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New Technologies (new + technology)
Selected AbstractsTHE DOUBLE ROLE OF SKILLED LABOR, NEW TECHNOLOGIES AND WAGE INEQUALITYMETROECONOMICA, Issue 1 2005Hartmut Egger ABSTRACT We examine the relationship between the supply of skilled labor, technological change and relative wages. In accounting for the role of skilled labor in both production activities and productivity- enhancing ,support' activities we derive the following results. First, an increase in the supply of skilled labor raises the employment share of non-production labor within firms, without lowering relative wages. Second, new technologies raise wage inequality only in so far as they give incentives to firms to reallocate skilled labor towards non-production activities. In contrast, skill-biased technological change of the sort usually considered in the literature does not affect wage inequality. [source] Anthropology and the New Technologies of CommunicationCULTURAL ANTHROPOLOGY, Issue 3 2006Brian Keith Axel This article is a set of reflections on how a modern linguistic ideology of communication produces a fundamental misrecognition of the formation of the modern liberal subject as a naturally communicating subject. I explore the complex features of this misrecognition as a legacy of Cold War procedures of knowledge production about communication and technology to suggest that ethnographies of new technologies of communication unwittingly proliferate presumptions about the ontological integrity of the human prior to communication and prior to the advent of technologies of communication. This dilemma offers an alternative point of departure for the study of new technologies of communication in pursuit of a renewed, critical investigation into the circulation of modern cultural forms of intelligibility. [source] Globalization, Societal Change, and New Technologies: What They Mean for the Future of AdolescenceJOURNAL OF RESEARCH ON ADOLESCENCE, Issue 1 2002Reed W. Larson Nations around the world are undergoing rapid changes that are altering the nature of adolescence in their societies. This volume examines current trends in adolescent experience across nations, with the objective of identifying emerging problems and opportunities in adolescents' preparation for adulthood. This introduction reviews methods used by futurists and how these methods are applicable to adolescence, and provides an overview of some of the macrochanges that are shaping the societies in which adolescents of the future will live. The macrochanges considered include demographic trends, globalization, trends in government, and changes in technology. Subsequent articles in this volume examine how these and other changes are altering adolescents' transition to adult work, preparation for adult interpersonal lives, civic and community engagement, and health and well-being. The final article focuses on social policy and is followed by a conclusion with the main points and trends in the volume. [source] Using Acquired Knowledge and New Technologies in Alcoholism Treatment TrialsALCOHOLISM, Issue 3 2002Barbara A. Flannery This article represents the proceedings of a symposium held at the 2001 RSA meeting in Montreal, Canada. The organizer and chair was Barbara A. Flannery and the discussant was Raye Z. Litten. The presentations were (1) The use of biomarkers in alcohol-dependence treatment trials, by John P. Allen; (2) Strategies for enhancing patient compliance in clinical treatment trials, by Helen M. Pettinati; (3) The predictive utility of an alcohol-craving measure, by Barbara A. Flannery; (4) What should be the primary outcome measures in a clinical trial, by Damaris J. Rohsenow; (5) Innovative strategies for assessing functional outcomes in alcoholism treatment clinical trials, by Ron A. Cisler. [source] Learning the New Technologies: Strategies for SuccessNEW DIRECTIONS FOR ADULT & CONTINUING EDUCATION, Issue 98 2003Kathleen P. King Educators of adults come to professional development in educational technology with many needs and concerns. The model presented in this chapter provides principles, insights, and strategies to meet these needs and prepare educators for lifelong learning in this challenging area. [source] 3rd Workshop on Semiconductor Nanodevices and Nanostructured Materials (NanoSemiMat-3)PHYSICA STATUS SOLIDI (C) - CURRENT TOPICS IN SOLID STATE PHYSICS, Issue S2 2004E. F. da Silva Jr. The 3rd Workshop on Semiconductor Nanodevices and Nanostructured Materials (NanoSemiMat-3) took place in Salvador, Bahia, Brazil, 24,27 March 2004. The NanoSemiMat network is part of the Brazilian Initiative on Nanoscience and Nanotechnology (N&N). The papers include the following topics: Photodetectors, Lasers and LEDs, Porous Materials, New Materials, New Technologies, Molecular Technology and Interfaces, Nanostructured Materials and Nanobiotechnology. The presentations reflect theoretical and experimental research on nanostructured semiconductor materials such as III,V and II,VI, Si and SiC based nanodevices, wide gap materials, ceramics, polymers, porous materials, optical and transport properties of low-dimensional structures, magnetic nanostructures and structures under the influence of high fields, spintronics and sensor applications. This issue is devoted to Prof. J. R. Leite, Sao Paulo, former Regional Editor of physica status solidi and Guest Editor in memoriam of the present Proceedings. [source] Preface: phys. stat. sol. (c) 1/S2PHYSICA STATUS SOLIDI (C) - CURRENT TOPICS IN SOLID STATE PHYSICS, Issue S2 2004E. F. da Silva Jr. The papers in this special issue of physica status solidi (c) are selected manuscripts including diverse research lines presently in development in the ambit of the NanoSemiMat network in Brazil. The 3rd Workshop on Semiconductor Nanodevices and Nanostructured Materials (NanoSemiMat-3) took place in Salvador, Bahia, Brazil, at the Catussaba Resort Hotel, during the period of 24,27 March 2004. The NanoSemiMat network is part of the Brazilian Initiative on Nanoscience and Nanotechnology (N&N), with strategic cooperative research support in this area. The initiative started in 2001, through the formation of four research networks nationwide in different scientific fields associated to NanoScience and Nanotechnology (N&N). The 3rd Workshop on Nanodevices and Nanostructured Materials (NanoSemiMat-3) is an evolution of the two previous meetings which were held in Recife, PE, Brazil and Natal, RN, Brazil in 2002 and 2003, respectively. The meeting comprised 16 invited plenary talks, each 30 minutes long, given by eminent researchers from Brazil, Canada, France, Germany and the United States of America. These invited talks extend through different topics of N&N associated to Nanodevices and Nanostructured Materials: Photodetectors, Lasers and LEDs, Porous Materials, New Materials, and New Technologies, among others. There were short talks presented by representatives of the other N&N networks in Brazil dealing with Molecular Technology and Interfaces, Nanostructured Materials and Nanobiotechnology. Also a poster session, with about 60 presentations, highlighted the main research activities presently being developed by the network members at the different sites which constitute the NanoSemiMat network. The presentations reflected theoretical and experimental research lines which lead to the development of basic and applied research in nanostructured semiconductor materials such as III,V and II,VI, Si and SiC based nanodevices, wide gap materials, ceramics, polymers, porous materials, optical and transport properties of low dimensional structures, magnetic nanostructures and structures under the influence of high fields, spintronics and sensor applications. The participants of the workshop came from 20 research institutions within Brazil and from 7 research laboratories and universities in Europe and North America. In total about 120 researchers, members of the network, invited researchers, representatives of supporting and funding agencies in Brazil, undergraduate and graduate students, technical staff and supporting personal as well as researchers from complementary fields were present. The realization of the NanoSemiMat-3 was possible due to the financial support of the Brazilian Ministry of Science and Technology (MCT) and the Brazilian National Research Council (CNPq) and the logistic support of Federal University of Bahia. All activities during the NanoSemiMat-3 were open to the general public with interest in nanoscience and nanotechnology. In this third workshop of the series, we highlight the expansion of its format, with plenary and invited talks, poster sessions, as well as the presence of seven invited speakers from abroad. We expect that the continuation of the NanoSemiMat series will be a forum for discussions of state-of-the-art research developed in Brazil on N&N and the multidisciplinary field of semiconductor nanodevices and nanostructured materials as well as its superposition to other branches of science. (© 2004 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim) [source] SMEs and New Technologies: Learning E-Business and Development.R & D MANAGEMENT, Issue 3 2008By Banji Oyelaran-Oyeyinka, Kaushalesh Lal No abstract is available for this article. [source] Proteomics: Recent Applications and New TechnologiesBASIC AND CLINICAL PHARMACOLOGY & TOXICOLOGY, Issue 5 2006Mollisa M. Elrick Proteomic analyses have recently been