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Novel Presentation (novel + presentation)

Distribution by Scientific Domains
Medical Sciences75%

Selected Abstracts

Novel presentation of intraneural nodular fasciitis of the sciatic nerve

JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM, Issue 1 2007
Brian M. Parrett
[source]

Inflammatory pseudotumor of the testis: A novel presentation of acute retroviral syndrome

INTERNATIONAL JOURNAL OF UROLOGY, Issue 4 2005
NEEMA NAVAI
Abstract Inflammatory pseudotumors are a rare entity, the etiology of which is not well understood. It has been postulated that these non-neoplastic lesions are the result of a reaction to trauma, surgery, infection or local irritation, though in many cases an underlying cause is never found. In this case, a 30-year-old man with previously undiagnosed human immunodeficiency virus presented with a 2-week history of painless right testicular mass measuring 1 × 1 cm. The patient underwent right radical orchiectomy with histopathological analysis revealing an inflammatory pseudotumor of the testis. Further work up pointed to acute retroviral syndrome as the likely cause. [source]

Sickle liver disease,An unusual presentation in a compound heterozygote for HbS and a novel ,-thalassemia mutation

AMERICAN JOURNAL OF HEMATOLOGY, Issue 9 2007
Timothy J.S. Cross
A 38-year-old Ghanaian man presented with a 6-month history of worsening pruritus, jaundice, and ascites. He was previously fit and well and rarely drank alcohol. Screening tests for chronic liver disease including viral, autoimmune, and other metabolic causes including iron overload were unremarkable. A liver biopsy performed at the referring hospital demonstrated intralobular cholestasis and cirrhosis. He was listed for liver transplantation but subsequently developed sepsis with multiple organ failure and died. The sickle solubility test was positive. Blood smear showed cells consistent with liver failure and no sickle cells. Hemoglobin electrophoresis revealed HbA2 2.8%, HbF 0.5%, and HbS greater than HbA (49.6% vs. 41.3%) in the absence of blood transfusion. Sequence analysis of the ,IVS2-844 C , A). A diagnosis of sickle hepatopathy causing decompensated cirrhosis was made. This case is unusual insomuch as this patient was asymptomatic for over 35 years and represents a novel presentation of sickle cell disease. Sickle cell disease should be considered in appropriate patients when unusual presentations of liver disease arise. Am. J. Hematol., 2007. © 2007 Wiley-Liss, Inc. [source]

The hippocampus plays a critical role at encoding discontiguous events for subsequent declarative memory expression in mice

HIPPOCAMPUS, Issue 4 2007
Frédérique Mingaud
Abstract The hypothesis that hippocampal activity at encoding is causally related to subsequent declarative memory expression is tested in the mouse, by using lidocaine inactivation of the hippocampus in combination with c-fos neuroimaging analysis. We employed a two-stage radial maze paradigm of spatial discrimination, which was previously shown to dissociate between declarative and nondeclarative expression of memory related to the same acquired material. In Stage 1 (encoding), mice learnt the constant location of food among a set of six arms (three baited, three unbaited) by being submitted repeatedly to discontiguous experiences with each arm separately ("go/no-go" discrimination). In Stage 2 (test-session), they are challenged with novel presentations of the arms, which are either combined into pairs of opposite valence ("two-choice" discrimination), or opened all six together ("six-choice" discrimination). Previous experiments have demonstrated that the "two-choice" situation is a critical test for declarative memory while "six-choice" discrimination may rely on procedural memory. We observed that (i) hippocampal activity measured by c-fos mRNA expression was increased by "go/no-go" learning, and this activation was blocked by pre-training local infusions of lidocaine; (ii) when performed just before each session of Stage 1, such inactivation spared the acquisition of "go/no-go" discrimination but produced, subsequently, a selective deficit in the "two-choice" test (not in the "six-choice" test). This study indicates that the hippocampus is "spontaneously" engaged in encoding processes necessary for long-term storage of discontiguous experiences under a form enabling flexible declarative memory expression. © 2007 Wiley-Liss, Inc. [source]