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Novel Synthesis (novel + synthesis)
Selected AbstractsChemInform Abstract: Studies on the Chemistry of 2-[3-(2-Nitrophenyl)-2-oxopropyl]benzaldehydes: Novel Syntheses of 5H-Benzo[b]carbazole-6,11-diones and Indolo[1,2-b]isoquinoline-6,11-diones.CHEMINFORM, Issue 6 2010Marcos Fernandez Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] Novel Syntheses of 5-Aminothieno[2,3-c]pyridazine, Pyrimido[4,,5,:4,5]thieno[2,3-c]pyridazine, Pyridazino[4,,3,:4,5]thieno[3,2-d][1,2,3]triazine and Phthalazine Derivatives.CHEMINFORM, Issue 52 2003Mohamed S. A. El-Gaby Abstract For Abstract see ChemInform Abstract in Full Text. [source] [4 + 1] Cycloaddition Reactions of o-Thioquinones with Isocyanides: Novel Syntheses of 2-Imino-1,3-oxathioles.CHEMINFORM, Issue 28 2003Vijay Nair Abstract For Abstract see ChemInform Abstract in Full Text. [source] Novel Synthesis of 4H -Quinolizine Derivatives Using Sulfonyl Ketene DithioacetalsEUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 33 2009Masayori Hagimori Abstract In the synthesis of 4H -quinolizine derivatives involving the use of a sulfonyl ketene dithioacetal, we found a novel reaction in which the remaining methylsulfanyl group was replaced with a proton after the ring-closure reaction in the quinolizine skeleton under mild conditions, without the use of any metallic reagent. The reaction of 3,3-bis(methylsulfanyl)-2-phenylsulfonylacrylonitriles (1a,b) with 2-pyridylacetonitrile (2a) in the presence of potassium carbonate as a base in DMSO afforded 4-imino-2-methylsulfanyl-3-phenylsulfonyl-4H -quinolizine-1-carbonitriles (3a,b). The methylsulfanyl group at the 2-position of 3a,b was readily removed under methanol reflux conditions to afford 4-imino-3-phenylsulfonyl-4H -quinolizine-1-carbonitriles (4a,b) in good yields. Alkyl 3-phenylsulfonyl-4H -quinolizine-1-carboxylates (4c,f) were directly synthesized from sulfonyl ketene dithioacetal (1a,b) with alkyl 2-pyridylacetates (2b,c) and involved desulfanylation by simple hydrolysis. In addition, the fluorescent properties of these compounds were investigated. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009) [source] A Novel Synthesis of Highly Substituted Perhydropyrrolizines, Perhydroindolizines, and Pyrrolidines: Inhibition of the Peptidyl-Prolyl cis/trans Isomerase (PPIase) Pin1HELVETICA CHIMICA ACTA, Issue 2 2007Romain Siegrist Abstract In this paper, we describe the synthesis and biological evaluation of highly substituted perhydropyrrolizines that inhibit the peptidyl-prolyl cis/trans isomerase (PPIase) Pin1, an oncogenic target. The enzyme selectively catalyzes the cis/trans isomerization of peptide bonds between a phosphorylated serine or threonine, and proline, thereby inducing a conformational change. Such structural modifications play an important role in many cellular events, such as cell-cycle progression, transcriptional regulation, RNA processing, as well as cell proliferation and differentiation. Based on computer modeling (Fig.,2), the new perhydropyrrolizinone derivatives (,)- 1a,b, decorated with two substituents, were selected and synthesized (Schemes,1,3). While enzymatic assays showed no biological activity, 15N,1H-HSQC-NMR spectroscopy revealed that (,)- 1a,b bind to the WW recognition domain of Pin1, apparently in a mode that does not inhibit PPIase activity. To enforce complexation into the larger active site rather than into the tighter WW domain of Pin1 and to enhance the overall binding affinity, we designed a perhydropyrrolizine scaffold substituted with additional aromatic residues (Fig.,5). A novel, straightforward synthesis towards this class of compounds was developed (Schemes,4 and 5), and the racemic compounds (±)- 22a,22d were found to inhibit Pin1 with Ki values (Ki,=,inhibition constant) in the micromolar range (Table,2). To further enhance the potency of these