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Terms modified by Oxford Selected AbstractsREGULATING CARS AND BUSES IN CITIES: THE CASE OF PEDESTRIANISATION IN OXFORDECONOMIC AFFAIRS, Issue 2 2003Graham Parkhurst Debates about whether traffic regulations that limit car use will enhance or hinder a particular urban economy are complex and often emotive. The present article considers evidence from the implementation of a radical traffic restraint and pedestrianisation scheme in Oxford in 1999. The most important achievement was a 17% reduction in car trips to the centre, which did not affect overall visitor numbers. The local economy did though experience a period of difficult trading around the time of implementation. [source] CCLRC Portal infrastructure to support research facilitiesCONCURRENCY AND COMPUTATION: PRACTICE & EXPERIENCE, Issue 6 2007Asif Akram Abstract The emergence of portal technology is providing benefits in developing portlet interfaces to applications to meet the current and future requirements of CCLRC facilities support. Portlets can be reused by different projects, e.g. the high-profile Integrative Biology project (with the University of Oxford), and in different Java Specification Request 168 Portlet Specification (JSR 168) compliant portal frameworks. Deployment and maintenance of applications developed as portlets becomes easier and manageable. A community process is already beginning and many portal frameworks come with free-to-use useful portlets. As rendering is carried out in the framework, applications can be easily accessible and internationalized. Portlets are compatible with J2EE, thus providing additional capabilities required in the service-oriented architecture (SOA). We also describe how Web service gateways can be used to provide many of the functionalities encapsulated in a portal server in a way to support Grid applications. Portals used as a rich client can allow users to customize or personalize their user interfaces and even their workflow and application access. CCLRC facilities will be able to leverage the work so far carried out on the National Grid Service (NGS) and e-HTPX portals, as they are fully functional and have received detailed user feedback. This demonstrates the usefulness of providing advanced capabilities for e-Research and having the associated business logic in a SOA loosely coupled from the presentation layer for an Integrated e-Science Environment. Copyright © 2006 John Wiley & Sons, Ltd. [source] The Higher Education Policy Institute (HEPI) Report SummariesCRITICAL QUARTERLY, Issue 3 2004Anthony Smith These reports are useful summaries of a quantity of research undertaken over a course of years by the independent HEPI research unit, based in Oxford. They are researched responses to the range of issues and questions which have been current in UK higher education over the last five or six years. Future social historians will surely discern, through their tiny print and clear thought, the growing instrumentality of this era, the nervous concern of the authorities, as costs rise, to ensure that university education brings economic benefit to the nation as a whole. [source] A new US,UK diagnostic project: mood elevation and depression in first-year undergraduates at Oxford and Stanford universitiesACTA PSYCHIATRICA SCANDINAVICA, Issue 1 2008R. A. Chandler Objective:, To investigate differences in prevalence of mood elevation, distress and depression among first-year undergraduates at Oxford and Stanford universities. Method:, An online survey was sent to Oxford and Stanford first-year undergraduate students for two consecutive years in the winter of 2005 and 2006. Students completed a survey that assessed mood symptoms and medication use. Results:, Both universities had similar rates of distress by General Health Questionnaire (Oxford , 42.4%; Stanford , 38.3%), depression by Primary Care Evaluation of Mental Disorders (Oxford , 6.2%; Stanford , 6.6%), and psychotropic and non-psychotropic medication usage (psychotropic: Oxford , 1.5%; Stanford 3.5%; non-psychotropic: Oxford , 13.3%; Stanford , 18%). Oxford had higher rates of mood elevation by Mood Disorder Questionnaire (MDQ) (Oxford , 4%; Stanford , 1.7%). Conclusion:, Oxford and Stanford students have similar rates of mood distress, depression and general medication usage. Students at Oxford have a higher prevalence of MDQ scores that possibly indicate a bipolar disorder, while Stanford students are prescribed more psychotropics. [source] With Friends Like TheseDIPLOMATIC HISTORY, Issue 1 2005KEVIN BOYLE PeterBusch , All the Way With JFK? Britain, the U.S., and the Vietnam War . Oxford : Oxford University Press , 2003 . xiv + 240 pp. Notes, index. [source] Simulation of the dissolution of weathered versus unweathered limestone in carbonic acid solutions of varying strengthEARTH SURFACE PROCESSES AND LANDFORMS, Issue 6 2007M. J. Thornbush Abstract A simulation was undertaken within a climatic chamber to investigate limestone dissolution under varied carbonic acid (H2CO3) strengths as a possible analogue for future increases in atmospheric CO2 arising from global warming. Twenty-eight samples cut from a block of Bath (Box Hill) limestone from Somerville College, Oxford, which had been removed during restoration after 150 years in an urban environment, were weighed and placed in closed bottles of thin plastic containing varying concentrations of H2CO3. Half of the stone samples were derived from exposed surfaces of the stone block (weathered) while the others were obtained from the centre of the block on unexposed surfaces (unweathered). The purpose of this was to compare dissolution of previously weathered versus unweathered surfaces in strong (pH 4·73) versus weak (pH 6·43) solutions of H2CO3. A temperature of c. 19 °C was maintained within the chamber representing a plausible future temperature in Oxford for the year 2200 given current warming scenarios. The simulation lasted 25 days with a few stone samples being removed midway. Stone samples show reduced weight in all cases but one. There was greater dissolution of stone samples in a strong H2CO3 solution as conveyed by higher concentrations of total hardness and Ca2+ in the water samples as well as enhanced microscopic dissolution features identified using SEM. The simulation confirms that enhanced atmospheric CO2 under global warming, given adequate moisture, will accelerate dissolution rates particularly of newly replaced limestone building stones. However, previously weathered surfaces, such as those on historical stone exposed for a century or more, appear to be less susceptible to the effects of such increased rainfall acidity. Conservation techniques which remove weathered surfaces, such as stone cleaning, may accelerate future decay of historical limestone structures by increasing their susceptibility to dissolution. Copyright © 2006 John Wiley & Sons, Ltd. [source] EARLY ISLAMIC CHARITIES AS CATALYSTS OF INSTITUTIONAL INNOVATIONECONOMIC AFFAIRS, Issue 3 2010Benedikt Koehler Islamic societies may appear unsuitable catalysts for fostering individual enterprise and institutional innovation. This view is challenged by examination of the evolution of charities in early Islam, the so-called waqf. Mohammed's prescription of providing alms engendered an extensive and varied range of charitable institutions. One example is the creation of Islam's earliest centres of higher learning, madrasahs. Key concepts of Common Law, such as trusts, may have copied Islamic legal concepts; the constitutions of the earliest colleges of Oxford and Cambridge universities replicated the design of charitable madrasahs. [source] REGULATING CARS AND BUSES IN CITIES: THE CASE OF PEDESTRIANISATION IN OXFORDECONOMIC AFFAIRS, Issue 2 2003Graham Parkhurst Debates about whether traffic regulations that limit car use will enhance or hinder a particular urban economy are complex and often emotive. The present article considers evidence from the implementation of a radical traffic restraint and pedestrianisation scheme in Oxford in 1999. The most important achievement was a 17% reduction in car trips to the centre, which did not affect overall visitor numbers. The local economy did though experience a period of difficult trading around the time of implementation. [source] THE POPULATION GENETICS OF SPOROPHYTIC SELF-INCOMPABILITY IN SENECIO SQUALIDUS L. (ASTERACEAE): THE NUMBER, FREQUENCY, AND DOMINANCE INTERACTIONS OF S ALLELES ACROSS ITS BRITISH RANGEEVOLUTION, Issue 2 2006Adrian C. Brennan Abstract Sporophytic self-incompatibility (SSI) was studied in 11 British Senecio squalidus populations to quantify mating system variation and determine how its recent colonization of the United Kingdom has influenced its mating behavior. S allele number, frequency, and dominance interactions in populations were assessed using full diallels of controlled pollinations. A mean of 5.1 S alleles per population was observed, and no population contained more than six S alleles. Numbers of S alleles within populations of S. squalidus declined with increasing distance from the center of its introduction (Oxford). Cross-classification of S alleles allowed an estimate of approximately seven and no more than 11 S alleles for the entire British S. squalidus population. The low number of S alleles observed in British S. squalidus compared to other SI species is consistent with the population bottleneck associated with S. squalidus introduction to the Oxford Botanic Garden and subsequent colonization of Britain. Extensive S allele dominance interactions were observed to be a feature of the S. squalidus SSI system and may represent an adaptive response to improve limited mate availability imposed by the presence of so few S alleles. Multilocus allozyme genotypes were also identified for individuals in all populations and geographic patterns of S locus and allozyme loci variation investigated. Less interpopulation structure was observed for the S locus than for allozyme diversity-a finding indicative of the effects of negative frequency-dependent selection at the S locus maintaining equal S phenotypes within populations and enhancing effective migration between populations [source] Teaching and Learning Guide for: Memoryscape: How Audio Walks Can Deepen Our Sense of Place by Integrating Art, Oral History and Cultural GeographyGEOGRAPHY COMPASS (ELECTRONIC), Issue 5 2008Toby Butler Author's Introduction This article is concerned with the history and practice of creating sound walks or ,memoryscapes': outdoor trails that use recorded sound and spoken memory played on a personal stereo or mobile media to experience places in new ways. It is now possible to cheaply and easily create this and other kinds of located media experience. The development of multi-sensory-located media (,locedia') presents some exciting opportunities for those concerned with place, local history, cultural geography and oral history. This article uses work from several different disciplines (music, sound art, oral history and cultural geography) as a starting point to exploring some early and recent examples of locedia practice. It also suggests how it might give us a more sophisticated, real, embodied and nuanced experience of places that the written word just can not deliver. Yet, there are considerable challenges in producing and experiencing such work. Academics used to writing must learn to work in sound and view or image; they must navigate difficult issues of