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Selected AbstractsTemporal Extrapolation of PVA Results in Relation to the IUCN Red List Criterion ECONSERVATION BIOLOGY, Issue 1 2003Oskar Kindvall For a population viability analysis ( PVA) to be useful for assessing a species' threat category, the results must have been expressed as the full extinction probability function over time or at least for the three specified time frames. Often this is not the case, and extrapolations from different kinds of PVA results ( e.g., mean time to extinction ) are often necessary. By means of analytic models, we investigated the possibilities of extrapolation. Based on our results, we suggest that extrapolation is not advisable due to the huge errors that can occur. The extinction probability function is the best kind of summary statistic to use when applying criterion E, but even then the threat categorization may be ambiguous. If the extinction risk is low in the near future but increases rapidly later on, a species may be classified as vulnerable even though it is expected to become extinct within 100 years. To avoid this, we suggest that the guidelines to the IUCN Red List criteria include three reference lines that allow for interpretation of the PVA results in the context of the three threat categories within the entire period of 100 years. If the estimated extinction probability function overshoots one of these functions, the species should be classified accordingly. Resumen: Las categorías de amenaza de la lista roja de la IUCN ( críticamente en peligro, en peligro y vulnerable ) están definidos por un juego de criterios ( A-E ). El criterio E se define cuantitativamente por tres límites especificados de riesgo de extinción ( 50%, 20% y 10% ), cada uno de los cuales se asocia a un marco temporal determinado. Para poder usar el análisis de viabilidad poblacional ( PVA ) durante la evaluación de la categoría de amenaza de una especie, los resultados deben ser expresados en función de probabilidad de extinción total sobre un tiempo o al menos para los tres marcos temporales especificados. Frecuentemente este no es el caso y las extrapolaciones de diferente tipo de resultados de PVA ( tiempo promedio de extinción ) son usualmente necesarias. Por medio de modelos analíticos investigamos las posibilidades de extrapolación. En base a nuestros resultados sugerimos que la extrapolación no es recomendable debido a una enorme cantidad de errores que pueden ocurrir. La función de probabilidad de extinción es el mejor tipo de resumen estadístico a usar cuando se aplica el criterio E, pero, aún así, la categorización de amenaza puede ser ambigua. Si el riesgo de extinción es bajo en un futuro inmediato pero incrementa muy rápidamente después, una especie puede ser clasificada como vulnerable aunque se espere que se extinga dentro de los próximos 100 años. Para evitar esto, sugerimos que los lineamientos de los criterios de la Lista Roja de la UICN incluyan tres lineas de referencia que permitan la interpretación de los resultados del PVA en el contexto de las tres categorías dentro de un periodo completo de 100 años. Si la función de probabilidad de extinción estimada se extiende más allá de una de estas funciones, las especies deberán ser clasificadas según sea el caso. [source] Habitat Loss and Extinction in the Hotspots of BiodiversityCONSERVATION BIOLOGY, Issue 4 2002Thomas M. Brooks None of these hotspots have more than one-third of their pristine habitat remaining. Historically, they covered 12% of the land's surface, but today their intact habitat covers only 1.4% of the land. As a result of this habitat loss, we expect many of the hotspot endemics to have either become extinct or,because much of the habitat loss is recent,to be threatened with extinction. We used World Conservation Union [ IUCN ] Red Lists to test this expectation. Overall, between one-half and two-thirds of all threatened plants and 57% of all threatened terrestrial vertebrates are hotspot endemics. For birds and mammals, in general, predictions of extinction in the hotspots based on habitat loss match numbers of species independently judged extinct or threatened. In two classes of hotspots the match is not as close. On oceanic islands, habitat loss underestimates extinction because introduced species have driven extinctions beyond those caused by habitat loss on these islands. In large hotspots, conversely, habitat loss overestimates extinction, suggesting scale dependence (this effect is also apparent for plants). For reptiles, amphibians, and plants, many fewer hotspot endemics are considered threatened or extinct than we would expect based on habitat loss. This mismatch is small in temperate hotspots, however, suggesting that many threatened endemic species in the poorly known tropical hotspots have yet to be included on the IUCN Red Lists. We then asked in which hotspots the consequences of further habitat loss (either absolute or given current rates of deforestation) would be most serious. Our results suggest that the Eastern Arc and Coastal Forests of Tanzania-Kenya, Philippines, and Polynesia-Micronesia can least afford to lose more habitat and that, if current deforestation rates continue, the Caribbean, Tropical Andes, Philippines, Mesoamerica, Sundaland, Indo-Burma, Madagascar, and Chocó,Darién,Western Ecuador will lose the most species in the near future. Without urgent conservation intervention, we face mass extinctions in the hotspots. Resumen: Casi la mitad del total de plantas vasculares del mundo y un tercio de los vertebrados terrestres son endémicos en 25 "áreas críticas" para la biodiversidad, cada una de las cuales tiene por lo menos 1500 especies de plantas endémicas. En ninguno de estos sitios permanece más de un tercio de su hábitat prístino. Históricamente, cubrían 12% de la superficie terrestre, pero en la actualidad su hábitat intacto cubre solo 1.4% del terreno. Como resultado de esta pérdida de hábitat esperamos que muchas de las especies endémicas a estos sitios estén extintas o , porque la pérdida de hábitat es reciente , se encuentren amenazadas de extinción. Utilizamos Listas Rojas de UICN para comprobar esta predicción. En general, entre la mitad y dos tercios de las plantas amenazadas y el 57% de los vertebrados terrestres amenazados son endémicos de áreas críticas para la biodiversidad. Para aves y mamíferos en general, las predicciones de extinción en las áreas críticas para la biodiversidad, basadas en la pérdida de hábitat, coinciden con el número de especies consideradas