conducted on tissues, biofluids, subcellular components and enzymatic pathways as well as various disease and toxicological states, in both animal models and man. In addition, several recent studies have attempted to integrate proteomics data with genomics and/or metabonomics data in a systems biology approach. The translation of proteomic technology and bioinformatics tools to clinical samples, such as in the areas of disease and toxicity biomarkers, represents one of the major opportunities and challenges facing this field. An ongoing challenge in proteomics continues to be the analysis of the serum proteome due to the vast number and complexity of proteins estimated to be present in this biofluid. Aside from the removal of the most abundant proteins, a number of interesting approaches have recently been suggested that may help reduce the overall complexity of serum analysis. In keeping with the increasing interest in applications of proteomics, the tools available for proteomic analyses continue to improve and expand. For example, enhanced tools (such as software and labeling procedures) continue to be developed for the analysis of 2D gels and protein quantification. In addition, activity-based probes are now being used to tag, enrich and isolate distinct sets of proteins based on enzymatic activity. One of the most active areas of development involves microarrays. Antibody-based microarrays have recently been released as commercial products while numerous additional capture agents (e.g. aptamers) and many additional types of microarrays are being explored. [source] New Technology and Methodologies for Intraoperative, Perioperative, and Intraprocedural Monitoring of Surgical and Catheter Interventions for Congenital Heart DiseaseECHOCARDIOGRAPHY, Issue 8 2002Mary J. Rice M.D. We review the new technology and methods available for support of intraoperative and intraprocedural imaging in the catheterization laboratory for surgical and interventional catheterization procedures in the treatment of congenital heart disease. The methods reviewed include miniaturized probes and new ways of using them perioperatively for cardiac imaging from transesophageal, substernal, and intracardiac imaging locations. The smaller and more versatile the probes, the better adapted they will be in providing methods to improve the outcomes in babies born with serious forms of congenital heart disease. [source] ,Download': ,Postcards Home' Contemporary Art and New Technology in the Primary SchoolINTERNATIONAL JOURNAL OF ART & DESIGN EDUCATION, Issue 1 2005Steve Herne ,Postcards Home' using photography, scanning, digital image manipulation, text and colour printing was the third ,Download' project devised by the education department of the Whitechapel Art Gallery, London, England. It was led by artist Laurie Long with teachers and pupils from Pooles Park primary school in Islington, an inner city borough in North London. Based on the production of a postcard featuring an image of personal significance, the children were involved in exploring and constructing their own and others' identities whilst developing their technology skills in creative ways. The project raises interesting questions about the applicability of contemporary art practices to the primary classroom. The research is based on participant observation and includes the voices of the artist and teachers involved. [source] Applicant and Recruiter Reactions to New Technology in Selection: A Critical Review and Agenda for Future ResearchINTERNATIONAL JOURNAL OF SELECTION AND ASSESSMENT, Issue 2-3 2003Neil AndersonArticle first published online: 30 JUL 200 This paper presents a narrative review of recent research into applicant and recruiter reactions to new technology in employee selection. Different aspects of the use of new technology are noted including computer-based testing, Internet-based recruitment and candidate assessment, telephone-based and video-based interviews, video-based situational judgment tests, and virtual reality scenarios. It is argued that an appropriate way to conceptualize these advances is as ,technical innovations' as defined in the creativity and innovation research in Industrial, Work, and Organizational (IWO) psychology. Applicant reactions research is reviewed thematically, and studies into three main themes are discussed: Applicant preferences and reactions, equivalence, and adverse impact. Following Bartram (2001), an amphibian-monarchistic analogy is employed at several stages in the review. Four major criticisms of the extant applicant reactions research base are noted: its atheoretical orientation, a short-termist concentration upon reactions level outcomes, an over-reliance on students as surrogates, and a