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Nodal Flow (nodal + flow)

Distribution by Scientific Domains
Life Sciences100%

Selected Abstracts

Fluid dynamics of nodal flow and left,right patterning in development

DEVELOPMENTAL DYNAMICS, Issue 12 2008
Julyan H.E. Cartwright
Abstract The manner in which the nodal flow determines the breaking of left,right symmetry during development is a beautiful example of the application of fluid dynamics to developmental biology. Detailed understanding of this crucial developmental process has greatly advanced by the transfer of ideas between these two disciplines. In this article, we review our and others' work on applying fluid dynamics and dynamical systems to the problem of left,right symmetry breaking in vertebrates. Developmental Dynamics 237:3477,3490, 2008. © 2008 Wiley-Liss, Inc. [source]

A mutation in the zebrafish Na,K-ATPase subunit atp1a1a.1 provides genetic evidence that the sodium potassium pump contributes to left-right asymmetry downstream or in parallel to nodal flow

DEVELOPMENTAL DYNAMICS, Issue 7 2006
Elin Ellertsdottir
Abstract While there is a good conceptual framework of dorsoventral and anterioposterior axes formation in most vertebrate groups, understanding of left-right axis initiation is fragmentary. Diverse mechanisms have been implied to contribute to the earliest steps of left-right asymmetry, including small molecule signals, gap junctional communication, membrane potential, and directional flow of extracellular liquid generated by monocilia in the node region. Here we demonstrate that a mutation in the zebrafish Na,K-ATPase subunit atp1a1a causes left-right defects including isomerism of internal organs at the anatomical level. The normally left-sided Nodal signal spaw as well as its inhibitor lefty are expressed bilaterally, while pitx2 may appear random or bilateral. Monocilia movement and fluid circulation in Kupffer's vesicle are normal in atp1a1am883 mutant embryos. Therefore, the Na,K-ATPase is required downstream or in parallel to monocilia function during initiation of left-right asymmetry in zebrafish. Developmental Dynamics 235:1794,1808, 2006. © 2006 Wiley-Liss, Inc. [source]

Breaking the left,right axis: do nodal parcels pass a signal to the left?

BIOESSAYS, Issue 10 2005
Dominic Norris
In mammals, left,right symmetry is broken by a mechanically driven leftward flow of liquid at the embryonic node (nodal flow). Various models have emerged explaining how this may happen. Work from Tanaka and colleagues1 has provided a new mechanism by which nodal flow may be breaking symmetry. They describe small membrane-bound particles, which they term nodal vesicular parcels (NVPs), that are carried to the left side of the node. In the paper, they argue how signals carried within these parcels may break L,R symmetry. BioEssays 27:991,994, 2005. © 2005 Wiley Periodicals, Inc. [source]