extintas o amenazadas independientemente. En dos clases de áreas críticas para la biodiversidad la coincidencia no es muy grande. En islas oceánicas, la pérdida de hábitat subestima la extinción porque las especies introducidas han causado más extinciones que las producidas por la reducción del hábitat. Por lo contrario, la pérdida de hábitat sobrestima la extinción en áreas críticas para la biodiversidad extensas, lo que sugiere una dependencia de escala (este efecto también es aparente para plantas). Para reptiles, anfibios y plantas mucho menos especies endémicas son consideradas amenazadas o extintas por pérdida de hábitat. Sin embargo, esta discordancia es pequeña en áreas críticas para la biodiversidad en zonas templadas templadas, lo que sugiere que muchas especies endémicas amenazadas en las poco conocidas áreas críticas para la biodiversidad en zonas tropicales aun están por incluirse en las Listas Rojas. Posteriormente nos preguntamos en que áreas críticas para la biodiversidad serían más serias las consecuencias de una mayor pérdida de hábitat (absoluta o con las tasas actuales de deforestación). Nuestros resultados sugieren que el Arco Oriental y los Bosques Costeros de Tanzania/Kenia, Filipinas, Polinesia/Micronesia no pueden soportar mayores pérdidas y que, si continúan las tasas de deforestación actuales, el Caribe, Andes Tropicales, Filipinas, Mesoamérica, Sundaland, Indo-Burma, Madagascar y Chocó/Darién/Ecuador Occidental perderán más especies en el futuro. Sin acciones urgentes de conservación, habrá extinciones masivas en las áreas críticas para la biodiversidad. [source] UNITED STATES V. BOOKER AS A NATURAL EXPERIMENT: USING EMPIRICAL RESEARCH TO INFORM THE FEDERAL SENTENCING POLICY DEBATE,CRIMINOLOGY AND PUBLIC POLICY, Issue 3 2007PAUL J. HOFER Research Summary: In United States v. Booker, the U.S. Supreme Court held that the federal sentencing guidelines must be considered advisory, rather than mandatory, if they are to remain constitutional under the Sixth Amendment. Since the decision, the U.S. Sentencing Commission has provided policy makers with accurate and current data on changes and continuity in federal sentencing practices. Unlike previous changes in legal doctrine, Booker immediately increased the rates of upward and downward departures from the guideline range. Government-sponsored downward departures remain the leading category of outside,the-range sentences. The rate of within-range sentences, although lower than in the period immediately preceding Booker, remains near rates observed earlier in the guidelines era. Despite the increase in departures, average sentence lengths for the overall caseload remain stable, because of offsetting increases in the seriousness of the crimes being sentenced and in the severity of penalties for those crimes. Analyses of the reasons that judges reported for downward departures suggest that treatment of criminal history and offender characteristics are the two leading areas of dissatisfaction with the guidelines. Policy Implications: Assessment of changes in sentencing practices following Booker by different observers depends partly on competing institutional perspectives and on different degrees of trust in the judgment of judges, prosecutors, the Sentencing Commission, and Congress. No agreement on whether Booker has bettered or worsened the system can be achieved until agreement exists on priorities among the purposes of sentencing and the goals of sentencing reform. Both this lack of agreement and an absence of needed data make consensus on Booker's effects on important sentencing goals, such as reduction of unwarranted disparity, unlikely in the near future. Similarly, lack of baseline data before Booker on the effectiveness of federal sentencing at crime control makes before-after comparisons impossible. Despite these limitations, research provides a sounder framework for policy making than do anecdotes or speculation and sets valuable empirical parameters for the federal sentencing policy debate. [source] Role of ancillary techniques in diagnosing and subclassifying non-Hodgkin's lymphomas on fine needle aspiration cytologyCYTOPATHOLOGY, Issue 5 2006P. DeyArticle first published online: 8 SEP 200 Non-Hodgkin's lymphomas (NHL) are tumours of the lymphoid cells. During the process of development of lymphoid cells, neoplasia may evolve at any point. Neoplastic cells usually carry the imprint of cell of origin at the stage of origin. Various types of NHL may have similar morphology with wide variation in origin, immunophenotype and other biological features. Different ancillary laboratory techniques may help to overcome the limitations of morphology in this aspect. The commonly used ancillary techniques in lymphomas are immunocytochemistry (IC), flow cytometry, Southern blot (SB) technique, polymerase chain reaction (PCR) and fluorescent in situ hybridization (FISH). In addition, laser scanning cytometry (LSC) and DNA microarray technologies are in the research phase. Various laboratory techniques are used for immunophenotyping, demonstration of monoclonality, identification of chromosomal translocation, assessment of cell kinetics and expression of mRNA in the tumour cells. Flow cytometry helps in rapid immunophenotying of NHL and it has an added advantage over IC in recognizing the co-expression of CD markers. Fine needle aspiration cytology (FNAC) combined with flow immunophenotyping may help us to diagnose and subclassify certain NHLs, such as follicular lymphoma and mantle cell lymphoma, which were previously recognized as pure morphological entities. Loss of morphology is one of the important limitations of flow cytometry. LSC can overcome this limitation by studying morphology along with the immunophenotyping pattern of individual cells. Chromosomal changes in NHL can be identified by SB, PCR and FISH. Molecular diagnosis of NHL helps in diagnosis, subclassification, prognostic assessment and even in planning of therapy. DNA microarray is a relatively newer and promising technology. It gives information about the expression of several thousands of genes in a tumour in a single experiment. In the near future, FNAC combined with ancillary techniques may play a major role in diagnosis, subclassification and management of lymphomas. [source] Does the MBA Experience Support Diversity?DECISION SCIENCES JOURNAL OF INNOVATIVE EDUCATION, Issue 2 2010Demographic Effects on Program Satisfaction ABSTRACT Using data provided by graduates from 128 MBA programs, we examined the extent to which age, gender, and