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Obvious Benefit (obvious + benefit)
Selected AbstractsMating Effort and Cryptic Sperm Choice in Scorpionflies: Male Investment Strategy vs.ETHOLOGY, Issue 12 2008Female Control In this study, we examined which sex controls sperm transfer during copulation in scorpionflies. Therefore male scorpionflies were doubly mated to females of high and low fecundity to explore whether they allocate sperm according to female quality. While mating order had no effect males transferred sperm at higher rates when mating with low-quality instead of high-quality females. As there is no obvious benefit from providing low-fecundity females with more sperm, we suggest a condition-dependent female ability to counteract sperm transfer. Therefore, we disabled females at the beginning of copulations using the insecticide Propoxur which leads to total paralysis caused by tremors. While the provoked muscle contractions led to significantly smaller numbers of sperm transferred, Propoxur treatment had no effect on males. We suggest female counteracting of sperm transfer to be adaptive by decreasing the relative amount of sperm transferred by low-quality males and increasing the proportion of offspring sired by high-quality males. [source] Efficacy of pharmacological treatment of dystonia: evidence-based review including meta-analysis of the effect of botulinum toxin and other cure optionsEUROPEAN JOURNAL OF NEUROLOGY, Issue 6 2004Y. Balash The treatment of both generalized and focal dystonia is symptomatic. There is no evidence-based information about the efficacy of the different methods of the pharmacological therapeutic options currently being applied in dystonia. The specific questions addressed by this study were which treatments for dystonia have proven efficacy and which of them have unproven results. Following evidence-based principles, a literature review based on MEDLINE and the Cochrane Library, augmented by manual search of the most important journals was performed to identify the relevant publications issued between 1973 and 2003. All articles appearing in the professional English literature, including case reports, were considered. In the presence of comparable studies the meta-analysis was performed to obtain pooled information and make a reasonable inference. Based on this review, we conclude: (i) botulinum toxin has obvious benefit (level A, class I,II evidence) for the treatment of cervical dystonia and blepharospasm; (ii) trihexyphenidyl in high dosages is effective for the treatment of segmental and generalized dystonia in young patients (level A, class I,II evidence); (iii) all other methods of pharmacological intervention for generalized or focal dystonia, including botulinum toxin injections, have not been confirmed as being effective according to accepted evidence-based criteria (level U, class IV studies). [source] Combination therapy of thymosin alpha-1 and lamivudine for HBeAg positive chronic hepatitis B: A prospective randomized, comparative pilot studyJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Issue 5 2008Hyun Woong Lee Abstract Background and Aim:, Monotherapy of lamivudine, interferon-alpha (IFN-,), and thymosin alpha-1 (T,1) is unlikely to be sufficient for the eradication of a chronic hepatitis B virus (HBV) infection. The aim of our study is to elucidate whether the combination of T,1 and lamivudine is superior to lamivudine monotherapy in hepatitis B e antigen (HBeAg) positive naïve patients with chronic hepatitis B. Methods:, Sixty-seven patients were assigned to two different groups in a randomized manner. The combination group (n = 34) received T,1 (1.6 mg subcutaneously, twice a week) and lamivudine (100 mg orally, daily) for 24 weeks, followed by continuous lamivudine therapy. The monotherapy group (n = 33) received lamivudine monotherapy continuously. Results:, The incidence of HBeAg seroconversion at 24 weeks was 26.5% (9/34) in the combination group and 6.1% (2/33) in the monotherapy group (P = 0.024). However, there was no statistically significant difference between 26.5% (9/34) in the combination group and 12.1% (4/33) in the monotherapy group at 52 weeks (P = 0.138). The emergence of viral breakthrough gradually increased to 35.3% (12/34) in the combination group, and to 21.2% (7/33) in the monotherapy group at 52 weeks (P = 0.201). Conclusions:, The combination treatment of T,1 and lamivudine did not have an obvious benefit of virological and biochemical response as compared to the lamivudine monotherapy during the combination period. In addition, after the cessation of T,1 treatment, the combination therapy did not prevent the occurrence of viral and biochemical breakthroughs. [source] Hearing Results After Primary Cartilage Tympanoplasty,THE LARYNGOSCOPE, Issue 12 2000Matthew J. Gerber MD Abstract Objectives/Hypothesis Cartilage,perichondrium grafting of the tympanic membrane has been used in an effort to reduce recurrence or progression of middle ear disease. The rigidity of cartilage has obvious benefit in preventing tympanic membrane retraction, but concern has been raised regarding its sound conduction properties. Few studies in the literature address hearing results after cartilage tympanoplasty. The purpose of this study was to investigate the hearing results after primary cartilage tympanoplasty and compare them with results after primary tympanoplasty with temporalis fascia. Study Design A retrospective review of all ear surgeries using cartilage between 1994 and 1999 was performed. Methods Only primary