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Negative Changes (negative + change)
Selected AbstractsThermodynamic analysis of binding of p -substituted benzamidines to trypsinFEBS JOURNAL, Issue 6 2001Reinskje Talhout Understanding the structural basis of inhibitor,enzyme interactions, important for the design of new drugs, requires a complete thermodynamic characterization of the binding process as well as a description of the structure of the complex. In this paper, the binding of p -substituted benzamidinium derivatives to the structurally well-characterized serine proteinase bovine pancreatic trypsin has been studied using isothermal titration calorimetry. These experiments have permitted a complete characterization of the temperature dependence of the inhibitor-binding thermodynamics. At 25 °C, both the enthalpy and entropy of binding are favourable for all studied derivatives, but this is only true for a relatively narrow temperature range. As binding is characterized by a negative change in heat capacity, the process is characterized by enthalpy,entropy compensation, resulting in a change of the net thermodynamic driving force for association from entropic to enthalpic with increasing temperature. These phenomena are not unusual when hydrophobic forces play an important role. The trend in the relative binding potencies can, to a significant extent, be attributed to the electron-donating/withdrawing character of the substituent at the para position, as shown by the Hammett plot for the different inhibitors; the more polar the p -substituted benzamidine, the less potent it will be as a trypsin inhibitor. This behaviour might result from a bulk solvation effect, meaning that the more polar, lower potency inhibitors will be more stabilized in water than the less polar, higher potency inhibitors. [source] Changes in externalizing and internalizing behaviours over a school-year: differences between 6-year-old boys and girlsINFANT AND CHILD DEVELOPMENT, Issue 2 2006Annie Hammarberg Abstract The purpose of this study was to investigate changes in externalizing and internalizing problem behaviours in 6-year-olds with a focus on sex differences. Teachers rated problem behaviours at the beginning and at the end of the school year, 8 months apart, in 370 children (197 boys and 173 girls) attending 22 school preparatory classrooms. Although the majority of the children were quite stable, considerable negative and positive changes for both boys and girls in problem behaviours were found. The results showed that girls were more likely to change their externalizing behaviours in a positive direction than boys, whereas a tendency to the opposite pattern was found for internalizing behaviours. Boys were also found to be more prone to a negative change in problem behaviours of both types than girls were. Copyright © 2006 John Wiley & Sons, Ltd. [source] Innovative approach to health promotion for the over 45s: using a health check logINTERNATIONAL JOURNAL OF OLDER PEOPLE NURSING, Issue 4 2008BAppSc (AN), June N. Sheriff CM, MHPEd Objectives., To determine effectiveness of the health check log (HCL) in promoting health-related quality of life and health awareness, health monitoring skills and timely consultation with health professionals for a cohort of community-dwelling people over 45 years, compared with a similar cohort not recording the HCL. Design., An exploratory longitudinal study using a quasi-experimental methodology and data triangulation. Outcome measures included the SF-36 health survey; a semi-structured participant feedback survey and participant focus group discussions. Sample., A convenience sample (n = 309) of community dwellers over the age of 45 living in the South Eastern Sydney/Illawarra Area Health Service, Sydney, Australia. Results., The majority of participants recording the HCL reported health benefits. The SF-36 health survey found younger age is a predictor for positive change in ,social functioning' (, = ,0.14, t = 2.25, P < 0.05), while non-pension income was a predictor of positive ,physical functioning' (, = 0.12, t = 2.02, P < 0.05) and ,general health' (, = 0.13, t = 2.11, P < 0.05). Alternatively, full-time employment (, = ,0.12, t = 2.02, P < 0.05) and not living alone (, = 0.18, t = 3.09, P < 0.01) predicted negative change in ,role , physical'. Participant reactions to recording the HCL via feedback survey and focus group discussions were mostly positive. Conclusions., The majority who maintained the HCL benefited by achieving improved health and knowledge of health monitoring, which was, however, moderated by age, income source, employment status and living arrangements. [source] Improving food purchasing choices through increased understanding of food labels, using itemized till receipts to measure these changesJOURNAL OF HUMAN NUTRITION & DIETETICS, Issue 4 2008P.M. Rigby Background:, Rising obesity and the associated risks of diabetes and heart disease require changes in diet to bring about healthier eating. To achieve this, people need to understand nutrition and daily requirements but are frequently confused by nutrition information on food labels. The introduction of the Food Standards Agency's ,Traffic Light' and the alternative ,Guideline Daily Amount' systems may help or further confuse the public. A previous study showed that although 63% of study participants read labels, only 25% claimed to understand them, also knowledge of nutrient requirements and functions was low (Rigby, 2004). Ransley et al., (2001) have shown that till receipts can be used to estimate fat and energy intake. The aim of the current study was to investigate whether an intervention designed to improve understanding of nutrition and labels