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Novel Metabolites (novel + metabolite)
Selected AbstractsA Novel Metabolite from the Hybrid Soft Coral Sinularia maxima x Sinularia polydactyla: A Biosynthetically Mixed Skeleton Linking Cembrane and Africanane Terpenoids.CHEMINFORM, Issue 23 2004Haidy Nasr Kamel Abstract For Abstract see ChemInform Abstract in Full Text. [source] Isofusidienols: Novel Chromone-3-oxepines Produced by the Endophytic Fungus Chalara sp.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 4 2008Sandra Lösgen Abstract Four novel metabolites, named isofusidienol A, B, C, and D (1,4), were produced by cultures of Chalara sp. (strain 6661), an endophytic fungus isolated from Artemisia vulgaris. The unprecedented chromone-3-oxepine structure of the compounds was established by detailed spectroscopic analysis and in the case of isofusidienol A (1) verified by an X-ray analysis. Additionally, two xanthones, known 5 and its 8-chloro derivative 6, were isolated. Presumably, 5 is the biosynthetic precursor of the isofusidienols. The isofusidienols exhibit antifungal activity against Candida albicans and antibacterial activity against gram-positive and gram-negative bacteria. Inhibition of Bacillus subtilis could be achieved with less than 0.625 ,g of 1 on 6-mm filter disks in plate diffusion assays. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008) [source] Chondrochloren A and B, New ,-Amino Styrenes from Chondromyces crocatus (Myxobacteria)EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Issue 14 2003Rolf Jansen Abstract In a screening for biologically active metabolites of the genus Chondromyces, two novel metabolites, chondrochloren A (1) and B (2), were isolated from several strains of C. crocatus. Compounds 1 and 2 are unique chloro-hydroxy-styryl amides of a highly modified C14 carboxylic acid, which comprises an unsaturated ketone, two hydroxy, two methoxy and three methyl groups. After assignment of the absolute configuration of both carbinol stereocenters by Mosher's method, NMR spectroscopic data combined with MM2 calculations allowed the prediction of the preferred conformation in solution. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003) [source] Assignments of 1H and 13C NMR spectral data for ondansetron and its two novel metabolites, 1-hydroxy-ondansetron diastereoisomersMAGNETIC RESONANCE IN CHEMISTRY, Issue 10 2006Mingyu Duan Abstract Assignments of 1H and 13C NMR chemical shifts were made by means of heteronuclear single quantum coherence (HSQC) and heteronuclear multiple bond correlation (HMBC) experiments for ondansetron, and by means of 1H- 1H correlation spectroscopy (1H- 1H COSY) and two-dimensional nuclear Overhauser effect spectroscopy (NOESY) experiments for two novel metabolites (M1 and M2) of ondansetron. These two metabolites were isolated for the first time from Mucor circinelloides. Copyright © 2006 John Wiley & Sons, Ltd. [source] Primary and secondary metabolism, and post-translational protein modifications, as portrayed by proteomic analysis of Streptomyces coelicolorMOLECULAR MICROBIOLOGY, Issue 4 2002A. R. Hesketh Summary The newly sequenced genome of Streptomyces coelicolor is estimated to encode 7825 theoretical proteins. We have mapped approximately 10% of the theoretical proteome experimentally using two-dimensional gel electrophoresis and matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry. Products from 770 different genes were identified, and the types of proteins represented are discussed in terms of their anno-tated functional classes. An average of 1.2 proteins per gene was observed, indicating extensive post-translational regulation. Examples of modification by N-acetylation, adenylylation and proteolytic processing were characterized using mass spectrometry. Proteins from both primary and certain secondary metabolic pathways are strongly represented on the map, and a number of these enzymes were identified at more than one two-dimensional gel location. Post-translational modification mechanisms may therefore play a significant role in the regulation of these pathways. Unexpectedly, one of the enzymes for synthesis of the actinorhodin polyketide antibiotic appears to be located outside the cytoplasmic compartment, within the cell wall matrix. Of 20 gene clusters encoding enzymes characteristic of secondary metabolism, eight are represented on the proteome map, including three that specify the production of novel metabolites. This information will be valuable in the characterization of the new metabolites. [source] | ||||||||||