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Oxygen Fraction (oxygen + fraction)
Selected AbstractsGasification of char particles in packed beds: analysis and resultsINTERNATIONAL JOURNAL OF ENERGY RESEARCH, Issue 12 2001S. Dasappa Abstract In this paper a packed bed of char particles is considered for experimental study and analysis. The packed char bed is modelled by extending the single-particle analysis (Dasappa et al., 1994a, Chem. Eng. Sci.49,2:223,232. Dasappa et al., 1994b, Twenty-fifth Symposium (International) on Combustion, pp. 1619,1628. Dasappa et al., 1998, Twenty-seventh Symposium (International) on Combustion, pp. 1335,1342.). All the reactions related to gasification are introduced into the reaction system as in Dasappa et al. (1998). The propagation of the reaction front into the packed char bed against the air stream is modelled. The results are compared with the experimental data on a model quartz reactor using charcoal. Experimental data of propagation of the reaction front through the packed bed from the present study and of Groeneveld's charcoal gasifier are used for comparison. Using the analysis of Dosanjh et al. 1987 (Combust. Flame68:131,142), it is shown that heat loss dominates the heat generation at the quench condition. It is also shown that increasing the oxygen fraction in air has resulted in flame front to propagate into the char bed. The critical air mass flux for peak propagation rate in a bed of char is found to be 0.1 kg m,2 s. Copyright © 2001 John Wiley & Sons, Ltd. [source] Hepatic effects of an open lung strategy and cardiac output restoration in an experimental lung injuryACTA ANAESTHESIOLOGICA SCANDINAVICA, Issue 5 2010M. KREDEL Background: Ventilation with high positive end-expiratory pressure (PEEP) can lead to liver dysfunction. We hypothesized that an open lung concept (OLC) using high PEEP impairs liver function and integrity dependent on the stabilization of cardiac output. Methods: Juvenile female Pietrain pigs instrumented with flow probes around the common hepatic artery and portal vein, pulmonary and hepatic vein catheters underwent a lavage-induced lung injury. Ventilation was continued with a conventional approach (CON) using pre-defined combinations of PEEP and inspiratory oxygen fraction or with an OLC using PEEP set above the lower inflection point of the lung. Volume replacement with colloids was guided to maintain cardiac output in the CON(V+) and OLC(V+) groups or acceptable blood pressure and heart rate in the OLC(V,) group. Indocyanine green plasma disappearance rate (ICG-PDR), blood gases, liver-specific serum enzymes, bilirubin, hyaluronic acid and lactate were tested. Finally, liver tissue was examined for neutrophil accumulation, TUNEL staining, caspase-3 activity and heat shock protein 70 mRNA expression. Results: Hepatic venous oxygen saturation was reduced to 18 ± 16% in the OLC(V,) group, while portal venous blood flow decreased by 45%. ICG-PDR was not reduced and serum enzymes, bilirubin and lactate were not elevated. Liver cell apoptosis was negligible. Liver sinusoids in the OLC(V+) and OLC(V,) groups showed about two- and fourfold more granulocytes than the CON(V+) group. Heat shock protein 70 tended to be higher in the OLC(V,) group. Conclusions: Open lung ventilation elicited neutrophil infiltration, but no liver dysfunction even without the stabilization of cardiac output. [source] Anaesthesia for the obese patient with special emphasis on propofol, rocuronium and inspiratory oxygen fractionACTA ANAESTHESIOLOGICA SCANDINAVICA, Issue 4 2010C. S. Meyhoff No abstract is available for this article. [source] A simple method to reduce the inspiratory oxygen fraction for high pulmonary blood flow patients in an operating roomPEDIATRIC ANESTHESIA, Issue 12 2007AYAKO ASAKURA MD Summary Background:, Low inspired oxygen acutely increases pulmonary vascular resistance and decreases pulmonary-systemic blood flow ratio. We present a simple method to lower inspired oxygen fraction (FIO2 < 0.21) without supplemental nitrogen, during mechanical ventilation by an anesthesia machine. Methods:, After institutional approval, seven healthy adult volunteers and three infants (0,12 month old) scheduled for congenital heart surgery were enrolled in this study. All the infants were diagnosed with congestive heart failure because of high pulmonary blood flow and were thought to benefit from low FIO2. The volunteers performed spontaneous ventilation (fresh air flow rate = 10 l·min,1, tidal volume = 600 ml, frequency = 10 br·min,1). The infants were mechanically ventilated with air (fresh air flow rate = 6 l·min,1, tidal volume = 10 ml·kg,1, 15 < frequency < 30 br·min,1 to adjust PaCO2 between 5.8 kPa and 6.5 kPa (45,50 mmHg), after induction of general anesthesia and tracheal intubation. The fresh gas flow rates were determined by the following formula. Fresh gas flow rate = (FIO2 , FEO2) EVE/(0.21 + FIO2 , FEO2 , target FIO2). We recorded FIO2 every 5 min for 30 min. When arterial oxygen saturation decreased >15%, fresh gas flow rates were increased to adjust FIO2 to 0.21. Results:, In all of the seven volunteers and three infants target FIO2 was achieved in <10 min. FIO2 was kept at 0.18 ± 0.01 (SD) by calculated fresh air flow rates. In one infant, SpO2 decreased >15% 20 min after lowering FIO2, we had to discontinue this study, and increase fresh gas flow to ventilate the infant with FIO2 0.21. In the other two infants, FIO2 was maintained throughout the study. Conclusions:, This simple and convenient method to decrease FIO2, has a utility in clinical situations, in which pulmonary vascular resistance is to be increased to improve systemic oxygen delivery in patients with high pulmonary blood flow during cardiac surgery. [source] The acute hypoxic ventilatory response under halothane, isoflurane, and sevoflurane anaesthesia in rats,ANAESTHESIA, Issue 3 2010N. Karanovic Summary The relative order of potency of anaesthetic agents on the hypoxic ventilatory response has been tested in humans, but animal data are sparse. We examined the effects of 1.4, 1.6, 1.8, and 2.0 MAC halothane, isoflurane, and sevoflurane on phrenic nerve activity in euoxia (baseline) and during acute normocapnic hypoxia (inspired oxygen fraction 0.09) in adult male Sprague-Dawley rats. With halothane, all animals became apnoeic even in euoxia, and the hypoxic response was completely abolished at all anaesthetic levels. With isoflurane, 5 of 14 animals exhibited phrenic nerve activity in euoxia at 1.4 MAC and demonstrated a hypoxic response (302% of baseline activity), but all became apnoeic and lost the hypoxic response at higher doses. With sevoflurane, phrenic nerve activity and a hypoxic response was preserved in at least some animals at all doses (i.e. even the highest dose of 2.0 MAC). Similar to the rank order of potency previously observed in humans, the relative order of potency of depression of the hypoxic ventilatory response in rats was halothane (most depressive) > isoflurane > sevoflurane (p = 0.01 for differences between agents). [source] Evaluation of the Pneupac Ventipac portable ventilator in critically ill patientsANAESTHESIA, Issue 11 2001apparatus We assessed adequacy of ventilation in 20 critically ill patients with multiple organ failure using a Pneupac Ventipac portable ventilator and the effects on patients' haemodynamic stability. Baseline data were recorded over 15 min for a range of respiratory, haemodynamic and oxygen transport variables during ventilation with a standard intensive care ventilator (Engström Erica). Patients were then ventilated for 40 min using the portable ventilator. Finally, they were ventilated for a further 40 min using the standard intensive care ventilator. Heart rate, arterial and pulmonary artery pressures were recorded at 5-min intervals throughout the study period. Cardiac index and other haemodynamic data derived from a pulmonary artery catheter were recorded at 20-min intervals. Blood gas analysis was performed and oxygen transport data (oxygen delivery, oxygen consumption and physiological shunt) were calculated at the end of each of the three periods of ventilation. In general, no significant adverse effects of ventilation using the portable ventilator were observed for any of the variables studied. Arterial Po2 increased significantly during ventilation with the portable ventilator, reflecting the use of a higher inspired oxygen fraction during this part of the study. Oxygen consumption decreased significantly in one patient during ventilation by the portable ventilator although none of the other variables measured in this patient was altered. We conclude that ventilation of critically ill patients using the Pneupac Ventipac portable ventilator was safe, satisfactory and associated with minimal adverse effects on respiratory, haemodynamic and oxygen transport variables. [source] Brain glucose and lactate levels during ventilator-induced hypo- and hypercapnia,CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING, Issue 4 2004R. A. van Hulst Summary Objective:, Levels of glucose and lactate were measured in the brain by means of microdialysis in order to evaluate the effects of ventilator-induced hypocapnia and hypercapnia on brain metabolism in healthy non-brain-traumatized animals. Design and setting:, Prospective animal study in a university laboratory. Subjects:, Eight adult Landrace/Yorkshire pigs. Interventions:, The microdialysis probe was inserted in the brain along with a multiparameter sensor and intracranial pressure (ICP) probe. The animals were ventilated in a pressure-controlled mode according to the open lung concept with an inspired oxygen fraction of 0·4/1·0. Starting at normoventilation (PaCO2 ±40 mmHg) two steps of both hypercapnia (PCO2 ± 70 and 100 mmHg) and hypocapnia (PaCO2 ± 20 and 30 mmHg) were performed. Under these conditions, brain glucose and lactate levels as well as brain oxygen (PbrO2), brain carbon dioxide (PbrCO2), brain pH (brpH), brain temperature and ICP were measured. Results:, At hypercapnia (PaCO2 = 102·7 mmHg) there were no significant changes in brain glucose and lactate but there was a significant increase in PbrCO2, PbrO2 and ICP. In contrast, at hypocapnia (PCO2 = 19·8 mmHg) there was a significant increase in brain lactate and a significant decrease in both brain glucose and PbrCO2. Conclusions:, Hypocapnia decreases brain glucose and increases brain lactate concentration, indicating anaerobic metabolism, whereas hypercapnia has no influence on levels of brain glucose and brain lactate. [source] | ||||||||||