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Novel N1 (novel + n1)

Distribution by Scientific Domains
Chemistry100%

Selected Abstracts

Organocatalytic Ring Expansion of ,-Lactams to ,-Lactams Through a Novel N1,C4 Bond Cleavage.

CHEMINFORM, Issue 1 2006
Direct Synthesis of Enantiopure Succinimide Derivatives.
No abstract is available for this article. [source]

Novel N1 -(Benzyl)cinnamamidine Derived NR2B Subtype-Selective NMDA Receptor Antagonists.

CHEMINFORM, Issue 25 2003
Neil R. Curtis
Abstract For Abstract see ChemInform Abstract in Full Text. [source]

Synthesis of novel N1 -(2-furanidyl)-5-fluorouracil derivatives of ,-hydroxy(thio)phosphonates

HETEROATOM CHEMISTRY, Issue 3 2002
Guochen Chi
Several N1 -(2-furanidyl)-5-fluorouracil derivatives of ,-hydroxythiophosphonates were synthesized via oxidation by Moffatt's method of N1 -(2-furanidyl)- N3 -(hydroxyalkyl)-5-fluorouracil, followed by the addition of diethyl thiophosphite. The phosphonate products were obtained by the oxidation of the corresponding thiophosphonates with m-chloroperoxybenzoic acid. The crystal structure of compound 6a was determined by X-ray diffraction. © 2002 Wiley Periodicals, Inc. Heteroatom Chem 13:211,215, 2002; Published online in Wiley Interscience (www.interscience.wiley.com). DOI 10.1002/hc.10021 [source]

Synthesis of Novel 2,5-Disubstituted 1,3,4-Thiadiazoles for Their Potential Anticonvulsant Activity: Pharmacophoric Model Studies

ARCHIV DER PHARMAZIE, Issue 8 2009
Harish Rajak
Abstract A series of novel N1 -[5-(4-substituted phenyl)-1,3,4-thiadiazol-2-yl]- N4 -(4-substituted benzaldehyde)-semicarbazone 1,12, N1 -[5-(4-substituted phenyl)-1,3,4-thiadiazol-2-yl]- N4 -[1-(4-substituted phenyl)ethanone]-semicarbazone 13 - 16, and N1 -[5-(4-substituted phenyl)-1,3,4-thiadiazol-2-yl]- N4 -[1-(4-substituted phenyl) (phenyl) methanone]-semicarbazone 17,20 were synthesized for their anticonvulsant activity. The chemical structures of the compounds were proved by elemental and spectral (IR, 1H-NMR, 13C-NMR, and MS) analysis. The anticonvulsant potential of the compounds was investigated using maximal electroshock seizure (MES) and subcutaneous pentylenetrtrazole (scPTZ) models. Compound 19 was found to possess significant anticonvulsant activity in both the models employed for anticonvulsant evaluation. Compounds 8, 13, 15, and 16 also demonstrated a marked anticonvulsant property. The results of the present study validated that the pharmacophore model with four binding sites is essential for anticonvulsant activity. The efforts were also made to establish structure-activity relationships among the synthesized compounds. [source]