patchiness of coverage of crucial research questions. The second part of this paper explores neglected issues of recruiter adoption of new technology for employee selection. Again drawing from advances in the innovation and creativity literatures, this section explores likely antecedent factors at the individual and organizational levels of analysis. A general model of recruiter adoption of new technology is posited as a framework for future research in this area. For both applicant and recruiter reactions further research is called for and implications for practice are noted throughout. [source] Factors Affecting Training Effectiveness in the Context of the Introduction of New Technology,A US Case StudyINTERNATIONAL JOURNAL OF TRAINING AND DEVELOPMENT, Issue 4 2001Constantine Kontoghiorghes The purpose of this exploratory study was to identify the key factors within and outside the training context that could affect training effectiveness. The most important variables that were found to facilitate trainee learning and training transfer are: measurement of trainee knowledge before and immediately after training; supervisory support and encouragement for the application of new skills and knowledge; intrinsic rewards for applying newly learned skills and knowledge; a participative/sociotechnical organisation that is characterised by a high degree of employee involvement; and, a continuous learning environment that encourages frequent participation in multiskill training and retraining programs. [source] Improved bioluminescent enzyme immunoassay for the rapid detection of Salmonella in chicken meat samplesLETTERS IN APPLIED MICROBIOLOGY, Issue 5 2005S. Fukuda Abstract Aims:, To evaluate an improved bioluminescent enzyme immunoassay (BEIA) using biotinylated firefly luciferase for the rapid detection of Salmonella in naturally contaminated chicken meat samples. Methods and Results:, Capture agents and lipopolysaccharide (LPS) extraction reagents for Salmonella were investigated to improve the sensitivity of the BEIA. Also, the use of Oxoid SPRINT (Simple Pre-enrichment and Rapid Isolation New Technology) as a pre-enrichment and selective medium for 26-h BEIA detection of Salmonella in chicken meat samples was examined. The use of polymyxin B as a capture agent on solid support and 3-[(3-Cholamidopropyl) dimethylammonio] propanesulfonic acid (CHAPS) for extraction of the LPS facilitated sensitive detection of Salmonella. Of 120 chicken meat samples, 25 samples were positive using the improved BEIA with the SPRINT and 25 samples were positive using the SPRINT followed by the standard isolation methods. Conclusions:, The improved BEIA, in which polymxin B was used as a capture agent and CHAPS was used for extraction of the antigen, had a sensitivity of 96·0% and a specificity of 98·9% for the detection of Salmonella in chicken meat. Significance and Impact of the Study:, The improved BEIA combined with the SPRINT medium for the detection of Salmonella in chicken meat samples produced comparable results to the culture methods in 26 h. [source] New Technology in Schools: Is There a Payoff?,THE ECONOMIC JOURNAL, Issue 522 2007Stephen Machin Despite its high relevance to current policy debates, estimating the causal effect of Information and Communication Technology (ICT) investment on educational standards remains fraught with difficulties. We exploit a change in the rules governing ICT funding across different school districts of England to devise an Instrumental Variable strategy to identify the causal impact of ICT expenditure on pupil outcomes. The approach identifies the effect of being a ,winner' or a ,loser' in the new system of ICT funding allocation to schools. Our findings suggest a positive impact on primary school performance in English and Science, though not for Mathematics. [source] Adoption and Diffusion of New Technology in Agriculture: Genetically Modified Corn and SoybeansCANADIAN JOURNAL OF AGRICULTURAL ECONOMICS, Issue 4 2002Bernard Hategekimana [source] Ethical problems in cytologyCYTOPATHOLOGY, Issue 1 2004. Znidar Great advances in medical science have raised a number of ethical issues, many of which affect cytopathology. Some of the main issues addressed in this paper relate to the organization of a cytology laboratory: internal and external quality control, adequate staffing levels and staff education, cytopathology reporting format and contents, confidentiality issues, relationship with the clinicians and involvement of cytopathologists in clinical management teams. Quality control has to be provided within cytology departments but external quality assurance is also essential, with national monitoring. New technologies should be used according to the best scientific