cases in which the ossicular chain was intact and no mastoid surgery was performed were included. Indications for surgery included tympanic membrane perforation, retraction, and cholesteatoma. Pre- and postoperative speech reception thresholds and air,bone gaps at 500 Hz, 1000 Hz, 2000 Hz, and 4000 Hz were compared. Results Eleven patients comprised the cartilage study group, and there were 11 age- and temporally matched control subjects. The mean improvement in speech reception threshold for both the study group and the control group was 10 dB. The majority of patients in both groups had ABG closure to within 10 dB at all frequencies examined. There were no statistically significant differences in speech reception threshold improvement or air,bone gap closures between the two groups. Conclusions These results demonstrate that hearing results after cartilage tympanoplasty are comparable to those after temporalis fascia tympanoplasty. Therefore, when indicated, a cartilage,perichondrium graft can be used for prevention of disease recurrence or progression without fear of impairing hearing. [source] NERVE STIMULATION IN THYROID SURGERY: IS IT REALLY USEFUL?ANZ JOURNAL OF SURGERY, Issue 5 2007Thorbjorn J Loch-Wilkinson Background: Monitoring of the recurrent laryngeal nerve (RLN) has been claimed in some studies to reduce rates of nerve injury during thyroid surgery compared with anatomical dissection and visual identification of the RLN alone, whereas other studies have found no benefit. Continuous monitoring with endotracheal electrodes is expensive whereas discontinuous monitoring by laryngeal palpation with nerve stimulation is a simple and inexpensive technique. This study aimed to assess the value of nerve stimulation with laryngeal palpation as a means of identifying and assessing the function of the RLN and external branch of the superior laryngeal nerve (EBSLN) during thyroid surgery. Methods: This was a prospective case series comprising 50 consecutive patients undergoing total thyroidectomy providing 100 RLN and 100 EBSLN for examination. All patients underwent preoperative and postoperative vocal cord and voice assessment by an independent ear, nose and throat surgeon, laryngeal examination at extubation and all were asked to complete a postoperative dysphagia score sheet. Dysphagia scores in the study group were compared with a control group (n = 20) undergoing total thyroidectomy without nerve stimulation. Results: One hundred of 100 (100%) RLN were located without the use of the nerve stimulator. A negative twitch response occurred in seven (7%) RLN stimulated (two bilateral, three unilateral). Postoperative testing, however, only showed one true unilateral RLN palsy postoperatively (1%), which recovered in 7 weeks giving six false-positive and one true-positive results. Eighty-six of 100 (86%) EBSLN were located without the nerve stimulator. Thirteen of 100 (13%) EBSLN could not be identified and 1 of 100 (1%) was located with the use of the nerve stimulator. Fourteen per cent of EBSLN showed no cricothyroid twitch on EBSLN stimulation. Postoperative vocal function in these patients was normal. There were no instances of equipment malfunction. Dysphagia scores did not differ significantly between the study and control groups. Conclusion: Use of a nerve stimulator did not aid in anatomical dissection of the RLN and was useful in identifying only one EBSLN. Discontinuous nerve monitoring by stimulation during total thyroidectomy confers no obvious benefit for the experienced surgeon in nerve identification, functional testing or injury prevention. [source] First Exposure in Man: Toxicological ConsiderationsBASIC AND CLINICAL PHARMACOLOGY & TOXICOLOGY, Issue 2000Per Spindler Recommendations on the type and extent of preclinical safety studies that should be conducted prior to first dose in man have been developed by the International Conference on Harmonisation, and the European Committee for Proprietary Medicinal Products. These recommendations include studies designed to characterise local tolerance and general toxicity of the drug candidate as well as its genotoxic potential and ability to interfere with reproduction. For trials which can be categorised as low dose PK screening trials and trials with products where rodent and non-rodent (primarily dog) models do not show any biological response (e.g. some biotechnology-derived hormones and cytokines) other testing paradigms should be used. The present recommendations for preclinical testing have had an important impact on the documented impressive safety record of phase I clinical trials. In this spirit we extend our warmest and sincerest thanks to Professor Jens S. Schou for his long and deep engagement in European and International harmonisation of preclinical test recommendations. His efforts have had a substantial impact on the present testing recommendations, which are of obvious benefit to the safety of the patient. [source] Should tissue from pregnancy termination and uterine evacuation routinely be examined histologically?BJOG : AN INTERNATIONAL JOURNAL OF OBSTETRICS & GYNAECOLOGY, Issue 6 2000Victoria Heath Senior House Officer Objective To assess the value of routine histological examination of tissue samples collected at termination of pregnancy in the first trimester and emergency surgical uterine evacuation. Setting The gynaecological department of a teaching hospital. Design Prospective study of women attending the gynaecological department in a 12-month period. Participants All women undergoing a therapeutic first