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Nanofiber Scaffold (nanofiber + scaffold)

Distribution by Scientific Domains
Polymers and Materials Science100%

Selected Abstracts

Self-Organization of a Chiral D -EAK16 Designer Peptide into a 3D Nanofiber Scaffold

MACROMOLECULAR BIOSCIENCE, Issue 8 2008
Zhongli Luo
Abstract Self-assembling peptide nanofiber scaffolds are an excellent material for applications such as tissue repair, tissue regeneration, instant stopping of bleeding, and slow drug release. We report a new self-assembling peptide D -EAK16 consisting purely of D -amino acids. D -EAK16 and L -EAK16 display mirror-image CD spectra at 20,°C. Like L -EAK16, D -EAK16 self-assembles into nanofibers, thus demonstrating that chiral self-assembling peptide nanofiber scaffolds can be made from both L - and D -amino acids. We also show that D -peptide nanofibers are resistant to natural proteases and may thus be useful in biotechnology, nanobiotechnology, tissue repair and tissue regeneration as well as other medical applications. [source]

Electrospinning of Collagen Nanofiber Scaffolds from Benign Solvents

MACROMOLECULAR RAPID COMMUNICATIONS, Issue 7 2009
Bin Dong
Abstract Nanofiber scaffolds of collagen have been fabricated via electrospinning using benign solvent systems as a replacement for 1,1,1,3,3,3 hexafluoro-2-propanol. Simple binary mixtures of phosphate-buffered saline and ethanol have been found to be highly effective for electrospinning. FTIR spectra suggest that the triple helical structure of collagen was conserved after dissolution and electrospinning. Crosslinking of the electrospun collagen scaffolds was achieved with standard methods. [source]

Self-Organization of a Chiral D -EAK16 Designer Peptide into a 3D Nanofiber Scaffold

MACROMOLECULAR BIOSCIENCE, Issue 8 2008
Zhongli Luo
Abstract Self-assembling peptide nanofiber scaffolds are an excellent material for applications such as tissue repair, tissue regeneration, instant stopping of bleeding, and slow drug release. We report a new self-assembling peptide D -EAK16 consisting purely of D -amino acids. D -EAK16 and L -EAK16 display mirror-image CD spectra at 20,°C. Like L -EAK16, D -EAK16 self-assembles into nanofibers, thus demonstrating that chiral self-assembling peptide nanofiber scaffolds can be made from both L - and D -amino acids. We also show that D -peptide nanofibers are resistant to natural proteases and may thus be useful in biotechnology, nanobiotechnology, tissue repair and tissue regeneration as well as other medical applications. [source]