methods, following cytological analysis. Scientific work in cytology has to respect the general principles of scientific ethics. The patient's interest has to be the main reason for such work. [source] New technologies in self-help: another effective way to get better?EUROPEAN EATING DISORDERS REVIEW, Issue 3 2003Chris WilliamsArticle first published online: 25 APR 200 First page of article [source] New genomic avenues in behavioural neuroendocrinology ,EUROPEAN JOURNAL OF NEUROSCIENCE, Issue 3 2002S. L. Lightman Abstract Neuroendocrine systems play a key role not only in the maintenance of whole-body homeostasis but also as the link between behavioural, endocrine and autonomic responses to environmental stimuli. It is becoming increasingly clear that neuroendocrine regulatory mechanisms are under the control of a combination of factors including genetic background, environment and early-life programming. Patterns of gene expression are increasingly being used to provide information on the genotypes associated with particular behaviours, and modulation of specific parts of the genome allow investigation of the contribution of particular genes. The sequencing of the genome provides a unique opportunity to elucidate the genetic contribution to neuroendocrine and behavioural processes, and to investigate the interactions between genetic and environmental factors. Although drugs can be used to activate or inhibit neurotransmitters and receptors, they lack specificity. New technologies now permit the activation or inactivation of both neurotransmitters and receptors in specific areas of the brain for defined periods, including crucially important developmental windows when activation appears to have long-term consequences. The future challenges are to define the critical mechanisms through which the genetic constitution of an individual human or experimental animal interacts with environmental cues to result in altered physiological or even pathological behaviour and endocrine function. [source] Preferential flow and transport in soil: progress and prognosisEUROPEAN JOURNAL OF SOIL SCIENCE, Issue 1 2008B. E. Clothier Summary Soil is the first filter of the world's water; its buffering and filtering determine the quality and quantity of our reserves of subterranean and surface water. Preferential flow can either enhance, or curtail, the capacity of the soil to buffer and filter, and it can compromise, or boost, other ecosystem services. We ask ,when do preferential flow and transport matter?' We identify 12 of 17 ecosystem services that benefit from preferential flow and three that are affected detrimentally. We estimate by simple arithmetic the value of preferential flow to ecosystem services to be globally some US$304 billion (109) per year. We review the 1989 Monte Veritą meeting on preferential flow processes and summarize the 2006 presentations, some of which are published in this issue of the Journal. New technologies and innovative experiments have increased our understanding of the conditions that initiate and sustain preferential flows. We identify contemporary exigencies, and suggest avenues for their resolution. We are progressing through observation-led discovery. Our prognosis is that new data will enable us to develop better models, and more aptly to parameterize existing models, and thereby predict the impact, benefits and detriments of preferential flow in soil. [source] The New Economy and the Work,Life Balance: Conceptual Explorations and a Case Study of New MediaGENDER, WORK & ORGANISATION, Issue 1 2003Diane Perrons Given the varied claims made about the new economy and its implications for the organization of work and life, this article critically evaluates some conceptualizations of the new economy and then explores how the new media sector has materialized and been experienced by people working in Brighton and Hove, a new media hub. New technologies and patterns of working allow the temporal and spatial boundaries of paid work to be extended, potentially allowing more people, especially those with caring responsibilities, to become involved, possibly leading to a reduction in gender inequality. This article, based on 55 in-depth interviews with new media owners, managers and some employees in small and micro enterprises, evaluates this claim. Reference is made to the gender-differentiated patterns of ownership and earnings; flexible working patterns, long hours and homeworking and considers whether these working patterns are compatible with a work,life balance. The results indicate that while new media creates new opportunities for people to combine interesting paid work with caring responsibilities, a marked gender imbalance remains. [source] Enhancing