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New Work (new + work)
Terms modified by New Work Selected AbstractsLatest news and product developmentsPRESCRIBER, Issue 8 2008Article first published online: 12 MAY 200 Glargine preferred to lispro as type 2 add-on Basal insulin glargine (Lantus) and insulin lispro (Humalog) at mealtimes improved glycaemic control equally well in patients with type 2 diabetes poorly controlled by oral agents, but patient satisfaction was greater with basal insulin (Lancet 2008;371:1073-84). The 44-week APOLLO trial, funded by Sanofi Aventis, was a nonblinded randomised comparison of basal and prandial insulin regimens added to oral treatment in 418 patients. It found similar reductions in HbA1C (,1.7 vs ,1.9 per cent respectively). Fasting and nocturnal glucose levels were lower with insulin glargine and postprandial levels were lower with insulin lispro. The basal regimen was associated with fewer hypoglycaemic events (5.2 vs 24 per patient per year), less weight gain (3.01 vs 3.54kg) and greater improvement in patient satisfaction scores. Treating hypertension cuts mortality in over-80s Treating hypertension in the over-80s reduces all-cause mortality by 21 per cent, the HYVET study has shown (N Engl J Med online: 31 March 2008; doi: 10.1056/NEJMoa 0801369). Compared with placebo, treatment with indapamide alone or with perindopril for an average of 1.8 years also reduced the incidence of fatal stroke by 39 per cent, cardiovascular death by 23 per cent and heart failure by 64 per cent. The incidence of stroke was reduced by 30 per cent but this was of borderline statistical significance. Fewer serious adverse events were reported with treatment than with placebo. New work for NICE The DoH has announced the 18th work programme for NICE. Seven public health interventions include preventing skin cancer, smoking by children and excess weight gain during pregnancy. Public health guidance will include the provision of contraceptive services for socially disadvantaged young people. Two new clinical guidelines are sedation in young people and management of fractured neck of femur. New technology appraisals may include eight therapies for cancer, two new monoclonal antibodies for psoriasis and rheumatoid arthritis, an oral retinoid for severe chronic hand eczema and methylnaltrexone for opioid-induced bowel dysfunction. Combinations no better against CV disease Taking ezetimibe and simvastatin (Inegy) does not appear to slow the progression of atherosclerosis more than high-dose simvastatin alone, say researchers from The Netherlands (N Engl J Med 2008;358: 1431-43). In patients with hypercholesterolaemia, there was no difference in regression or progression of atherosclerosis after two years' treatment with simvastatin 80mg per day alone or combined with ezetimibe 10mg per day. Adverse event rates were similar. In patients with vascular disease or high-risk diabetes, there was no difference between the ACE inhibitor ramipril 10mg per day or the ARB telmisartan (Micardis) 80mg per day as monotherapy, or their combination, in the risk of a composite outcome of cardiovascular death, MI, stroke and admission for heart failure (N Engl J Med 2008;358:1547-59). Combined treatment was associated with higher risks of hypotensive symptoms, syncope and renal dysfunction. Twice-daily celecoxib increases CV risk Taking celecoxib (Celebrex) twice daily carries a higher risk of cardiovascular events than the same total dose taken once daily, a metaanalysis suggests (Circulation 2008; doi: 10.1161/ CIRCULATIONAHA.108. 764530). The analysis of six placebo-controlled trials involving a total of 7950 patients taking celecoxib for indications other than rheumatoid arthritis found that the combined risk of cardiovascular death, myocardial infarction, stroke, heart failure or thromboembolic event increased with dose over the range 400-800mg per day. The risk was significantly greater with 200mg twice daily (HR 1.8) than 400mg once daily (HR 1.1). Patients at greatest baseline risk were at disproportionately increased risk from celecoxib. Long-term etanercept effective in AS An open-label study suggests that etanercept (Enbrel) remains effective in the treatment of ankylosing spondylitis in the long term (Ann Rheum Dis 2008;67:346-52). Of 257 patients who completed six months' treatment with etanercept and who entered the nonblinded extension study, 126 completed a total of 168-192 weeks' treatment. The commonest adverse events were injection-site reactions (22 per cent), headache (20 per cent) and diarrhoea (17.5 per cent). The annual rate of serious infections was 0.02 per