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Multiple Strategies (multiple + strategy)
Selected AbstractsHow to identify patients with vulnerable plaquesDIABETES OBESITY & METABOLISM, Issue 10 2008Salim S. Virani Multiple strategies are available for clinicians to identify patients at high risk for cardiovascular events. Two commonly discussed strategies are the identification of vulnerable plaques and the identification of vulnerable patients. The strategy of identifying vulnerable patients is less invasive, easy to implement and not restricted primarily to one vascular bed (e.g. coronary or cerebral). This review discusses the utility as well as the limitations of global risk assessment tools to identify such patients. The utility of biomarkers [C-reactive protein, lipoprotein-associated phospholipase A2 and lipoprotein(a)] and non-invasive measures of atherosclerosis burden (coronary artery calcium scores, carotid intima,media thickness and ankle,brachial index) in identifying patients at high risk for cardiovascular events are also discussed. [source] Multiple strategies for O2 transport: from simplicity to complexityIUBMB LIFE, Issue 8-9 2007Paolo Ascenzi Abstract O2carriers (extracellular and intracellular as well as monomeric and multimeric) have evolved over the last billion of years, displaying iron and copper reactive centers; very different O2carriers may co-exist in the same organism. Circulating O2carriers, faced to the external environment, are responsible for maintaining an adequate delivery of O2to tissues and organs almost independently of the environmental O2partial pressure. Then, intracellular globins facilitate O2transfer to mitochondria sustaining cellular respiration. Here, molecular aspects of multiple strategies evolved for O2transport and delivery are examined, from the simplest myoglobin to the most complex giant O2carriers and the red blood cell, mostly focusing on the aspects which have been mainly addressed by the so called 'Rome Group'. [source] Predicting vascular access failure: A collective reviewNEPHROLOGY, Issue 4 2002Kevan R POLKINGHORNE SUMMARY: The maintenance of vascular access for haemodialysis contributes a large burden of morbidity and cost to any dialysis unit. Identifying vascular access at risk of thrombosis is an evolving and important aspect to the management of any haemodialysis patient. Haemodynamic profiles of native fistulas and arteriovenous grafts differ significantly, and, as such, the sensitivity of the specific monitoring techniques to detect dysfunction varies depending on access type. Multiple strategies are now available for monitoring vascular access including measuring intra-access pressure and access blood flow, or screening for significant stenoses with Doppler ultrasonography. the ability of each strategy to detect significant stenosis is reviewed by looking at the evidence for both arteriovenous fistula (AVF) and arteriovenous grafts (AVG), separately. the majority of published literature involves AVG, and measuring access blood flow is the modality of choice. the best method for measuring flow is not known. For AVF, much less is known, and it is not clear whether monitoring will decrease the thrombosis risk and prolong access life. Recommendations for AVF cannot be made until more evidence becomes available. [source] Experience of Middle- and Old-Aged Women's AgingNURSING & HEALTH SCIENCES, Issue 3 2002Seung Eun Chung Many studies on aging have explored the effects of disease and other problems on the elderly. These studies have resulted in a view of aging that focuses on losses. How aging is perceived may affect the adaptation of the elderly to life changes. Therefore, there needs to be a better understanding of aging from the perspective of the middle-aged and older-aged adults. This qualitative study used a hermeneutic phenomenological approach to discover meaning in the aging experience. The purpose of this study was to explore the experience of middle-aged and older-aged women. Participants consisted of 10 women (five middle-aged women and five older-aged women) aged 40 years or more who lived in Chongiu. Multiple strategies for data collecting were utilized including an in-depth face-to-face interview and an analysis of the literature on aging, based on Van Manen's methodology of phenomenological research. The following themes emerged: (i) middle-aged women: changing of physical shape, the attachment of youth, loss of self-confidence, and preparing for one's own old age; (ii) old-aged women: changing of physical function, being ousted from the younger generation, rhythmical pattern of life and death, and reflection on life. [source] Successful Organ Transplantation from Donors Poisoned with a Carbamate InsecticideAMERICAN JOURNAL OF TRANSPLANTATION, Issue 6 2010J. H. Garcia Currently, liver transplantation is the only option for patients with end-stage liver disease. In Brazil, the mortality rate on the waiting list is about 25%. Multiple strategies to expand the donor pool are being pursed, however, grafts from poisoned donors are rarely used. This report documents successful liver, kidney and heart transplantations from four female donors who suffered brain death by hypoxia despite cardiopulmonary resuscitation following Aldicarb exposure ([2-methyl-2-(methylthio)propionaldehyde O-(methylcarbamoyl)-oxime]). The success rate of 12 grafts from four donors poisoned by Aldicarb was 91% 6 months after transplantation. Poisoned patients are another pool of organ donors who at present are probably underused by transplantation services. More studies are necessary to confirm the safety for the recipients. [source] Neural system interactions underlying human transitive inferenceHIPPOCAMPUS, Issue 8 2010Sandra N. Moses Abstract Human problem solving relies on multiple strategies supported by dynamic neural network interactions. The transitive inference (TI) problem solving task can be accomplished by the extraction of relations among stimuli or by responding to reinforcement histories of items using associative learning. Relational and associative strategies are assumed to rely on the hippocampus and caudate nucleus, respectively; which compete to control behavior. However, we found that increased recruitment of both systems in TI is correlated with greater accuracy and awareness, and reduced associative responding to single items. Contrary to prior assumptions, the hippocampus and