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Novel Biomaterial (novel + biomaterial)

Distribution by Scientific Domains

Polymers and Materials Science	75%

Selected Abstracts

in vitro Evaluation of Biodegradable Poly(butylene succinate) as a Novel Biomaterial

MACROMOLECULAR BIOSCIENCE, Issue 5 2005
Haiyan Li
Abstract Summary: Poly(butylene succinate) (PBSU) can be easily synthesized by condensation polymerization of the starting materials of succinic acid and butan-1,4-diol. It has good degradability and possesses excellent processability. Due to these advantages, PBSU was first evaluated in the present study for its potential application as a novel biomaterial. The in vitro biocompatibility of the PBSU was evaluated by monitoring proliferation and differentiation of osteoblasts cultured on the PBSU film substrates for different periods. The results showed that the PBSU was biocompatible as the osteoblasts could proliferate and differentiate on the PBSU plates. In addition, the hydrolytic degradation behavior of the PBSU films in the phosphate-buffered saline (PBS) was also investigated and the results suggested that the PBSU degraded in the PBS solution with the same behavior as that of the degradable poly(, -hydroxyesters). In addition to the biocompatibility and hydrolytic degradation, some physical properties, including hydrophilicity, and mechanical and thermal properties of the PBSU substrates, were also determined and the results revealed that the PBSU was hydrophilic and ductile with excellent processability. The biocompatibility of the PBSU, together with the advantages of hydrolytic degradability, hydrophilicity, and excellent processability, indicated that PBSU has the potential to be used as a biomaterial for tissue repair. Alkaline phosphate activity of osteoblasts cultured on PBSU and TCPS substrates for different time periods. [source]

Rigid, Self-Assembled Hydrogel Composed of a Modified Aromatic Dipeptide,

ADVANCED MATERIALS, Issue 11 2006
A. Mahler
A simple dipeptide self-assembles into a biocompatible hydrogel (see figure and inside cover). This novel biomaterial is extremely simple to prepare and has a remarkable rigidity. It is very stable under extreme conditions, can be injected, and can be shaped according to the vessel it has been assembled in. The hydrogel allows a wide variety of possible biomedical applications including tissue engineering, axonal regeneration, and controlled drug release. [source]

Evaluation of a novel biomaterial for intrasubstance muscle laceration repair

JOURNAL OF ORTHOPAEDIC RESEARCH, Issue 3 2007
Bradley D. Crow
Abstract The authors compare the effects of small intestinal submucosa (SIS) treatment to suture repair with respect to histologic and functional outcomes for complete muscle lacerations in a rabbit model. The authors hypothesized that SIS treatment of full-thickness muscle belly lacerations would significantly improve muscle function, strength, and regeneration compared to the current standard-of-care treatment. Muscle belly lacerations were created in the extensor digitorum longus (EDL) of both hind limbs of each rabbit. After randomization, lacerations were left unrepaired (n,=,48) or repaired using a 4-0 Prolene modified Kessler stitch (n,=,48). A flap of SIS graft was sutured into half (n,=,24 each) of the repaired and unrepaired muscles forming four study groups. Suture repair with SIS augmentation of complete muscle lacerations resulted in healed tissue that most closely resembled normal muscle in terms of morphology and function when compared to current standard-of-care treatments. Active force production in this group reached 79% of uninjured controls 12 weeks after surgery. SIS may have important clinical advantages over suture repair alone and warrants further clinical study. © 2006 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 2007 [source]