privacy, consider the power relations of the outsider's ,gaze' and make decisions about the representation of places in work that local people may try and have strong feelings about. Creating such work is an active, multi-sensory and profoundly challenging experience that can offer students the chance to master multi-media skills as well as apply theoretical understandings of the histories and geographies of place. Author Recommends 1.,Perks, R., and Thomson, A. (2006). The oral history reader, 2nd ed. London: Routledge. This is a wonderful collection of significant writing concerned with oral history. Part IV, Making Histories features much of interest, including a thought-provoking paper on the challenges of authoring in sound rather than print by Charles Hardy III, and a moving interview with Graeme Miller, the artist who created the Linked walk mentioned in the memoryscape article. These only feature in the second edition. 2.,Cresswell, T. (2004). Place: a short introduction. Oxford, UK: Blackwell. A refreshingly clear and well-written guide to the different theoretical takes on what makes places , a good starting point for further reading. 3.,Carlyle, A. (ed.). (2008). Autumn leaves: sound and the environment in artistic practice. Paris, France: Double Entendre. This is a collection of short essays and examples of located sonic media art; it includes interviews with practitioners and includes Hildegard Westekamp's Soundwalking, a practical guide to leading students on a mute walk. Lots of thought provoking, applied reading material for students here. 4.,Blunt, A., et al. (eds) (2003). Cultural geography in practice. London: Arnold. A great book for undergraduate and postgraduate students , concepts explained and lots of examples of actually doing cultural geography. The chapter on mapping worlds by David Pinder is particularly useful in this context. 5.,Pinder, D. (2001). Ghostly footsteps: voices, memories and walks in the city. Ecumene 8 (1), pp. 1,19. This article is a thoughtful analysis of a Janet Cardiff sound walk in Whitechapel, East London. Online Materials http://www.memoryscape.org.uk This is my project website, which features two online trails, Dockers which explores Greenwich and the memories of the London Docks that are archived in the Museum of London, and Drifting which is a rather strange experiment-combining physical geography and oral history along the Thames at Hampton Court, but still makes for an interesting trail. Audio, maps and trails can be downloaded for free, so students with phones or iPods can try the trails if you are within reach of Surrey or London. The site features an online version, with sound-accompanying photographs of the location. http://www.portsofcall.org.uk This website has three more trails here, this time of the communities surrounding the Royal Docks in East London. The scenery here is very dramatic and anyone interested in the regeneration of East London and its impact on local communities will find these trails interesting. Like Dockers, the walks feature a lot of rare archive interviews. This project involved a great deal of community interaction and participation as I experimented with trying to get people involved with the trail-making process. The site uses Google maps for online delivery. http://www.soundwalk.com This New York-based firm creates exceptionally high-quality soundwalks, and they are well worth the money. They started by producing trails for different districts of New York (I recommend the Bronx Graffiti trail) and have recently made trails for other cities, like Paris and Varanassi in India. http://www.mscapers.com This website is run by Hewlett Packard, which has a long history of research and development in located media applications. They currently give free licence to use their mscape software which is a relatively easy to learn way of creating global positioning system-triggered content. The big problem is that you have to have a pricey phone or personal digital assistant to run the software, which makes group work prohibitively expensive. But equipment prices are coming down and with the new generations of mobile phones developers believe that the time when the player technology is ubiquitous might be near. And if you ask nicely HP will lend out sets of equipment for teaching or events , fantastic if you are working within reach of Bristol. See also http://www.createascape.org.uk/ which has advice and examples of how mscape software has been used for teaching children. Sample Syllabus public geography: making memoryscapes This course unit could be adapted to different disciplines, or offered as a multidisciplinary unit to students from different disciplines. It gives students a grounding in several multi-media techniques and may require support/tuition from technical staff. 1.,Introduction What is a located mediascape, now and in the future? Use examples from resources above. 2.,Cultural geographies of site-specific art and sound Theories of place; experiments in mapping and site-specific performance. 3.,Walk activity: Westergard Hildekamp , sound walk, or one of the trails mentioned above The best way , and perhaps the only way , to really appreciate located media is to try one in the location they have been designed to be experienced. I would strongly advise any teaching in this field to include outdoor, on-site experiences. Even if you are out of reach of a mediascape experience, taking students on a sound walk can happen anywhere. See Autumn Leaves reference above. 4.,Researching local history An introduction to discovering historical information about places could be held at a local archive and a talk given by the archivist. 