inhibitors, the optically pure ligands (+)- 22a and (+)- 33b,c were prepared (Schemes,6 and 7) and shown to inhibit Pin1 with Ki values down to the single-digit micromolar range. According to 15N,1H-HSQC-NMR spectroscopy and enzymatic activity assays, binding occurs at both the WW domain and the active site of Pin1. Furthermore, the new synthetic protocol towards perhydropyrrolizines was extended to the preparation of highly substituted perhydroindolizine ((±)- 43; Scheme,8) and pyrrolidine ((±)- 48a,b; Scheme,9) derivatives, illustrating a new, potentially general access to these highly substituted heterocycles. [source] Samarium-Doped Ceria Nanowires: Novel Synthesis and Application in Low-Temperature Solid Oxide Fuel CellsADVANCED MATERIALS, Issue 14 2010Ying Ma Samarium-doped ceria (SDC) nanowires are synthesized by a novel, template-, surfactant-free and cost-effective method, using citric acid as precipitating/complexing agent for formation of citrate precursor nanowires. The single SOFC based on SDC nanowires/Na2CO3 nanocomposites as electrolyte is fabricated and the maximum power densities of 417 and 522,mW,cm,2 at 550 and 600,°C are achieved, showing great potential for low-temperature SOFCs. [source] Novel Synthesis of SrBi2Nb2O9 Powders From Hydroxide PrecursorsINTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY, Issue 1 2008Upendra Nath Gupta Simple hydroxide precursors were used for the first time for the synthesis of a typical Aurivillius compound (SrBi2Nb2O9 (SBN)) at a low temperature. This method is very advantageous because it circumvents the use of SrCO3 in the case of conventional ceramics as well in the coprecipitation methods, thereby lowering the formation of the product phase. Commercially purchased strontium hydroxide is mixed thoroughly with freshly precipitated bismuth and niobium hydroxides in a stoichiometric ratio and heated at different temperatures ranging from 100°C to 750°C for 12 h. The sequence of the reaction and evolution of the product phase was monitored by X-ray diffraction (XRD) studies by recording the XRD for samples calcined at different temperatures. The incipient SBN phase begins to form at temperatures as low as 400°C, and phase formation was complete only at 650°C as revealed by the XRD observations. The differential thermal/thermogravimetric analyses) also corroborate this result. The morphology and average particle size of these powders were investigated by transmission electron microscopy studies. [source] Novel Synthesis of Pt6Si5 Nanowires and Pt6Si5,Si Nanowire Heterojunctions by Using Polycrystalline Pt Nanowires as Templates ,ADVANCED MATERIALS, Issue 7-8 2003J. Luo Pt6Si5 nanowires and Pt6Si5,Si nanowire heterojunctions (see Figure) have been synthesized by electrodeposition using polycrystalline Pt nanowires as templates. In the synthesis, the polycrystalline nature of the Pt nanowires played an important role. A dependence between the diameters of the products and the Pt nanowires was detected. These junctions would find applications in future nano-electronics. [source] ChemInform Abstract: Novel Synthesis of 3-Arylated 5,6-Dimethoxybenzo[d]isothiazole 1,1-Dioxides (IV).CHEMINFORM, Issue 37 2010Fei Xie No abstract is available for this article. [source] ChemInform Abstract: Novel Synthesis of 3-Methylisoxazolo[5,4-e][1,2,4]triazepin-4-ones.CHEMINFORM, Issue 16 2010S. Ryng Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Reactions of 3-(Polyfluoroacyl)chromenones with Heterocyclic Amines: Novel Synthesis of Polyfluoroalkyl-Containing Fused Pyridines.CHEMINFORM, Issue 13 2010Anton Kotljarov Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Reactions of 3-(Polyfluoroacyl)chromenones with Heterocyclic Amines: Novel Synthesis of Polyfluoroalkyl-Containing Fused Pyridines.CHEMINFORM, Issue 13 2010Anton Kotljarov Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Gallium(III) Chloride