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Necessary Cause (necessary + cause)

Distribution by Scientific Domains

Medical Sciences	50%

Selected Abstracts

Human papillomavirus (HPV) genotype distribution in invasive cervical cancers in France: EDITH study ,

INTERNATIONAL JOURNAL OF CANCER, Issue 2 2008
Jean-Luc Prétet
Abstract Invasive cervical cancer (ICC) remains a significant cause of morbidity and mortality in France. Since human papillomavirus (HPV) is the necessary cause of ICC, the aim of this study was to assess the type-specific prevalence of HPV in ICC in France in order to locally evaluate the potential benefit of an HPV 16/18 L1 virus-like particles (VLP) vaccination. A total of 516 histological specimens collected in 15 centers were analyzed. Among them, 86% had a diagnosis of squamous cell carcinoma (SCC) whereas 14% were adenocarcinomas (ADC). HPV genotyping was performed using the INNO-LiPA assay allowing the specific detection of 24 HPV genotypes both high risk (HR) and low risk (LR). The overall HPV prevalence in ICC was 97%. The most prevalent genotypes were HPV 16 (73%) and HPV 18 (19%) followed by HPV 31 (7%), 33, 68, 45, 52 and 58 (4.1,2.3%). HPV 16 and/or 18 were associated with 82% of ICC, 10% being HPV 16 and 18 coinfections. While HPV 16 was the most prevalent type in both SCC (74%) and ADC (64%), HPV 18 was by far more prevalent in ADC (37%) compared to SCC (16%; p < 0.001). Multiple infections with at least two different HR HPV genotypes were observed in 22% of ICC. Given the high HPV 16/18 prevalence and taking into account possible production of crossneutralizing antibodies against other HPV types, HPV 16/18 L1 VLP vaccination would be expected to significantly reduce the burden of ICC in France. © 2007 Wiley-Liss, Inc. [source]

Hypercholesterolemia and inflammation in atherogenesis: Two sides of the same coin

MOLECULAR NUTRITION & FOOD RESEARCH (FORMERLY NAHRUNG/FOOD), Issue 11 2005
Daniel SteinbergArticle first published online: 3 NOV 200
Abstract An abundance of experimental, clinical, and epidemiologic data capped by stunning interventional results with the statins has established hypercholesterolemia as a major causative factor in atherogenesis. In familial hypercholesterolemia and in animal models it is a sufficient cause. Some degree of hypercholesterolemia, perhaps 30,50 mg/dL, may even be a necessary cause. It is equally clear that from the very beginning atherogenesis has a strong inflammatory component, i. e., it is characterized by penetration of monocytes and of T-cells into the developing lesion. These cells, through the secretion of cytokines and growth factors, through immune responses, and through complex cross-talk with elements of the artery wall modulate the growth of the lesion and affect its stability. But inflammation has to occur in response to something. What is that something? What is the "injury" in "response-to-injury"? The case will be made that oxidized lipids in oxidized LDL or generated in response to prooxidative changes in the cells of the artery wall should be considered a plausible candidate. There is no need to consider hypercholesterolemia and inflammation as alternative hypotheses. Both are very much involved. Optimal intervention and prevention will probably require attention to both. [source]

Human papillomavirus integration: detection by in situ hybridization and potential clinical application

THE JOURNAL OF PATHOLOGY, Issue 1 2004
Mark F Evans
Abstract Human papillomaviruses (HPVs) are accepted as a necessary cause of cervical neoplasia. However, the benefits of testing simply for high-risk HPV types are limited because of their high prevalence in intraepithelial lesions of all grades, the majority of which regress if left untreated. One factor considered to be of key importance for the progression of intraepithelial lesions to invasive disease is integration of HPV into the host cell genome. Although questions remain about the prevalence of integration amongst pre-invasive lesions, sensitive in situ hybridization techniques utilizing tyramide reagents may aid determination of the significance of HPV infection by enabling routine detection of both high-risk HPV and its physical status. This will provide important data relevant not only to our understanding of the biology of HPV-associated neoplasia, but also potentially to clinical testing for HPV. Copyright © 2003 John Wiley & Sons, Ltd. [source]

Islamic Radicalisation among North Africans in Britain

BRITISH JOURNAL OF POLITICS & INTERNATIONAL RELATIONS, Issue 4 2008
Jonathan Githens-Mazer
This article examines how symbols of Islamic repression and massacre affect radicalisation among North Africans living in the UK. It suggests that these symbols are an insufficient but necessary cause in the larger process of ,radicalisation', because they provide a basis for perceptions of injustice. In this context, myths, memories and symbols of colonial repression, contemporary repression of free political expression in North African states and current perceptions of western ,oppression' of Islam may be perceived as rationales for ,oxygenation'. Oxygenation here denotes exchanges among different Muslim communities throughout Britain which potentially facilitate terrorist networks. Oxygenation in turn contributes to ,blowback', here in the guise of perceptions among British Muslims of global oppression of the Umma, especially understood in light of the Iraqi and Afghani insurgencies. This article also explores how these symbols may be cultivated and disseminated at popular and elite levels. [source]