5.,Creating located multimedia using Google maps/Google earth A practical exercise-based session going through the basics of navigating Google maps, creating points and routes, and how to link pictures and sound files. 6.,Recording sound and oral history interviews A practical introduction to the techniques of qualitative interviewing and sound recording. There are lots of useful online guides to oral history recording, for example, an online oral history primer http://www.nebraskahistory.org/lib-arch/research/audiovis/oral_history/index.htm; a more in depth guide to various aspects of oral history http://www.baylor.edu/oral%5fhistory/index.php?id=23566 or this simple oral history toolkit, with useful links to project in the North of England http://www.oralhistorynortheast.info/toolkit/chapter1.htm 7.,Sound editing skills Practical editing techniques including working with clips, editing sound and creating multi-track recordings. The freeware software Audacity is simple to use and there are a lot of online tutorials that cover the basics, for example, http://www.wikieducator.org/user:brentsimpson/collections/audacity_workshop 8.,Web page design and Google maps How to create a basic web page (placing pictures, text, hyperlinks, buttons) using design software (e.g. Dreamweaver). How to embed a Google map and add information points and routes. There is a great deal of online tutorials for web design, specific to the software you wish to use and Google maps can be used and embedded on websites free for non-profit use. http://maps.google.com/ 9,and 10. Individual or group project work (staff available for technical support) 11.,Presentations/reflection on practice Focus Questions 1What can sound tell us about the geographies of places? 2When you walk through a landscape, what traces of the past can be sensed? Now think about which elements of the past have been obliterated? Whose past has been silenced? Why? How could it be put back? 3Think of a personal or family story that is significant to you. In your imagination, locate the memory at a specific place. Tell a fellow student that story, and describe that place. Does it matter where it happened? How has thinking about that place made you feel? 4What happens when you present a memory of the past or a located vision of the future in a present landscape? How is this different to, say, writing about it in a book? 5Consider the area of this campus, or the streets immediately surrounding this building. Imagine this place in one of the following periods (each group picks one): ,,10,000 years ago ,,500 years ago ,,100 years ago ,,40 years ago ,,last Thursday ,,50 years time What sounds, voices, stories or images could help convey your interpretation of this place at that time? What would the visitor hear or see today at different points on a trail? Sketch out an outline map of a located media trail, and annotate with what you hear/see/sense at different places. Project Idea small group project: creating a located mediascape Each small group must create a located media experience, reflecting an aspect of the history/geography/culture of an area of their choosing, using the knowledge that they have acquired over the course of the semester. The experience may be as creative and imaginative as you wish, and may explore the past, present or future , or elements of each. Each group must: ,,identify an area of interest ,,research an aspect of the area of the groups choosing; this may involve visiting local archives, libraries, discussing the idea with local people, physically exploring the area ,,take photographs, video or decide on imagery (if necessary) ,,record sound, conduct interviews or script and record narration ,,design a route or matrix of media points The final project must be presented on a website, may embed Google maps, and a presentation created to allow the class to experience the mediascape (either in the classroom or on location, if convenient). The website should include a brief theoretical and methodological explanation of the basis of their interpretation. If the group cannot be supported with tuition and support in basic website design or using Google mapping with sound and imagery, a paper map with locations and a CD containing sound files/images might be submitted instead. For examples of web projects created by masters degree students of cultural geography at Royal Holloway (not all sound based) see http://www.gg.rhul.ac.uk/MA/web-projects.html [source] The information needs of doctors-in-training: case study from the Cairns Library, University of OxfordHEALTH INFORMATION & LIBRARIES JOURNAL, Issue 3 2000Maureen Forrest The objective of this study was to find out more about the information needs of doctors-in-training and to identify their preferred sources of information. The methodology included interviews with consultants and administrators, a focus group discussion with library staff and a postal questionnaire sent to 347 doctors-in-training (there was a 43% return). The shortcomings of a questionnaire primarily composed of closed questions were addressed by the inclusion of one-to-one interviews which offered the opportunity for more in-depth commentary on specific issues highlighted in the questionnaire. Results indicated the frequency with which various types of information sources were consulted and how this related to the ,ease of access' of each information source. There was also the opportunity to comment on future information needs. It was clear from the interviews as well as comments made on the questionnaire that the two most important requirements for doctors-in-training were ,more time to find and obtain information' and ,better access to information sources when and where they are needed'. The results, although not surprising, included specific suggestions that have been used for the