ethnicity predicted student perceptions of the MBA experience. We found that women and minorities were more likely to see program costs and the availability of financial support as significant factors in their program enrollment decisions than were Caucasian males. The most consistent predictor of students' perceptions of their educational experience was whether the MBA program was full time or part time, with full-time programs generally perceived more favorably. Our findings suggest that because diversity measures of age, gender, and ethnicity were not consistent predictors across the different perception areas, at minimum, MBA programs presently do not consistently inhibit diversity. However, given the increasing percentage of women and minorities that comprise the undergraduate population, maintaining the present path in program accessibility may create enrollment problems for MBA programs perhaps in the very near future. Therefore, we conclude with a discussion of the changing demographics in higher education and their potential implications for MBA programs and suggestions for how MBA programs might respond. [source] Imaging the developing brain with fMRIDEVELOPMENTAL DISABILITIES RESEARCH REVIEW, Issue 3 2003M.C. Davidson Abstract Advancements in magnetic imaging techniques have revolutionized our ability to study the developing human brain in vivo. The ability to noninvasively image both anatomy and function in healthy volunteers, including young children, has already enhanced our understanding of brain and behavior relations. The application of these techniques to developmental research offers the opportunity to further explore these relationships and allows us to ask questions about where, when and how cognitive abilities develop in relation to changes in underlying brain systems. It is also possible to explore the contributions of maturation versus learning in the development of these abilities through cross-sectional and longitudinal research involving training and intervention procedures. Current imaging methodologies, in conjunction with new and rapidly evolving techniques, hold the promise of even greater insights into developmental issues in the near future. These methodologies and their application to development and learning are discussed in the current paper. MRDD Research Reviews 2003;9:161,167. © 2003 Wiley-Liss, Inc. [source] Genetics of type 2 diabetes mellitus: status and perspectivesDIABETES OBESITY & METABOLISM, Issue 2 2005Lars Hansen Throughout the last decade, molecular genetic studies of non-autoimmune diabetes mellitus have contributed significantly to our present understanding of this disease's complex aetiopathogenesis. Monogenic forms of diabetes (maturity-onset diabetes of the young, MODY) have been identified and classified into MODY1,6 according to the mutated genes that by being expressed in the pancreatic ,-cells confirm at the molecular level the clinical presentation of MODY as a predominantly insulin secretory deficient form of diabetes mellitus. Genomewide linkage studies of presumed polygenic type 2 diabetic populations indicate that loci on chromosomes 1q, 5q, 8p, 10q, 12q and 20q contain susceptibility genes. Yet, so far, the only susceptibility gene, calpain-10 (CAPN10), which has been identified using genomewide linkage studies, is located on chromosome 2q37. Mutation analyses of selected ,candidate' susceptibility genes in various populations have also identified the widespread Pro12Ala variant of the peroxisome proliferator-activated receptor-, and the common Glu23Lys variant of the ATP-sensitive potassium channel, Kir6.2 (KCNJ11). These variants may contribute significantly to the risk type 2 diabetes conferring insulin resistance of liver, muscle and fat (Pro12Ala) and a relative insulin secretory deficiency (Glu23Lys). It is likely that, in the near future, the recent more detailed knowledge of the human genome and insights into its haploblocks together with the developments of high-throughput and cheap genotyping will facilitate the discovery of many more type 2 diabetes gene variants in study materials, which are statistically powered and phenotypically well characterized. The results of these efforts are likely to be the platform for major progress in the development of personalized antidiabetic drugs with higher efficacy and few side effects. [source] Role of histone and transcription factor acetylation in diabetes pathogenesisDIABETES/METABOLISM: RESEARCH AND REVIEWS, Issue 5 2005Steven G. Gray Abstract Globally, diabetes (and, in particular, type 2 diabetes) represents a major challenge to world health. Currently in the United States, the costs of treating diabetes and its associated complications exceed $100 billion annually, and this figure is expected to soar in the near future. Despite decades of intense research efforts, the genetic basis of the events involved in the pathogenesis of diabetes is still poorly understood. Diabetes is a complex multigenic syndrome primarily due to beta-cell dysfunction associated with a variable degree of insulin resistance. Recent advances have led to exciting new developments with regard to our understanding of the mechanisms that regulate insulin transcription. These include data that implicate chromatin as a critical regulator of this event. The ,Histone Code' is a widely accepted hypothesis, whereby sequential modifications to the histones in chromatin lead to regulated transcription of genes. One of the modifications used in the histone code is acetylation. This is probably the best characterized modification of histones, which is carried out under the control of histone acetyltransferases (HATs) and histone deacetylases (HDACs). These enzymes also regulate the activity of a number of transcription factors through acetylation. Increasing evidence links possible dysregulation of these mechanisms in the pathogenesis of diabetes, with important therapeutic implications. Copyright © 2005 John Wiley & Sons, Ltd. [source] ENDOSCOPIC SUBMUCOSAL DISSECTION FOR ESOPHAGEAL SQUAMOUS CELL NEOPLASMSDIGESTIVE ENDOSCOPY, Issue 2 2009Mitsuhiro Fujishiro Endoscopic submucosal dissection (ESD) has gradually gained acceptance as one of the standard treatments for early esophageal cancer, as well as for early gastric cancer in Japan, but standardization of the knowledge is still incomplete. The final goal to perform ESD is not to resect the lesion in an en bloc fashion, but to save the patient from esophageal cancer-related death. Thus, the indications should be considered based on the entire