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New Dawn (new + dawn)
Selected AbstractsA New Dawn for the Treatment of Type 2 Diabetes: Integrating Incretin Mimetics Into Clinical PracticeJOURNAL OF THE AMERICAN ACADEMY OF NURSE PRACTITIONERS, Issue 2007Article first published online: 28 JUN 200 First page of article [source] Evidence-Based Child and Adolescent Mental Health Services: Oxymoron or Brave New Dawn?CHILD AND ADOLESCENT MENTAL HEALTH, Issue 2 2001Paul Ramchandani Professionals working in child and adolescent mental health services are increasingly encouraged to examine the evidence underlying their clinical practice. Embracing evidence-based practice can present difficulties, as barriers to changing practice exist. These difficulties are examined, along with the meaning of evidence-based practice in a multidisciplinary speciality, and the potential benefits that develop from it. [source] A new dawn , the ecological genetics of mycorrhizal fungiNEW PHYTOLOGIST, Issue 2 2000D. LEE TAYLOR Many human activities, such as ore mining and smeltering, sewage sludge treatment and fossil fuel consumption, result in toxic soil concentrations of ,heavy metals' (Al, Cd, Co, Cr, Cu, Hg, Mn, Ni, Pb, Ti, Zn and others) (Gadd, 1993). There are also natural soils, such as serpentine, with levels of heavy metals that inhibit or preclude the growth of many plants and soil micro-organisms. However, certain plants and microorganisms do grow in these metalliferous sites. Understanding the physiology, ecology and evolution of tolerance to elevated soil metal concentrations is important in an applied setting, and is also of interest in theoretical biology. Applied importance relates to the improvement of forest health in areas subject to increasing pollution, rehabilitation of severely polluted sites by phytostabilization of metals, and metal removal using hyperaccumulating plants (Krämer, 2000; Ernst, 2000). Areas of theoretical interest include the evolution of local adaptation (Sork et al., 1993) and how it is shaped by the combined influences of natural selection, gene flow and genetic architecture, as well as metal influences on various species interactions (Pollard, 2000). A paper appears on pages 367,379 in this issue by Jan Colpaert and coworkers which adroitly combines the disparate fields of physiology, genetics and ecology to answer several outstanding questions concerning heavy metal tolerance in mycorrhizal fungi. Mycorrhizal fungi, which interact mutualistically with the majority of plant species, are well known for improving the P status of their hosts (Smith & Read, 1997). Some mycorrhizal fungi are also able to mobilize N and P from organic substrates and to provide plants with improved micronutrient and water acquisition, pathogen resistance, and a variety of other benefits (Smith & Read, 1997). One of these additional benefits is the amelioration of toxicity in metalliferous soils. [source] Intracellular antibodies and cancer: New technologies offer therapeutic opportunitiesBIOESSAYS, Issue 7 2010David Pérez-Martínez Abstract Since the realisation that the antigen-binding regions of antibodies, the variable (V) regions, can be uncoupled from the rest of the molecule to create fragments that recognise and abrogate particular protein functions in cells, the use of antibody fragments inside cells has become an important tool in bioscience. Diverse libraries of antibody fragments plus in vivo screening can be used to isolate single chain variable fragments comprising VH and VL segments or single V-region domains. Some of these are interfering antibody fragments that compete with protein-protein interactions, providing lead molecules for drug interactions that until now have been considered difficult or undruggable. It may be possible to deliver or express antibody fragments in target cells as macrodrugs per se. In future incarnations of intracellular antibodies, however, the structural information of the interaction interface of target and antibody fragment should facilitate development of binding site mimics as small drug-like molecules. This is a new dawn for intracellular antibody fragments both as macrodrugs and as precursors of drugs to treat human diseases and should finally lead to the removal of the epithet of the ,undruggable' protein-protein interactions. [source] | ||||||||||