strategic planning of the library service to deliver the best possible support to users within the current framework of evidence-based medicine. [source] The subiculum comes of ageHIPPOCAMPUS, Issue 11 2006Liset Menendez de la Prida Abstract The subiculum has long been considered as a simple bidirectional relay region interposed between the hippocampus and the temporal cortex. Recent evidence, however, suggests that this region has specific roles in the cognitive functions and pathological deficits of the hippocampal formation. A group of 20 researchers participated in an ESF-sponsored meeting in Oxford in September, 2005 focusing on the neurobiology of the subiculum. Each brought a distinct expertise and approach to the anatomy, physiology, psychology, and pathologies of the subiculum. Here, we review the recent findings that were presented at the meeting. © 2006 Wiley-Liss, Inc. [source] The ,reforming' Sunderland/Stanhope ministry and the opening of the 1718,19 session of parliament in the house of lords*HISTORICAL RESEARCH, Issue 199 2005Clyve Jones This article discusses a procedural change in the use of proxy votes at divisions in the house of lords, drawing on a memorandum of November 1718, to Lord Oxford, which describes the opening of the 1718,19 session of parliament. This apparently minor development was indicative of a change in the way that the ,reforming' ministry headed by Lords Sunderland and Stanhope conducted business in parliament. [source] English University Benefactors in the Middle AgesHISTORY, Issue 283 2001Alan B. Cobban The medieval universities of Oxford and Cambridge owed an enormous debt to the generosity of a plurality of benefactors of diverse social origins. Given their limited incomes, the universities could not have functioned at a successful level without the substantial material aid of benefactors. Although the English monarchy made a valuable contribution to several areas of university and collegiate life, it nevertheless appears that this monarchical beneficence was less extensive than might have been supposed. The English male nobility gave the occasional gift of property and made donations to loan-chests but before 1500 only one nobleman was a principal founder of a secular academic college. This opened the way for queens consort and female members of the greater aristocracy to emerge as significant benefactresses in both the university and collegiate spheres. Indeed, it could be argued that women from the upper echelons of society came to rank in importance as university and college benefactors with lesser ecclesiastics, knights, burgesses, merchants, current and former members of colleges and university servants. However, taking the donations of the episcopate in the round, it is probably true to say that the English bishops made the most decisive contribution [source] How Zaynab Became the First Arabic NovelHISTORY COMPASS (ELECTRONIC), Issue 1 2009Elliott Colla This paper is part of a History Compass conference cluster tracing the formation of national culture in Egypt. Guest edited by Walter Armbrust, this cluster of articles was originally part of a conference in Oxford on January 12,13, 2007, organized by Walter Armbrust, Ronald Nettler, and Lucie Ryzova, and funded by the Middle East Centre (St. Antony's), The Faculty of Oriental Studies, The Khalid bin ,Abdullah Al-Sa'ud Professorship (Professor Clive Holes), and The Centre for Political Ideologies. The cluster is made up of the following articles: Guest Editor: Walter Armbrust ,The Formation of National Culture in Egypt in the Interwar Period: Cultural Trajectories', Walter Armbrust, History Compass 6 (2008), DOI: 10.1111/j.1478-0542.2008.00571.x,Repackaging the Egyptian Monarchy: Faruq in the Public Spotlight, 1936,1939', Matthew Ellis, History Compass 6 (2008), DOI: 10.1111/j.1478-0542.2008.00572.x,How Zaynab Became the First Arabic Novel', Elliott Colla, History Compass 6 (2008), DOI: 10.1111/j.1478-0542.2008.00573.x,Women in the Singing Business, Women in Songs', Frédéric Lagrange, History Compass 6 (2008), DOI: 10.1111/j.1478-0542.2008.00574.x,Long Live Patriarchy: Love in the Time of ,Abd al-Wahhab', Walter Armbrust, History Compass 6 (2008), DOI: 10.1111/j.1478-0542.2008.00575.x,Football as National Allegory: Al-Ahram and the Olympics in 1920s Egypt', Shaun Lopez, History Compass 6 (2008), DOI: 10.1111/j.1478-0542.2008.00576.x,The Professional Worldview of the Effendi Historian', Yoav Di-Capua, History Compass 6 (2008), DOI: 10.1111/j.1478-0542.2008.00577.x Despite a long-standing critical consensus that Muhammad Husayn Haykal's 1914 novel Zaynab was the first ,mature' Arabic novel, there is much evidence to the contrary. First, in terms of genre, Zaynab was not the first book calling itself by the term that later critics would call ,novel'; second, in terms of the bibliographic record, it was not a unique book on the cultural market in 1914; third, in terms of literary style, it was not at the time a particularly unique formal or thematic experiment in prose fiction; and finally, in terms of reception, it was not recognized as significant even by the small market segment and cultural field in which it initially appeared. This article revisits this critical debate and suggests that the canonization of Zaynab as the first Arabic novel cannot be explained by the work itself, but rather by subsequent developments , most especially, in the film adaptations of the novel and in the nationalization of university curricula during the Nasserist period. [source] IBD international genetics consortium: International cooperation making sense of complex diseaseINFLAMMATORY BOWEL DISEASES, Issue 3 2003Juleen A. Cavanaugh Ph.D. Abstract The Inflammatory Bowel Disease International Genetic