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New Doors (new + door)

Distribution by Scientific Domains
Medical Sciences28%
Business, Economics, Finance and Accounting28%

Selected Abstracts

The Asset Pricing Palette: Cash Flows, Returns and Trading Behavior

FINANCIAL REVIEW, Issue 4 2001
Andrea J. Heuson
G12 Abstract Asset pricing is the topic of the 2001 Eastern Finance Association Symposium and the five papers selected for this collection, which are summarized below, span a broad range of subjects that fall under the umbrella of the determinants of market prices. For example, the Schwartz and Moon article that introduces the symposium uses real options methodology to value firms whose cash flows are subject to multiple sources of uncertainty while the Luders and Peisl and Mixon analytical models that close the selections incorporate dual stochastic processes to derive relationships between information flow, trading volume and price volatility that are consistent with empirical evidence. In between, Mishra and O'Brien present new evidence on the important of index and factor selection when estimating the required return on equity and Spahr and Schwebach revisit the issue of time diversification by reintroducing a statistical construct from earlier times. Each of the works included here makes an important contribution to our understanding of the asset pricing process in a distinct area and opens new doors onto avenues for future research. [source]

Pharmacological interventions in aging and age-associated disorders

GERIATRICS & GERONTOLOGY INTERNATIONAL, Issue 2 2007
Kenichi Kitani
In the present study, past attempts using different pharmaceuticals and chemicals which were reported to prolong lifespans of animals are critically reviewed. Despite a large number of trials in animals and humans, the validity of supplementation of antioxidant vitamins such as vitamins A, E and C for improving human health remains unresolved at present. A recent approach using antioxidant mimetics called the EUK series which, despite an initial enthusiastically reported success in prolonging the lifespan of nematodes, remains again unsettled because of the failure in reproducing the initial success by follow-up studies. ,-Phenyl- tert -butylnitrone and related nitrones were initially introduced as radical scavengers. Some of these (e.g. disodium 2,4-disulfophenyl-N- tert -butylnitrone) are at phase 3 clinical trials as an agent to treat cerebral stroke. This effect, however, appears at least in part to be related to signal transduction which makes these agents effective against cerebral stroke even when they are administered later than its onset. (,)Deprenyl is a monoamine oxidase-B inhibitor and has some neuroprotective and anti-apoptotic effects. The drug has also been shown to prolong the lifespans of at least four different animal species. The drug upregulates superoxide dismutase and catalase activities in selective brain regions of dopaminergic nature. These effects on antioxidant enzyme activities are suspected to be causally related to its effect on lifespans of animals. Future trials using these and other drugs are expected to open new doors for interventions in aging and age-associated disorders in humans. [source]

Five conversations on the frontiers of leadership

LEADER TO LEADER, Issue 33 2004
David Whyte
Paying attention to the things we are not talking about can open new doors. [source]

Cardiac 17O MRI: Toward direct quantification of myocardial oxygen consumption

MAGNETIC RESONANCE IN MEDICINE, Issue 6 2010
Kyle S. McCommis
Abstract A new 17O-labeled blood contrast agent was injected intravenously in control dogs. Electrocardiogram (ECG)-triggered myocardial T1, imaging was performed to obtain spin-locking T1,-weighted myocardial signals for the detection of resultant metabolite H217O water in the heart. Bolus and slow injection methods of various doses of the 17O-labeled and 16O-labeled agents were carried out in order to evaluate the sensitivity of this method and determine the optimal injection method. Bolus injection provided approximately 1% signal reduction, whereas slow injection with larger amount of agent yielded 11.9 ± 0.6% signal reduction. Myocardial oxygen consumption rate was determined by a technique to quantify cerebral oxygenation consumption rate previously developed in 17O brain studies. With either injection method, myocardial oxygen consumption rate at rest was 5.0 , 5.6 ,mol/g/min. Therefore, it appears feasible to detect metabolically generated HO water in vivo in the heart, using the 17O-labeled blood tracer. Myocardial oxygen consumption rate can then be quantified in vivo, which may open new doors for the assessment of myocardial metabolism. Magn Reson Med 63:1442,1447, 2010. © 2010 Wiley-Liss, Inc. [source]

Advances on the compositional analysis of glycosphingolipids combining thin-layer chromatography with mass spectrometry

MASS SPECTROMETRY REVIEWS, Issue 3 2010
Johannes Müthing
Abstract Glycosphingolipids (GSLs), composed of a hydrophilic carbohydrate chain and a lipophilic ceramide anchor, play pivotal roles in countless biological processes, including infectious diseases and the development of cancer. Knowledge of the number and sequence of monosaccharides and their anomeric configuration and linkage type, which make up the principal items of the glyco code of biologically active carbohydrate chains, is essential for exploring the function of GSLs. As part of the investigation of the vertebrate glycome, GSL analysis is undergoing rapid expansion owing to the application of novel biochemical and biophysical technologies. Mass spectrometry (MS) takes part in the network of collaborations to further unravel structural and functional aspects within the fascinating world of GSLs with the ultimate aim to better define their role in human health and disease. However, a single-method analytical MS technique without supporting tools is limited yielding only partial structural information. Because of its superior resolving power, robustness, and easy handling, high-performance thin-layer chromatography (TLC) is widely used as an invaluable tool in GSL analysis. The intention of this review is to give an insight into current advances obtained by coupling supplementary techniques such as TLC and mass spectrometry. A retrospective view of the development of this concept and the recent improvements by merging (1) TLC separation of GSLs, (2) their detection with oligosaccharide-specific proteins, and (3) in situ MS analysis of protein-detected GSLs directly on the TLC plate, are provided. The procedure works on a nanogram scale and was successfully applied to the identification of cancer-associated GSLs in several types of human tumors. The combination of these two supplementary techniques opens new doors by delivering specific structural information of trace quantities of GSLs with only limited investment in sample preparation. © 2009 Wiley Periodicals, Inc. Mass Spec Rev 29:425-479, 2010 [source]

,Private life' and ,work life': difficulties and dilemmas when making and maintaining friendships with ethnographic participants

AREA, Issue 3 2009
Sarah Marie Hall
This paper addresses the difficulties and dilemmas that may occur when friendships are formed with participants during an ethnographic research project. The ongoing, reciprocal relationships developed with participants are considered essential in the data collection of ethnography, as an avenue through which research can be carried out. However, while friendships in the field may open new doors to research, they can also create new (ethical) challenges. This paper revisits these issues, alongside research ethics guidelines, using three different scenarios: the negotiation of methods of contact, the maintenance of contact with participants and the sharing of research diaries with participants. From these discussions, two issues arise that may have implications for future ethnographic research: the obstacle of social networking websites and the negotiation of appropriate research ethics when participants become our friends. [source]

Telomerase: not just for the elongation of telomeres,

BIOESSAYS, Issue 2 2006
Rodrigo T. Calado
Telomerase RNA component (TERC) and telomerase reverse transcriptase (TERT) function together to elongate telomeres and to protect chromosomal ends. Recent studies have discovered that overexpression of telomerase's TERT subunit promoted epidermal stem-cell mobilization, hair growth and stem-cell proliferation without changes in length of telomeres.1,2 This telomerase functional characteristic is TERC independent and is operated through a mechanism other than telomere elongation. These findings open new doors for future explorations to understand telomerase function and its interaction with other cell components in the regulation of cell senescence and tumorigenesis. BioEssays 28: 109,112, 2006. © 2006 Wiley periodicals, Inc. [source]