technology development through integrated environmental analysis: Toward sustainable nonlethal military systemsINTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT, Issue 2 2010Oral S. Saulters Abstract New technologies are not only critical in supporting traditional industrial and military success but also play a pivotal role in advancing sustainability and sustainable development. With the current global economic challenges, resulting in tighter budgets and increased uncertainty, synergistic paradigms and tools that streamline the design and dissemination of key technologies are more important than ever. Accordingly, a proactive and holistic approach can facilitate efficient research, design, testing, evaluation, and fielding for novel and off-the-shelf products, thereby assisting developers, end users, and other diverse stakeholders in better understanding tradeoffs in the defense industry and beyond. By prioritizing mechanisms such as strategic life-cycle environmental assessments (LCEA); programmatic environment, safety, and occupational health evaluations (PESHE); health hazard assessments (HHA); and other innovative platforms and studies early within systems engineering, various nonlethal military technologies have been successfully developed and deployed. These efforts provide a framework for addressing complex environment, safety, and occupational health risks that affect personnel, infrastructure, property, socioeconomic, and natural/cultural resources. Moreover, integrated, comprehensive, multidisciplinary, and iterative analyses involving flexible groups of specialists/subject matter experts can be applied at various spatiotemporal scales in support of collaborations. This paper highlights the Urban Operations Laboratory process utilized for inclusive and transformative environmental analysis, which can translate into advantages and progress toward sustainable systems. Integr Environ Assess Manag 2010;6:281,286. © 2009 SETAC [source] New technologies for chemical geneticsJOURNAL OF CELLULAR BIOCHEMISTRY, Issue S37 2001Leslie A. Walling Abstract Chemical genetics, in which small molecules are used in lieu of mutations to study biological processes, requires large and diverse chemical libraries to specifically perturb different biological pathways. Here we describe a suite of technologies that enable chemical libraries prepared by split-pool solid phase synthesis to be screened in a diverse range of chemical genetic assays. Compounds are synthesized on 500 micron high-capacity polystyrene beads, and arrayed into individual wells of 384-well plates using a hand-held bead arrayer. Compounds are cleaved from synthesis beads using a chemically-resistant ceramic dispensing system, producing individual stock solutions of single compounds. Nanoliter volumes of these solutions are then transferred into assay plates using an array of stainless steel pins mounted on a robotic arm. We have designed reusable 1536- and 6144-well assay plates made of silicone rubber that can be cast in the laboratory and filled by hand. This integrated technology platform enables hundreds of biological assays to be performed from the product of a single synthesis bead, enabling the results of different chemical genetic experiments to be directly compared. J. Cell. Biochem. Suppl. 37: 7,12, 2001. © 2002 Wiley-Liss, Inc. [source] Use and Standardisation of Mauritian Creole in Electronically Mediated Communication1JOURNAL OF COMPUTER-MEDIATED COMMUNICATION, Issue 3 2009Aaliya Rajah-Carrim New technologies have affected language use and attitudes in many communities. Kreol, a French-lexified Creole and the nonstandardised first language of the majority of Mauritians, is now gaining ground as a written language in the specific context of electronic-mediated communication. This has led to the emergence of writing norms among users of the language. These norms are founded on etymological phonemic and mixed conventions. This study based on data gathered through questionnaires analyses the attitudes of 66 young Mauritians towards the three orthographies used in electronically mediated communication and the standardisation of the language in new technologies. It also briefly discusses some of the spelling conventions used in Internet postings. I show that the etymological system is perceived as most readable, learnable and closest to French. Users believe that Kreol can act as a unifying factor among different ethnolinguistic groups in Mauritius. Responses also highlight the potential of users and electronic-mediated communication in bringing about the standardisation of Kreol. [source] Consumer Awareness and Willingness to Pay for High-Pressure Processing of Ready-to-Eat FoodJOURNAL OF FOOD SCIENCE EDUCATION, Issue 