patient, not just the target lesion itself, and pre-, peri- and postoperative management of the patient is also very important, as well as technical aspects of ESD. In terms of the techniques of ESD, owing to refinement of the procedural strategy, invention of the devices, and the learning curve, acceptable safety and favorable middle-term efficacy have been obtained. We believe that ESD will become a standard treatment for early esophageal cancer not only in Japan but also worldwide in the near future. [source] From introduction to the establishment of alien species: bioclimatic differences between presence and reproduction localities in the slider turtleDIVERSITY AND DISTRIBUTIONS, Issue 1 2009Gentile Francesco Ficetola ABSTRACT Aim, Understanding the factors determining the transition from introduction of aliens to the establishment of invasive populations is a critical issue of the study of biological invasions, and has key implications for management. Differences in fitness among areas of introduction can define the zones where aliens become invasive. The American slider turtle Trachemys scripta has been introduced worldwide, and has negative effects on freshwater communities, but only a subset of introduced populations breed successfully. We used species distribution models to assess the factors influencing the slider distribution in Italy, by analysing bioclimatic features that can cause the transition from presence of feral adults to breeding populations. We also evaluated whether climate change might increase the future suitability for reproduction. Location,, Central and Northern Italy. Methods,, The distribution of slider turtle was obtained from the literature, unpublished reports and field surveys. We used Maxent to build bioclimatic models. Results,, Reproductive populations are associated to a clear bioclimatic envelope with warmer climate, more solar radiation and higher precipitations than populations where reproduction is not observed. Several Mediterranean areas currently have climatic features suitable for sliders. Scenarios of climate change predict the expansion of these areas. In the near future (2020), the proportion of populations in areas suitable for reproduction will dramatically increase. Main conclusion,, Our study shows that bioclimatic differences can determine the areas where aliens become invaders. Management should be focused to these source areas. However, climate change can increase fitness in the future, and therefore the interactions between climate change and fitness can boost the invasiveness of this alien species. [source] Alien spider introductions to Europe supported by global tradeDIVERSITY AND DISTRIBUTIONS, Issue 2 2008Manuel Kobelt ABSTRACT Global trade is permanently ongoing and increases its volume every year. In this study, the occurrence of 87 unintentionally introduced spider species alien to Europe is analysed. The analysis includes (1) the introduction potential of six different origin areas of the world according to trade volume, area size, and geographical distance; (2) the body size of native and alien species; and (3) occurrence in or at buildings (synanthropic) or in natural habitats. We found the eastern Palearctic as the most influencing origin area with 44 introduced spider species to Europe. The eastern Palearctic and the Indomalayan provided a significantly higher number of introductions than expected, whereas the Nearctic, Neotropical, and Afrotropical provided a significantly lower number of introduced species than expected. This can be explained with their lower trade volume, smaller area, larger geographical distance to Europe, and stronger climate differences to Europe. Comparing the body size of introduced and native European spider species of the same family, we found for Theridiidae significantly larger alien spiders and for all other tested families a trend to a larger body size of alien species compared to the native spiders. The family affiliation of alien spiders is the most important factor for synanthropic occurrence in Europe. On the base of a very conservative estimation of spider species introductions to Europe combined with possible effects of climate change, we predict for the near future a permanent increase in the number of alien spider species in Europe. [source] Extinction debt on oceanic islandsECOGRAPHY, Issue 2 2010Kostas A. Triantis Habitat destruction is the leading cause of species extinctions. However, there is typically a time-lag between the reduction in habitat area and the eventual disappearance of the remnant populations. These "surviving but ultimately doomed" species represent an extinction debt. Calculating the magnitude of such future extinction events has been hampered by potentially inaccurate assumptions about the slope of species,area relationships, which are habitat- and taxon-specific. We overcome this challenge by applying a method that uses the historical sequence of deforestation in the Azorean Islands, to calculate realistic and ecologically-adjusted species,area relationships. The results reveal dramatic and hitherto unrecognized levels of extinction debt, as a result of the extensive destruction of the native forest:>95%, in<600,yr. Our estimations suggest that more than half of the extant forest arthropod species, which have evolved in and are dependent on the native forest, might eventually be driven to extinction. Data on species abundances from Graciosa Island, where only a very small patch of secondary native vegetation still exists, as well as the number of species that have not been found in the last 45,yr, despite the extensive sampling effort, offer support to the predictions made. We argue that immediate action to restore and expand native forest habitat is required to avert the loss of numerous endemic species in the near future. [source] Coordinated voltage control of transformer taps with provision for hierarchical structure in power systemELECTRICAL ENGINEERING IN JAPAN, Issue 4 2009Yoshiki Nakachi Abstract Participation of distributed generators (DGs), such as wind turbines, cogeneration systems, etc., is a natural trend from an ecological point of view and will continue to increase. The outputs of these DGs mainly depend on weather conditions but do not correspond to the changes of electrical load demand necessarily. On the other hand, due to deregulation of the electric power market, the power flow in a power system will uncertainly vary with several power transactions. Thus, complex power flow by DGs or transactions will cause voltage