Home About us Contact
|
Home About us Contact | ||
|
|
||
Next Time (next + time)
Selected AbstractsRobust ,, filtering for uncertain differential linear repetitive processesINTERNATIONAL JOURNAL OF ADAPTIVE CONTROL AND SIGNAL PROCESSING, Issue 3 2008Ligang Wu Abstract The unique characteristic of a repetitive process is a series of sweeps or passes through a set of dynamics defined over a finite duration known as the pass length. At the end of each pass, the process is reset and the next time through the output, or pass profile, produced on the previous pass acts as a forcing function on, and hence contributes to, the dynamics of the new pass profile. They are hence a class of systems where a variable must be expressed in terms of two directions of information propagation (from pass-to-pass and along a pass, respectively) where the dynamics over the finite pass length are described by a matrix linear differential equation and from pass to pass by a discrete updating structure. This means that filtering/estimation theory/algorithms for, in particular, 2D discrete linear systems is not applicable. In this paper, we solve a general robust filtering problem with a view towards use in many applications where such an action will be required. Copyright © 2007 John Wiley & Sons, Ltd. [source] August 2003: Reflections on a French Summer DisasterJOURNAL OF CONTINGENCIES AND CRISIS MANAGEMENT, Issue 4 2005Why were its medical consequences so serious? The heat wave of August 2003 caused a hecatomb in France. Its extent and consequences (INVS 2003) require analysis in order to understand why such a situation occurred and how to avoid that the same medical disaster will be caused in the future by identical climatic conditions. This natural disaster had no known precedent in France. The heatwave lasted for three weeks in August 2003 and led to 14800 deaths. However, the human toll of this catastrophe cannot be explained solely by the violence of the attack. Any analysis of this dramatic crisis, as for any public health threat, should take into account the agent involved, the population concerned, the specific relation between the agent and the target, and, based upon this, the crisis management needed. The analysis presented in this article, following the described line, shows that the crisis management was far from optimal. Learning from this situation should allow us to do better, next time such a climatic catastrophe occurs. A key factor is promoting adequate citizen response. [source] When Did You Last Talk With Your Legislators?JOURNAL OF THE AMERICAN ACADEMY OF NURSE PRACTITIONERS, Issue 4 2003FAANP, Jan Towers PhD January 2003 marked the beginning of the 108th Congress. If you have not yet spoken with your federal legislators about nurse practitioners (NPs), now is the time to do so. As legislators begin introducing new bills for this session of Congress, it will be important for NPs to inform their legislators about problems and issues facing them and their patients that need to be addressed. If you have never talked with your legislators, you will want to make an appointment the next time he or she comes home. Most legislators have offices in a centrally located town in their district or, in the case of senators, in the capital and in the larger metropolitan areas of the stat represent. A call to "Telephone Information" should help you to locate their offices and local phone numbers. If you have difficulty finding them, the League of Women Voters or your local Republican and Democratic headquarters should have the information you need. If you have visited your legislator, let them know that you have spoken before and that you would like to talk again. If you had a previous successful interaction the legislator may remember you with pleasure and will want to meet with you again. If possible, when visiting your congressperson, take a group of NPs with you. Be sure to let the staff know that you are a constituent. Legislators are elected to represent the people in their electoral district in government. As a result, they are particularly interested in the concerns of the population responsible for putting them in office. [source] Standardizing Emergency Department,based Migraine Research: An Analysis of Commonly Used Clinical Trial Outcome MeasuresACADEMIC EMERGENCY MEDICINE, Issue 1 2010Benjamin W. Friedman MD Abstract Objectives:, Although many high-quality migraine clinical trials have been performed in the emergency department (ED) setting, almost as many different primary outcome measures have been used, making data aggregation and meta-analysis difficult. The authors assessed commonly used migraine trial outcomes in two ways. First, the authors examined the association of each commonly used outcome versus the following patient-centered variable: the research subject's wish, when