Consortium was formed in Oxford in 1997. Since then it has grown to include twelve groups from around the world that are each actively involved in identifying the genes that are involved in susceptibility to IBD. The approach of the IBDIGC is to attempt to overcome one of the major issues in complex disease analysis,that of obtaining sufficient power to analyze successfully the inheritance of IBD,by collaboratively studying large numbers of well documented families with multiple affected individuals. This strategy has been marked by considerable success with the publication of a paper authored by the IBDIGC substantiating the localization of IBD1 to chromosome 16. This publication served to encourage researchers and eventually resulted in the identification by several groups simultaneously of risk alleles in the NOD2 gene that cosegregate with disease. The IBDIGC provides a model for studies in complex disease genetics, showing that research groups both large and small can participate equally in complex disease gene identification through the formation of large international consortia. [source] BSMB Spring 2003 Meeting Report, OxfordINTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Issue 5 2003Article first published online: 16 DEC 200 First page of article [source] British Society for Matrix Biology and European Tissue Society Meeting, Oxford, 31 March,2 April 1999INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, Issue 1 2000Article first published online: 28 JUN 200 [source] Progress in tourism marketing by Metin Kozak and Luiza Andreu (eds), Elsevier, Oxford, UK, 2006.INTERNATIONAL JOURNAL OF TOURISM RESEARCH, Issue 5 2007No. of pages: 326. No abstract is available for this article. [source] Optimal timing and dosing of platelet transfusionsISBT SCIENCE SERIES: THE INTERNATIONAL JOURNAL OF INTRACELLULAR TRANSPORT, Issue n1 2010N. M. Heddle Background, Over the past 20 years there have been more than 20 randomized controlled trials (RCTs) that have investigated various aspects of platelet transfusion therapy in haematology/oncology patients. These studies have focused on the best platelet product, the importance of ABO compatibility, pathogen inactivation of platelets, platelet triggers and the optimal platelet dose. Aims, This article summarizes current evidence to support the timing and dosing of platelet transfusions and to explore some ideas of where clinical research in this area may be heading. Materials and Methods, The articles reviewed in this presentation were identified through a search of PubMed using the term, platelet transfusion and setting limits to identify clinical studies, human studies and manuscripts in English. Results and Discussion, Three RCTs have informed practices around platelet transfusion trigger with the largest study by Rebulla et al., being the primary study that has changed practices worldwide, with a move towards a lower prophylactic platelet transfusion trigger of 10 × 109/l. Two groups (Germany and Oxford, UK) are currently investigating whether we can push the boundaries of prophylactic platelet transfusions even further by eliminating this form of therapy. Preliminary results from these studies have been published but we will await the final results to determine whether this research will indeed change practice. Over the past year there has also been two major studies (one by the BEST Collaborative, and the second by the US Transfusion Medicine/Hemostasis Network), that provide new information to guide platelet dosing. The Study by the BEST Collaborative (SToP) compared low dose platelets to standard dose platelets with WHO bleeding greater than or equal to Grade 2 as the primary outcome. The US study (PLADO) compared three doses (low, medium and high) and measured the same outcome (WHO bleeding , Grade 2). Conclusions, Although all of these studies further our knowledge to prescribe platelet transfusions, they also raise some interesting questions about the clinical relevance of the outcomes that we are currently using for these studies. The trend over the past decade has been to use bleeding as the primary outcome; however, bleeding is a complex composite outcome (Grades 2, 3 and 4) comprised of some surrogate components (Grades 2 and 3). It is also an outcome that may be difficult to measure and grade in a consistent and reliable manner. The clinical relevance of this outcome is also complex and may vary depending on the perspective from which it is viewed. [source] Hans Adolf Krebs (1900-1981),His Life and TimesIUBMB LIFE, Issue 3 2000Marion Stubbs A symposium to mark the centenary of the birth of Sir Hans Krebs was held in St. Catherine's College, University of Oxford, UK, during September 13-15, 2000. It was organized by Marion Stubbs, a long-time associate of Krebs, and Geoff Gibbons, the head of the Metabolic Research Laboratory that was established for Krebs after his retirement from the Chair of Biochemistry at the University of Oxford. The speakers, from all parts of the world, were Krebs' friends and associates, dating from all stages of his career in the UK, beginning with Reg Hems, who joined Krebs in the early 1940s. The three children of Hans and Margaret Krebs-Helen, Paul, and John-were present. Sir John Krebs, F.R.S., Royal Society Research Professor of Zoology at Oxford, gave the welcoming address. This article was adapted by Drs. Stubbs and Gibbons from one of the same title that appeared in the program book. We thank them for their kind cooperation. We also thank Mrs. Helen Lowell (née Krebs) for conveying the permission of the Krebs' children to reproduce the illustrations in this article. - William Whelan, Editor-in-Chief [source] Men's Health: Perspectives, Diversity and Paradox by Mike Luck, Margaret Bamford