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Neovascular Membrane (neovascular + membrane)

Distribution by Scientific Domains

Medical Sciences	100%

Kinds of Neovascular Membrane

choroidal neovascular membrane

Selected Abstracts

Letter to the Editor: Limited long-term efficacy of intravitreous anti-VEGF pharmacotherapy in sarcoidosis complicated by peripapillary choroidal neovascular membrane

ACTA OPHTHALMOLOGICA, Issue 6 2010
Sumit P. Shah
No abstract is available for this article. [source]

2255: Inflammatory neovascular membrane

ACTA OPHTHALMOLOGICA, Issue 2010
P NERI
Purpose To describe the most common mistakes in the management of inflammatory choroidal neovascularization (CNV). Methods The current literature is reviewed and the experience of a tertiary referral centre is reported. Results CNV is a potentially sight-threatening sequela of uveitis. Several mistakes can be done during patients examination: CNV might not be recognized both at biomicroscopy and at fluorescein angiography (FA), for instance. Moreover, since some doctors are not aware of the importance of Indocyanine Green Angiography (ICGA), the choroidal involvement during inflammatory CNV might not be appreciated. These are just some examples of possible errors which can be done during the daily practice. The outcome of subfoveal CNV is poor if untreated: several procedures have been considered, even though there is lack of guidelines. The most important mistake can be represented by the lack of criticism on the treatment techniques: several methods have been proposed, albeit some of them should not be used on the basis of the treatment rationale and on the better knowledge of CNV pathophysiology. The presentation shows the most typical cases where the above mentioned mistakes have been done, suggesting some methods in order to avoid them. Conclusion CNV secondary to uveitis is a severe sequela, which can lead to significant visual impairment. Several mistakes can be done during both the diagnosis and the therapeutic procedures. Although no guideline is provided, the current medical literature can give the basis for a successful treatment strategy. [source]

Intravitreal ranibizumab as primary treatment for neovascular membrane associated with angioid streaks

ACTA OPHTHALMOLOGICA, Issue 3 2010
Konstantinidis Lazaros
No abstract is available for this article. [source]

Inflammatory choroidal neovascular membrane in presumed ocular Lyme borreliosis

ACTA OPHTHALMOLOGICA, Issue 3 2009
Radgonde Amer
Abstract. Introduction:, Lyme disease is a multisystemic disease with protean ocular manifestations. We describe the occurrence of inflammatory choroidal neovascular membrane (CNVM) in two patients suffering from presumed Lyme disease. Methods:, Descriptive review of the clinical records of two patients. Results:, Patient 1: 16-year-old healthy male presenting with a visual acuity of counting fingers [oculus dexter (OD)] and 6/6 [oculus sinister (OS)] 3 months after a tick bite. He had papillitis and an exudative subretinal macular lesion OD. Treatment was started with intravenous (IV) ceftriaxone; a week later, IV methylprednisolone was administered with a tapering dose of oral steroids thereafter. Three months later, VA had improved to 3/60 OD. Patient 2: 38-year-old healthy female presenting with reduced left-eye vision (6/24) 6 weeks after a tick bite. She also suffered from erythema migrans and arthralgias. She had left-eye papillitis, macular haemorrhages and vascular sheathing. Treatment was started with IV ceftriaxone. One month later, there was profound loss of vision with development of CNVM. Treatment was declined by the patient and eventually retinal fibrosis developed. Conclusion:, Inflammatory CNVM has not been described previously in the setting of ocular Lyme borreliosis. We herein describe the occurrence of inflammatory CNVM in two patients whose diagnosis with Lyme disease was clinically based , both were sero-negative. Visual outcome in the two patients was profoundly impaired because of the ensuing macular scar. [source]

Macular hole following intravitreal ranibizumab injection for choroidal neovascular membrane caused by age-related macular degeneration

ACTA OPHTHALMOLOGICA, Issue 2 2009
Giuseppe Querques
[source]

Laser photocoagulation for choroidal neovascular membrane associated with optic disc drusen

ACTA OPHTHALMOLOGICA, Issue 2 2004
Marie N. Delyfer
Abstract. Purpose:, To report two cases of choroidal neovascular membrane associated with optic disc drusen which were successfully treated using argon laser photocoagulation. Methods:, Choroidal neovascular complications of optic disc drusen were diagnosed in two of our patients, a 36-year-old woman and a 14-year-old girl. In both cases visual acuity was 20/100 in the affected eye. Fundus examination and angiography revealed a choroidal neovascular membrane. Computer tomography identified bilateral calcified drusen of the optic discs. Photocoagulation of neovascular tissues was immediately performed. Results:, Visual acuity improved progressively, reaching 20/20 10 months after treatment in one case and 20/30 in the other. No recurrence was observed during follow-up. Conclusion:, Early diagnosis and immediate laser photocoagulation of vision-threatening choroidal neovascular membranes associated with optic disc drusen helps stop progression towards the macula and improves longterm visual acuity. [source]