trimester medical or surgical abortion or an emergency surgical evacuation of a failed pregnancy, suspected incomplete spontaneous miscarriage or incomplete induced abortion. Main outcome Association of pre-operative clinical diagnosis and the post-operative histological result. Results Of 1576 women studied, the histological report confirmed that products of conception were obtained in 1465 (93%); in two women (0.13%) molar changes were reported confirming the pre-operative diagnosis by ultrasound. Products of conception were not confirmed in the tissue specimens in 0.5% medical terminations, 5% surgical terminations, 10% evacuations following a previous evacuation, 12% evacuations for a failed pregnancy, and 19% evacuations for an incomplete miscarriage. In 87 women (6%), decidua was reported; two of these women had undergone an evacuation for an ultrasound diagnosis of spontaneous miscarriage, but in both a tubal ectopic pregnancy was subsequently diagnosed. Conclusion There did not appear to be any obvious benefit from routine histological examination of tissue removed at termination of pregnancy or emergency uterine evacuation. The histological result was sometimes not consistent with the pre-operative diagnosis and may result in unnecessary further investigation and treatment unless due consideration is given to the clinical presentation. [source] Lithology and fluid prediction from amplitude versus offset (AVO) seismic dataGEOFLUIDS (ELECTRONIC), Issue 4 2003D. J. Davies Abstract Seismic reflection data as used in the oil industry is acquired and processed as multitrace data with source-receiver offsets from a few hundred metres (short offset) to several kilometres (long offset). This set of data is referred to as ,pre-stack'. The traces are processed by velocity analysis, migration and stacking to yield a data volume of traces with ,zero-offset'. The signal-to-noise enhancement resulting from this approach is very significant. However, reflection amplitude changes in the pre-stack domain may also be analysed to yield enhanced rock physics parameter estimates. Pre-stack seismic data is widely used to predict lithology, reservoir quality and fluid distribution in exploration and production studies. Amplitude versus offset (AVO) data, especially anomalous signals, have been used for decades as indicators of hydrocarbon saturation and favourable reservoir development. Recently, enhanced quantification of these types of measurement, using seismic inversion techniques in the pre-stack domain, have significantly enhanced the utility of such measurements. Using these techniques, for example, probability of the occurrence of hydrocarbons throughout the seismic data can be estimated, and as a consequence the many pre-stack volumes acquired in a three-dimensional (3D) can be survey, reduced to a single, more interpretable volume. The possibilities of 4D time lapse observation extend the measurements to changes in fluid content (and pressure) with time, and with obvious benefits in establishing the accuracy of dynamic reservoir models and improvements in field development planning. As an illustration, recent results from the Nelson Field (UK North Sea), are presented where we show the method by which probability volumes for oil sands may be calculated. The oil,sand probability volumes for three 3D seismic datasets acquired in 1990, 1997 and 2000 are compared and production effects in these data are demonstrated. [source] A collaborative approach to the environmental assessment process prior to oil exploration activities offshore the Falkland IslandsAQUATIC CONSERVATION: MARINE AND FRESHWATER ECOSYSTEMS, Issue 1 2002Liz Hopkins Abstract 1.Operating Companies awarded acreage in the Falkland Islands First Offshore Licensing Round began exploration for oil and gas in 1996. Appropriate environmental management is an important aspect of exploration activities in any new frontier area and the Falklands Islands were no exception. Operators with drilling commitments established the Falklands Operators Sharing Agreement (FOSA), which included an Environmental Workgroup (EWG) to take responsibility for the environmental issues associated with exploration activities. 2.The EWG was established early in the exploration programme and commissioned a number of specific environmental studies relating to the offshore environment of the Islands. The data made available by this research provided a valuable input to the assessment of potential environmental impacts from the planned exploration activities. By undertaking environmental impact assessments prior to exploration activities FOSA were able to identify and adopt operational and management controls to ensure potential environmental impacts were, where possible, minimized or avoided. 3.The EWG also provided the main point of contact with the regulators on environmental matters and through the Falkland Islands Exploration & Production Environmental Forum facilitated consultation with government departments such as Fisheries, and other stakeholders such as Falklands Conservation. 4.The co-operative approach taken by the operators with regard to the environmental management of the exploration activities offshore the Falkland Islands is considered to have been very successful. The most obvious benefits were through the shared resources resulting in financial savings, however, other benefits have included, avoiding duplication of effort, the promoting of ,working togetherness' and a reduced burden on consultees. Copyright © 2002 John Wiley & Sons, Ltd. [source] | |||||||||||||