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New Synthetic Strategies (new + synthetic_strategy)
Selected AbstractsEfficient C,C Double-Bond Formation Reaction via a New Synthetic Strategy: A Self-Sorting Tandem Reaction.CHEMINFORM, Issue 40 2006Guodong Yin Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF. [source] Merging Organic and Polymer Chemistries to Create Glycomaterials for Glycomics ApplicationsMACROMOLECULAR BIOSCIENCE, Issue 8 2006Géraldine Coullerez Abstract Summary: Oligosaccharides at cell surfaces are known to play a critical role in many biological processes such as biorecognition, interactions between cells and with artificial surfaces, immune response, infection and inflammation. In order to facilitate studies of the role of sugars, an increasing number of novel tools are becoming available. New synthetic strategies now provide much more efficient access to complex carbohydrates or glycoconjugates. Branched carbohydrates and hybrids of carbohydrates conjugated to polymers have been prepared using solution and/or solid-phase synthesis and advanced methods of polymerization. These materials are essential for the development of methodologies to study and map the molecular structure-function relationship at interfaces. This article highlights recent advances in the synthesis of carbohydrates and polymer hybrids mimicking the properties and functionalities of the natural oligosaccharides, as well as selected applications in biology, biotechnology and diagnostics. [source] Interfacing biocatalysis and organic synthesis,JOURNAL OF CHEMICAL TECHNOLOGY & BIOTECHNOLOGY, Issue 12 2007Roland Wohlgemuth Abstract The path to new chemical entities often shows the limitations of existing tools both in biocatalysis and organic chemistry. Organic synthetic procedures to prepare a compound in a target-oriented synthesis can damage other functional parts of the molecule. Protection,deprotection schemes can lead to a dead end, when a certain protecting group cannot be cleaved off. In biocatalysis, on the other hand, the required biocatalytic toolbox and methodology might not be readily available, therefore limiting a biocatalytic approach. New toolboxes, ingredients, and methodologies at the interface of classical organic synthesis and biocatalytic reactions bridge the gap between these two areas. Since product isolation and purification involves a substantial amount of time in the preparation of chemicals, methodologies to simplify these tasks are necessary to get the pure product into the bottle with less work-up time. Efficient and safe new pharmaceuticals, intermediates and analytical reagents need to be prepared under certain safety, health, environmental and economical boundary conditions. Biocatalytic reactions have been shown to overcome these limitations successfully and are becoming increasingly important in industrial manufacturing. Building bridges between biocatalysis and organic synthesis will therefore create roads to new synthetic strategies and technological frontiers of both fundamental and practical interest. Copyright © 2007 Society of Chemical Industry [source] General Synthesis and Aggregation Behaviour of a Series of Single-Chain 1,,-Bis(phosphocholines)CHEMISTRY - A EUROPEAN JOURNAL, Issue 18 2007Simon Drescher Abstract The synthesis and physicochemical characterisation of a series of polymethylene-1,,-bis(phosphocholines) with even-numbered chain lengths between 22 and 32 carbon atoms is described. Two new synthetic strategies for the preparation of long-chain 1,,-diols as hydrocarbon building blocks are presented. The temperature-dependent self-assembly of the single-chain bolaamphiphiles was investigated by cryo transmission electron microscopy (cryo-TEM), differential scanning calorimetry (DSC), and Fourier transform infrared spectroscopy (FTIR). [source] | ||||||||||