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New Lines (new + line)
Selected AbstractsThe Anticipated Capitalisation Effect of a New Metro Line on Housing Prices,FISCAL STUDIES, Issue 2 2008Claudio A. Agostini H54; R21; R53 Abstract Housing units with closer access to public transportation enjoy a higher market value than those with similar characteristics but poorer access. This difference can be explained by the lower cost of transport to the main workplaces and shopping areas in town. For this reason, investments in public transport infrastructure, such as building a new metro line, are capitalised totally or partially into land and housing prices. This work empirically analyses the degree of capitalisation into housing prices of the benefits of the new Line 4 of the Santiago metro system, which began operating in December 2005. We focus on anticipated capitalisation into housing prices at the moment construction of Line 4 was announced and at the moment information on the basic engineering project was unveiled, identifying the location of the future stations. We use a unique database containing all home buying and selling transactions in the Greater Santiago area between December 2000 and March 2004. The results show that the average apartment price rose by between 4.2 per cent and 7.9 per cent after construction was announced and by between 3.1 per cent and 5.5 per cent after the location of the stations was identified. These increases were not distributed evenly, but depended on the distance from the apartment to the nearest station. An indirect effect of this kind of capitalization is that property tax collections will increase if property is reappraised following the price rise. This effect is not negligible in magnitude and could represent 11 to 17 per cent of investment in the new metro line. This raises and interesting discussion on how the metro network extension is financed. [source] E1-Ngn2/Cre is a new line for regional activation of Cre recombinase in the developing CNSGENESIS: THE JOURNAL OF GENETICS AND DEVELOPMENT, Issue 4 2004Joachim Berger Abstract We generated a transgenic mouse line named E1-Ngn2/Cre that expresses Cre recombinase and GFP under the control of the E1 enhancer element of the gene Ngn2 (Scardigli et al.: Neuron 31:203,217, 2001). Cre-recombinase activity and GFP fluorescence are consistent with the reported expression pattern controlled by the E1-Ngn2 enhancer. Recombination was detected in the progenitor domains p1 and p2 in the ventricular zone of the neural tube and in distinct domains of the pretectum, the dorsal and ventral thalamus, the tegmentum of the mesencephalon, and the hindbrain. In the developing cortex, Cre-recombinase activity is confined to a subpopulation of progenitors predominantly in the region of the ventral and lateral pallium. The E1-Ngn2/Cre mouse line thus provides an excellent novel tool for a region-specific conditional mutagenesis in the developing CNS. genesis 40:195,199, 2004. © 2004 Wiley-Liss, Inc. [source] Consequences of EC7 on the design of tunnelsGEOMECHANICS AND TUNNELLING, Issue 1 2010Article first published online: 24 FEB 2010 The cover picture shows the assembly of an arch formwork carriage on contract H2-2 Radfeld Mitte, where a 1,600 m long cut-and-cover tunnel is being built for the Lower Inn Valley railway The Brenner Railway Company is currently constructing about 40 km of new line between Kundl/Radfeld and Baumkirchen in the Lower Inn valley in Austria. Almost 32 km of this route will run in tunnels, troughs, box-section cut-and-cover and in a gallery. Track installation in the flatlands of the Tyrol is also on schedule and the new line will be open for traffic in 2012. (Photo: ÖBB H2-2, Arge D2 Consult , Hyder Consulting GmbH). Das Titelbild zeigt den Aufbau eines Gewölbeschalwagens im Baulos H2-2 Radfeld Mitte. Dort ist für die Unterinntalbahn unter anderem ein 1.600 m langer Tunnel in offener Bauweise zu errichten. Zwischen Kundl/Radfeld und Baumkirchen erstellt die ÖBB-Infrastruktur AG rund 40 km zweigleisige Neubautrasse. Fast 32 km dieser Anlage befinden sich in Tunneln, Wannen, Unterflurtrassen und in einer Galerie. Der Schienenausbau im Tiroler Unterland liegt im Zeitplan, die neue Bahnstrecke wird 2012 in Betrieb gehen (Foto: ÖBA H2-2, Arge D2 Consult , Hyder Consulting GmbH). [source] Brenner railway construction in the Lower Inn ValleyGEOMECHANICS AND TUNNELLING, Issue 6 2009Article first published online: 13 NOV 200 The Brenner Railway Company is currently constructing about 40 km of new line between Kundl/Radfeld and Baumkirchen in the Lower Inn valley in Austria. Almost 32 km of this route will run in tunnels, troughs, box-section cut-and-cover and in a gallery. The route will have to cross the motorway, existing railways and the River Inn many times. The basic structure