could improve food purchases and whether these changes could be measured from till receipts. Method:, Participants were recruited from the general public (80 female; 23 males) (age <30 years (23), 31,45 years (25), 46,60 years (30), >60 years (22). Subjects were randomly assigned to either the intervention group (n = 78) who were provided with an information booklet and credit card sized nutrition and labelling information to use when shopping, or the control group (n = 25), who received the information after four weeks of normal shopping. The intervention group provided an initial till receipt pre intervention and was then given the nutrition and labelling material. Further till receipts were returned from successive shopping trips over the following 4 weeks. The nine categories of food used for comparison were: fruit and vegetables, saturated fats, monounsaturated fats, polyunsaturated fats, white cereals, wholegrain cereals, processed foods, full fat and reduced fat items. Ethics approval was obtained from NWW Wales NHS Trust ethics committee. Results:, Each of the nine food categories on till receipts were calculated as a percentage of the total shopping, excluding non-food items. General linear model repeated measures analyses showed differences between study participants' food purchases. For the intervention group, purchases in three of the nine food categories showed significant improvements: increased purchases of fruits and vegetables (P < 0.001); reduction in purchases of saturated fats (P < 0.001); and reduction of white cereal purchases (P < 0.050). The control group showed no differences in any category. Discussion:, Although the intervention group did show improvements in most of the other food categories, they were not statistically significant. Positive changes were found in seven of the nine categories, with only one, wholegrain cereals, showing a decrease in purchases rather than an increase. The control group displayed a random pattern over the four till receipts, with eight categories either showing negative change or no change; only one showed a positive change. The disproportionate group sizes may mean that it is not be possible to draw firm conclusions regarding the effectiveness of the intervention. Conclusions:, This study demonstrates that positive changes in improving food-purchasing choices, as measured by till receipts, can be made by using educational interventions. Further larger studies using routinely collected supermarket data would enable the study to be replicated on a much larger scale. References, Ransley, J.K., Donnelly, J.K., Khara, T.N., Botham, H., Arnott, H., Greenwood, D.C. & Cade, J.E. (1991) The use of supermarket till receipts to determine the fat and energy intake in a UK population. Public Health Nutr. 4, 1279,1286. Rigby, P. (2004) Effecting change. Understanding nutritional information. Can increased knowledge and understanding in relation to nutritional information bring about a change in eating habits? PhD Thesis WA: Bangor University. [source] Androgens and energy allocation: Quasi-experimental evidence for effects of influenza vaccination on men's testosteroneAMERICAN JOURNAL OF HUMAN BIOLOGY, Issue 1 2009Zachary L. Simmons Androgens are proposed to allocate finite energetic resources away from immune function and toward anabolic processes related to reproductive effort. In situations of pathogen exposure, the significant energetic demands associated with mounting an immune response are expected to produce a decrease in androgen levels and commensurate redistribution of energy. We tested the hypothesis that even the mild immune challenge associated with vaccination may cause a decline in men's testosterone. As predicted, men who received an influenza vaccination exhibited a more negative change in testosterone over a 2-week period than did men in a nonequivalent control group who were not vaccinated. These results suggest that men's androgen concentrations may be finely calibrated to trade-offs between the energetic demands of immune responses and other life history problems. Am. J. Hum. Biol., 2009. © 2008 Wiley-Liss, Inc. [source] Credit Ratings and Taxes: The Effect of Book,Tax Differences on Ratings ChangesCONTEMPORARY ACCOUNTING RESEARCH, Issue 2 2010BENJAMIN C. AYERS G29; H25; H32; M41 This paper examines whether credit analysts utilize the information contained in the difference between book and taxable income in analyzing a firm's credit risk. Increased book,tax differences may be informative for credit rating agencies as they may signal decreased earnings quality or changes in the firm's off,balance sheet financing. Results suggest a significant negative association between positive changes in book,tax differences and ratings changes. This evidence is consistent with large positive changes in book,tax differences signaling decreased earnings quality and/or increased off,balance sheet financing. We also find that large negative changes in book,tax differences result in less favorable rating changes, consistent with these changes signaling decreased earnings quality. In additional analyses, we find that the association between changes in book,tax differences and rating changes is attenuated for high,tax-planning firms (e.g., where book,tax differences more likely reflect tax planning than decreased earnings quality). [source] Plant species response to land use change ,Campanula rotundifolia, Primula veris and Rhinanthus minorECOGRAPHY, Issue 1 2005Regina Lindborg Land use change is a crucial driver behind species loss at the landscape scale. Hence, from a conservation perspective, species response to habitat degradation or improvement of habitat quality, is important to examine. By using indicator