person. Response and partial remission rates after 192 weeks were similar to those reported after 96 weeks. Metformin reduces risk Metformin reduces the risk of developing diabetes in individuals at increased risk, a meta-analysis suggests (Am J Med 2008;121:149-57.e2). The study included 31 mostly small, randomised, controlled trials involving a total of 4570 participants and lasting at least eight weeks (8267 patient-years of treatment). Metformin was associated with reductions in body mass (,5.3 per cent), fasting glucose (,4.5 per cent) and insulin resistance (,22.6 per cent); lipid profiles also improved. The odds of developing diabetes were reduced by 40 per cent,an absolute risk reduction of 6 per cent over 1.8 years. MHRA clarifies cough and colds advice Press reports mistakenly suggested that the MHRA had banned some cough and cold remedies when it issued new guidance on treating young children, the MHRA says. The Agency's advice followed a review of over-thecounter cough and cold medicines for children by the Commission on Human Medicines. Children under two are at increased risk of adverse reactions and should no longer be treated with products containing antihistamine (chlorphenamine, brompheniramine, diphenhydramine), antitussives (dextromethorphan, pholcodine), expectorants (guaifenesin, ipecacuanha) and decongestants (phenylephrine, pseudoephedrine, ephedrine, oxymetazoline and xylometazoline). The MHRA said these products, which are classified as general sale medicines, should be removed from open shelves until available in new packaging that complies with the advice. They may still be supplied by a pharmacist for the treatment of older children. Coughs and colds should be treated with paracetamol or ibuprofen for fever, a simple glycerol, honey or lemon syrup for cough, and vapour rubs and inhalant decongestants for stuffy nose. Saline drops can be used to thin and clear nasal secretions in young babies. Parents are being urged not to use more than one product at a time to avoid inadvertently administering the same constituent drug twice. Perindopril brand switch Servier Laboratories is replacing its current formulations of perindopril (Coversyl, Coversyl Plus) with a new product that is not bioequivalent. The current Coversyl brand contains perindopril erbumine (also known as tert -butylamine). The new formulation contains perindopril arginine; it will be distinguished by new brand names (Coversyl Arginine, Coversyl Arginine Plus) and new packaging. Coversyl 2, 4 and 8mg tablets are equivalent to Coversyl Arginine 2.5, 5 and 10mg. Servier says the change is part of the simplification and harmonisation of global manufacturing; the arginine salt is already used in other countries and offers greater stability and a longer shelf-life. Both Coversyl and Coversyl Arginine will be in the supply chain for the next few weeks. Generic perindopril will continue to be the erbumine salt and prescriptions for generic perindopril are not affected. New from NICE Diabetes in pregnancy: management of diabetes and its complications from preconception to the postnatal period. Clinical Guidance No. 63, March 2008 This clinical guideline focuses on additional aspects of care for women with gestational diabetes (88 per cent of cases) or pre-existing diabetes (of which about 40 per cent is type 2 diabetes) and their babies. To date, insulin aspart (NovoRapid) is the only drug in the guideline specifically licensed for use in pregnancy and NICE advises obtaining informed consent to implement its recommendations for using other insulins and oral hypoglycaemic agents. As with other guidelines, NICE begins by stressing the importance of patient-centred care and involving women in decisions about their treatment. The guideline is divided into six sections, dealing with consecutive periods of pregnancy. Preconceptual planning should include empowering women to help them reduce risks, optimising glycaemic control (after retinal assessment) and increasing monitoring intensity, and providing information about the effects of pregnancy on diabetes. Metformin may be recommended as an adjunct or alternative to insulin, but other oral hypoglycaemic agents should be replaced with insulin, although glibenclamide is an option during pregnancy. Isophane insulin is the preferred long-acting insulin; lispro (Humalog) and aspart are considered safe to use. ACE inhibitors and angiotensin-II receptor blockers should be replaced with other antihypertensive agents and statins should be discontinued. Recommendations for screening and treatment of gestational diabetes build on previous guidance (CG62). Drug treatment will