of more than 29 km of two-track rail tunnel for the new railway line has already been completed. Track installation in the flatlands of the Tyrol is also on schedule and the new line will be open for traffic in 2012. Issue 6/09 reports on interesting tasks, problems encountered and particular features of the construction of the Lower Inn railway (Photo: ÖBB/Bstieler). Zwischen Kundl/Radfeld und Baumkirchen errichtet die Brenner Eisenbahn Gesellschaft rund 40 km Neubautrasse. Fast 32 Kilometer dieser Anlage befinden sich in Tunneln, Wannen, Unterflurtrassen und in einer Galerie. Mehrmals ist die Querung der Autobahn, der bestehenden Eisenbahn sowie des Inns erforderlich. Mehr als 29 km zweigleisige Eisenbahntunnel für die neue Unterinntalbahn sind mittlerweile im Rohbau fertig gestellt. Der Schienenausbau im Tiroler Unterland liegt im Zeitplan, die neue Bahnstrecke wird 2012 in Betrieb gehen. Das Heft 6/09 berichtet über interessante Aufgaben, Fragestellungen und Besonderheiten beim Bau der Unterinntalbahn. (Foto: ÖBB/Bstieler). [source] The therapeutic potential of the proteasome in leukaemia,HEMATOLOGICAL ONCOLOGY, Issue 2 2008Scott Marshall McCloskey Abstract Many cellular processes converge on the proteasome, and its key regulatory role is increasingly being recognized. Proteasome inhibition allows the manipulation of many cellular pathways including apoptotic and cell cycle mechanisms. The proteasome inhibitor bortezomib has enhanced responses in newly diagnosed patients with myeloma and provides a new line of therapy in relapsed and refractory patients. Malignant cells are more sensitive to proteasome inhibition than normal haematopoietic cells. Proteasome inhibition enhances many conventional therapies and its role in leukaemia is promising. Copyright © 2008 John Wiley & Sons, Ltd. [source] Civic Spaces: Mexican Hometown Associations and Immigrant ParticipationJOURNAL OF SOCIAL ISSUES, Issue 1 2010S. Karthick Ramakrishnan The study of civic participation and social capital in the United States has, until recently, been silent on the role of immigrant-serving organizations. There is a new line of scholarship, which indicates that ethnic organizations are generally disadvantaged in relation to White mainstream organizations on factors such as resources and political visibility. Our fieldwork on Mexican hometown associations (HTAs) in Los Angeles shows that transnational associations are even more disadvantaged than ethnic organizations that primarily serve the native born. However, this marginality leaves some counterintuitive advantages, namely the creation of safe spaces where undocumented immigrants, recent immigrants, and those with limited English proficiency can get involved in civic and political activities. We explore the extent to which these dynamics vary by gender and immigrant generation, and over time as Mexican hometown associations increasingly turn their attention to political issues in the United States. [source] Impulsive Dirac-delta forces in the rocking motionEARTHQUAKE ENGINEERING AND STRUCTURAL DYNAMICS, Issue 7 2004F. Prieto Abstract In this work the classical theory of one block rocking motion is revisited. A Dirac-delta type interaction as impact mechanism is found to be an alternative for the traditional model. Numerical computations with this new formulation have shown that the agreement with the classical theory is excellent for the case of slender blocks and small displacements. Good agreement with experimental data has also been found for the case of arbitrary angles and slenderness. The approach presented in this paper opens new lines for further theoretical developments and computational applications. Copyright © 2004 John Wiley & Sons, Ltd. [source] Tissue-type plasminogen activator-plasmin-BDNF modulate glutamate-induced phase-shifts of the mouse suprachiasmatic circadian clock in vitroEUROPEAN JOURNAL OF NEUROSCIENCE, Issue 8 2009Xiang Mou Abstract The mammalian circadian clock in the suprachiasmatic nucleus (SCN) maintains environmental synchrony through light signals transmitted by glutamate released from retinal ganglion terminals. Brain-derived neurotrophic factor (BDNF) is required for light/glutamate to reset the clock. In the hippocampus, BDNF is activated by the extracellular protease, plasmin, which is produced from plasminogen by tissue-type plasminogen activator (tPA). We provide data showing expression of proteins from the plasminogen activation cascade in the SCN and their involvement in circadian clock phase-resetting. Early night glutamate application to SCN-containing brain slices resets the circadian clock. Plasminogen activator inhibitor-1 (PAI-1) blocked these shifts in slices from wild-type mice but not mice lacking its stabilizing protein, vitronectin (VN). Plasmin, but not plasminogen, prevented inhibition