2 2009Doris T. Hicks ABSTRACT:, Commercial, nonthermal processing of food, such as high hydrostatic-pressure processing (HPP), has increased. The safety and quality of foods produced by HPP has not been well communicated to the public. An online, nationwide consumer survey was implemented to assess awareness of alternative food processing technologies, consumer food safety attitudes and knowledge, and willingness to pay (WTP) for HPP products. The consumer survey was administered by ZoomerangŌ, an online survey clearinghouse. The survey was completed by 1204 adults. Frequencies and crosstabs were calculated on Zoomerang and SPSS used for one-way ANOVA and chi-square analyses. The survey assessed knowledge of HPP, attitudes about new food processing techniques, WTP for HPP foods and demographics. Overall, many demographic characteristics reflected U.S. census population. While traditional methods, that is, canning, freezing, and microwaving were all well recognized by over 80% of respondents, only 8% recognized HPP. Trends indicated an increase in age, education, and income reflected greater food safety knowledge. Regardless of demographics, no survey respondent exhibited knowledge mastery (80%). Given an explanation of HPP and its benefits, 39% of respondents indicated they would be WTP an additional cost, with higher income and education having the most impact. Majority of respondents indicated a WTP of $0.25 to $0.50 regardless of the value of the food product. More respondents were WTP slightly more for a more expensive product. New technologies often encounter a stumbling block in consumer acceptance and processing costs. A consumer's WTP, once they were informed, could encourage industry to look favorably on this technology. [source] Molecular genetics of bipolar disorder and depressionPSYCHIATRY AND CLINICAL NEUROSCIENCES, Issue 1 2007TADAFUMI KATO md Abstract, In this review, all papers relevant to the molecular genetics of bipolar disorder published from 2004 to the present (mid 2006) are reviewed, and major results on depression are summarized. Several candidate genes for schizophrenia may also be associated with bipolar disorder: G72, DISC1, NRG1, RGS4, NCAM1, DAO, GRM3, GRM4, GRIN2B, MLC1, SYNGR1, and SLC12A6. Of these, association with G72 may be most robust. However, G72 haplotypes and polymorphisms associated with bipolar disorder are not consistent with each other. The positional candidate approach showed an association between bipolar disorder and TRPM2 (21q22.3), GPR50 (Xq28), Citron (12q24), CHMP1.5 (18p11.2), GCHI (14q22-24), MLC1 (22q13), GABRA5 (15q11-q13), BCR (22q11), CUX2, FLJ32356 (12q23-q24), and NAPG (18p11). Studies that focused on mood disorder comorbid with somatic symptoms, suggested roles for the mitochondrial DNA (mtDNA) 3644 mutation and the POLG mutation. From gene expression analysis, PDLIM5, somatostatin, and the mtDNA 3243 mutation were found to be related to bipolar disorder. Whereas most previous positive findings were not supported by subsequent studies, DRD1 and IMPA2 have been implicated in follow-up studies. Several candidate genes in the circadian rhythm pathway, BmaL1, TIMELESS, and PERIOD3, are reported to be associated with bipolar disorder. Linkage studies show many new linkage loci. In depression, the previously reported positive finding of a gene,environmental interaction between HTTLPR (insertion/deletion polymorphism in the promoter of a serotonin transporter) and stress was not replicated. Although the role of the TPH2 mutation in depression had drawn attention previously, this has not been replicated either. Pharmacogenetic studies show a relationship between antidepressant response and HTR2A or FKBP5. New technologies for comprehensive genomic analysis have already been applied. HTTLPR and BDNF promoter polymorphisms are now found to be more complex than previously thought, and previous papers on these polymorphisms should be treated with caution. Finally, this report addresses some possible causes for the lack of replication in this field. [source] Taxes, Time, and Support for SecurityPUBLIC BUDGETING AND FINANCE, Issue 2 2008AMY K. DONAHUE New technologies have been developed in response to terrorism. These present problems for local officials: implementing technologies will be expensive, and no technologies exist that can be used to gauge demand. We apply contingent valuation methodologies to determine support for additional taxes to pay for new terrorism-related technologies and services. We present findings from a national survey about people's attitudes toward terrorism prevention and response. We find that respondents generally support new services and technologies and local tax increases to pay for them. We