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New Rationale (new + rationale)
Selected AbstractsWELFARE IMPACT OF A BAN ON CHILD LABORECONOMIC INQUIRY, Issue 4 2010JORGE SOARES This article presents a new rationale for imposing restrictions on child labor. In a standard overlapping generation model where parental altruism results in transfers that children allocate to consumption and education, the Nash-Cournot equilibrium results in suboptimal levels of parental transfers and does not maximize the average level of utility of currently living agents. A ban on child labor decreases children's income and generates an increase in parental transfers bringing their levels closer to the optimum, raising children's welfare as well as average welfare in the short run and in the long run. Moreover, the inability to work allows children to allocate more time to education, and it leads to an increase in human capital. Besides, to increase transfers, parents decrease savings and hence physical capital accumulation. When prices are flexible, these effects diminish the positive welfare impact of the ban on child labor. (JEL D91, E21) [source] Restoration of DNA-binding and growth-suppressive activity of mutant forms of p53 via a PCAF-mediated acetylation pathway,JOURNAL OF CELLULAR PHYSIOLOGY, Issue 2 2010Ricardo E. Perez Tumor-derived mutant forms of p53 compromise its DNA binding, transcriptional, and growth regulatory activity in a manner that is dependent upon the cell-type and the type of mutation. Given the high frequency of p53 mutations in human tumors, reactivation of the p53 pathway has been widely proposed as beneficial for cancer therapy. In support of this possibility p53 mutants possess a certain degree of conformational flexibility that allows for re-induction of function by a number of structurally different artificial compounds or by short peptides. This raises the question of whether physiological pathways for p53 mutant reactivation also exist and can be exploited therapeutically. The activity of wild-type p53 is modulated by various acetyl-transferases and deacetylases, but whether acetylation influences signaling by p53 mutant is still unknown. Here, we show that the PCAF acetyl-transferase is down-regulated in tumors harboring p53 mutants, where its re-expression leads to p53 acetylation and to cell death. Furthermore, acetylation restores the DNA-binding ability of p53 mutants in vitro and expression of PCAF, or treatment with deacetylase inhibitors, promotes their binding to p53-regulated promoters and transcriptional activity in vivo. These data suggest that PCAF-mediated acetylation rescues activity of at least a set of p53 mutations. Therefore, we propose that dis-regulation of PCAF activity is a pre-requisite for p53 mutant loss of function and for the oncogenic potential acquired by neoplastic cells expressing these proteins. Our findings offer a new rationale for therapeutic targeting of PCAF activity in tumors harboring oncogenic versions of p53. J. Cell. Physiol. 225: 394,405, 2010. © 2010 Wiley-Liss, Inc. [source] State Sovereignty After 9/11: Disorganised HypocrisyPOLITICAL STUDIES, Issue 2 2007Amitav Acharya This article examines the implications of the 9/11 attacks and the US-led ,global war on terror' for debates about state sovereignty. To support its attacks on Afghanistan and Iraq, the Bush administration put forth a ,selective sovereignty' thesis that would legitimise intervention in states that are accused of supporting terrorists. This new rationale for intervention was paradoxically justified as a means of ensuring a ,well-ordered world of sovereign states', which had been imperilled by transnational terrorist networks. This article argues that the ,selective sovereignty' thesis exaggerates the challenge posed by terrorist organisations to Westphalian sovereignty, and understates the US's own unprincipled violation of its core norm of non-intervention. A related argument of this article is that on the face of it, the ,selective sovereignty' approach fits the notion of ,organised hypocrisy' put forward by Stephen Krasner, which refers to ,the presence of long-standing norms [in this case non-intervention] that are frequently violated' for the sake of some ,higher principles', violations that are generally tolerated by the international community. But the higher principles evoked by the US to justify its war on Iraq, such as the human rights of the Iraqis, and democracy promotion in the Middle East, are now clearly seen to have been a façade to mask the geopolitical and ideological underpinnings of the invasion. In this sense, the war on terror has revived national security and naked self-interest as the principal rationale for intervention, notwithstanding the self-serving efforts by some Bush administration officials to ,graft' the ,selective sovereignty' thesis on to the evolving humanitarian intervention principle. This policy framework is hypocrisy for sure, but as the international response to the war on Iraq (including the lack of UN authorisation for the war and the transatlantic discord it generated) demonstrates, it should be viewed more as a case of ,disorganised hypocrisy'. [source] Hedging under counterparty credit uncertaintyTHE JOURNAL OF FUTURES MARKETS, Issue 3 2008Olivier Mahul This study investigates optimal production and hedging decisions for firms facing price risk that can be hedged with vulnerable contracts, i.e., exposed to nonhedgeable endogenous counterparty credit risk. When vulnerable forward contracts are the only hedging instruments available, the firm's optimal level of production is lower than without credit risk. Under plausible conditions on the stochastic dependence between the commodity price and the counterparty's assets, the firm does not sell its entire production on the vulnerable forward market. When options on forward contracts are also available, the optimal hedging strategy requires a long put position. This provides a new rationale for the hedging role of options in the over-the-counter markets exposed to counterparty credit risk. © 2008 Wiley Periodicals, Inc. Jrl Fut Mark 28: 248,263, 2008 [source] Rattling the Hesam: International Distractions from Internal Problems in IranASIAN POLITICS