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Obstetric Data (obstetric + data)

Distribution by Scientific Domains

Medical Sciences	80%

Selected Abstracts

ORIGINAL ARTICLE: Pre-Eclampsia, Placental Abruption and Increased Risk of Atopic Sensitization in Male Adolescent Offspring

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, Issue 5 2009
Leea Keski-Nisula
Problem, The aim of this study was to investigate maternal pre-eclampsia (PE), placental abruption (PA) and atopy among offspring. Method of study, Obstetric data was recorded from 378 women who were included into the Caesarean delivery birth cohort during 1990,1992. When their children were 15,17 years old skin prick tests (SPTs) and inhalant allergen-specific (IAS) immunoglobulin E (IgE) were determined among offspring. Results, Adolescents whose mothers had either PE or PA at the time of delivery had more atopy and especially more severe atopy as measured by the incidence of SPTs positive for ,5 allergens (RR: 4.28, 95% CI: 1.54,11.92; P < 0.005) and elevated IAS IgE levels (,1.0 kU/L) (RR: 4.27, 95% CI: 1.08,16.99; P < 0.039). This increased risk was particularly observed in male adolescents. Conclusion, Maternal PE and PA were associated with an increased risk of severe atopy, especially in male adolescent offspring. [source]

Birth characteristics and adult cancer incidence: Swedish cohort of over 11,000 men and women

INTERNATIONAL JOURNAL OF CANCER, Issue 4 2005
Valerie A. McCormack
Abstract Associations between larger size at birth and increased rates of adult cancer have been proposed but few empirical studies have examined this hypothesis. We investigated overall and site-specific cancer incidence in relation to birth characteristics in a Swedish population-based cohort of 11,166 singletons born in 1915,1929 for whom we have detailed obstetric data and who were alive in 1960. A total of 2,685 first primary cancers were registered during follow-up from 1960 to 2001. A standard deviation (SD) increase in birth weight for gestational age (GA) was associated with (sex-adjusted) increases of 13% (95% CI = 0.03,0.23) in the rates of digestive cancers and of 17% (95% CI = 0.01,0.35) in the rates of lymphatic cancers. Women who had higher birth weights also had increased rates of breast cancer under age 50 years (by 39% per SD increase; 95% CI = 0.09,0.79), but reduced rates (by 24%; 95% CI = 0.07,0.38) of endometrial (corpus uteri) cancer at all ages. There was no evidence of associations with other cancer sites. For overall cancer incidence, men had an 8% increased risk at all ages per SD increase in birth weight for GA while women only had an increased risk under age 50 years (mainly driven by the association with breast cancer). These findings provide evidence of a modest association of birth size and adult cancer risk, resulting from positive associations with a few cancer sites and a possible inverse association with endometrial cancer. © 2005 Wiley-Liss, Inc. [source]

Lactate concentration in umbilical cord blood is gestational age-dependent: a population-based study of 17 867 newborns

BJOG : AN INTERNATIONAL JOURNAL OF OBSTETRICS & GYNAECOLOGY, Issue 6 2008
N Wiberg
Objective, To study the influence of gestational age on lactate concentration in arterial and venous umbilical cord blood at birth and to define gestational age-specific reference values for lactate in vigorous newborns. Design, Population-based comparative. Setting, University hospitals. Sample, Vigorous newborns with validated umbilical cord blood samples. Material and methods, From 2000 to 2004, routine cord blood gases, lactate and obstetric data from two university hospitals were available for 17 867 newborns from gestational week 24 to 43. After validation of blood samples and inclusion only of singleton pregnancies aimed for vaginal delivery, 10 700 women remained. Among those, reference values were defined in 10 169 vigorous newborns, that is in newborns with a 5-minute Apgar score corresponding to the gestational age-specific median value minus 1 point score, or better. Main outcome measures, Cord lactate concentration relative to gestational age. Results, The arterial and venous lactate concentrations increased monotonously with gestational age from 34 weeks. Considerable differences were found between mean and median values, but after logarithmic transformation the log-lactate values were normally distributed. Simple linear regression analysis showed a significant association between the log-lactate values and gestational age (P < 10,6, R2= 0.024). Reference curves were constructed after anti-logarithmic transformation. Both the gestational age and the time of the second stage of labour influenced, independently of each other, the lactate concentrations. Conclusions, Lactate concentrations in arterial and venous umbilical cord blood are increasing significantly with advancing gestational age. [source]

Persistent urinary incontinence and delivery mode history: a six-year longitudinal study

BJOG : AN INTERNATIONAL JOURNAL OF OBSTETRICS & GYNAECOLOGY, Issue 2 2006
Christine MacArthur
Objective, To investigate the prevalence of persistent and long term postpartum urinary incontinence and associations with mode of first and subsequent delivery. Design, Longitudinal study. Setting, Maternity units in Aberdeen (Scotland), Birmingham (England) and Dunedin (New Zealand). Population, Women (4214) who returned postal questionnaires three months and six years after the index birth. Methods, Symptom data were obtained from both questionnaires and obstetric data from case-notes for the index birth and the second questionnaire for subsequent births. Logistic regression investigated the independent effects of mode of first delivery and delivery mode history. Main outcome measures, Urinary incontinence,persistent (at three months and six years after index birth) and long term (at six years after index birth). Results, The prevalence of persistent urinary incontinence was 24%. Delivering exclusively by caesarean section was associated with both less persistent (OR = 0.46, 95% CI 0.32,0.68) and long term urinary incontinence (OR = 0.50, 95% CI 0.40,0.63). Caesarean section birth in addition to vaginal delivery, however, was not associated with significantly less persistent incontinence (OR 0.93, 95% CI 0.67,1.29). There were no significant associations between persistent or long term urinary incontinence and forceps or vacuum extraction delivery. Other significantly associated factors were increasing number of births and older maternal age. Conclusions, The risk of persistent and long term urinary incontinence is significantly lower following caesarean section deliveries but not if there is another vaginal birth. Even when delivering exclusively by caesarean section, the prevalence of persistent symptoms (14%) is still high. [source]

Association of parental consanguinity with congenital malformations among Arab newborns in Jerusalem

CLINICAL GENETICS, Issue 1 2004
R Bromiker
The aim of this work was to determine the impact of parental consanguinity on congenital malformations in a mixed urban and rural Arab community in Jerusalem, Israel. Arab mothers admitted to four hospitals in west Jerusalem were interviewed after delivery. Demographic and obstetric data were recorded. Neonatal data were extracted from the medical records of the nursery. When malformations were suspected, a 4- to 10-month follow up was achieved for confirming the diagnosis. Of 561 infants, 253 (45%) were born to consanguineous couples. The incidence of major congenital malformations in the offspring was 8.7, 7.1 and 2.6% in cases of first cousins, all consanguineous, and non-consanguineous couples, respectively. No association was found between parental consanguinity and prematurity (p = 0.357) or low birth weight (p = 0.589). Parental consanguinity was also associated with an increased incidence of death in previous siblings (p < 0.000). The increased incidence of congenital malformations and infant mortality in cases of inbreeding prompt the necessity of establishing programs to avoid these complications in the offspring. [source]