deviation. It will be difficult to sustain the voltage quality by using conventional voltage/reactive power control in the near future. In this paper, in order to avoid such voltage deviation and to decrease the frequency of transformer tap operations, the coordinated voltage control scheme of transformer taps on account of hierarchical structure in the power system is proposed. In the proposed scheme, integral of voltage deviation at each layer bus is applied to decide the timing of each transformer tap operation. Numerical simulations confirm that the proposed scheme is able to respond to every condition on voltage deviation. © 2008 Wiley Periodicals, Inc. Electr Eng Jpn, 166(4): 48,55, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/eej.20531 [source] A practical 3D measurement system based on projection pattern control techniquesELECTRONICS & COMMUNICATIONS IN JAPAN, Issue 11 2009Genki Cho Abstract Most of the recent 3D image measurement methods have employed certain pattern projection techniques because of their higher reliabilities. Especially, the intensity-modulated technique can detect more stripe addresses by a single projection and therefore is very much expected for its practical use in the near future. The traditional techniques of this type, however, have encountered several serious problems where 3D measurements are difficult in sensitivity, speed and accuracy or fatally impossible for unknown objects. In order to solve these problems, we propose an automatic control technique of angle and space frequency of projection pattern. Furthermore, for security of measurement accuracy and measurement speed, projection pattern intensity control technique and optimal intensity-modulation projection technique are adopted in the proposal measurement system. By using the proposed technique the automatic 3D measurement intended for the geostationary objects and the swaying objects were realized in experimental results. © 2009 Wiley Periodicals, Inc. Electron Comm Jpn, 92(11): 34,41, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/ecj.10147 [source] Cover Picture: Electrophoresis 9/2008ELECTROPHORESIS, Issue 9 2008Article first published online: 28 APR 200 Regular issues provide a wide range of research and review articles covering all aspects of electrophoresis. Here you will find cutting-edge articles on methods and theory, instrumentation, nucleic acids, CE and CEC, miniaturization and microfluidics, proteomics and two-dimensional electrophoresis. The 20 papers gathered here span areas across miniaturization theory, basic technologies and applications. While not comprehensive, this special issue represents a selection of the state-of-the-art science of miniaturization and its application in various areas of life sciences. We feel to a large degree that this special issue sets a good foundation, and we are looking forward to another thought-provoking update in the near future. Issue 9 also offers one Fast Track article describing particularly important investigations in electrophoresis: "AC Electrokinetic separation and detection of DNA nanoparticles in high conductance solutions." [source] Compatible solutes of organisms that live in hot saline environmentsENVIRONMENTAL MICROBIOLOGY, Issue 9 2002Helena Santos Summary The accumulation of organic solutes is a prerequisite for osmotic adjustment of all microorganisms. Thermophilic and hyperthermophilic organisms generally accumulate very unusual compatible solutes namely, di- myo -inositol-phosphate, di-mannosyl-di- myo -inositol-phosphate, di-glycerol-phosphate, mannosylglycerate and mannosylglyceramide, which have not been identified in bacteria or archaea that grow at low and moderate temperatures. There is also a growing awareness that some of these compatible solutes may have a role in the protection of cell components against thermal denaturation. Mannosylglycerate and di-glycerol-phosphate have been shown to protect enzymes and proteins from thermal denaturation in vitro as well, or better, than compatible solutes from mesophiles. The pathways leading to the synthesis of some of these compatible solutes from thermophiles and hyperthermophiles have been elucidated. However, large numbers of questions remain unanswered. Fundamental and applied interest in compatible solutes and osmotic adjustment in these organisms, drives research that, will, in the near future, allow us to understand the role of compatible solutes in osmotic protection and thermoprotection of some of the most fascinating organisms known on Earth. [source] Smallpox Vaccination for Emergency Physicians,ACADEMIC EMERGENCY MEDICINE, Issue 6 2003AAEM/SAEM Smallpox Vaccination Working Group Abstract On December 13, 2002, President Bush formally announced the national smallpox vaccination program. The plan involves vaccinating health care workers who would respond to possible smallpox cases, including emergency physicians. Although not all aspects of the program are clearly established, it appears that vaccination of health care workers will occur in the near future. This joint statement has been used by the American Academy of Emergency Medicine and the Society for Academic Emergency Medicine regarding smallpox vaccination for emergency physicians. [source] Navigating toward Fetal and Maternal Health: The Challenge of Treating Epilepsy in PregnancyEPILEPSIA, Issue 10 2004Torbjörn Tomson Summary:, A rational approach to the treatment of women of childbearing potential with epilepsy has been hampered by the lack of conclusive data on the comparative teratogenic potential of different antiepileptic drugs (AEDs). Although, several cohort studies on birth defects associated with AED use during pregnancy have been published, these have generally failed to demonstrate differences in malformation rates between AEDs, probably mainly due to insufficient power. In particular, pregnancies with new generation AEDs have been too few. In recent years, pregnancy registries have been introduced to overcome this problem,EURAP (an international collaboration), the North American, and the U.K. AED and pregnancy registries are observational studies that prospectively assess pregnancy outcome after AED exposure using slightly different methods. Each has enlisted 3,5,000 pregnancies in women with epilepsy, and the North American and the U.K. have released preliminary observations. Thus the U.K. registry reported a higher malformation rate with valproate, 5.9% (4.3,8.2%; 95% CI), than with carbamazepine, 2.3% (1.4,3.7%), and lamotrigine, 2.1% (1.0,4.0%). Most of the