asked 24 hours after investigational medication administration, to receive the same medication the next time they presented to an ED with migraine ("would take again"). This variable was chosen as the criterion standard because it provides a simple, dichotomous, clinically sensible outcome, which allows migraineurs to factor important intangibles of efficacy and adverse effects of treatment into an overall assessment of care. The second part of the analysis assessed how sensitive to true efficacy each outcome measure was by calculating sample size requirements based on results observed in previously conducted clinical trials. Methods:, This was a secondary analysis of data previously collected in four ED-based migraine randomized trials performed between 2003 and 2007. In each of these trials, subjects were asked 24 hours after administration of an investigational medication whether or not they would want to receive the same medication the next time they came to the ED with a migraine. Odds ratios (ORs) with 95% confidence intervals (CIs), adjusted for sex and medication received, were calculated as measures of association between the most commonly used outcome measures and "would take again." The sensitivity of each outcome measure to treatment efficacy was determined by calculating the sample size that would be required to detect a statistically significant result using estimates of that outcome obtained in two clinical trials. Results:, Data from 378 subjects were used for this analysis. Adjusted ORs for association of "would take again" and other commonly used primary headache outcomes are as follows: achieving a pain-free state by 2 hours, OR = 3.1 (95% CI = 1.8 to 5.4); sustained pain-free status, OR = 4.5 (95% CI = 1.9 to 11.0); and no need for rescue medication, OR = 3.7 (95% CI = 2.1 to 6.6). An improvement on a standardized 11-point pain scale of ,33% had an adjusted OR = 5.2 (95% CI = 2.2 to 12.4). The best performing alternate outcome, ,33% improvement, correctly classified 288 subjects and misclassified 77 subjects when compared to "would take again." At least 33% improvement and pain-free by 2 hours required the smallest sample sizes, while sustained pain-free and "would take again" required many more subjects. Conclusions:, "Would take again" was associated with all migraine outcome measures we examined. No individual outcome was more closely associated with "would take again" than any other. Even the best-performing alternate outcome misclassified more than 20% of subjects. However, sample sizes based on "would take again" tended to be larger than other outcome measures. On the basis of these findings and this outcome measure's inherent patient-centered focus, "would take again," included as a secondary outcome in all ED migraine trials, is proposed. ACADEMIC EMERGENCY MEDICINE 2010; 17:72,79 © 2010 by the Society for Academic Emergency Medicine [source] Die Chemie des Katers: Alkohol und seine FolgenCHEMIE IN UNSERER ZEIT (CHIUZ), Issue 1 2007Klaus Roth Prof. Das Überfluten jeder einzelnen Zelle unseres Körpers mit einer großen Menge Ethanol führt zu Störungen im Stoffwechsel aller Organe. Dies erklärt die große Variationsbreite der Symptome nach zu großer Ethanolaufnahme. Gegen den Kater gibt es keine echte Heilung. "Chemie in unserer Zeit" empfiehlt: Viel reines Wasser gegen den Wasserverlust, eine Aspirin oder Ibuprofen gegen die pochenden Kopfschmerzen, Fruchtsaft gegen den Glucosemangel, Muttis kräftige Hühnerbrühe gegen den Elektrolytverlust, eine Vitamintablette wegen ihres sehr wirksamen Placebo-Effekts, Zuspruch und Mitleidsbekundungen der Lieben und dann , wenn der Kreislauf und die Kontrolle der unteren Extremitäten den aufrechten Gang es zulassen, einen Spaziergang an der frischen Luft. Dabei sollte man intensiv über die Sinnlosigkeit übermäßigen Trinkens nachdenken. Das hilft, und am nächsten Tag ist alles vorbei , zumindest bis zum nächsten Mal. Na dann: Helau und Alaaf! Flooding of every cell in our body with a huge amount of ethanol affects the entire metabolism of all organs. This explains the broad variation of symptoms after drinking to much. There is no real cure für hangover. "Chemie in unserer Zeit" recommends much pure water against the dehydration, aspirin or ibuprofen against the throbbing headaches, fruit juice against hypoglycemia, Mom's powerful chicken soup to compensate for electrolyte losses, a vitamine pill because of its powerful placebo-effect, compassion and words of comfort of the loved ones and finally , if blood circulation and control of the lower extremities admit an upright walk , a long stroll in fresh air. Meanwhile one should think deeply about the pointlessness of excessive drinking. This all helps and on the next day it will all be over , at least until next time. Well then: Cheers and Bottoms up! [source] | ||||||||||