be needed by 10-20 per cent , this includes insulin (soluble, aspart or lispro) and/or metformin or glibenclamide, tailored to individual need. Antenatal care includes optimising glycaemic control. Insulin lispro or aspart should be considered in preference to soluble insulin. If glycaemic control cannot be achieved with insulin injections, an insulin pump may be indicated. The guideline includes a timetable for appointments and the care that should offered after each interval. Recommendations for intrapartum care, which supplement those in CG55, include frequent monitoring of blood glucose. Neonatal care includes recommendations for monitoring and screening the infant and the management of hypoglycaemia. Postnatal care (supplementing CG37) involves adjusting maternal treatment to avoid hypoglycaemia and recommendations for returning to community care. Metformin and glibenclamide are the only oral agents suitable for breastfeeding women. Women with gestational diabetes need advice about glycaemic control and planning for future pregnancies. Lifestyle advice and measurement of annual fasting plasma glucose should be offered. Inhaled corticosteroids for the treatment of chronic asthma in adults and in children aged 12 years and over. Technology Appraisal No. 138, March 2008 The latest technology appraisal of asthma treatments covers inhaled steroids for adults and children over 12 with chronic asthma. It makes only two recommendations. First, the cheapest appropriate option is recommended. Second, when a steroid and a long-acting beta2-agonist are indicated, the decision to prescribe a combined inhaler or separate devices should take into account therapeutic need and likely adherence. Combined inhalers are currently less expensive than separate devices, though they may not remain so. When a combined inhaler is chosen it should be the cheapest. NICE concludes that, at equivalent doses, there is little difference in the effectiveness or adverse event profile of the available steroids or the fixed-dose combinations. According to specialist advice, choosing the best device for an individual remains the overriding concern. Continuous positive airway pressure for the treatment of obstructive sleep apnoea/hypopnoea syndrome. Technology Appraisal No. 139, March 2008 NICE recommends continuous positive airway pressure (CPAP) for adults with moderate or severe obstructive sleep apnoea, and for those with a milder disorder if quality of life and functioning are impaired and alternative strategies such as lifestyle change have failed. Diagnosis and treatment is the responsibility of a specialist team. A CPAP device costs £250-£550 and lasts for seven years. Copyright © 2008 Wiley Interface Ltd [source] The New Sovereignty in International Relations,INTERNATIONAL STUDIES REVIEW, Issue 3 2003David A. Lake The academic study of sovereignty is undergoing a mini-renaissance. Stimulated by criticisms of classical conceptions of sovereignty in systemic theories of politics, scholars returned to sovereignty as a topic of inquiry in the late 1980s and early 1990s. Their studies are finally bearing fruit. This essay focuses on the new conceptions of sovereignty that are emerging and (1) discusses the fundamental nature of sovereignty, (2) reviews the classical perspective on sovereignty, (3) surveys new constructivist alternatives to this classical view, (4) examines important new work on the problematic nature of sovereignty, (5) identifies continua of hierarchic relationships that make sense of the various forms of mixed or restricted sovereignty that we observe in world politics, and (6) argues why it is important to study alternative, hierarchic relationships in international relations. The principal themes throughout are that sovereignty is far more problematic than recognized in the classical model, that important elements of hierarchy exist in the global system, and that both our theories and practice of international politics would be improved by explicitly incorporating variations in hierarchy. [source] Increasing longevity through caloric restriction or rapamycin feeding in mammals: common mechanisms for common outcomes?AGING CELL, Issue 5 2009Lynne S. Cox Summary Significant extension of lifespan in important mammalian species is bound to attract the attention not only of the aging research community, but also the media and the wider public. Two recent papers published by Harrison et al. (2009) in Nature and by Colman et al. (2009) in Science report increased longevity of mice fed with rapamycin and of rhesus monkeys undergoing caloric restriction, respectively. These papers have generated considerable