more recent cohort studies have also identified a nonsignificant trend toward a higher teratogenicity with valproate. These signals need to be interpreted with some caution since none of the studies to date have fully assessed the impact of possible confounders, such as type of epilepsy, family history of birth defects, etc. However, with increasing number of pregnancies it should be possible in the near future for the pregnancy registries to take such confounding factors into account and thus make more reliable assessments of the causal relationship between exposure to specific AEDs and teratogenic risks. While awaiting more conclusive results, it appears reasonable to be cautious in prescribing valproate to women considering to become pregnant if other suitable treatment alternatives, and with less teratogenic potential, are available. Any attempt to change treatment should, however, be accomplished well before conception. The importance of maintained seizure control must also be kept in mind, and the woman who needs valproate to control her seizures should not be discouraged from pregnancy, provided that counseling at the best of available knowledge is given. [source] Toll-like receptors' two-edged sword: when immunity meets apoptosisEUROPEAN JOURNAL OF IMMUNOLOGY, Issue 12 2007Bruno Salaun Abstract Toll-like receptors (TLR) have emerged as key players in the detection of pathogens and the induction of anti-microbial immune response. TLR recognize pathogen-associated molecular patterns, and trigger anti-microbial innate immune responses ranging from the secretion of pro-inflammatory mediators to the increase of natural killer cell cytotoxicity. Besides activating the innate immune response, TLR engagement also shapes the adaptive immune response. Indeed, the broad diversity of signaling pathways initiated by TLR is progressively unraveled. Recent reports suggested that among the anti-microbial defenses they initiate, members of the TLR family can induce apoptosis. This review focuses on this newly described function of TLR, and emphasizes the similarities and differences between the different apoptosis-signaling pathways described downstream of TLR. The functional relevance of TLR-triggered apoptosis is also discussed, as therapeutic applications are likely to ensue in the near future. [source] Mycoplasma pneumoniae -associated myelitis: a comprehensive reviewEUROPEAN JOURNAL OF NEUROLOGY, Issue 2 2006S. Tsiodras Myelitis is one of the most severe central nervous system complications seen in association with Mycoplasma pneumoniae infections and both acute transverse myelitis (ATM) as well as acute disseminated encephalomyelitis (ADEM) have been observed. We reviewed all available literature on cases of Mycoplasma spp. associated ATM as well as ADEM with dominant spinal cord pathology and classified those cases according to the strength of evidence implicating M. pneumoniae as the cause. A wide range of data on diagnosis, epidemiology, immunopathogenesis, clinical picture, laboratory diagnosis, neuroimaging and treatment for this rare entity is presented. The use of highly sensitive and specific molecular diagnostic techniques may assist in clearly elucidating the role of M. pneumoniae in ATM/ADEM syndromes in the near future. Immunomodulating therapies may have a role in treating such cases. [source] A CENTENNIAL CELEBRATION FOR QUANTITATIVE GENETICSEVOLUTION, Issue 5 2007Derek A. Roff Quantitative genetics is at or is fast approaching its centennial. In this perspective I consider five current issues pertinent to the application of quantitative genetics to evolutionary theory. First, I discuss the utility of a quantitative genetic perspective in describing genetic variation at two very different levels of resolution, (1) in natural, free-ranging populations and (2) to describe variation at the level of DNA transcription. Whereas quantitative genetics can serve as a very useful descriptor of genetic variation, its greater usefulness is in predicting evolutionary change, particularly when used in the first instance (wild populations). Second, I review the contributions of Quantitative trait loci (QLT) analysis in determining the number of loci and distribution of their genetic effects, the possible importance of identifying specific genes, and the ability of the multivariate breeder's equation to predict the results of bivariate selection experiments. QLT analyses appear to indicate that genetic effects are skewed, that at least 20 loci are generally involved, with an unknown number of alleles, and that a few loci have major effects. However, epistatic effects are common, which means that such loci might not have population-wide major effects: this question waits upon (QTL) analyses conducted on more than a few inbred lines. Third, I examine the importance of research into the action of specific genes on traits. Although great progress has been made in identifying specific genes contributing to trait variation, the high level of gene interactions underlying quantitative traits makes it unlikely that in the near future we will have mechanistic models for such traits, or that these would have greater predictive power than quantitative genetic models. In the fourth section I present evidence that the results of bivariate selection experiments when selection is antagonistic to the genetic covariance are frequently not well predicted by the multivariate breeder's equation. Bivariate experiments that combine both selection and functional analyses are urgently needed. Finally, I discuss the importance of gaining more insight, both theoretical and empirical, on the evolution of the G and P matrices. [source] New developments in our understanding of acne pathogenesis and treatmentEXPERIMENTAL DERMATOLOGY, Issue 10 2009Ichiro Kurokawa Abstract:, Interest in sebaceous gland physiology and its diseases is rapidly increasing. We provide a summarized update of the current knowledge of the pathobiology of acne vulgaris and new treatment concepts that have emerged in the last 3 years (2005,2008). We have tried to answer questions arising from the exploration of sebaceous gland biology, hormonal factors, hyperkeratinization, role of bacteria, sebum, nutrition, cytokines and toll-like receptors (TLRs). Sebaceous glands play an important role as active participants in the innate immunity of the skin. They produce neuropeptides, excrete antimicrobial peptides and exhibit characteristics of stem cells. Androgens affect sebocytes and infundibular keratinocytes in a complex manner influencing