by PAI-1. Both plasmin and active BDNF reversed ,2 -antiplasmin inhibition of glutamate-induced shifts. ,2 -Antiplasmin decreased the conversion of inactive to active BDNF in the SCN. Finally, both tPA and BDNF allowed daytime glutamate-induced phase-resetting. Together, these data are the first to demonstrate expression of these proteases in the SCN, their involvement in modulating photic phase-shifts, and their activation of BDNF in the SCN, a potential ,gating' mechanism for photic phase-resetting. These data also demonstrate a functional interaction between PAI-1 and VN in adult brain. Given the usual association of these proteins with the extracellular matrix, these data suggest new lines of investigation into the locations and processes modulating mammalian circadian clock phase-resetting. [source] Considering safety issues in minimum losses reconfiguration for MV distribution networksEUROPEAN TRANSACTIONS ON ELECTRICAL POWER, Issue 5 2009Angelo Campoccia Abstract This paper offers a new perspective over the traditional problem of the multiobjective optimal reconfiguration of electrical distribution systems in regular working state. The issue is indeed here formulated including also safety issues. Indeed, dimensioning the earth electrodes of their own secondary substations, distribution companies take into account the probable future configurations of the network due to transformations of overhead lines into cable lines or realization of new lines. On the contrary, they do not consider that, during normal working conditions, the structure of the network can be modified for long periods as a consequence of reconfiguration manoeuvres, with differences between the design current of the earthing systems and the fault current in certain substations significant. As a consequence, often distribution companies limit the implementation of the optimal reconfiguration layouts because they are unable to suitably evaluate the safety issue. In the paper, the problem is formulated including a further objective in order to account for the safety. A suitable constrained multiobjective formulation of the reconfiguration problem is therefore used aiming at: the minimal power losses operation, the verification of safety at distribution substations, the load balancing among the HV/MV transformers while keeping the voltage profile regular. The application carried out uses an NSGA-II algorithm whose performance is compared to that of a fuzzy logic-based multiobjective evolutionary algorithm. In the considered automated network, the remote control of tie-switches is possible and their layout is the optimization variable. After a brief description of the optimal reconfiguration problem for automated distribution networks, the most recent papers on the topic are reported and commented. Then the problem formulation and the solution algorithm are described in detail. Finally, test results on a large MV distribution network are reported and discussed. Copyright © 2008 John Wiley & Sons, Ltd. [source] Understanding and altering the longitudinal course of marriageJOURNAL OF MARRIAGE AND FAMILY, Issue 4 2004Thomas N. Bradbury Weak and counterintuitive findings linking couples' interactional processes to marital outcomes have prompted new lines of research on how marriages change. Recent findings reviewed here highlight the value of (a) expanding conceptions of marital interaction by considering how social support and positive affect moderate the effects of problem-solving skills on changes in marital quality; (b) examining partners' individual strengths and vulnerabilities as antecedents of marital aggression and hostile interaction; and (c) recognizing the central role of chronic and acute circumstances in governing fluctuations in spouses' judgments of marital quality. We outline implications of these findings for ongoing efforts to prevent adverse marital outcomes, and for recent federal initiatives to strengthen healthy marriages among people with low incomes. [source] Spatial knowledge diffusion through collaborative networks,PAPERS IN REGIONAL SCIENCE, Issue 3 2007Corinne Autant-Bernard The theory of endogenous growth and the geography and growth synthesis both consider that local growth and spatial concentration of economic activities emanate from localised knowledge spillovers (Lucas 1988; Martin and Ottaviano 1999). Since the end of the 1980's, the spatial dimension of knowledge diffusion has been investigated from an empirical point of view, and the existence and role of local spillovers has been generally confirmed (see among others Jaffe 1989; Audretsch and Feldman 1996). The concern that now arises is to unravel the mechanisms underlying and explaining the geographical knowledge spillovers. The aim of this special issue is to present the latest new findings on such questions and to