debate in the aging community. Here we assess what is new about these findings, how they fit with our knowledge of lifespan extension from other studies and what prospects this new work holds out for improvements in human longevity and human health span. [source] Old English Literature and Feminist Theory: A State of the FieldLITERATURE COMPASS (ELECTRONIC), Issue 6 2008Mary Dockray-Miller Feminist and gender scholars working in Anglo-Saxon studies in the past ten years have been asking new and important questions of a variety of Old English and Anglo-Latin texts. Most crucially, this interdisciplinary new work redefines the historiographical paradigms of Anglo-Saxon cultural production and reception so that women must now be regularly included in discussions of Anglo-Saxon cultural agency. This paradigm shift can and should inform broader cultural understandings of the history of gender relations, despite current communication problems among the varied subfields of medieval studies and gender studies. Furthermore, the pedagogy of both medievalists and faculty specializing in later periods must be informed by this shift as well. [source] A Holistically Deweyan FeminismMETAPHILOSOPHY, Issue 3 2001Jane Duran The argument that a holistic analysis of Dewey's work, drawing not only on the major portions subject to extensive commentary (such as Experience and Nature) but also on his aesthetics, provides fuel for feminist theorizing is sustained by advertence to the standard commentary and also to new work in aesthetic feminism itself. Sleeper, Rorty, Hickman and Russell are cited, and the recent resurgence of interest in developing the intersection between analytic aesthetics and feminist aesthetics is alluded to. It is concluded that the enterprising feminist theorist may suffer from an embarrassment of riches in attempting to approach Dewey but that such an approach is well worth the effort. [source] LIVING A DISTRIBUTED LIFE: MULTILOCALITY AND WORKING AT A DISTANCEANNALS OF ANTHROPOLOGICAL PRACTICE, Issue 1 2008Brigitte Jordan In the last few years, new collaboration and communication technologies have led to a deterritorialization of work, allowing for the rise of new work- and lifestyles. In this article, I use my own transition from the life of a corporate researcher to that of a multilocal mobile consultant for tracking some of the patterns I see in a changing cultural and economic environment where work and workers are no longer tied to a specific place of work. My main interest lies in identifying some of the behavioral shifts that are happening as people are caught up in and attempt to deal with this changing cultural landscape. Writing as a knowledge worker who now moves regularly from a work,home place in the Silicon Valley of California to another in the tropical lowlands of Costa Rica, I use my personal transition as a lens through which to trace new, emergent patterns of behavior, of values, and of social conventions. I assess the stresses and joys, the upsides and downsides, the challenges and rewards of this work- and lifestyle and identify strategies for making such a life successful and rewarding. Throughout, there emerges an awareness of the ways in which the personal patterns described reflect wider trends and cumulatively illustrate global transformation of workscapes and lifescapes. These types of local patterns in fact constitute the on-the-ground material reality of global processes that initiate and sustain widespread culture change and emergent societal transformations. [source] Outline of the International Organization for Standardization Standard for Circulatory Support Devices (ISO 14708-5)ARTIFICIAL ORGANS, Issue 9 2010Kou Imachi Abstract The rapid progress of artificial heart and circulatory support devices enables us to apply them to severe heart failure patients. Many types of circulatory support devices have been developed in the United States, Europe, and Japan. This situation urged the establishment of an International Organization for Standardization (ISO) Standard for the circulatory support devices. A new work, "Cardiac Ventricular Assist Devices," was proposed to the ISO/TC150/SC6 (TC150: Technical Committee of Implants for Surgery, SC6: Sub-committee of Active Implants) in 2000, and the work was finalized for publication at a 2009 meeting of the ISO/TC150 in Kyoto. In this article, the authors would like to introduce the ISO system and the outline of the ISO Standard for Circulatory Support Devices. [source] Subacute sclerosing panencephalitis after intrauterine infectionACTA PAEDIATRICA, Issue 9 2004M Dasopoulou Subacute sclerosing panencephalitis (SSPE), in the majority of cases, is caused by the wild measles virus, although there are some reports relating SSPE to vaccination. This paper presents an inborn that was infected during pregnancy by the measles virus and developed SSPE within the first year of life after a short incubation period. He progressed rapidly after a mild arrest with treatment. Subacute sclerosing panencephalitis is a fatal degenerative disease and, although it had largely disappeared because of nearly universal measles vaccination, it still remains a serious infection among children affected by human immunodeficiency virus (HIV). The lack of newer cases of SSPE occurring among normal children nowadays should not wane alertness by obstetricians and paediatricians, to recognize the risk with measles during pregnancy and the need for prevention and recognition of SSPE at an early stage. Although some references exist which report on SSPE cases related to vaccination, new work weakens the possible links between measles vaccine and SSPE. Conclusion: This report would like to stress the importance and success of reducing the SSPE problem with the aid of general measles vaccination with high coverage. [source] Technology and the World the Slaves MadeHISTORY COMPASS (ELECTRONIC), Issue 2 2006Robert Gudmestad The study of American slavery is a crowded field and each year the historical profession witnesses the publication of several new books. Despite this steady onslaught of scholarship, significant gaps remain in our understanding of slavery and its influence on the South. One area that has lacked sustained attention is the nexus of slavery and technological development. Several new books demonstrate that changes in technology profoundly altered the lives and labor of slaves. Historians have approached the presence of technology in a slave society from several different traditions. Some scholars argued that plantation development and mechanical progress were difficult to wed together, while others noted the progressive nature of southern agricultural production, but discussions of white attitudes and behavior overshadowed the effects of machinery on the lives of slaves. An innovative approach has emphasized the employment of slaves in factories, but such works have done little to provide insight into how technological innovation influenced plantation slaves. Several new studies have reversed these trends and promise to lead us in important directions. Examinations of the cotton gin, steamboats, sugar plantations, and clocks have revealed that technology brought enormous change to the bulk of slaves, not just those living in urban areas or working in factories. Patterns and practices of work, opportunities for autonomy, and time away from the master's unstinting gaze, all changed because of mechanical innovation. Taken together, these new works also provide clues to the making and remaking of the southern economy and society. [source] Finding fame: painting and the making of careers in Renaissance ItalyRENAISSANCE STUDIES, Issue 1 2010Michelle O'Malley Most of the papers in this collection consider issues concerning the design and function of objects; they address their intended sites, the requirements of their owners and the import they held for their users. The objects made by artists and artisans were also nexus points in their careers: objects stood as much for their makers as for their owners. They constituted connections between artists and their clients, and they often acted as agents for the creation of new objects. This paper looks at the design and function of works of art from the point of view of the profession. Specifically, it considers the role key commissions played in the creation of reputations and the launch of stellar careers. Looking at the very early careers of Botticelli, Ghirlandaio and Perugino, the paper investigates connections among clients and the paths individuals took to hiring the painters, examines the response the painters made to their early commissions, and looks at the associations and reputations these painters built up in the years before they were hired to paint the walls of the Sistine chapel in 1481. It considers the role of Cosimo Rosselli, the fourth member of the Sistine team, in identifying and defining fame, and proposes a new way of considering the route Florentine painters took to painting the chapel newly built by Sixtus IV. The paper aims to demonstrate the significance of works for the trajectory of their makers' professional lives and to suggest how certain works, in specific contexts, attracted clients and drew new works into being. [source] | |||||||||||||