cellular differentiation, proliferation, lipogenesis and comedogenesis. Retention hyperkeratosis in closed comedones and inflammatory papules is attributable to a disorder of terminal keratinocyte differentiation. Propionibacterium acnes, by acting on TLR-2, may stimulate the secretion of cytokines, such as interleukin (IL)-6 and IL-8 by follicular keratinocytes and IL-8 and -12 in macrophages, giving rise to inflammation. Certain P. acnes species may induce an immunological reaction by stimulating the production of sebocyte and keratinocyte antimicrobial peptides, which play an important role in the innate immunity of the follicle. Qualitative changes of sebum lipids induce alteration of keratinocyte differentiation and induce IL-1 secretion, contributing to the development of follicular hyperkeratosis. High glycemic load food and milk may induce increased tissue levels of 5,-dihydrotestosterone. These new aspects of acne pathogenesis lead to the considerations of possible customized therapeutic regimens. Current research is expected to lead to innovative treatments in the near future. [source] Osteopontin and the skin: multiple emerging roles in cutaneous biology and pathologyEXPERIMENTAL DERMATOLOGY, Issue 9 2009Franziska Buback Abstract:, Osteopontin (OPN) is a glycoprotein expressed by various tissues and cells. The existence of variant forms of OPN as a secreted (sOPN) and intracellular (iOPN) protein and its modification through post-translational modification and proteolytic cleavage explain its broad range of functions. There is increasing knowledge which receptors OPN isoforms can bind to and which signaling pathways are activated to mediate different OPN functions. sOPN interacts with integrins and CD44, mediates cell adhesion, migration and tumor invasion, and has T helper 1 (Th1) cytokine functions and anti-apoptotic effects. iOPN has been described to regulate macrophage migration and interferon-, secretion in plasmacytoid dendritic cells. Both sOPN and iOPN, through complex functions for different dendritic cell subsets, participate in the regulation of Th cell lineages, among them Th17 cells. For skin disease, OPN from immune cells and tumor cells is of pathophysiological relevance. OPN is secreted in autoimmune diseases such as lupus erythematosus, and influences inflammation of immediate and delayed type allergies and granuloma formation. We describe that OPN is overexpressed in psoriasis and propose a model to study OPN function in psoriatic inflammation. Through cytokine functions, OPN supports immune responses against Mycobacteria and viruses such as herpes simplex virus. OPN is also implicated in skin tumor progression. Overexpression of OPN influences invasion and metastasis of melanoma and squamous cell carcinoma cells, and OPN expression in melanoma is a possible prognostic marker. As OPN protein preparations and anti-OPN antibodies may be available in the near future, in-depth knowledge of OPN functions may open new therapeutic approaches for skin diseases. [source] Pathogenesis and therapy of cutaneous lymphomas , Progress or impasse?EXPERIMENTAL DERMATOLOGY, Issue 5 2006Reinhard Dummer Abstract:, The cutaneous environment hosts a number of hematopoietic neoplasms that are dominated by primary cutaneous (PC) T-cell lymphomas. Recent progress in molecular biology and immunology has provided tools to investigate the pathogenesis and the biology of these neoplasms. This review highlights newest findings concerning the immune biology of CD4+CD56+ hematodermic neoplasms, and PC T-cell and B-cell lymphomas, speculating how these can be translated into more sophisticated, biology-based treatment approaches in the near future. [source] A fatigue and creep study in austenitic stainless steel 316L used in exhaust pipes of naval gas turbinesFATIGUE & FRACTURE OF ENGINEERING MATERIALS AND STRUCTURES, Issue 9 2004R. F. MARTINS ABSTRACT Exhaust pipes of naval gas turbines are made of thin wall tubing of stainless steel grade AISI 316L. The tubes are fabricated by butt welding of different sections with longitudinal and circumferential joints. The plate thickness is about 4.0 mm, and the working temperature varies between 600 °C and 400 °C in the critical zones of the pipe, in the lower and central areas, respectively. The loadings in the tube induce high-temperature fatigue and creep-fatigue cracks have nucleated and propagated in the tube near some welded joints. The paper presents FCGR data obtained in CT specimens of used material taken from the pipes and tested at RT, 335, 500 and 600 °C. Preliminary creep data obtained in tension, in thin-sheet specimens (about 4 mm thickness), also taken from the conduct wall and tested at 500, 550 and 600 °C are also given. These results are crucial to perform a fatigue-creep interaction life assessment of the critical parts of the structure in the near future. Finally, the paper presents results of research work to investigate carbide precipitation and formation in virgin thin-sheet specimens subjected to several types of thermal exposures. In some cases, 3,4 d was the time interval between exposures. Grain size measurements were carried out together with microstructural observations in the SEM. The influence of time, temperature and time interval between thermal exposures was assessed comparing the microstructures. [source] Chenopodium probstii and Chenopodium missouriense: two North American plant species in the Czech Republic, Slovak Republic and neighbouring countriesFEDDES REPERTORIUM, Issue 5-6 2004J. Dostálek Ing. This paper presents the results of a floristic-taxonomic survey of two North American invasive species, Chenopodium probstiiAellen and Ch. missourienseAellen, in the Czech Republic, Slovak Republic and neighbouring countries. It is based mainly on the results of a re-analysis of the authors' herbarium material collected from 1957 to 2003, deposited mainly in the PRA Herbarium (herbarium of the Institute of Botany of the Academy of Sciences of the Czech Republic in Pr,honice near Prague). Also, the chorology and ecology of both species in Czechian and Slovakian are discussed. In addition, a summary of data on the occurrence of both species throughout their distribution is presented, with emphasis on European records. On the basis of this analysis, the hypothetical origin of Ch. probstii in North America is confirmed. First-time records of this species are presented for Egypt, North Korea, Poland, Slovenia, Croatia and Romania. The second species, Ch. missouriense, is reported for the first time from