Home About us Contact
|
Home About us Contact | ||
|
|
||
Novel Case (novel + case)
Selected AbstractsA Novel Case of L-transposition with a Right-dominant Double Aortic ArchCONGENITAL HEART DISEASE, Issue 4 2009David J. Goldberg MD ABSTRACT We describe a case of congenitally corrected transposition with a double aortic arch. This unique combination of lesions highlights the importance of a complete anatomic assessment prior to referral for surgery. [source] Microevolution in agricultural environments: how a traditional Amerindian farming practice favours heterozygosity in cassava (Manihot esculenta Crantz, Euphorbiaceae)ECOLOGY LETTERS, Issue 2 2005Benoît Pujol Abstract We demonstrate a novel case of selection for heterozygosity in nature, involving inadvertent human selection on a population of domesticated plants. Amerindian farmers propagate cassava (Manihot esculenta) clonally by cuttings. Seedlings also appear spontaneously in fields, and farmers allow them to grow, later using some for cuttings. These ,volunteers' contribute new genotypes. However, many are inbred, whereas multiplied clones are highly heterozygous. We demonstrate the selective retention of heterozygous volunteers. When farmers weeded fields, they killed small volunteers, but retained large ones. Plant size and heterozygosity were correlated, and both increased after weeding. The process we document allows maintenance of genotypically diverse and heterozygous clonal stocks. Demonstrating heterosis in nature usually requires large sample sizes, but novel features of our system allowed escape of this constraint. Traditional agroecosystems offer unusual opportunities for the microevolutionary studies required to give on-farm conservation of genetic resources a solid scientific basis. [source] A novel case of haemoglobin H disease associated with clinical and morphological characteristics of congenital dyserythropoietic anaemia type IEUROPEAN JOURNAL OF HAEMATOLOGY, Issue 4 2002M. Antonelou Abstract: We report, for the first time, an unusual case of congenital anaemia with the clinical diagnosis of haemoglobin H disease complicated by morphological features at the light and electron microscopy level very similar to those of CDA-I. The red cell indices and the globin chain biosynthetic ratio were not characteristic of the defective haemoglobin genotype. The haematological, clinical and morphological data strongly suggest the novel coexistence of the two defects in a patient. The disease is characterised by a unique dyserythropoietic phenotype of diagnostic importance, which possibly brings new data regarding the reciprocal interaction between the two diseases, especially concerning a specific abnormality in globin chain synthesis in CDA-I, as previously suggested. [source] Palladium Nanowire from Precursor Nanowire: Crystal-to-Crystal Transformation via In,Situ Reduction by Polymer Matrix,ADVANCED FUNCTIONAL MATERIALS, Issue 14 2007S. Porel Abstract Precursor nanowires of potassium palladium(II) chloride crystallized inside a poly(vinyl alcohol) film are reduced to palladium nanowires by the polymer itself under mild thermal annealing. The chemical reaction occurring in situ inside the polymer film, including byproduct formation, is investigated through electronic absorption and X-ray photoelectron spectroscopy together with atomic force and electron microscopy. The overall process can be described as a novel case of crystal-to-crystal transformation at the nanoscopic level. Optical limiting characteristics of the nanowire-embedded polymer film are explored. The fabrication procedure developed, involving chemistry inside a polymer matrix mediated by the polymer, opens up a convenient route to the fabrication of free-standing metal nanowire-embedded thin films. [source] Resolution of Menstrually Related Migraine Following Aggressive Treatment for Breast CancerHEADACHE, Issue 3 2010Todd A. Smitherman PhD (Headache 2010;50:485-496) Hormonal influences associated with the female menstrual cycle play strong roles in both migraine and particular types of breast cancer, but there is limited literature on the effects of breast cancer treatment regimens in women with migraine. The present case describes resolution of menstrually related migraine following aggressive treatment for infiltrating ductal carcinoma (neoadjuvant chemotherapy, single radical mastectomy, and locoregional radiation therapy) that was maintained with supplemental treatment using tamoxifen, an anti-estrogenic agent. This novel case is presented to stimulate further research into the hormonal mechanisms underlying migraine. [source] Light-chain-restricted plasmacellular infiltrates in necrobiosis lipoidica , a clue to an underlying monoclonal gammopathyJOURNAL OF CUTANEOUS PATHOLOGY, Issue 4 2005Adina M. Cioc Background:, Necrobiosis lipoidica (NL) is a member of the palisading granulomatous dermatitides that is associated, in most cases, with diabetes mellitus. However, there are an increasing number of cases of NL associated with other forms of systemic disease. We describe a novel case of NL associated with a light-chain-restricted plasmacellular infiltrate; subsequent investigations established an underlying monoclonal gammopathy. Methods:, Skin biopsy material was obtained and was processed in the usual fashion for hematoxylin and eosin (H&E) examination. Immunohistochemical staining was performed by utilizing kappa and lambda monoclonal antibodies (Dako Corporation, Carpentiera, CA, USA). Kappa and lambda in situ hybridization was also performed (Ventana Medical Systems, Tucson, AZ, USA). Results:, A 55-year-old woman with a 5-year history of bilateral thigh subcutaneous nodules underwent a skin biopsy, showing typical changes of NL; there was a concomitant prominent perivascular plasmacellular infiltrate. Kappa light chain restriction was observed amid the plasmacellular infiltrate. Bone marrow biopsy and immunophenotyping studies revealed a clonal plasmacytosis with kappa light chain restriction. Conclusions:, Granulomatous inflammation, including NL, may be a cutaneous paraneoplastic expression of low-grade B-cell lymphoproliferative disease in the context of an underlying plasma cell dyscrasia. [source] Self-expanding intracoronary stent for symptomatic myocardial bridgingCATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, Issue 7 2007S. Hinan Ahmed MD Abstract Myocardial bridging has been recognized as a potential cause of symptoms of angina, arrhythmias and even infarction. Various treatment strategies including beta-blockers, surgery and more recently intra-coronary stents have been used to manage bridging. We report a novel case of use of self-expanding stent for myocardial bridging in a patient with symptoms of angina and ischemia on nuclear imaging. We further present the 18-month follow up showing minima in-stent stenosis. To our knowledge, this is the first report of using a self-expanding stent in myocardial bridging. The use of self-expanding stents could be a potential treatment for symptomatic myocardial bridging. © 2007 Wiley-Liss, Inc. [source] | ||||||||||