Optical coherence tomography in choroidal neovascular membrane associated with Best's vitelliform dystrophy

ACTA OPHTHALMOLOGICA, Issue 2 2002
R. E. Andrade
ABSTRACT. A 29-year-old black male with Best's dystrophy presented an elevated choroidal neovascular membrane in the right eye that was diagnosed and followed with fluorescein-indocyanine green angiography and optical coherence tomography. The subretinal neovascularization was successfully treated with argon laser photocoagulation. One month later, the visual acuity improved and an optical coherence tomography confirmed regression of the serous macular detachment. The final clinical picture remained stable for 12 months of follow-up. [source]

The effect of photodynamic therapy on retrobulbar blood flow parameters

CLINICAL & EXPERIMENTAL OPHTHALMOLOGY, Issue 1 2008
Peykan Türkçüo, lu MD
Abstract Purpose:, To investigate the effect of photodynamic therapy (PDT) on retrobulbar blood flow parameters. Methods:, Twenty-four patients with choroidal neovascular membrane of at least four MPS disc area in one eye due to age-related macular degeneration scheduled for PDT were recruited. Peak systolic and end diastolic velocity of ophthalmic, central retinal and posterior ciliary artery of both eyes were measured with colour Doppler imaging and resistivity index were computed before, at the first and fourth weeks following PDT. Results:, Following PDT, the mean peak systolic velocity of posterior ciliary artery increased significantly to a value of 31.90 ± 13.44 at the first (P = 0001), then returned to an insignificant value of 29.95 ± 13.03 at the fourth week (P = 0.360), when compared with pre-PDT mean measurement (30.16 ± 13.15). Resistivity index of posterior ciliary artery also increased significantly to a value of 0.740 ± 0.77 at the first (P = 0.046), then returned to an insignificant value of 0.666 ± 0.14 at the fourth week (P = 0.407), when compared with pre-PDT mean measurement (0.709 ± 0.90). All the other measured data (peak systolic velocity, end diastolic velocity, resistivity index of ophthalmic and central retinal artery; end diastolic velocity of posterior ciliary artery of the treated eyes; all colour Doppler imaging measurements of untreated eyes) did not show any significant change at the first and fourth week following PDT, when compared with the pre-PDT values. Conclusion:, The peak systolic velocity and resistivity index of the posterior ciliary artery appear to increase in the first week and return to their baseline values at the fourth week following PDT. [source]

In vivo imaging of retinal inflammation in experimental autoimmune uveoretinitis

ACTA OPHTHALMOLOGICA, Issue 2009

Purpose Experimental animal models are essential for us to understand the pathogenesis of human diseases. Posterior uveoretinitis can be modelled in mice with IRBP immunization (i.e. experimental autoimmune uveitis, EAU), whereas a number of mouse models are also available for age-related macular degeneration (AMD). With the advancement in new technologies, it is now possible to image inflammatory retinal changes in experimental mice in vivo none invasively. The aim of the study is to clinical revisit the traditional retinal inflammation animal models with modern imaging techniques. Methods EAU was induced in C57B/6 mice with IRBP peptide 1-20. Aged CCL2 knockout mice were used as an AMD model. Retinal inflammatory changes were imaged in vivo non-invasively using topical endoscopic fundus imaging system and the scanning laser ophthalmoscopy (SLO) system. Results Inflammatory retinal changes in the early stages of EAU were characterised as retinal oedema, vascular sheathing, multiple small retinal infiltrates or large linear retinal infiltrates. "Snow-ball"-like vitreous infiltrates were observed in the inferior part of the fundus at the peak stage of EAU. Using SLO autofluorescent (AF)-macrophages were detected at the peak stages of EAU and were located predominately around inflamed retinal venules. At the late stages of EAU, retinal scars and intraretinal neovascular membranes were observed. In the retina aged CCL2 KO mice, regional retinal atrophy and dursen-like multiple lesions were observed. Dursen-like changes were autofluorescent in SLO examination. Ex vivo confocal microscopy indicated that they were not dursen but subretinal lipofuscin-loaded microglial cells. Conclusion EAU mimics many aspects of human posterior uveoretinitis including retinal vasculitis, multifocal choroiditis. Late stage EAU could be a good model for inflammation induced retinal neovascularisation. CCL2 KO mouse is a model of dry-AMD. [source]