identify some new lines of research for future work. Before presenting the content of this special issue, we very briefly review the main results of the empirical literature on the geography of innovation. We also explain the context of this special issue by pointing out some of the limitations faced by this literature and, by stressing the complex dynamic and network dimensions of the observed processes of production and diffusion of knowledge. [source] An update on the honesty of melanin-based color signals in birdsPIGMENT CELL & MELANOMA RESEARCH, Issue 2 2008Kevin J. McGraw Summary The control mechanisms and information content of melanin-based color signals in birds have generated much recent interest and controversy among evolutionary biologists. Initial experimental studies on this topic manipulated coarse metrics of an individual's condition (i.e. food intake, disease state) and failed to detect significant condition-dependence of melanin ornament expression. However, three new lines of research appear profitable and target specific factors associated with the production of melanin pigments. These include the role of (i) metals, (ii) amino acids, and (iii) testosterone and social interactions in shaping the extent and intensity of melanin-colored plumage patches. Here, I review recent studies of and evidence for these honesty-reinforcing mechanisms. [source] Lowering seed gossypol content in glanded cotton (Gossypium hirsutum L.) linesPLANT BREEDING, Issue 6 2008G. B. Romano Abstract Cottonseed is a rich source of high quality protein, but its value as an animal feed is limited by gossypol, a toxic polyphenolic compound contained in glands located throughout the plant. This compound helps protect the plant from pests. Totally glandless varieties have been developed, but not adopted as these plants are left vulnerable to pests. This study describes a breeding strategy to decrease the levels of gossypol in the seed while maintaining a high enough concentration of toxin in vegetative plant parts to offer protection from pests. Preliminary studies indicated that crosses between varieties with different gland densities and distributions produced a range of glanding patterns. By selecting within the resulting progeny, we have identified F7 generation progeny that have <0.30% total gossypol in the seed, while still possessing glands at critical locations on the vegetative plant parts. These new lines will be a valuable source of germplasm for developing low seed gossypol varieties. Seed from these varieties would provide a new source of inexpensive protein for animal feeding rations. [source] Organizing for Radical Innovation: An Exploratory Study of the Structural Aspects of RI Management Systems in Large Established FirmsTHE JOURNAL OF PRODUCT INNOVATION MANAGEMENT, Issue 6 2006Gina Colarelli O'Connor To escape the intense competition of today's global economy, large established organizations seek growth options beyond conventional new product development that leads to incremental changes in current product lines. Radical innovation (RI) is one such pathway, which results in organically driven growth through the creation of whole new lines of business that bring new to the world performance features to the market and may result in the creation of entirely new markets. Yet success is elusive, as many have experienced and scholars have documented. This article reports results of a three-year, longitudinal study of 12 large established firms that have declared a strategic intent to evolve their RI capabilities. In contrast to other academic research that has analyzed specific projects to understand management practices appropriate for RI, the present research reported explores the evolution of management systems for enabling radical innovation to occur repeatedly in large firms and reports on one aspect of this management system: organizational structures for enabling and nurturing RI. To consider organizational structure as a venue for capability development is new in the management of innovation and dynamic capabilities literatures. Conventional wisdom holds that RIs should be incubated outside the company and assimilated once they have gained traction in the marketplace. Numerous experiments with organizational structures were observed that instead work to manage the interfaces between the RI management system and the mother organization. These structures are described here, and insights are drawn out regarding radical innovation competency requirements, transition challenges, senior leadership mandates, and business-unit ambidexterity. The centerpiece of this research is the explication of the Discovery,Incubation,Acceleration framework, which details three sets of necessary, though not sufficient competencies, for building an RI capability. [source] | |||||||||||||||||||