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Distribution by Scientific Domains

Humanities and Social Sciences	50%

Selected Abstracts

Lesbian Television Personalities,A Queer New Subject

THE JOURNAL OF AMERICAN CULTURE, Issue 4 2009
Jennifer Reed
First page of article [source]

Asset mapping and Whanau action research: ,New' subjects negotiating the politics of knowledge in Te Rarawa

ASIA PACIFIC VIEWPOINT, Issue 3 2008
Yvonne Underhill-Sem
Abstract Te Runanga o Te Rarawa is the tribal council representing the interests of the marae (tribal commons) and hapu (a subtribal kin group) that make up the iwi (a Maori tribe) of Te Rarawa in the far north of Aotearoa/New Zealand. In April 2005, officials approached us to help them secure a valuable funding stream tagged to marshalling resources for material development in the area. They sought curriculum vitae and assistance in reframing the funding specifications. Intrigued, armed with a conceptual toolkit drawn from Gibson-Graham's ideas of post-development and asset-based community mapping, and confident that we could add value, we agreed to help. This paper examines the complex politics of our involvement and our changing positioning as researcher subjects. We argue that negotiating a politics of knowledge for projects of this nature requires engagement in complex representational politics of place and divisive identity politics that rage around it. There are no easy protocols for outside researchers, but with appropriate humility and sensitivity to these politics, we can rely on, and should stand up for, the value of our work, which lies in commitments to excellence in scholarship. We cannot and should not seek to control these politics, which will chew us up and spit us out , humanely and with good grace or otherwise. However, good academic work will recognise and adapt to them. In our particular case, we argue that our work had significant value; and in this paper, we trace the production of this value. [source]

A Bayesian predictive analysis of test scores

JAPANESE PSYCHOLOGICAL RESEARCH, Issue 1 2001
Hidetoki Ishii
In the classical test theory, a high-reliability test always leads to a precise measurement. However, when it comes to the prediction of test scores, it is not necessarily so. Based on a Bayesian statistical approach, we predicted the distributions of test scores for a new subject, a new test, and a new subject taking a new test. Under some reasonable conditions, the predicted means, variances, and covariances of predicted scores were obtained and investigated. We found that high test reliability did not necessarily lead to small variances or covariances. For a new subject, higher test reliability led to larger predicted variances and covariances, because high test reliability enabled a more accurate prediction of test score variances. Regarding a new subject taking a new test, in this study, higher test reliability led to a large variance when the sample size was smaller than half the number of tests. The classical test theory is reanalyzed from the viewpoint of predictions and some suggestions are made. [source]

Risk, sexuality and economy

THE BRITISH JOURNAL OF SOCIOLOGY, Issue 1 2002
Lisa Adkins
ABSTRACT From the mid 1980s onwards HIV/AIDS became a new subject of work reform, with a range of experts producing new knowledges on work and the worker in regard to HIV/AIDS and workplace organizations putting in place workplace HIV/AIDS policies and programmes. To date, much of the discussion in sociology in regard to such policies and programmes has focused on the issue of effectiveness and has been concerned with making such policy ,better'. In this article however, and with particular reference to sexuality, I suggest that such approaches fail to register that workplace HIV/AIDS policies concern new conceptualizations of worker identities. Specifically, I suggest that such policies may be viewed as part of an assemblage of work reforms which are reworking worker identities as risk identities. Thus I argue that workplace HIV/AIDS policies and programmes are best understood as risk rationalities. Further, I consider the alignment between such rationalities and neo-liberal modes of rule, and in particular consider the ways in which workplace HIV/AIDS policies render both HIV/AIDS and sexuality calculable and governable in terms of notions of risk, self-responsibility and self-management. [source]

Protein folding simulations: From coarse-grained model to all-atom model

IUBMB LIFE, Issue 6 2009
Jian Zhang
Abstract Protein folding is an important and challenging problem in molecular biology. During the last two decades, molecular dynamics (MD) simulation has proved to be a paramount tool and was widely used to study protein structures, folding kinetics and thermodynamics, and structure,stability,function relationship. It was also used to help engineering and designing new proteins, and to answer even more general questions such as the minimal number of amino acid or the evolution principle of protein families. Nowadays, the MD simulation is still undergoing rapid developments. The first trend is to toward developing new coarse-grained models and studying larger and more complex molecular systems such as protein,protein complex and their assembling process, amyloid related aggregations, and structure and motion of chaperons, motors, channels and virus capsides; the second trend is toward building high resolution models and explore more detailed and accurate pictures of protein folding and the associated processes, such as the coordination bond or disulfide bond involved folding, the polarization, charge transfer and protonate/deprotonate process involved in metal coupled folding, and the ion permeation and its coupling with the kinetics of channels. On these new territories, MD simulations have given many promising results and will continue to offer exciting views. Here, we review several new subjects investigated by using MD simulations as well as the corresponding developments of appropriate protein models. These include but are not limited to the attempt to go beyond the topology based G,-like model and characterize the energetic factors in protein structures and dynamics, the study of the thermodynamics and kinetics of disulfide bond involved protein folding, the modeling of the interactions between chaperonin and the encapsulated protein and the protein folding under this circumstance, the effort to clarify the important yet still elusive folding mechanism of protein BBL, the development of discrete MD and its application in studying the ,,, conformational conversion and oligomer assembling process, and the modeling of metal ion involved protein folding. © 2009 IUBMB IUBMB Life, 61(6): 627,643, 2009 [source]

Activated T cell subsets in human type 1 diabetes: evidence for expansion of the DR+ CD30+ subpopulation in new-onset disease

CLINICAL & EXPERIMENTAL IMMUNOLOGY, Issue 3 2007
C. Baker
Summary An important limitation in T cell studies of human autoimmune (type 1) diabetes is lack of direct access to cells infiltrating the pancreas. We hypothesized that cells recently released from the pancreas into the blood might express a characteristic combination of markers of activation. We therefore examined the recently activated circulating T cell population [CD3+, human leucocyte antigen D-related (HLA-DR+)] using cytokine production and 10 additional subset markers [CD69, CD25, CD122, CD30, CD44v6, CD57, CD71, CCR3 (CD193), CCR5 (CD195) or CXCR3 (CD183)], comparing newly diagnosed adult (ND) (age 18,40 years) patients (n = 19) to patients with diabetes for > 10 years [long-standing (LS), n = 19] and HLA-matched controls (C, n = 16). CD3+ DR+ cells were enriched by two-step immunomagnetic separation. No differences in basal or stimulated production of interleukin (IL)-4, IL-10, IL-13 or interferon (IFN)-, by CD3+ DR+ enriched cells were observed between the different groups of subjects. However, among the CD3+ DR+ population, significant expansions appeared to be present in the very small CD30+, CD69+ and CD122+ subpopulations. A confirmatory study was then performed using new subjects (ND = 26, LS = 15), three-colour flow cytometry, unseparated cells and three additional subset markers (CD38, CD134, CD4/CD25). This confirmed the expansion of the CD3+ DR+ CD30+ subpopulation in ND subjects. We conclude that a relative expansion in the T cell subpopulation with the activated phenotype CD3+ DR+ CD30+ is seen in the peripheral blood of subjects with newly diagnosed type 1 diabetes. This subpopulation represents less than 0·7% of circulating T cells and may provide a rich source of disease-specific T cells that can be isolated from blood. [source]