species it may be possible to monitor long-term survival of local populations associated with land use change. In this study we examined three potential indicator (response) species for species richness and composition in Scandinavian semi-natural grassland communities: Campanula rotundifolia, Primula veris and Rhinanthus minor. With field inventories and experiments we examined their response to present land use, habitat degradation and improvement of local habitat quality. At the time scale examined, C. rotundifolia was the only species responding to both habitat degradation and improvement of habitat quality. Neither R. minor nor P. veris responded positively to habitat improvements although both responded rapidly to direct negative changes in habitat quality. Even though C. rotundifolia responded quickly to habitat degradation, it did not disappear completely from the sites. Instead, the population structure changed in terms of decreased population size and flowering frequency. It also showed an ability to form remnant populations which may increase resilience of local habitats. Although P. veris and especially R. minor responded rapidly to negative environmental changes and may be useful as early indicators of land use change, it is desirable that indicators respond to both degradation and improvement of habitat quality. Thus, C. rotundifolia is a better response species for monitoring effects of land use change and conservation measures, provided that both local and regional population dynamics are monitored over a long time period. [source] Stabilization of phytosterols in rapeseed oil by natural antioxidants during heatingEUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY, Issue 11 2009Dominik Kmiecik Abstract Antioxidants are substances that can reduce negative changes in fat. Many antioxidants are very effective during storage, but during heating they lose their properties. It is very important to find antioxidants that will be stable at high temperatures and protect fat throughout the entire frying process. The aim of this study was to estimate the effect of natural and synthetic antioxidants on changes in phytosterols of rapeseed oil during heating. Oil with antioxidants was heated at 180,°C for 4,h in a Rancimat® and in an Oxidograph®. Ethanol extract of rosemary, ethanol extract of green tea, and BHT were used in the study. The contents of phytosterols (sitosterol, campesterol, avenasterol, brassicasterol, stigmasterol) and oxyphytosterols (7,- and 7,-hydroxysterol, 5,,6,- and 5,,6,-epoxysterol, 7-ketosterol and triols) were estimated by gas chromatography. In all samples with antioxidants, a lower decrease of phytosterols and a lower increase of total oxyphytosterols were observed in comparison with the control sample (without antioxidant). The antioxidant effect depends on the type of the antioxidant and the heating conditions. The best results were observed in samples with natural antioxidants. BHT was a substance that protected phytosterols as well, but not as effectively as the other antioxidants. [source] EVOLUTION OF GENETIC ARCHITECTURE UNDER DIRECTIONAL SELECTIONEVOLUTION, Issue 8 2006Thomas F. Hansen Abstract We investigate the multilinear epistatic model under mutation-limited directional selection. We confirm previous results that only directional epistasis, in which genes on average reinforce or diminish each other's effects, contribute to the initial evolution of mutational effects. Thus, either canalization or decanalization can occur under directional selection, depending on whether positive or negative epistasis is prevalent. We then focus on the evolution of the epistatic coefficients themselves. In the absence of higher-order epistasis, positive pairwise epistasis will tend to weaken relative to additive effects, while negative pairwise epistasis will tend to become strengthened. Positive third-order epistasis will counteract these effects, while negative third-order epistasis will reinforce them. More generally, gene interactions of all orders have an inherent tendency for negative changes under directional selection, which can only be modified by higher-order directional epistasis. We identify three types of nonadditive quasi-equilibrium architectures that, although not strictly stable, can be maintained for an extended time: (1) nondirectional epistatic architectures; (2) canalized architectures with strong epistasis; and (3) near-additive architectures in which additive effects keep increasing relative to epistasis. [source] Changes in family food habits: the role of migrationINTERNATIONAL JOURNAL OF CONSUMER STUDIES, Issue 3 2000Clara Opare-Obisaw Abstract The food habits of people generally dictate their nutritional well-being, which subsequently affects their physical and mental health. A change in environment is one of the major factors that could bring about positive or negative changes in food consumption patterns. The food habits of 50 migrant families living in a suburb of Accra were studied to find out what changes have taken place as a result of a change in living environment. The homemaker in each family was interviewed to obtain information on socioeconomic characteristics, past and present food procurement and consumption patterns, food avoidances and factors that influence food selection and consumption. The findings revealed that, although the majority stuck to foods they were accustomed to, there were striking changes in sources of food procurement, the number of meals prepared at home and the relative frequency of consumption of some staple foods. One-third of the study group felt that their diets had become poorer as a result of the change in environment. Two factors, time and money, were