Ocular Morbidities (ocular + morbidity)

Distribution by Scientific Domains

Selected Abstracts

Predictive factors of invasion in eyes with retinoblastoma enucleated after eye salvage treatments

Julia Balaguer MD
Abstract Background The impact of chemotherapy, focal therapies, radiation and co-existing ocular morbidities on histology of eyes with retinoblastoma enucleated following chemoreduction is not well known. Procedure Twenty-five eyes (23 patients) with retinoblastoma enucleated after failing eye-salvage therapy were evaluated. Reasons for enucleation (tumor progression, subretinal or vitreous seeds) and co-morbid conditions (neovascular glaucoma, cataract, vitreous hemorrhage and retinal detachment) were documented. All specimens were reviewed for evidence of ciliary body, choroidal, optic nerve, and scleral invasion. Results The median age at diagnosis was 14 months (range, 1,37 months). Twenty eyes were classified as Reese-Ellsworth Group IV,V at diagnosis. Twenty-four eyes had recurrent disease at enucleation; one eye was enucleated for neovascular glaucoma and vitreous hemorrhage. Co-existing ocular morbidities at enucleation included vitreous hemorrhage (n,=,6), retinal detachment (n,=,9), neovascular glaucoma (n,=,9) and cataracts (n,=,3). Histologic findings included choroidal invasion (n,=,7), ciliary body invasion (n,=,4), optic nerve invasion (n,=,6) and scleral invasion (n,=,3). The median time from diagnosis to enucleation was 11 months. Co-existing retinal detachment and vitreous hemorrhage significantly increased the likelihood of optic nerve invasion (P,=,0.014 and P,=,0.011, respectively). Prolonged time to enucleation was significantly associated with the likelihood of choroidal (P,=,0.010) and ciliary body (P,=,0.021) invasion as well as invasion of multiple sites. Conclusion In eyes with retinoblastoma enucleated after chemoreduction, co-existing ocular morbidities and time to enucleation are predictive of extra-retinal extension. Pediatr Blood Cancer 2009;52:351,356. 2008 Wiley-Liss, Inc. [source]

Ocular complications at the limits of viability

Ferdinand Pulzer
Abstract Aim: To evaluate the incidence of retinopathy of prematurity (ROP) and other ocular morbidities in extremely premature infants. Methods: A retrospective analysis of the prevalence and nature of ocular abnormalities in a cohort of 22 extremely pre-term infants born <25 + 0 weeks of estimated gestational age (GA) was performed. Results: The children were grouped according to the observed disorder: 13 out of 22 (59%) neonates with mild ophthalmologic findings (ROP , stage II) [Group 1], 5 out of 22 (23%) infants with ROP stage III or more (Group 2) and 4 out of 22 (18%) neonates with severe ocular morbidity (congenital cataract, microphthalmia, partial optic nerve atrophy and corneal perforation due to an ulcer with lens protrusion), partly combined with ROP , stage III (three of four). One child of 22 (5%) needed laser therapy. Out of 22 admitted infants, 20 (91%) were discharged alive. Conclusion: The high rate of ocular morbidity besides ROP in extremely pre-term infants is noteworthy. Mechanisms influencing the postnatal development of the eye, especially their relation to the grade of prematurity and neonatological therapeutical strategies, require further investigations. [source]