] The Diversity Imperative: Strategies to Address a Diverse Nursing WorkforceNURSING FORUM, Issue 3 2008Joanne Noone PhD TOPIC. There has been a call to action for the need to create a more diverse nursing workforce. PURPOSE. The purpose of this article is to outline and review strategies that schools of nursing education can use to increase the recruitment, retention, and success of a diverse nursing student body. SOURCES OF INFORMATION. A review of the nursing literature was performed using CINAHL and hand-searching references. Abstracts were reviewed and articles included if the topic of the article referred to strategies to increase the diversity of nursing students. CONCLUSIONS. A variety of strategies are being used to address this issue. A multifaceted approach is recommended. [source] Parking Externalities in Commercial Real EstateREAL ESTATE ECONOMICS, Issue 2 2010Bowman Cutter IV Local governments have employed a variety of strategies to reduce street congestion through an increase in parking supply. These policies have been criticized as an implicit subsidy that shifts costs from drivers to the public at large. Others have noted that parking lots and structures can lead to increased water and air pollution. However, there has not been an examination of whether parking, presumably by reducing congestion, generates external benefits. We measure whether nearby parking availability influences commercial property prices after controlling for property characteristics, including on-site parking. We find that publicly accessible parking, such as commercial parking garages, generates significant aggregate externalities. We also find evidence of a significant complementary relationship between building and parking area in property values. This suggests that parking regulation could have a significant impact on property development through its effect on the value of the marginal square foot of building area. [source] Double exposure in Mozambique's Limpopo River BasinTHE GEOGRAPHICAL JOURNAL, Issue 1 2010JULIE A SILVA This paper examines how double exposure to economic and environmental stressors , and the interaction between the two , affect smallholder farmers in Mozambique's Limpopo River Basin. Studying two case study villages we find that people, in general, are resilient to environmental stressors. However, most households show less resilience to the socioeconomic stressors and shocks that have been introduced or intensified by economic globalisation. Our findings indicate that economic change brought about by structural adjustment policies pressures rural people to alter their approach to farming, which makes it more difficult for them to respond to environmental change. For example, smallholder farmers find it difficult to make a transition to commercial farming within the Limpopo Basin, in part because farming techniques that are well adapted to managing environmental variability in the region , such as seeding many small plots , are not well suited to the economies of scale needed for profitable commercial agriculture. People use a variety of strategies to cope with interactive environmental and economic stressors and shocks, but many face considerable constraints to profitably exploiting market-based opportunities. We conclude that economic stressors and shocks may now be causing small-scale agriculture to be less well adapted to ecological and climate variability, making smallholders more vulnerable to future climate change. Some local level policy interventions, including those that support and build on local environmental knowledge, could assist rural agricultural societies in adapting to future environmental change in the context of economic globalisation. [source] Implementing Clinical Practice Guidelines in occupational therapy practice: Recommendations from the research evidenceAUSTRALIAN OCCUPATIONAL THERAPY JOURNAL, Issue 2 2010Mary Stergiou-Kita Background:,Clinical Practice Guidelines (CPGs) are prominent tools in evidence-based practice which integrate research evidence, clinical expertise and client input to develop recommendations for specific clinical circumstance. With the push to use research evidence in health care, it is anticipated that occupational therapists will become increasingly involved in implementing CPGs in practice. The research evidence has revealed several factors that can affect guideline uptake, and a variety of strategies that can facilitate implementation. Methods:,This narrative review examines the health-related literature in CPGs to answer the following questions. Based on the research evidence, (i) what are the factors that may influence guideline implementation? (ii) What implementation strategies may enhance guideline implementation? Results:,Factors within the guideline itself (e.g. quality, complexity and clarity), within the practitioner (e.g. experience, perceptions and beliefs), the patient (e.g. expectations