associated with the changes that had taken place. The study provides some evidence for the existence of inadequate diets among migrant families. This might even reflect a more serious situation facing the numerous migrant youth, who have no families to cater for them and, hence, put their health at risk. Home economists and other related professionals could be instrumental in drawing up intervention programmes to ensure adequate selection and consumption of food to promote good health among migrants to the city. [source] Positive and negative changes following occupational death exposureJOURNAL OF TRAUMATIC STRESS, Issue 6 2005P. Alex Linley Professionals who work in situations that expose them to death have long been of interest to traumatic stress research. However, the positive changes that these professionals may also experience have not been the subject of empirical scrutiny. This study examined occupational death exposure, death attitudes, subjective appraisals, intrusions, avoidance, social support, and positive and negative affect, and their associations with positive and negative psychological changes in funeral directors. Multivariate hierarchical regression analyses revealed that positive changes were significantly and independently predicted by an approach acceptance death attitude and social support; negative changes were significantly and independently predicted by fear of death, intrusions and avoidance, and occupational death exposure. The discussion focuses on how these findings extend the literature dealing with occupational death exposure, together with a consideration of limitations of the study that inform directions for future research. [source] FOREIGN DIRECT INVESTMENT IN SUB-SAHARAN AFRICA: CHANGING LOCATION-SPECIFIC ADVANTAGES AS SIGNALS OF COMPETITIVENESSTHE DEVELOPING ECONOMIES, Issue 3 2009Frank L. BARTELS F21; R3; P42; F23 This paper uses longitudinal factor analysis of location-specific advantages that are relevant to the foreign direct investment decisions of multinational enterprises (MNEs) in sub-Saharan Africa (SSA) to signal changes in location competitiveness. A total of 1,216 responses by MNEs to a survey in 15 SSA countries are analyzed. We find that, first, over a three-year period (2002,5), MNEs perceive a positive change in the market-servicing environment in SSA. Second, MNEs find negative changes in SSA regarding the availability of input factors and characteristics of market demand. [source] Bank Interest Rate Adjustments: Are They Asymmetric?THE ECONOMIC RECORD, Issue 237 2001G.C. Lim This paper is concerned with the asymmetric adjustments between three Australian bank interest rates: a bank bill rate, a loan rate and a deposit rate. A multivariate asymmetric error-correction model is applied to capture the interplay of long-run relationships between the levels of the rates and short-run relationships between the changes in the rates. The empirical analysis, for the sample period 1990:01,2000:04, shows that interest rate adjustments, in response to positive and negative shocks, are asymmetric in the short run, but not in the long run. In particular, the results suggest that banks adjust their loan and deposit rates, in response to a change in the bank-bill rate, at a faster rate during periods of monetary easings (negative changes) than during periods of monetary tightenings (positive changes). [source] A prospective, randomized, double-blind trial to evaluate the role of a short reducing course of oral corticosteroid therapy in the treatment of chronic prostatitis/chronic pelvic pain syndromeBJU INTERNATIONAL, Issue 2 2007Sylvia M. Bates OBJECTIVES To assess the validity of our observational experience that a short course of oral prednisolone therapy might be of value in the management of symptoms of chronic pelvic pain syndrome (CPPS) in men. PATIENTS AND METHODS Twenty-one men with CPPS (inflammatory or non-inflammatory) for ,6 months, and who had failed to improve with standard antibiotic therapy, were randomized to receive either a 1-month reducing course of oral prednisolone (nine) or an equivalent placebo regimen (12 men). The outcome measures used were the McGill Pain Questionnaire, the Hospital Anxiety and Depression Scale (HADS), General Health Questionnaire-30 (GHQ-30) and the National Institute of Health Chronic Prostatitis Symptom Index (NIH-CPSI), which were completed at baseline and 3 months. RESULTS Outcomes were analysed for the 18 patients (six treated, 12 placebo) who completed the 3 months of follow-up. At both baseline and 3 months, respectively, there was no statistically significant difference between the groups in the NIH-CPSI total score (P = 0.48 and 0.62; Mann,Whitney U -test), or in the HADS (anxiety, P = 0.85 and 0.67; depression P = 0.96 and 0.74), and there was no significant improvement or deterioration over time. Although not statistically significant, there was a trend to improvement in the depression score for the active group (P = 0.13). However, the clinical significance is doubtful, as both baseline and follow-up depression scores were within the normal range. No patient had clinically negative changes in depression. A 3-month follow-up analysis was not possible for the McGill Pain Questionnaire or GHQ-30 as not all patients completed the questionnaire. CONCLUSIONS Whilst the study showed no clinical benefit of using corticosteroids in the management of CPPS, the few patients recruited limited the validity of firm conclusions from the data. There was a trend towards an improvement of depression levels amongst subjects. The study highlights the difficulties of recruitment and illustrates the complex psychological profiles of patients with CPPS. [source] | |||||||||||||||||||