Catalyzed Three-Component Coupling of Naphthol, Alkyne and Aldehyde: A Novel Synthesis of 1,3-Disubstituted-3H-benzo[f]chromenes.CHEMINFORM, Issue 5 2010J. S. Yadav Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: A Novel Synthesis of Aryl Mesylates via One-Pot Demethylation,Mesylation of Aryl Methyl Ethers Using a Mixture of Phosphorus Pentoxide in Methanesulfonic Acid.CHEMINFORM, Issue 43 2009Babak Kaboudin Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Novel Synthesis of Methyl Ketones Based on the Blaise Reaction.CHEMINFORM, Issue 42 2009H. Surya Prakash Rao Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: InBr3 -Catalyzed Annulations of Cyclic 1,3-Diketones with Aryl Propargyl Alcohols: A Novel Synthesis of 2,4-Diaryldihydropyrans.CHEMINFORM, Issue 42 2009J. S. Yadav Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Cyclic ,-Acylvinyl Anionic Synthons: A Novel Synthesis of 2-Trimethylsilyl-3-methyl-cyclohexenone by the Wurtz,Fittig Coupling Reaction.CHEMINFORM, Issue 33 2009Divya Jyothi Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Wittig Olefination and Thiol Mediated 7-endo-Trig Radical Cyclization: Novel Synthesis of Oxepin Derivatives.CHEMINFORM, Issue 15 2009K. C. Majumdar Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Novel Synthesis of Aza-phthalimidine Hydroxylactams.CHEMINFORM, Issue 14 2009Bolin Fan Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: A Novel Synthesis of Alkylamino Substituted Methylenediphosphonates Using Bis(trichloromethyl) Carbonate and RCONR1R2.CHEMINFORM, Issue 10 2009Chuan-Ming Yu Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: A Novel Synthesis of 2-Functionalized Benzofurans by Palladium-Catalyzed Cycloisomerization of 2-(1-Hydroxyprop-2-ynyl)phenols Followed by Acid-Catalyzed Allylic Isomerization or Allylic Nucleophilic Substitution.CHEMINFORM, Issue 5 2009Bartolo Gabriele Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: A Novel Synthesis of Spiro[2.6]nonadienones by the Reaction of Magnesium Cyclopropylidenes with Naphtholates and Phenolates.CHEMINFORM, Issue 49 2008Tsuyoshi Satoh Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Reaction of Dithiolactones with Benzyne: A Novel Synthesis of Benzo-1,3-dithioles.CHEMINFORM, Issue 40 2008Kentaro Okuma Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Novel Synthesis of Substituted Pyrrolidines and Piperidines via Radical Addition,Ionic Cyclization Reaction of Oxime Ethers.CHEMINFORM, Issue 36 2008Okiko Miyata Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Base-Mediated Reaction of Hydrazones and Nitroolefins with a Reversed Regioselectivity: A Novel Synthesis of 1,3,4-Trisubstituted Pyrazoles.CHEMINFORM, Issue 36 2008Xiaohu Deng Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Enaminonitriles in Heterocyclic Synthesis: Novel Synthesis of 3-Aminopyrroles and Pyrrolo[3,2-d]pyrimidine Derivatives.CHEMINFORM, Issue 36 2008Abdellatif M. Salaheldin Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: A Novel Synthesis of 1,4-Bis(thiopyrano[2,3-d]thiazolyl)benzene Derivatives.CHEMINFORM, Issue 27 2008Nadia Hanafy Metwally Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: A Novel Synthesis of Pyrazolo[3,4-b]pyridine Derivatives Through Multicomponent Reaction in Ionic Liquid.CHEMINFORM, Issue 26 2008Xin Ying Zhang Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Novel Synthesis of Oxocine Derivatives by Wittig Olefination and Intramolecular Heck Reaction via 8-endo trig Cyclization.CHEMINFORM, Issue 23 2008K. C. Majumdar Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] ChemInform Abstract: Novel Synthesis of Medium-Sized Oxa-Heterocycles by Palladium-Catalyzed Intramolecular Heck Reaction.CHEMINFORM, Issue 5 2008K. C. Majumdar Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a "Full Text" option. The original article is trackable via the "References" option. [source] | ||||||||||||||||||||||||||||