also find that respondents are willing to pay more if programs have everyday uses that would enhance public safety, but are less supportive as inconveniences increase. [source] New technologies, organisation and age: firm-level evidence,THE ECONOMIC JOURNAL, Issue 509 2006Patrick Aubert We investigate the relationships between new technologies, innovative workplace practices and the age structure of the workforce in a sample of French firms. We find evidence that the wage-bill share of older workers is lower in innovative firms and that the opposite holds for younger workers. This age bias affects both men and women. It is also evidenced within occupational groups. More detailed analysis of employment inflows and outflows shows that new technologies essentially affect older workers through reduced hiring opportunities. In contrast, organisational innovations mainly affect their probability of exit, which decreases much less than for younger workers following reorganisation. [source] Cone-beam computed tomography of the maxillofacial region,an updateTHE INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY, Issue 4 2009Chung How Kau Abstract Background During the last few years, craniomaxillofacial diagnosis of the head has been confronted with an increasing number of innovations and improvements. The main progress occurred following the introduction of cone-beam technology in computed tomography in the 1990s. The number of manufacturers and devices using this technology for the maxillofacial region is growing rapidly and they are now becoming readily available. Materials This article focuses on cone-beam computed tomography (CBCT) devices applied to the maxillofacial region. CBCT serves as a bridge from two dimensions (2D) to three dimensions (3D), with lower irradiation than conventional CT. Different manufacturers and models are now available to satisfy the different needs of clinicians. Results A recent review of the manufacturers found 23 CBCT devices on the market. The specifications, applications and other issues of currently available CBCT devices are presented and discussed. Conclusions 3D imaging is developing at a very fast pace. New technologies and machines are emerging and CBCT is becoming readily available. Due to the growing demand for the technology based on the needs of clinicians, there is now a wide and growing selection of devices on the market. Some of the new advances now mean that CBCT imaging should be a well-considered option in maxillofacial imaging. Copyright © 2009 John Wiley & Sons, Ltd. [source] Marking high-technology market evolution through the foci of market stories: the case of local area networksTHE JOURNAL OF PRODUCT INNOVATION MANAGEMENT, Issue 6 2002Vasilis Theoharakis Previous research suggests that changing consumer and producer knowledge structures play a role in market evolution and that the sociocognitive processes of product markets are revealed in the sensemaking stories of market actors that are rebroadcasted in commercial publications. In this article, the authors lend further support to the story-based nature of market sensemaking and the use of the sociocognitive approach in explaining the evolution of high-technology markets. They examine the content (i.e., subject matter or topic) and volume (i.e., the number) of market stories and the extent to which content and volume of market stories evolve as a technology emerges. Data were obtained from a content analysis of 10,412 article abstracts, published in key trade journals, pertaining to Local Area Network (LAN) technologies and spanning the period 1981 to 2000. Hypotheses concerning the evolving nature (content and volume) of market stories in technology evolution are tested. The analysis identified four categories of market stories,technical, product availability, product adoption, and product discontinuation. The findings show that the emerging technology passes initially through a ,technical-intensive' phase whereby technology related stories dominate, through a ,supply-push' phase, in which stories presenting products embracing the technology tend to exceed technical stories while there is a rise in the number of product adoption reference stories, to a ,product-focus' phase, with stories predominantly focusing on product availability. Overall story volume declines when a technology matures as the need for sensemaking reduces. When stories about product discontinuation surface, these signal the decline of current technology. New technologies that fail to maintain the ,product-focus' stage also reflect limited market acceptance. The article also discusses the theoretical and managerial implications of the study's findings. [source] | ||||||||||||||||||||||||||||||||||||||||