and Peter Williamson, Blackwell Science, Oxford, 2000, 268 pages, £18·99, ISBN 0 632 05288 0.JOURNAL OF ADVANCED NURSING, Issue 2 2001Dean Whitehead No abstract is available for this article. [source] The Biology of Disease, 2nd edition edited by Jonathan Philips Paul Murray and Paul Kirk Blackwell Science, Oxford, 2001, 323 pages, £19·95, ISBN 0 632 05404 2.JOURNAL OF ADVANCED NURSING, Issue 5 2001Roger Watson No abstract is available for this article. [source] Reference and probability-matching priors in Bayesian analysis of mixed linear modelsJOURNAL OF ANIMAL BREEDING AND GENETICS, Issue 5 2002A. L. Pretorius Summary Determination of reasonable non-informative priors in multiparameter problems is not easy; common non-informative priors, such as Jeffrey's prior, can have features that have an unexpectedly dramatic effect on the posterior. In recognition of this problem Berger and Bernardo (Bayesian Statistics IV. Oxford University Press, Oxford, UK, pp. 35,70, 1992), proposed the Reference Prior approach to the development of non-informative priors. In the present paper the reference priors of Berger and Bernardo (1992) are derived for the mixed linear model. In spite of these difficulties, there is growing evidence, mainly through examples that reference priors provide ,sensible' answers from a Bayesian point of view. We also examine whether the reference priors satisfy the probability-matching criterion. The theory and results are applied to a real problem consisting of 879 weaning weight records, from the progeny of 17 sires. These important aspects are explored via Monte Carlo simulations. Zusammenfassung Reference und Probability-Matching Priors in Bayesian Analysen von gemischten linearen Modellen Die Festlegung von vernünftigen Non-Informative Priors in Multi-Paramter Analysen ist nicht leicht; gewöhnliche Non-Informative Priors, wie beispielsweise Jeffrey's Priors, können unerwartete dramatische Effekte auf die Lösungen haben. Zur Lösung dieses Problems schlagen Berger and Bernardo (Bayesian Statistics IV. Oxford University Press, Oxford, UK, pp. 35,70, 1992) den Reference Prior Ansatz zur Entwicklung von Non-Informative Priors vor. In der vorliegenden Untersuchung werden die von Berger and Bernardo (1992) vorgeschlagenen Reference Priors in linearen gemischten Modellen angewandt. Trotz der bekannten Schwierigkeiten gibt es hauptsächlich anhand von Beispielen mehr und mehr Anhaltspunkte, dass die Reference Priors aus der Sicht von Bayesians zu brauchbaren Antworten führen. Es wurde auch untersucht, ob diese Reference Priors den Probability-Matching Kriterien genügen. Die Theorie und die Ergebnisse sind an einem Beispiel mit 879 Datensätzen mit Absatzgewichten von Schafen, die von 17 Böcken abstammen, verifiziert worden. Die wichtigen Aspekte sind mittels Monte Carlo Simulation untersucht worden. [source] A path from Ih to C1 symmetry for C20 cage moleculeJOURNAL OF COMPUTATIONAL CHEMISTRY, Issue 12 2005Zhigang Wang Abstract The symmetry of the C20 cage is studied based on the intrinsical relationship among point groups (Bradley, C. J.; Cracknell, A. P. The Mathematical Theory of Symmetry in Solids; Claredon Press: Oxford, 1972). The structure of the C20 cage with Ih symmetry is constructed, as are eight other structures with subgroup symmetry. A path from Ih symmetry to C1 symmetry is obtained for the closed-shell electronic state, and the structure with D2h symmetry is the most stable on this path. Using the D2h structure the correlation energy correction is studied on the condition of restricted excitation space at the CCSD(T) level. We obtain curves on the relation between the orbital numbers and the total energy at the CCSD(T), CCSD, and MP2 level, respectively. The results of these curves obtained from MP2 and CCSD(T) methods have the same tendency, while the results of CCSD gradually diverge with an increase in orbital numbers. When the orbitals used in the calculation reach 460, the total energy is ,759.644 hartree at MP2 level and is ,759.721 hartree by the CCSD(T) method. From the calculation results, we find that a large basis set can improve the reliability of the MP2 method, and to restrict excitation space is necessary when using the CCSD(T) method. © 2005 Wiley Periodicals, Inc. J Comput Chem 12: 1279,1283, 2005 [source] Tackling NHS Jargon , Getting the Message Across (Sarah Carr, Radcliffe Medical Press, Oxford, £19.95, ISBN 1-85775-428-X)JOURNAL OF EVALUATION IN CLINICAL PRACTICE, Issue 1 2004Michael Loughlin PhD [source] Ethics, Management and Mythology: Rational Decision-making for Health Service Professionals (Michael Loughlin, Radcliffe Medical Press, Oxford, £24.95, ISBN 1,85775,574,X)JOURNAL OF EVALUATION IN CLINICAL PRACTICE, Issue 2 2002G. Bruce Charlton MD [source] The Kiss of Death and Cabal of Dons: Blackmail and Grooming in Georgian OxfordJOURNAL OF HISTORICAL SOCIOLOGY, Issue 4 2008GEORGE ROUSSEAU This article reconstructs the case of an Oxford University don accused of sexual impropriety in mid-eighteenth century England by an adolescent boy. It recreates the biographical and historical contexts involved in the scandal, and demonstrates what the various agendas and motivations were for the accusation, as well as explains how the case played itself out. The don's actions are shown to be far less straightforward than claimed by his adversaries. The chapter adds to the growing literature about adults and children in history. [source] A randomised, controlled trial of the effects of an energy-dense supplement on energy intake, appetite and blood lipids in malnourished community-based elderly patientsJOURNAL OF HUMAN NUTRITION & DIETETICS, Issue 4 2008G.P. Hubbard Background:, Disease-related malnutrition is common in the elderly and if left