caudate interact cooperatively to facilitate successful TI. We suggest that the dynamics of the relationship between the hippocampus and caudate depends critically upon task demands. © 2010 Wiley-Liss, Inc. [source] Multiple strategies for O2 transport: from simplicity to complexityIUBMB LIFE, Issue 8-9 2007Paolo Ascenzi Abstract O2carriers (extracellular and intracellular as well as monomeric and multimeric) have evolved over the last billion of years, displaying iron and copper reactive centers; very different O2carriers may co-exist in the same organism. Circulating O2carriers, faced to the external environment, are responsible for maintaining an adequate delivery of O2to tissues and organs almost independently of the environmental O2partial pressure. Then, intracellular globins facilitate O2transfer to mitochondria sustaining cellular respiration. Here, molecular aspects of multiple strategies evolved for O2transport and delivery are examined, from the simplest myoglobin to the most complex giant O2carriers and the red blood cell, mostly focusing on the aspects which have been mainly addressed by the so called 'Rome Group'. [source] Cell therapies: realizing the potential of this new dimension to medical therapeuticsJOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, Issue 6 2008Pawanbir Singh Abstract Stem cells promise to treat conditions poorly served by conventional therapeutics. Cells from both embryonic and somatic tissues are being used to create cell therapies for genetic, traumatic and degenerative conditions. The current human, healthcare and fiscal costs of these conditions are significant. This review summarizes the use of stem cells for neurological and cardiac disorders and diabetes to determine the requirements for generic translational research to assist such therapies to be a reality. While there are multiple strategies in each disease area, with no clear favourite, there are clear opportunities in treatments that use a single cell type. A key requirement is to work with pluripotent progenitor cells to cultivate and differentiate a sufficiently large population of functioning cells. Challenges also arise in determining and achieving timely delivery of the correct dose of cells to where they can most effectively treat the disease and best benefit individual patients. Copyright © 2008 John Wiley & Sons, Ltd. [source] Symbiont-mediated changes in Lolium arundinaceum inducible defenses: evidence from changes in gene expression and leaf compositionNEW PHYTOLOGIST, Issue 3 2007Terrence J. Sullivan Summary ,,Plants have multiple strategies to deal with herbivory, ranging from chemical or physical defenses to tolerating damage and allocating resources for regrowth. Grasses usually tolerate herbivory, but for some cool-season grasses, their strategy may depend upon their interactions with intracellular symbionts. Neotyphodium endophytes are common symbionts in pooid grasses, and, for some host species, they provide chemical defenses against both vertebrate and invertebrate herbivores. ,,Here, it was tested whether defenses provided by Neotyphodium coenophialum in Lolium arundinaceum (tall fescue) are inducible by both mechanical damage and herbivory from an invertebrate herbivore, Spodoptera frugiperda (fall armyworm), via a bioassay and by quantifying mRNA expression for lolC, a gene required for loline biosysnthesis. ,,Both mechanical and herbivore damage had a negative effect on the reproduction of a subsequent herbivore, Rhopalosiphum padi (bird cherry-oat aphid), and herbivore damage caused an up-regulation of lolC. Uninfected grass hosts also had significantly higher foliar N% and lower C : N ratio compared with infected hosts, suggesting greater allocation to growth rather than defense. ,,For L. arundinaceum, N. coenophialum appears to switch its host's defensive strategy from tolerance via compensation to resistance. [source] Strategies and tactics in NGO,government relationsNONPROFIT MANAGEMENT & LEADERSHIP, Issue 1 2010Insights from slum housing in Mumbai Relationships between nongovernmental organizations (NGOs) and government agencies have been variously described in the nonprofit literature as cooperative, complementary, adversarial, confrontational, or even co-optive. But how do NGO,government relationships emerge in practice, and is it possible for NGOs to manage multiple strategies of interaction at once? This article examines the experience of three leading NGOs in Mumbai, India, involved in slum and squatter housing. We investigate how they began relating with government agencies during their formative years and the factors that shaped their interactions. We find that NGOs with similar goals end up using very different strategies and tactics to advance their housing agendas. More significant, we observe that NGOs are likely to employ multiple strategies and tactics in their interactions with government. Finally, we find that an analysis of strategies and tactics can be a helpful vehicle for clarifying an organization's theory of change. [source] Do alternate escape tactics provide a means of compensation for impaired performance ability?BIOLOGICAL JOURNAL OF THE LINNEAN SOCIETY, Issue 2 2010KIMBERLY A. MILLER Whole-animal performance abilities can facilitate the avoidance of predation and consequently influence fitness, but determining the functional significance of antipredation tactics is difficult without understanding how alternate predator escape strategies are related. We measured maximal sprint speed and dive duration in the semi-aquatic skink Oligosoma suteri to determine how morphology and behaviour influence these alternate predator escape techniques and the relationship between the two measures. Gravid females and juveniles ran significantly slower, but had equivalent or longer dive durations than males and nongravid females. The two performance measures were not influenced by the same morphological and behavioural traits, and were not correlated among individuals. Thus, individuals that are poor sprinters because of their state (e.g. gravid or tail-less individuals) would have a greater likelihood of successful escape by adopting an alternate escape strategy. For species that use multiple strategies for the same function, quantifying selection on whole-animal performance will be difficult. © 2010 The Linnean Society of London, Biological Journal of the Linnean Society, 2010, 99, 241,249. [source] | |||||||||||||