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Nasal NO Output (nasal + no_output)

Distribution by Scientific Domains

Medical Sciences	100%

Selected Abstracts

Hypoxia Depresses Nitric Oxide Output in the Human Nasal Airways

THE LARYNGOSCOPE, Issue 3 2000
James S. J. Haight MD
Abstract Objectives The role of oxygen in the nasal air on nasal nitric oxide (NO) output was studied in 13 adult volunteers. Methods Nasal NO was measured while air containing oxygen (0%,100% in nitrogen) was aspirated through the nasal airway before and after the topical application of xylometazoline. Results The mean nasal NO output of the untreated nose was 507.8 ± 161.9 nL/min (mean ± SD) when 21% oxygen was aspirated through the nasal cavities in series and remained unaltered by 100% O2 (P = .79). Below 10% oxygen the reduction in nasal NO output correlated positively and significantly with the decrease in oxygen concentration (r2 = 0.14). NO output was 245.2 ± 153.4 nL/min at 0% oxygen, a significant decline from 21% oxygen (P < .0001). Nasal vasoconstriction induced by xylometazoline and alterations in the blood oxygen content by a maximal breath-holding or breathing 100% oxygen did not alter nasal NO in hypoxia (P = .41). Conclusions Nasal NO output is markedly depressed in hypoxia and is oxygen dependent at concentrations of less than 10%. Approximately 50% of nasally generated NO is produced from oxygen in nasal air or regulated by it. [source]

Nasal nitric oxide measurements before and after repeated humming maneuvers

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Issue 12 2003
M. Maniscalco
Abstract Background, It has been recently shown that humming greatly increases nasal nitric oxide (NO). This is most likely owing to a rapid washout of sinus NO caused by the oscillating sound waves. During repeated humming manoeuvres nasal NO gradually decreases, likely because NO accumulated in the sinuses is washed out. Aim, We studied whether humming before measurements would affect nasally exhaled NO. Materials and methods, NO output was measured by the chemiluminescence technique in orally and nasally exhaled air in 38 subjects: 18 healthy subjects (HS), 15 subjects with allergic rhinitis (AR) and five subjects with allergic nasal polyposis (AP). Each subject performed a NO measurement during quiet nasal exhalation either preceded by a period of silence/free speaking or immediately after five consecutive humming manoeuvres (posthumming). Results, Mean nasal NO output (95% CI) after a period of silence/free speaking was 231 nL min,1 (178,284) in HS, 434 nL min,1 (347,522) in AR (P < 0·001) and 262 nL min,1 (163,361) in AP. Post-humming nasal NO output was 16% (5 to 50%) lower in HS and 14% (1 to 49%) lower in AR, while it remained unchanged in AP subjects. Intra-subject coefficient of variation of quiet nasal exhalation was 12% in HS, 13% in AR and 5% in AP. Post humming intraindividual coefficient of variation significantly decreased in both HS and AR, but it did not change in AP. Conclusions, Nasal NO levels measured immediately after repeated humming manoeuvres are consistently lower and more reproducible than nasal NO levels measured after a period of silence or free speaking. Repeated humming effectively empties the sinuses, thereby probably minimizing the normal contribution from the sinuses to nasal NO. This may be useful to better estimate NO output from the nasal cavity mucosa in health and disease. [source]

Nasal Nitric Oxide in Children: A Novel Measurement Technique and Normal Values,,

THE LARYNGOSCOPE, Issue 10 2002
Hamid Daya FRCS (ORL)
Abstract Objectives To develop and standardize a technique for measuring nasal nitric oxide (NO) output in children and to determine normal values in this population. Study Design Prospective study evaluating a new technique for measuring nasal nitric oxide in a cohort of normal patients and a cohort of patients with nasal disease. Methods Nasal NO was measured using an aspiration technique, aspirating room air through the nasal cavities by means of a Teflon nozzle placed in one nasal vestibule while maintaining velopharyngeal closure using a party "blow-out" toy Results Nasal NO measurements were performed in 45 children (mean age, 11.0 y; age range, 3.2,17.6 y) There were 20 girls and 25 boys. All children were able to perform the maneuvers necessary for measurement of nasal NO output. Among the subgroup of normal healthy children (30), there was considerable variation in NO output between subjects, with a mean NO output of 481 nL/min and an SD of 283 nL/min. Conclusions Nasal NO can be readily measured in children using the presented technique. There is considerable variability in the values for nasal NO output in normal children. [source]