Slovakia and Austria. Sources of further dissemination of both species in their secondary European area of distribution are described. In Europe, both these invasive species are in the pro- cess of naturalisation (ephemerophyte , epoecophyte), approximately in the resting-phase lag; significant range expansion can be expected in the near future, especially for Ch. probstii. Chenopodium probstii und Chenopodium missouriense, zwei nordamerikanische Arten in der Tschechischen Republik, der Slowakischen Republik und benachbarten Ländern Diese Arbeit präsentiert Ergebnisse einer floristisch-taxonomischen Untersuchung von zwei nordamerikanischen Invasionsarten, und zwar Chenopodium probstiiAellen und Ch. missourienseAellen in der Tschechischen Republik, in der Slowakischen Republik und in benachbarten Ländern. Sie stützt sich vorwiegend auf Resultate des eigenen Herbarmaterials der Jahre 1957,2003, das vorwiegend im Herbarium PRA (= Herbarsammlung des Botanischen Instituts der Akademie der Wissenschaften der Tschechischen Republik in Pr,honice bei Praha) deponiert ist. Auch wurden Chorologie und Ökologie beider Arten in Tschechien und in der Slowakei analysiert. Gleichzeitig wurden die Angaben über das Vorkommen beider Arten im gesamten Areal unter besonderer Berücksichtigung der Geschichte ihrer Ausbreitung im sekundären Teil ihrer Areale, vor allem in Europa zusammengefasst. Durch diese Analyse wurde der Ursprung von Ch. probstii in Nordamerika bestätigt. Chenopodium probstii wurde als neue adventive Art auch in Ägypten und Nordkorea, in Europa zum ersten Mal in Polen, Slowenien, Kroatien und Rumänien beobachtet. Eine weitere Art, Ch. missouriense, wurde zum ersten Mal in der Slowakei und in Österreich erwähnt. Diasporenquellen beider Arten im sekundären europäischen Areal werden ebenfalls angeführt. In Europa sind beide invasive Arten im Prozess der Einbürgerung (Ephemerophyt , Epoökophyt), die vermutlich in der Ruhephase abläuft. Eine expansive Ausbreitung können wir in der nächsten Zeit vor allem von Ch. probstii erwarten. Bisher gehören beide Arten zu den potentiellen Unkräutern. [source] Type III secretion: The bacteria-eukaryotic cell expressFEMS MICROBIOLOGY LETTERS, Issue 1 2005Luís Jaime Mota Abstract Type III secretion (T3S) is an export pathway used by Gram-negative pathogenic bacteria to inject bacterial proteins into the cytosol of eukaryotic host cells. This pathway is characterized by (i) a secretion nanomachine related to the bacterial flagellum, but usually topped by a stiff needle-like structure; (ii) the assembly in the eukaryotic cell membrane of a translocation pore formed by T3S substrates; (iii) a non-cleavable N-terminal secretion signal; (iv) T3S chaperones, assisting the secretion of some substrates; (v) a control mechanism ensuring protein delivery at the right place and time. Here, we review these different aspects focusing in open questions that promise exciting findings in the near future. [source] RECENT AND FUTURE MANAGEMENT CHANGES IN LOCAL GOVERNMENT: CONTINUING FOCUS ON RATIONALITY AND EFFICIENCY?FINANCIAL ACCOUNTABILITY & MANAGEMENT, Issue 1 2008Henk J. Ter Bogt Dutch municipalities and provinces have recently introduced many changes relating to management control. This paper explores the role of economic and social rationality in the introduction of reforms, and the nature of possible future reforms. Based on interviews with politicians and professional managers and on documents, the paper examines experiences with recent management changes. In addition, it discusses ,change initiating factors'. Budget cuts and trends seem to be such change initiating factors. However, particularly more demanding citizens, increases in voters' volatility and politicians' uncertainty seemed to initiate changes. The paper speculates that in the near future, too, it could be a rational survival strategy for politicians and managers to focus on initiatives that are intended to enhance performance and efficiency. [source] A new approach to prioritizing marine fish and shellfish populations for conservationFISH AND FISHERIES, Issue 4 2001Einar Eg Nielsen Abstract There has been increasing awareness of the vulnerability of marine organisms to population extirpation and species extinction. While very few documented cases of species extinction exist in the marine environment, it is anticipated that managers will face the dilemma of prioritizing populations of marine fish and shellfish for protection in the near future. Current prioritization procedures have been developed from salmonid models with the intent of applying them to all marine organisms, and in some cases to freshwater and terrestrial taxa. In this review we provide evidence for the relevance of such a process for marine species and further suggest five broad categories of marine organisms that have distinctive traits influencing their genetic structure. The current prioritization models have been adapted to account for each of these species groups. Emphasis is placed on ,Classical Marine Species' which represent the opposite end of the continuum from the salmon model, displaying high within-population genetic variance. From this category, three cod (Gadus morhua) stocks were selected to evaluate a revised scheme developed specifically for ,Classical Marine Species' that includes performance measures such as (i) reduction in number of spawning populations; (ii) reduction of Ne : Nc (ratio of effective to census population size); (iii) changes in life-history traits; (iv) critical density for spawning success; and (v) patchy vs. continuous distribution pattern. When the salmonid scheme was applied, the cod examples were allocated low values, indicating that they were not under threat. However, when the revised scheme was applied, all three cod stocks were allocated high values, indicating that the revised scheme was more reflective of the particular life-history traits of this category of organisms. [source] Shire: a specialty global biopharmaceutical companyFUTURE PRESCRIBER, Issue 3 2009Article first published online: 13 AUG 200 This series of company profiles looks at some of the major players in the UK pharmaceutical industry, their current areas of expertise, and forthcoming products and initiatives that will have an impact on therapeutics and prescribing in the near future. In this article we provide an overview of Shire and its current portfolio, and look at its current pipeline and areas of research interest. Copyright © 2009 John Wiley & Sons, Ltd. [source] | |||||||||||||||||||||||||||||||||||||