untreated may have severe consequences (Stratton & Elia, 2003). One of the strategies used to combat malnutrition is the use of high-energy, low-volume [18.8 kJ mL,1 (4.5 kcal ml,1)] nutritional supplements. This study aimed to investigate the effects of an energy dense supplement on energy intake, appetite and blood lipids in elderly patients at risk of malnutrition. Methods:, In this randomised, controlled, parallel study, 42 community-based patients (mean (SD) age: 84 (7.0) years, mean body mass index (BMI): 20.9 (3.5) kg m,2), identified as being at medium or high risk of malnutrition [Malnutrition Universal Screening Tool (MUST) (Elia, 2003)] were randomised (using standard randomisation methods) to receive either; (i) 1674 kJ day,1 (400 kcal day,1) (in 3 × 30 mL doses) of an energy-dense supplement (Calogen, Nutricia®) (n = 19) or (ii) dietary advice in the form of a standardised dietary advice sheet (n = 23), for 4 weeks. Energy intake, appetite, blood lipids [i.e. total cholesterol, low density lipoprotein (LDL) cholesterol (subset analysis only)], body weight, gastro-intestinal tolerance, product compliance and product acceptability were assessed during the 4 week study. Results are presented as mean (SD). Paired t -test and one way anova statistical analyses were undertaken using SPSS v15. Ethical approval for this study was obtained from the appropriate committee. Results:, Supplementation with the energy dense supplement significantly increased mean total daily energy intake by +1736 kJ (+415 kcal, P = 0.009) from 6456 (2330) kJ [1543 (557) kcal] to 8192 (1477) kJ [1958 (353) kcal], with no significant effect on voluntary food intake or appetite scores (for hunger, fullness and desire to eat). In the dietary advice group, although mean total daily energy intake was also significantly increased by +1105 kJ (+264 kcal, P = 0.026) from 5623 (2107) kJ [1344 (503) kcal] to 6728 (2029) kJ [1608 (485) kcal], it was significantly lower than in the energy dense group [-1464 kJ (-350 kcal), P = 0.012] at week 4. Both energy-dense and dietary advice groups maintained weight during the study. No significant adverse effects on blood lipid concentrations were observed in either group, with a significant decrease in total cholesterol concentrations [from 4.26 (1.0) mM to 3.96 (0.8) mM, P = 0.03] and LDL cholesterol concentrations [from 2.32 (0.6) mM to 2.06 (0.5) mM, P = 0.03] in the energy dense group (subset analysis, n = 9). Both supplementation with energy dense supplement and dietary advice were well tolerated with no gastro-intestinal side effects. The energy dense supplement was well accepted with >80% of patients rating it as pleasant and convenient, with an enjoyable taste. Compliance with the energy dense supplement was high, with 95% of patients consuming the recommended dose of 3 × 30 mL throughout the study. Discussion:, This study in elderly patients with or at risk of malnutrition suggests that the energy dense supplement is effective in significantly improving total intakes of energy with no suppression of appetite or voluntary dietary intake, enabling patients to maintain weight and that the energy dense supplement is well tolerated and accepted, with excellent compliance and no adverse effects on blood lipids. Conclusions:, This randomised controlled trial suggests that an energy-dense supplement is an effective, well tolerated and safe method of providing energy supplementation for the management of elderly patients with or at risk of malnutrition in clinical practice. References, Elia, M. (2003) The "MUST" report. Nutritional screening for adults: a multidisciplinary responsibility. Redditch, UK: BAPEN. Available at http://www.bapen.org.uk (accessed on 15 March 2008). Stratton, R.J., Green, C.J. & Elia, M. (2003) Disease-related malnutrition: an evidence-based approach. Oxford: CABI publishing. [source] Medical ethics in the 21st centuryJOURNAL OF INTERNAL MEDICINE, Issue 1 2000M. Parker Abstract. Parker M, Hope T (Institute of Health Sciences, Headington, Oxford, UK). Medical ethics in the 21st century. J Intern Med 2000; 248: 1,6. Objectives. To foresee how medical ethics may develop in the 21st century. Design. We have looked into our crystal ball to see what factors are likely to drive medical ethics over the next few decades. We have given examples of how such factors might affect specific issues. Results. Those factors that we identified as likely to shape the future of medical ethics are: Globalization. Medical ethics is likely to have to grapple increasingly with ethical issues arising from the huge discrepancies in the level of health care available in different countries. Increase in longevity. We predict that there will be, at least amongst the richer nations, a significant increase in life expectancy. This will result in issues of resource allocation becoming increasingly problematic within medicine. Child enhancement. Developments in genetics combined with control of reproduction will make it possible to select our children for a broad range of characteristics. There are optimistic and pessimistic predictions as to how such power will be used. In either case, this area will be an important focus of concern in medical ethics. The biological determination of behaviour. Genetic research will lead to an increasing sense that undesirable behaviour is genetically determined. This will lead to a re-examination of such concepts as criminal responsibility. Therapeutic research and clinical practice. We predict that an increasing amount of clinical practice will be within the setting of clinical trials. The ethics of therapeutic research and clinical practice will need to be brought within a coherent framework. [source] | ||||||||||||||||||||||||||||||||||||||||