AND POLICY, Issue 1 2009John A. Tures President Mahmoud Ahmadinejad began waging a war of words against the state of Israel several months after he won Iran's 2005 election. This article explores the motives for his fiery rhetoric. A series of explanations including ideological zeal, inexperience, international pressure, unifying regional regimes, and inciting a war with Israel are evaluated and critiqued. This article offers a new rationale that examines internal politics as a motive for the Iranian leader's speeches. The diversionary theory of conflict, which claims that leaders try to overcome domestic shortcomings with foreign distractions, is examined in this context. But while this theory has typically been associated with war and unifying the country's political structure, this article contends that President Ahmadinejad's plan may not be full-scale war, but a verbal confrontation and subtle support for terror groups, which can be just as effective in achieving internal aims. Such a policy would also win converts among the rank-and-file Arabs. The resulting regional prestige is also designed to mask his domestic shortcomings in the political and economic arena. Blasting Israel and boosting groups such as Hizballah and Hamas, while receiving cheers from many Arab people for standing up to Israel, in other words, is designed to distract the Iranian people from the sinking economy and President Ahmadinejad's loss of power, blocked appointments, and criticism from even conservatives. In addition, rather than seeking support from the entire country, the president may be trying to outflank his conservative opponents, including many from the clergy, legislature, and ruling elite, who have become disenchanted with his anti-corruption crusades, appointments, and policies. If successful, this plan would pit his country's conservative majority (including young people and the Revolutionary Guard) against the minority moderates and some disaffected conservatives. Finally, this article critiques other theories and suggested strategies responding to the crisis and offers its own diversionary theory, as well as ideas about how to handle President Ahmadinejad's oratories. [source] Patient advocacy in newborn screening: Continuities and discontinuities,AMERICAN JOURNAL OF MEDICAL GENETICS, Issue 1 2008Diane B. Paul Abstract In the 1960s, patient advocacy groups were instrumental in efforts to mandate state testing of newborns for phenylketonuria (PKU), a recessively inherited disorder of phenylalanine metabolism. Advocacy groups have continued to actively lobby for the expansion of screening to other conditions detectable in newborns and, currently, for states' adoption of a uniform core screening panel. They have also been generally favorable to the offer of fee-based supplemental screening services. In the early years of newborn screening, groups such as the National Association for Retarded Children (NARC) were strongly imbued with a public-health ethic. This ethic has apparently eroded over time as the result of both broad social changes and the increasing entanglement of such groups with pharmaceutical and biotechnology companies. A history of newborn screening reveals both continuities and discontinuities in the agendas and funding of patient advocacy groups and in their rhetorical strategies. In particular, it demonstrates that there have always been tensions as well as partnerships with medical and other professionals, although the nature and intensity of the former have been affected by advocacy groups' increasing numbers, resources, and cultural authority. It also illuminates differences that have emerged as advocacy groups have informally allied with industry and adopted new rationales in support of access to testing. © 2008 Wiley-Liss, Inc. [source] Lost in Translation: A Multi-Level Case Study of the Metamorphosis of Meanings and Action in Public Sector Organizational InnovationPUBLIC ADMINISTRATION, Issue 1 2006Catherine Pope This paper explores the early implementation of an organizational innovation in the UK National Health Service (NHS) , Treatment Centres (TCs) , designed to dramatically reduce waiting lists for elective care. The paper draws on case studies of 8 TCs (each at varying stages of their development) and aims to explore how meanings about TCs are created and evolve, and how these meanings impact upon the development of the organizational innovation. Research on organizational meanings needs to take greater account of the fact that modern organizations like the NHS are complex multi-level phenomena, comprising layers of interlacing networks. To understand the pace, direction and impact of organizational innovation and change we need to study the interconnections between meanings across different organizational levels. The data presented in this paper show how the apparently simple, relatively unformed, concept of a TC framed by central government is translated and transmuted by subsequent layers in the health service administration, and by players in local health economies, and, ultimately, in the TCs themselves, picking up new rationales, meanings and significance as it goes along. The developmental histories of TCs reveal a range of significant re-workings of macro policy with the result that there is considerable diversity and variation between local TC schemes. The picture is of important disconnections between meanings, that in many ways mirror Weick's (1976) 'loosely coupled systems'. The emergent meanings and the direction of micro-level development of TCs appear more strongly determined by interactions within the local TC environment, notably between what we identify as groups of 'idealists', 'pragmatists', 'opportunists' and 'sceptics' than by the framing (Goffman 1974) provided by macro and meso organizational levels. While this illustrates the limitations of top down and policy-driven attempts at change, and highlights the crucial importance of the front-line local 'micro-systems' (Donaldson and Mohr 2000) in the overall scheme of implementing organizational innovations, the space or headroom provided by frames at the macro and meso levels can enable local change, albeit at variable speed and with uncertain outcomes. [source] | ||||||||||||||||