and preferences) and the practice context (e.g. resource availability, organisational culture and opinion leaders) can all affect implementation success. Currently, there is no conclusive evidence to support the use of one implementation strategy over another, in all situations. The choice of implementation strategy must take into account the guideline to be implemented, the practice context and the anticipated challenges to implementation. Conclusions:,By understanding the factors that can influence implementation and the strategies for successful implementation, occupational therapists will be better prepared to implement guidelines. Recommendations to assist with guideline uptake and implementation are provided. [source] Human rights commissions and public policy: The role of the Canadian Human Rights Commission in advancing sexual orientation equality rights in CanadaCANADIAN PUBLIC ADMINISTRATION/ADMINISTRATION PUBLIQUE DU CANADA, Issue 2 2008Annette Nierobisz The case study is informed by commission annual reports, speeches by past chief commissioners, presentations by the commission to parliamentary committees, and an examination of 442 sexual orientation complaints closed by the commission by 2005. The study shows that, from its inception, the commission had a simple and consistent message: sexual orientation should not be the basis for denying individuals employment, services or benefits. Using a variety of strategies, the CHRC facilitated the incorporation of this message into the Canadian Human Rights Act by promoting the designation of sexual orientation as a prohibited ground of discrimination. Subsequently, the commission became actively involved in securing equal access to employment-related benefits in the federal sphere for same-sex couples and also added its voice in support of legal recognition of same-sex marriage. The authors conclude by discussing how the unique position of human rights commissions gives them the potential to play an important role in public policy development, even when there may be a lack of political will or public support. Sommaire: Le présent article examine l'aptitude des commissions des droits de la personne à encourager les changements dans la politique publique en mettant l'accent sur la Commission canadienne des droits de la personne (CCDP) et son rôle dans la promotion des droits à l'égalité en matière d'orientation sexuelle au Canada. L' étude de cas tire ses informations des rapports annuels de la commission, des allocutions prononcées par d'anciens présidents de la commission, des présentations faites par la commission aux comités parlementaires, et d'un examen de 442 plaintes relatives à l'orientation sexuelle traitées par la commission jusqu'en 2005. L' étude indique que, depuis sa création, la commission avait un message simple et unanime : l'orientation sexuelle ne devrait pas être un motif invoqué pour refuser de l'emploi, des services ou des avantages sociaux à des particuliers. Grâce à diverses stratégies, la CCDP a facilité l'intégration de ce message à la Loi canadienne sur les droits de la personne en faisant en sorte que l'orientation sexuelle soit désignée comme un motif de discrimination interdit. Par la suite, la commission a été active sur la scène fédérale pour assurer que les conjoints de même sexe bénéficient de l' égalité d'accès aux avantages liés à l'emploi, et elle a également soutenu la reconnaissance légale du mariage des conjoints de même sexe. En conclusion, les auteurs discutent la position unique des commissions des droits de la personne qui leur offre le potentiel de jouer un rôle important dans l' élaboration des politiques gouvernementales, même avec un manque de volonté politique ou de soutien public. [source] Therapeutic potential of RNA interference against cancerCANCER SCIENCE, Issue 8 2006Fumitaka Takeshita One of the most dramatic events of the past 5 years in the field of molecular biology has been the discovery of RNA interference (RNAi). Although RNAi is an evolutionarily conserved phenomenon for sequence-specific gene silencing in mammalian cells, exogenous small interfering RNA (siRNA) and vector-based short hairpin RNA (shRNA) can also invoke RNAi responses. Both are now not only experimental tools for analyzing gene function but are expected to be excellent avenues for drug target discovery and the emerging class of gene medicine for targeting incurable diseases such as cancer. The success of cancer therapeutic use of RNAi relies on the development of safe and efficacious delivery systems that introduce siRNA and shRNA expression vectors into target tumor cells. For their delivery, a variety of strategies have been used, most of them based on traditional gene therapy delivery systems. In this review, we present siRNA delivery method strategies and discuss the potential of RNAi-based gene therapy in cancer treatment. (Cancer Sci 2006; 97: 689,696) [source] | |||||||||||||||||||