Home  About us  Contact
 

Of Novel (of + novel)

Distribution by Scientific Domains
Medical Sciences50%

Kinds of Of Novel

  • variety of novel
    		•

    Selected Abstracts

    Synthesis, analgesic, anti-inflammatory and ulcerogenic index activities of novel 2-methylthio-3-substituted-5,6-dimethyl thieno [2,3- d] pyrimidin-4(3H)-ones

    DRUG DEVELOPMENT RESEARCH, Issue 3 2007
    V. Alagarsamy
    Abstract A variety of novel 2-methylthio-3-substituted amino-5,6-dimethyl thieno [2,3- d] pyrimidin-4(3H)-ones were synthesized by reacting 3-amino-2-methylthio-5,6-dimethyl thieno [2,3- d] pyrimidin-4(3H)-one with different aldehydes and ketones. The starting material 3-amino-2-methylthio-5,6-dimethyl thieno [2,3- d] pyrimidin-4(3H)-one was synthesized from 2-amino-3-carbethoxy-4,5-dimethyl thiophene. The compounds were investigated for their analgesic activity in albino mice, and for their anti-inflammatory and ulcerogenic index activities in Wistar rats. The compound 2-(1-ethylpropylideneamino)-2-methylthio-5,6-dimethyl thieno [2,3- d] pyrimidin-4(3H)-one (AS2) showed the most potent analgesic activity of the series. It also showed more potent anti-inflammatory activity when compared to the reference standard, diclofenac sodium. The test compounds showed only mild ulcerogenic potential when compared to aspirin. Drug Dev Res 68:134,142, 2007. © 2007 Wiley-Liss, Inc. [source]

    Bulk Metallic Glasses with Functional Physical Properties

    ADVANCED MATERIALS, Issue 45 2009
    W. H. Wang
    Abstract In this review, we report on the formation of a variety of novel, metallic, glassy materials that might well have applications as functional materials. The metallic glasses, with excellent glass-forming ability, display many fascinating properties and features such as excellent wave-absorption ability, exceptionally low glass-transition temperatures (,35,60,°C) approaching room temperature, ultralow elastic moduli comparable to that of human bone, high elasticity and high strength, superplasticity and polymer-like thermoplastic formability near room temperature, an excellent magnetocaloric effect, hard magnetism and tunable magnetic properties, heavy-fermion behavior, superhydrophobicity and superoleophobicity, and polyamorphism, all of which are of interest not only for basic research but also for technological applications. A strategy based on elastic-moduli correlations for fabrication of bulk metallic glasses (BMGs) with controllable properties is presented. The work has implications in the search for novel metallic glasses with unique functional properties, for advancing our understanding of the nature and formation of glasses, and for extending the applications of the materials. [source]

    Synthesis and antimicrobial activity of 6,6,-arylidene-bis-[5-hydroxy-9-methyl-2,3-diaryl thieno[3,2- g -]thiocoumarins]

    JOURNAL OF HETEROCYCLIC CHEMISTRY, Issue 2 2005
    P. Vijay Kumar Reddy
    A variety of novel 6,6,-arylidene-bis-[5-hydroxy-9-methyl-2,3-diaryl-thieno[3,2- g]thiocoumarins] 3a-d, 4a-d, 5a-d, and 6a-d were obtained by a reaction between 5-hydroxy-9-methyl-2,3-diarylthieno[3,2- g]thiocoumarins 1a-d with aromatic aldehydes 2a-d in isopropyl alcohol. The synthesized compounds were tested for their antimicrobial activity. [source]

    Today's allergic rhinitis patients are different: new factors that may play a role

    ALLERGY, Issue 9 2007
    R. Mösges
    Most of today's patients suffering from allergic rhinitis (AR) are sensitized to more than one trigger and suffer from persistent and moderate/severe symptoms, which severely impair their quality of life (QOL). The objective of this article was to review the data on the effect of increased air pollution, changes in indoor environment/lifestyle/affluence, exposure to new allergens and psychologically stressful lifestyles, as also to explore their potential in the development of this more ,aggressive' form of disease. Increased fossil fuel-generated air pollution may increase the risk of allergic sensitization, airway responsiveness to allergens, and allergenicity and the bioavailability of airborne allergens. Changes in indoor environment/lifestyle/affluence appear to have led to more time being spent indoors and resulted in perennial exposure to indoor allergens, changes in sensitization patterns, and polysensitization to a variety of novel cross-reacting exotic food and pet allergens. Although evidence suggests an association between psychological stress and increased risk for atopy and allergic disease, further studies are required to demonstrate this unequivocally. The more persistent and moderate/severe nature of the disease suggests a need for modification of current treatment strategies and advocacy of the use from the outset of agents, which are both efficacious and safe in managing severe and persistent AR symptoms and in improving the QOL of affected individuals. [source]